Pengaruh Penambahan Petidin 0,25 mg/kgBB pada Bupivakain 0,25% untuk Blok Infraorbital terhadap Lama Analgesia Pascabedah pada Operasi Labioplasti Anak

Anthon Vermana Ritonga, Ruli Herman Sitanggang, Ezra Oktaliansah

Abstract


Nyeri pascabedah labioplasti dapat dicegah dengan regional blok infraorbital bilateral. Bupivakain 0,25% biasa digunakan untuk blok infraorbital dan penambahan petidin akan memperpanjang lama kerjanya. Penelitian telah dilakukan dengan uji klinis acak terkontrol tersamar tunggal terhadap 40 pasien ASA II usia 3 bulan–1 tahun yang menjalani operasi labioplasti di ruang operasi bedah sentral Rumah Sakit Dr. Hasan Sadikin Bandung pada Maret–Mei 2012. Setelah randomisasi secara blok permutasi, subjek dikelompokkan >menjadi dua, yaitu 20 subjek menggunakan bupivakain 0,25% 1 mL pada tiap sisi (kelompok B) dan 20 subjek menggunakan kombinasi bupivakain 0,25% dan petidin 0,25 mg/kgBB 1 mL pada tiap sisi (kelompok >BP) yang diberikan setelah induksi anestesi. Data tentang lama analgesi diuji dengan Mann-Whitney. Analisis statistik menunjukkan bahwa perbedaan lama analgesia antara kedua kelompok sangat bermakna (p<0,0001). Simpulan, peningkatan lama analgesia kombinasi bupivakain 0,25% dan petidin 0,25 mg/kg BB menghasilkan masa bebas nyeri sampai 36 jam, sedangkan pada bupivakain 0,25% lebih singkat sekitar 18 jam. Tidak dijumpai efek samping dalam penelitian ini.

Kata kunci: Blok infraorbital, bupivakain, labioplasti, petidin


Comparison Between the Addition of Pethidine 0.25 mg/kgBW in Bupivacain 0.25% with Bupivacain 0.25% for Infraorbital Blockade in Labioplasty Surgery in Children to the Length of Post Operative Analgesia


Labioplasty postoperative pain can be prevented by bilateral infraorbital regional block. Bupivacaine 0.25% is usually used in infraorbital block and pethidine as an adjuvant can prolong the postoperative analgesic. The research was a single-blind randomized clinical trial included 40 children ASA II aged 3 months–1 year underwent labioplasty surgery in central operating theatre Dr. Hasan Sadikin Hospital-Bandung during March–May 2012. After block of permutation randomization, the subjects were grouped into two, 20 subjects (group B) using bupivacaine 0.25% 1 mL on each side and 20 subjects (group of BP) using combination of pethidine bupivacaine 0.25% and 0.25 mg/kgBW 1 mL on each side after the induction of anesthesia. Measurement data of length of analgesia were tested with the Mann-Whitney Test. Statistical analysis showed that the difference of the length of analgesia between two groups analgesia was highly significant (p<0.0001). The conclusion of this study is that the increase of the length of analgesia in combination of bupivacaine 0.25% and pethidine 0.25 mg/kgBW produce pain-free period to 36 hours, whereas bupivacaine 0.25% is shorter, about 18 hours. The incidence of adverse effect was not found in this study.

Key words: Bupivacaine, infraorbital block, labioplasty, pethidine

 

DOI: http://dx.doi.org/10.15851/jap.v1n2.121


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