A Study of Hypoalbuminemia and Pleural Effusionin Pediatric Nephrotic Syndrome
Abstract
Background: Nephrotic syndrome (NS) is a kidney disease that is most often found in children. Hypoalbuminemia in NS can cause a decrease in oncotic pressure causing extravasation of fluid into the interstitial space. In conditions of severe hypoalbuminemia, fluid extravasation may cause occurrence of pleural effusion. The objectives of this study was to analyze the correlation between hypoalbuminemia and pleural effusion in children with NS.
Methods: An analytical study was conducted on 69 medical records of pediatric nephrotic syndrome from 1 January 2008–31 December 2013 in dr. Hasan Sadikin General Hospital. Inclusion criteria were pediatric patients between 1-14 years old with NS. Exclusion criteria were patients who already had albumin transfusion, malnutrition, patients with chronic disease, and incomplete medical record information. Contingency coefficient test was carried out to discover the correlation between variables.
Results: Out of 89 samples, 69 samples were included. Characteristics of the included patients are male (n=48), female (n=21), age 1–5 (n=24), 6–10 (n=22), 11–14 (n=23), mild hypoalbuminemia (n=3), moderate hypoalbuminemia (n=27), severe hypoalbuminemia (n=39), patients with pleural effusion (n=23), and non-pleural effusion (n=46). There was a significant correlation between hypoalbuminemia and pleural effusion with p=0.000 (p<0.05) and moderate correlation (r=0.437).
Conclusions: Hypoalbuminemia has correlation with pleural effusion in pediatric nephrotic syndrome.
Keywords: Hypoalbuminemia, pediatric nephrotic syndrome, pleural effusion
DOI: 10.15850/amj.v4n2.1075
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Trihono P, Alatas H, Tambunan T, Pardede S. Konsensus tata laksana sindrom nefrotik idiopatik pada anak. Unit Kerja Koordinasi Nefrologi Ikatan Dokter Anak Indonesia Jakarta: Badan Penerbit IDAI. 2008.
Ponco E. Hubungan kadar kolesterol total darah dengan frekuensi relaps pada anak dengan sindrom nefrotik di Bagian/SMF Ilmu Kesehatan Anak FKUP/RS Hasan Sadikin kurun waktu 1995-1999 [thesis]. Bandung: Universitas Padjadjaran. 1999.
Siddall EC, Radhakrishnan J. The pathophysiology of edema formation in the nephrotic syndrome. Kidney Int J. 2012;82(6):635-42.
Nilawati G. Profil sindrom nefrotik pada ruang perawatan anak RSUP Sanglah Denpasar. Sari Pediatri. 2012;14(4):269-72.
Webster WS, Abela D. The effect of hypoxia in development. Birth Defects Res (Part C). 2007;81(3):215-28.
Liu L, Cash TP, Jones RG, Keith B, Thompson CB, Simon MC. Hypoxia-induced energy stress regulates mRNA translation and cell growth. Mol Cell J. 2006;21(4):521-31.
McGrath E, Barber C. Bilateral pleural effusions. Can Med Assoc J. 2010;182(17):1879-82.
Rehan M, Alam MT, Aurangzeb M, Imran K, Farrukh SZ, Masroor M. The frequency of various diseases in patients presenting with pleural effusion. Gomal J Med Sci. 2013;11(1):78-83.
Light RW. The undiagnosed pleural effusion. Clin Chest Med J. 2006;27(2):309-19.
Zaffanello M, Franchini M. Thromboembolism in childhood nephrotic syndrome: a rare but serious complication. Hematology. 2007;12(1):69-73.
Kerlin BA, Blatt NB, Fuh B, Zhao S, Lehman A, Blanchong C, et al. Epidemiology and risk factors for thromboembolic complications of childhood nephrotic syndrome: a Midwest Pediatric Nephrology Consortium (MWPNC) study. J Pediatr. 2009;155(1):105-10.
DOI: https://doi.org/10.15850/amj.v4n2.1075
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