Correlation between Serum Mid-Regional Pro-Adrenomedullin and Sequential Organ Failure Assessment (SOFA) Score in Patient with Sepsis
Abstract
Most sepsis will develop into multi organ failure (MOF). To assess manifestation of MOF, SOFA score that includes several laboratory parameters for each organ is used. However, this requires time and is also costly. Recently, Mid-Regional Pro-Adrenomedullin (MR proADM) biomarkers are stated to be an alternative marker of MOF in sepsis because MR proADM is secreted by endothelials that may increase in sepsis or bacterial infection. The aim of this study was to analyze the correlation between serum MR proADM levels and SOFA score. This was a cross-sectional observational analytical study conducted in Dr. Hasan Sadikin General Hospital (RSHS) Bandung from August 2017 to July 2018. This study was a part of the bigger sepsis biomarker study. Samples used in this study consisted of 50 stored serum from the Sepsis Biomarker study in which the MR proADM was measured. Analysis using Spearman’s correlation test showed a moderate positive correlation between serum MR proADM level and SOFA score (r = 0,582, p=0.000), showing that MR proADM serum was directly proportional to SOFA score. It is concluded that MR proADM can be considered as one of the biomarkers for multi organ failure.
Korelasi Kadar Mid Regional ProAdrenomedullin Serum dengan Skor Sequential Organ Failure Assessment (SOFA) pada Penderita Sepsis
Sebagian besar sepsis akan berlanjut menjadi multi organ failure (MOF). Untuk mengetahui MOF digunakan skor SOFA yang memerlukan beberapa parameter laboratorium untuk tiap-tiap organ dan membutuhkan waktu dengan biaya yang mahal. Saat ini diketahui biomarker Mid Regional proAdrenomedullin (MR proADM) dapat digunakan sebagai biomarker MOF pada sepsis karena MR proADM disekresi oleh endotel yang akan meningkat pada keadaan sepsis atau infeksi bakteri. Tujuan penelitian ini mengetahui korelasi kadar MR proADM serum dengan skor SOFA. Penelitian ini bersifat observasional analitik dengan rancangan potong lintang dilaksanakan di RSUP Dr. Hasan Sadikin (RSHS) Bandung pada bulan Agustus 2017 sampai Juli 2018. Penelitian ini bagian dari payung penelitian “Biomarker pada sepsis”. Bahan pemeriksaan berupa bahan biologis tersimpan sebanyak 50 sampel dan dilakukan pemeriksaan MR proADM. Hasil analisis menggunakan Spearman’s correlation test menunjukkan korelasi positif sedang antara kadar MR proADM serum dan skor SOFA (r=0,582; p=0,000). Hal ini menunjukkan semakin tinggi kadar MR proADM serum maka semakin tinggi skor SOFA. Simpulan, terdapat korelasi positif sedang dan bermakna antara MR proADM dengan skor SOFA, sehingga MR proADM dapat dipertimbangkan sebagai salah satu biomarker pada multi organ failure.
Keywords
Full Text:
PDFReferences
Singer M, Deutschman CS, Seymour CW, Shankar-Hari M, Annane D, Bauer M, et al. The Third international consensus definitions for sepsis and septic shock (Sepsis-3). JAMA. 2016;315(8):801–10.
Paricahua LI, Goncalves AFO, Pacheco SOdS, Pacheco FJ. Sepsis mortality in critical care and prior statin therapy: a retrospective cohort study in Central Argentina. J Clin Diagn Res. 2017;11(6):17–21.
Antonelli M, DeBacker D, Dorman T, Kleinpell R, Levy M, Rhodes A. Surviving sepsis campaign. [cited 2018 March 30] Available from: www.sccmorg/sepsisredefined.
Andaluz-Ojeda D, Nguyen HB, Meunier-Beillard N, Cicuéndez R, Quenot JP, Calvo D, et al. Superior accuracy of mid-regional proadrenomedullin for mortality prediction in sepsis with varying levels of illness severity. Ann Intensive Care. 2017;7(15):1–10.
Blom J, Giove TJ, Pong WW, Blute TA, Eldred WD. Evidence for a functional adrenomedullin signaling pathway in the mouse retina. Mol Vis. 2012;18:1339–53.
Kurniati I. Korelasi antara 25 Hydroxy vitamin d serum dengan skor sequential organ failure assesment (SOFA) pada penderita sepsis. [dissertation] Bandung: Universitas Padjadjaran; 2017.
Gurasim MH. Korelasi antara kadar soluble urokinase plasminogen activator receptor (suPAR) serum dengan disfungsi organ berdasarkan skor sequential organ failure assesment (SOFA) pada penderita sepsis. [dissertation] Bandung: Universitas Padjadjaran; 2017.
Frissyerly. Validitas pemeriksaan kadar soluble trigerring receptor expressed on myeloid cell-1 (sTREM-1) terhadap skor sequential organ failure assesment (SOFA) sebagai penanda diagnosis sepsis. Bandung: Universitas Padjadjaran; 2017.
Dwiyani S. Korelasi antara kadar presepsin dengan skor sequential organ failure assesment (SOFA) sebagai penanda disfungsi organ pada penderita sepsis. Bandung: Universitas Padjadjaran; 2017.
Dahlan MS. Statistik untuk kedokteran dan kesehatan. Edisi ke-6. Jakarta: Salemba Medika; 2014. p. 223–44.
Feidhmeannach na Seirbhise Slainte Health Service Executive. National Sepsis Report 2016. [cited 2018 June 3rd]. Available from: https://wwwhseie/eng/services/publications/clinical-strategy-and-programmes/national-sepsis-report-2016pdf. 2017.
Martín S, Pérez A, Aldecoa C. Sepsis and immunosenescence in the Elderly Patient: a review. Front Med (Lausanne). 2017;4(20): 1–10.
Gille J, Ostermann H, Dragu A, Sablotzki A. MR-proADM: a new biomarker for early diagnosis of sepsis in burned patients. J Burn Care Res. 2017;38(5):290–8.
Ponce AG, Paredez SC, Ochoa KF, Schnoor M. Regulation of endothelial and epithelial barrier functions by peptide hormones of the adrenomedullin family. Tissue Barriers. 2016;4(4):1–19.
Angeletti S, Spoto S, Fogolari M, Cortigiani M, Fioravanti M, Florio Ld, et al. Diagnostic and prognostic role of procalcitonin (PCT) and MR proAdrenomedullin (MR proADM) in bacterial infections. APMIS. 2015;123(9):740–8.
DOI: https://doi.org/10.15395/mkb.v51n2.1456
Article Metrics
Abstract view : 495 timesPDF - 334 times
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
MKB is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License
View My Stats