Hubungan Platelet Lymphocyte Ratio (PLR) dengan Status Mortalitas H-28         pada Pasien Sepsis Associated Acute Kidney Injury

Franz Josef Tarigan; Tinni T. Maskoen; Dhany Budipratama

doi:10.15851/jap.v12n1.3626

Hubungan Platelet Lymphocyte Ratio (PLR) dengan Status Mortalitas H-28 pada Pasien Sepsis Associated Acute Kidney Injury

Franz Josef Tarigan, Tinni T. Maskoen, Dhany Budipratama

Abstract

Inflamasi merupakan proses yang berperan penting dalam perkembangan Sepsis-associated acute kidney injury (S-AKI). Rasio platelet-limfosit (PLR) merupakan penanda inflamasi baru yang mulai sering digunakan untuk memperkirakan mortalitas. Pada fase inflamasi terjadi peningkatan produksi platelet akibat cedera endotel disertai dengan peningkatan rekrutmen limfosit ke ginjal sehingga dapat tergambar pada nilai PLR. Penelitian ini dilakukan untuk melihat hubungan PLR dengan mortalitas pada pasien S-AKI di ICU RSUP Dr. Hasan Sadikin. Metode yang digunakan pada penelitian ini adalah case-control secara retrospektif dengan menggunakan rekam medis 136 pasien S-AKI di ICU RSUP Dr. Hasan Sadikin pada tahun 2021–2022 yang sesuai dengan kriteria inklusi dan eksklusi dan dibagi menjadi kelompok bertahan hidup 68 orang dan kelompok mortal 68 orang. Penelitian dilakukan mulai dari Maret 2022 sampai Februari 2023. Pengambilan sampel dilakukan secara vkonsekutif, kemudian dilakukan analisis statistik chi-square untuk melihat hubungan nilai PLR dengan status mortalitas h-28. Didapatkan rasio odd pada PLR sebesar 165 dan nilai cut-off PLR penelitian ini adalah 120. Terdapat hubungan antara nilai PLR dan mortalitas h-28 pada pasien S-AKI. Pasien dengan nilai PLR≥120 memiliki risiko mortalitas h-28 lebih tinggi. Peningkatan nilai rasio platelet dan limfosit pada pasien cedera ginjal akut akibat sepsis yang mortal terjadi karena peningkatan penggunaan leukosit ke ginjal dan peningkatan produksi platelet akibat inflamasi yang berat.

Keywords

Rasio platelet limfosit; sepsis; sepsis-associated acute kidney injury; status mortalitas

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