Anti-Aging Activities of Asparagus Gel Ethanol Extract in Cosmetic Gel Agent for Facial Skin
Abstract
Asparagus is a vegetable that contains phenolic compounds with antioxidant properties that scavenges aging-triggering free radicals. This study aimed to investigate the components and anti-aging potentials of Ethanol Extract form Asparagus (EEA). The study was performed in February 2020 at the Pharmacy Laboratory, University of North Sumatera. The EEA was obtained through maceration using 96% ethanol. An antioxidant assay was performed and the total phenol and flavodoid content were determined using the spectroscopic method. Three gel formulas with different concentrations of EEA was prepared (F1: 1.5%, F2: 2.5%, and F3: 3.5%), and F0 was used as control. The parameters evaluated were moisture, oil content, texture, collagen, wrinkle, pigment, sensitivity, and pore. The result showed that asparagus had a moderate antioxidant activity (IC50: 118,992) with the total phenol and flavonoid contents of 15,9407 mg GAE/g and 3,2286 mg QE/g extract, respectively. The highest aging activities was seen in F3 (3.5%), followed by F2 (2.5%) and F1 (1.5%). The percentage of moisture, oil, texture, collagen, wrinkle, spot, sensitivity, and pore recovery were found to be 40.15%, 49.73%, 71.76%, 17.70%, 70.93%, 49.34%, 42.56% and 25.31%, respectively. Hence, it can be concluded that the EEA Gel at the highest concentration (3.5%) has a high content of phenol and flavonoid which can improve the skin moisture, oil content, texture, collagen, wrinkles, spots, sensitivity, and pores, which promotes anti-aging activities.
Keywords
Full Text:
PDFReferences
Sumantri IB, Wahyuni HS, Mustanti LF. Total phenolic, total flavonoid and phytochemical screening by FTIR spectroscopic of standardized extract of Mikania micrantha leaf. Pharmacogn J. 2020;12(6):1395–401.
Putra B, Waluyo S. The Book Of Anti Aging Rahasia Awet Muda Mind, Body, Spirit. PT Elex Media Komputindo; 2010.
Mondal SC, Singh P, Kumar B, Singh SK, Gupta SK, Verma A. Ageing and potential anti-aging phytochemicals: an overview. World J Pharm Pharm Sci. 2015;4(1):426–54.
Singh DB, Ahmed N, Singh SR, Mir KA, Lal S. Variation in chlorophyll and carotenoid contents in kale (Brassica oleracea) as influenced by cultivars and harvesting dates. Indian J Agric Sci. 2014;84(10):1178–81.
Ardhie A. Radikal bebas dan peran antioksidan dalam mencegah penuaan. Medicinus Anti Aging. Sci J Pharm Dev Med Appl. 2011;24(1):4–9.
Styawan W, Linda R, Mukarlina. Pemanfaatan tumbuhan sebagai bahan kosmetik oleh suku melayu di Kecamatan Sungai Pinyuh Kabupaten Mempawah. J Protobiont. 2016;5(2):45–52.
Rathod HJ, Mehta DP. A Review on Pharmaceutical Gel. Int J Pharm Sci. 2015;1(1):33–47.
Ginting E, Utomo JS, Yulifianti R. Potensi ubi jalar ungu sebagai pangan fungsional. Iptek Tanam Pangan. 2015;6(1):116–38.
Mutia MS, Chiuman L. Hepatoprotective effect of citrus sinensis (L.) osbeck ethanol extract in paracetamol-induced rats efek hepatoprotektif ekstrak etanol citrus sinensis l. osbeck pada tikus yang diinduksi parasetamol. MKB. 2019;51(4):189–93. https://doi.org/10.15395/mkb.v51n4.1794
Widowati W, Ratnawati H, Retnaningsih C, Lindayani, Rusdi UD, Winarno W. Free radical scavenging and α-glucosidase inhibitor activity of ethanolic extract of mucuna pruriens L. JFI. 2011;5(3):117–24.
Juanda D, Budiana W, Ridwan IM. Penetapan kadar total fenol dan aktivitas antioksidan dari jus buah lima spesies jeruk. Jurnal Farmasi Galenika. 2015;2(1):36–42.
Azizah DN, Kumolowati E, Faramayuda F. Penetapan kadar flavonoid metode AlCl3 pada ekstrak metanol kulit buah kakao (Theobroma cacao L.). Kartika J Ilm Farm. 2014;2(2):45–9.
Ardana M, Aeyni V, Ibrahim A. Formulasi dan optimasi basis gel HPMC (Hidroxy Propyl Methyl Cellulose) dengan berbagai variasi konsentrasi. J Trop Pharm Chem. 2015;3(2):101–8.
Khan HMS, Akhtar N, Rasool F, Khan BA, Mahmood T, Khan MS. In vivo evaluation of stable cream containing flavonoids on hydration and TEWL of human skin. World Academy Science Engineering Technology. 2010;47:896–9.
Zalukhu ML, Phyma AR, Pinzon RT. Proses menua, stres oksidatif , dan peran antioksidan. Cermin Dunia Kedokt. 2016;43(10):733–6.
Roya K, Fatemeh G. Screening of total phenol and flavonoid content, antioxidant and antibacterial activities of the methanolic extracts of three Silene species from Iran. Intl J Agri Crop Sci. 2013;5(3):305–12.
NSS Ambarwati, T Supiani, L Jubaedah. Pengaruh masker nanas untuk untuk mengurangi kadar minyak pada kulit wajah berminyak. Jurnal Tata Rias. 2012;1(1).
Choi DS, Kim S, Lim YM, Gwon HJ, Park JS, Nho YC, et al. Hydrogel incorporated with chestnut honey accelerates wound healing and promotes early HO-1 protein expression in diabetic (db/db) mice. Tissue Eng Regen Med. 2012;9(1):36–42.
Charissa M, Joshita D, Elya B. Uji Aktivitas antioksidan dan penghambatan tirosinase serta uji manfaat gel ekstrak kulit batang taya (Nauclea subdita) terhadap Kulit. J Kefarmasian Indones. 2017;6(2):98–107.
Noormindhawati L. Jurus ampuh melawan penuaan dini. Jakarta: Elex Media Komputindo; 2013.
DOI: https://doi.org/10.15395/mkb.v53n3.2314
Article Metrics
Abstract view : 819 timesPDF - 652 times
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
MKB is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License
View My Stats