Clinical Characteristics of Rhabdomyosarcoma in Children: A 4-Year Study in a Tertiary Hospital

Lelani Reniarti; Nur Fatharani; Nur Suryawan

doi:10.15850/amj.v7n3.1871

Clinical Characteristics of Rhabdomyosarcoma in Children: A 4-Year Study in a Tertiary Hospital

Lelani Reniarti, Nur Fatharani, Nur Suryawan

Abstract

Background: Rhabdomyosarcoma (RMS) is the most common soft-tissue sarcomas (STS) in children. Even though the survival rate has increased, the mortality rates remain significantly higher in developing countries due to delay in diagnosis contributed by its diverse and clinical manifestations. This study aimed to describe the clinical characteristics of RMS patients at the Department of Child Health, Dr. Hasan Sadikin General Hospital, Bandung, Indonesia.

Methods: A descriptive cross-sectional retrospective study was conducted using a total sampling method on medical records of RMS patients aged ≤ 18-year-old during a 4-year period (2015-2018). Data on patient demographics, clinical manifestations, biopsy procedure, histopathological subtype, tumor size, primary site, pre-treatment staging, and treatment were reviewed and presented.

Results: Of 30 data retrieved, male (57%), aged 1 to 5-year-old (47%), and diagnosed through open biopsy (63%) comprised the majority of the patients. More than half of the patients came with advanced stage of the disease (80%) and were treated with chemotherapy (83%). Most RMS patients had a tumor located in the head and neck region (40%) with a size of >5 cm (70%) and embryonal subtypes (43%). The remaining patients experienced alveolar subtype (17%), spindle cell subtype (13%), and unknown subtype (27%) of RMS.

Conclusion: Children with a tumor in the head and neck region should be suspected as rhabdomyosarcoma, as there are various clinical characteristics of RMS in children found in this study.

Keywords

Clinical characteristics, primary site, rhabdomyosarcoma

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References

Diaconescu S, Burlea M, Miron I, Aprodu S, Mihăilă D, Olaru C, et al. Childhood rhabdomyosarcoma. Anatomo-clinical and therapeutic study on 25 cases. Surgical implications. Rom J Morphol Embryol. 2013;54(3):531-37.

Hessissen L, Kanouni L, Kili A, Nachef MN, El Khorassani M, Benjaafar N, et al. Pediatric rhabdomyosarcoma in Morocco. Pediatr Blood Cancer. 2010;54(1):25-28.

Alex RA, Nayak DR, Devaraja K, Reddy NA, Singh R, Shetty S. Head-and-neck rhabdomyosarcoma: Our experience. Ann Indian Acad Otorhinolaryngol Head Neck Surg. 2018;2(1):1-4.

Hawkins DS, Spunt SL, Skapek SX, Committee COGSTS. Children's Oncology Group's 2013 blueprint for research: Soft tissue sarcomas. Pediatr Blood Cancer. 2013;60(6):1001-08.

Rini AT, Edhy K, Gatot D, Windiastuti E, Ciputra Y. Rabdomiosarkoma Pada Anak: Gambaran Klinis di 2 Institusi. Indonesian Journal of Cancer. 2008;2(2).

Gatot D, Windiastuti E. Rabdomiosarkoma pada Anak: Luaran Klinis pada Pasien yang Mendapat Terapi. Indonesian Journal of Cancer. 2011;5(2).

Perez EA, Kassira N, Cheung MC, Koniaris LG, Neville HL, Sola JE. Rhabdomyosarcoma in children: a SEER population based study. J Surg Res. 2011;170(2):e243-e51.

Hayes-Jordan A, Andrassy R. Rhabdomyosarcoma in children. Curr Opin Pediatr. 2009;21(3):373-78.

Ferrari A, Miceli R, Casanova M, Meazza C, Favini F, Luksch R,

et al. The symptom interval in children and adolescents with soft tissue sarcomas. Cancer. 2010;116(1):177-83.

Ibikunle AA, Taiwo AO, Braimah RO, Abdullahi K, Malami UA. Orofacial Rhabdomyosarcoma: A 5-year Clinicopathologic Study from Sub-Saharan Africa. Clin Cancer Invest J. 2018;7(2):56.

Crist WM, Anderson JR, Meza JL, Fryer C, Raney RB, Ruymann FB, et al. Intergroup rhabdomyosarcoma study-IV: results for patients with nonmetastatic disease. J Clin Oncol. 2001;19(12):3091-102.

Rudzinski ER, Anderson JR, Hawkins DS, Skapek SX, Parham DM, Teot LA. The World Health Organization classification of skeletal muscle tumors in pediatric rhabdomyosarcoma: a report from the Children's Oncology Group. Arch Pathol Lab Med. 2015;139(10):1281-87.

Li M, Bian X, Jing R, Zhang A, Sun N, Ju X, et al. Retrospective analysis of rhabdomyosarcoma (RMS) in children in a single center. Thorac Cancer. 2018;9(9):1180-84.

Dorak MT, Karpuzoglu E. Gender differences in cancer susceptibility: an inadequately addressed issue. Front Genet. 2012;3:268.

Nassar A. Core needle biopsy versus fine needle aspiration biopsy in breast—a historical perspective and opportunities in the modern era. Diagn Cytopathol. 2011;39(5):380-88.

Badr M, Al-Tonbary Y, Mansour A, Hassan T, Beshir M, Darwish A, et al. Epidemiological characteristics and survival studies of rhabdomyosarcoma in East Egypt: a five-year multicenter study. ISRN Oncol. 2012;2012.

Ma X, Huang D, Zhao W, Sun L, Xiong H, Zhang Y, et al. Clinical characteristics and prognosis of childhood rhabdomyosarcoma: a ten-year retrospective multicenter study. Int J Clin Exp Med. 2015;8(10):17196.

Sultan I, Qaddoumi I, Yaser S, Rodriguez-Galindo C, Ferrari A. Comparing adult and pediatric rhabdomyosarcoma in the surveillance, epidemiology and end results program, 1973 to 2005: an analysis of 2,600 patients. J Clin Oncol. 2009;27(20):3391-97.

Bansal D, Das A, Trehan A, Kapoor R, Panda NK, Srinivasan R, et al. Pediatric rhabdomyosarcoma in India: A single-center experience. Indian Pediatr. 2017;54(9):735-38.

Akyüz C, Sarı N, Yalçın B, Varan A, Kutluk T, Büyükpamukçu M. Long-term survival results of pediatric rhabdomyosarcoma patients: a single-center experience from Turkey. Pediatr Hematol Oncol. 2012;29(1):38-49.

DOI: https://doi.org/10.15850/amj.v7n3.1871