IgG levels in Human Papillomavirus Infection Associated with Clinical Stage of Head and Neck Squamous Cell Carcinoma

Yussy Afriani Dewi; Agung Dinasti Permana; Fanny Yudhiono

doi:10.15850/amj.v8n3.2171

IgG levels in Human Papillomavirus Infection Associated with Clinical Stage of Head and Neck Squamous Cell Carcinoma

Yussy Afriani Dewi, Agung Dinasti Permana, Fanny Yudhiono

Abstract

Background: Head and neck squamous cell carcinoma (HNSCC) is an invasive neoplasm of epithelial tissue in the head and neck and one of the etiologies of HNSCC is human papillomavirus (HPV) which maybe associated with the clinical stage of HNSCC. HPV infection in squamous cell epithelium produces specific IgG antibodies against HPV. IgG titer of HPV can help identify patients who are at risk for HPV-related cancers. This study aimed to explore the association between IgG titer of HPV with the clinical stages of HNSCC.

Methods: The design of this study was analytic cross sectional, conducted at the Outpatient Clinic of Otorhinolaryngology-Head and Neck Surgery, Division of Oncology, Dr. Hasan Sadikin General Hospital Bandung period September-December 2017. Patients with HNSCC were recruited, and history was taken. Furthermore, histopathologic examination and HPV IgG serology examination was performed using the ELISA method. The HPV IgG levels were compared by stage and data were analyzed using the Shapiro Wilks test and Unpaired T test.

Result: The HPV IgG was high in 75% (n=21) of HNSCC patients in the advanced stage and low in 25% (n=7) of patients in the early stage. There was a significant relationship between HPV IgG titer and early and advanced stage of HNSCC (p=0.001).

Conclusion: The HPV IgG titer is related to the clinical stage of HNSCC indicating that the higher the HPV IgG level, the more advanced the clinical stage. Further study is needed to explore HPV IgG levels as a prognostic marker in HNSCC.

Keywords

HNSCC stage, HPV IgG, squamous cell carcinoma

Full Text:

PDF

References

Agrawal GP, Joshi PS, Agrawal A. Role of HPV-16 in pathogenesis of oral epithelial dysplasia and oral Squamous cell carcinoma and correlation of p16INK4a expression in HPV-16 positive cases: an immunohistochemical study. ISRN Pathology.2013;2013:807095.

Yan W, Wistuba, II, Emmert-Buck MR, Erickson HS. Squamous cell carcinoma-similarities and differences among anatomical sites. Am J Cancer Res. 2011;1(3):275–300.

Syrjänen S. Human papillomaviruses in head and neck carcinomas. N Engl J Med. 2007;356(19):1993–5.

Sabirin MSM, Permana AD, Soeseno B. Epidemiologi penderita tumor ganas kepala leher di Departemen Telinga Hidung Tenggorokan-Kepala Leher Rumah Sakit Dr. Hasan Sadikin Bandung, Indonesia, periode 2010–2014. Tunas Medika Jurnal Kedokteran & Kesehatan. 2016;3(1):269.

Kreimer AR, Johansson M, Waterboer T, Kaaks R, Chang-Claude J, Drogen D, et al. Evaluation of human papillomavirus antibodies and risk of subsequent head and neck cancer. J Clin Oncol. 2013;31(21):2708–15.

Cleary RK, Cmelak AJ. Human papillomavirus–positive oropharyngeal squamous cell carcinoma demographics, prognosis, and staging. Clin Oncol. 2016;1:1018.

Kerishnan JP, Gopinath SC, Kai SB, Tang T-H, Ng HL-C, Rahman ZAA, et al. Detection of human papillomavirus 16-Specific IgG and IgM antibodies in patient sera: a potential indicator of oral squamous cell carcinoma risk factor. Int J Med Sci. 2016;13(6):424–31.

Jiang R, Ekshyyan O, Moore-Medlin T, Rong X, Nathan S, Gu X, et al. Association between human papilloma virus/Epstein-Barr virus coinfection and oral carcinogenesis. J Oral Pathol Med. 2015;44(1):28–36.

Sathish N, Wang X, Yuan Y. Human papillomavirus (HPV)-associated oral cancers and treatment strategies. J Dent Res. 2014;93(7 Suppl):29S–36S

Khanal S, Joh J, Kwon AM, Zahin M, Perez CA, Dunlap NE, et al. Human papillomavirus E7 serology and association with p16 immunohistochemistry in squamous cell carcinoma of the head and neck. Exp Mol Pathol. 2015;99(2):335–40.

Rakhmawulan IA, Dewi YA, Nasution N. Profile of head and neck cancer patients at Department of Otorhinolaringology-Head and Neck Surgery Dr. Hasan Sadikin General Hospital Bandung. AMJ. 2015;2(4):474–9.

Liang C, Marsit CJ, McClean MD, Nelson HH, Christensen BC, Haddad RI, et al. Biomarkers of HPV in head and neck squamous cell carcinoma. Cancer Res. 2012;72(19):5004–13.

Anderson KS, Wallstrom G, Langseth H, Posner M, Cheng JN, Alam R, et al. Pre-diagnostic dynamic HPV16 IgG seropositivity and risk of oropharyngeal cancer. Oral Oncol. 2017;73:132–7.

Dalianis T. Human papillomavirus and oropharyngeal cancer, the epidemics, and significance of additional clinical biomarkers for prediction of response to therapy (Review). Int J Oncol. 2014;44(6):1799–805.

Fakhry C, Qualliotine JR, Zhang Z, Agrawal N, Gaykalova DA, Bishop JA, et al. Serum antibodies to HPV-16 early proteins warrant investigation as potential biomarkers for risk stratification and recurrence of HPV-associated oropharyngeal cancer. Cancer Prev Res (Phila). 2016;9(2):135–41.

DOI: https://doi.org/10.15850/amj.v8n3.2171