Characteristics of Liposarcoma Patients: 5-Year Data

Miftahur Rahmah; Afiati Afiati; Unwati Sugiri

doi:10.15850/amj.v5n1.1329

Characteristics of Liposarcoma Patients: 5-Year Data

Miftahur Rahmah, Afiati Afiati, Unwati Sugiri

Abstract

Background: Liposarcoma is the second highest soft tissue sarcoma in adults with prevalence of 15% to 25%. If the size of liposarcoma is very large, it may cause abdominal pain, weight loss, gastrointestinal bleeding, even kidney failure. Therefore, for early detection of liposarcoma, the characteristics of liposarcoma should be investigated. This study aimed to determine liposarcoma characteristics based on age, sex, location and histopathologic type according to WHO (World Health Organization) Classification of Tumors 2013.

Methods: A descriptive study was conducted from August to October 2015 at the Department of Anatomic Pathology, Dr. Hasan Sadikin General Hospital, Bandung, Indonesia. Data was obtained from database of patients with liposarcoma at the Department of Anatomic Pathology in the period of January 2010 to December 2014. The collected data was presented in the form of figures and tables.

Results: Out of 102 cases, the percentage of liposarcoma was highest between the age of 50 and 59 years (31.37%), followed by the age of 40–49 years (28.43%). The percentage were slightly higher in males (54.9%) compared to females with a ratio of 1.22:1. Femur (23.52%), intraabdomen (22.55%) and retroperitoneum (11.76%) were the most common locations affected. The most common histopathologic subtype was myxoid liposarcoma (52.95%) exceeding a half of the total cases.

Conclusions: Liposarcoma most likely occurs in the age range of 40–60 years, the percentage is slightly higher in males, and abdomen and lower extremities are the most common location affected. Myxoid liposarcoma is the most common subtype.

Keywords

Liposarcoma, lower extremities, myxoid liposarcoma

Full Text:

PDF

References

Lu J, Qin Q, Zhan L, Yang X, Xu Q, Yu J, et al. Computed tomography manifestations of histologic subtypes of retroperitoneal liposarcoma.Asian Pac J Cancer Prev. 2014;15(15):6041–6.

Ouni FE, Jemni H, Trabelsi A, Maitig MB, Arifa N,Rhouma KB, et al. Liposarcoma of the extremities: MR imaging features and their correlation with pathologic data. Orthop Traumatol Surg Res. 2010;96(8):876–83.

Goldblum JR, Folpe AL,Weiss SW. Enzinger and Weiss’s soft tissue tumors. 6th ed. Philadelphia: Saunders; 2014. p. 443–521.

Fletcher CDM, Bridge JA, Hogendoorn PCW, Mertens F. WHO classification of tumours of soft tissue and bone. 4th ed. Lyon: IARC; 2013. p. 19–44.

Tsuruta A, Notohara K, Park T, Itoh T. Dedifferentiated liposarcoma of the rectum: a case report. World J Gastroenterol. 2012;18(41):5979–81.

Lu W, Lau J, Xu MD, Zhang Y, Jiang Y, Tong HX, et al. Recurrent abdominal liposarcoma: analysis of 19 cases and prognostic factors. World J Gastroenterol. 2013;19(25):4045–52.

Cha EJ. Dedifferentiated liposarcoma of the small bowel mesentery presenting as a submucosal mass. World J Gastrointest Oncol. 2011;3(7):116–8.

Takeda K, Aimoto T, Yoshioka M, Nakamura Y, Yamahatsu K, Ishiwata T, et al. Dedifferentiated liposarcoma arising from the mesocolon ascendens : report of a case. J.Nippon Med Sch. 2012;79(5):385–90.

Crago AM, Singer S. Clinical and molecular approaches to well-differentiated and dedifferentiated liposarcoma. Curr Opin Oncol. 2011;23(4):373–8.

Perez-Ponce Y, Castellanos-Alejandre R, Guerrero-Romero JF, Estrada-Leon F, Torres-Lobaton A. Retroperitoneal liposarcoma as etiology of abdominal pain. Case report and literature review. Cir Cir. 2008;76(1):77–82.

Wanchick K, Lucha P. Dedifferentiated retroperitoneal liposarcoma presenting as lower gastrointestinal bleeding, a case report and review of the literature. Mil Med. 2009;174(3):328–30.

Gupta A, Pacha O, Skaria R, Huynh T, Truong L, Abdellatif A. Retroperitoneal sarcoma presenting as acute renal failure, secondary to bilateral renal artery invasion. Clin Nephrol. 2012;78(2):164–8

Petronella P, Scorzelli M, Lannacci G, Feretti M, Fiore A, Freda F, et al. Clinical considerations on the retroperitoneal liposarcomas. Ann Ital Chir. 2012;83(1):35–9.

Na JC, Choi KH, Yang SC, Han WK. Surgical experience with retroperitoneal liposarcoma in a single Korean tertiary medical center. Korean J Urol. 2012;53(5):310–6.

Milone M, Pezzullo LS, Salvatore G, Pezzullo MG, Leongito M, Esposito FMI. Management of high-grade retroperitoneal liposarcomas: personal experience. Updates Surg. 2011;63(2):119–24.

Lee SY, Goh BKP, Teo MCC, Chew MH, Chow PKH, Wong WK, et al. Retroperitoneal liposarcomas: the experience of a tertiary Asian center. World J Surg Oncol. 2011;9(1):1–6.

Kumar V, Abbas AK, Fausto N, Aster JC. Robbin and Cotran Pathologic Basis of Disease. 8th ed. Philadelphia: Saunders; 2010. p. 1248–50.

Jain SK, Mitra A, Kaza RC, Malagi S. Primary mesentericliposarcoma: an unusual presentation of a rare condition. J GastrointestOncol. 2012;3(2):147–50.

DOI: https://doi.org/10.15850/amj.v5n1.1329