Microbial Diversity and Antimicrobial Susceptibility from Wound Dehiscence Isolates in an Indonesian Tertiary Referral Hospital

Felicia Aviana, Ni Nengah Dwi Fatmawati

Abstract


Healthcare-associated infections (HAIs) remain a critical issue for public health in Indonesia, with wound dehiscence associated with surgical site infections (SSIs) being one of them. Globally, SSIs are known as the most common postoperative complications with a heightened prevalence, particularly in low to middle-income countries. With its retrospective and descriptive design, this study aimed to illustrate the microbial patterns identified in Prof. Dr. I.G.N.G. Ngoerah General Hospital from 12 January 2020 to 12 December 2022. The study includes all patients who underwent surgery and were subsequently diagnosed with wound dehiscence and SSIs. Specimens were collected from patients and submitted to the Microbiology Laboratory at the hospital above. Bacterial identification and susceptibility testing to antimicrobials were performed using the Vitek 2 Compact System (bioMerieux, Marcy l'Etoile, France). Patient information was sourced from medical records. Out of 172 samples, 151 (87.8%) yielded positive cultures. Among these, 151 (87.8%) were found to be positive. Gram-negative bacteria were found to be most prevalent, with Escherichia coli (20.2%) and Pseudomonas aeruginosa (19.6%) being the most frequently isolated bacteria. The bacteria isolated were mostly susceptible to amikacin (72.1%), followed closely by meropenem (71.4%). This information could contribute to the development of an empirical antibiotic therapy protocol for wound dehiscence or SSI cases in this local context.


Keywords


Antibiotics, bacterial infection, postoperative complication, surgical site infection

Full Text:

PDF

References


  1. Modi J, Patel Y, Trivedi M, Bochiya G. An abdominal wound dehiscence of emergency explorative laparotomy and their management at tertiary care centre: an observational study. International Surgery Journal. 2023;10(9):1448–54.
  2. WUWHS. Surgical Wound Dehiscence: Improving Prevention and Outcomes. World Union of Wound Healing Societies (WUWHS) Consensus Document. London: Wound International; 2018.
  3. Sandy‐Hodgetts K, Carville K, Leslie GD. Determining risk factors for surgical wound dehiscence: a literature review. Int Wound J. 2015;12(3):265–75. doi:10.1111/iwj.12088
  4. WHO. Report on the Burden of Endemic Health Care-Associated Infection Worldwide. Clean Care is Safer Care. Geneva: WHO Library Cataloguing-in-Publication Data; 2011.
  5. Pinchera B, Buonomo AR, Schiano Moriello N, Scotto R, Villari R, Gentile I. Update on the management of surgical site infections. Antibiotics. 2022;11(11):1608. doi:10.3390/antibiotics11111608
  6. CDC. Procedure Associated Module: Surgical Site Infection (SSI) Event. National Healthcare Safety Network. Atlanta: Centers for Disease Control and Prevention; 2023.
  7. Alamrew K, Tadesse TA, Abiye AA, Shibeshi W. Surgical antimicrobial prophylaxis and incidence of surgical site infections at Ethiopian Tertiary-Care Teaching Hospital. Infect Dis (Auckl). 2019;12(1):1–7.
  8. Sartelli M, Coccolini F, Carrieri A, Labricciosa FM, Cicuttin E, Catena F. The “torment” of surgical antibiotic prophylaxis among surgeons. Antibiotics. 2021;10(11):1357. doi:10.3390/antibiotics10111357
  9. Isik O, Kaya E, Dundar HZ, Sarkut P. Surgical site infection: re-assessment of the risk factors. Chirurgia (Bucur). 2015;110(5):457–61
  10. Deka S, Kalita D, Mahanta P, Baruah D, Mahanta Sr P. High prevalence of antibiotic-resistant gram-negative bacteria causing surgical site infection in a Tertiary Care Hospital of Northeast India. Cureus. 2020;12(12):1–10. doi:10.7759/cureus.12208
  11. Narula H, Chikara G, Gupta P. A prospective study on bacteriological profile and antibiogram of postoperative wound infections in a tertiary care hospital in Western Rajasthan. J Family Med Prim Care. 2020;9(4):1927–34. doi:10.4103/jfmpc.jfmpc_1154_19
  12. Seyffert J, Harding T, Sanghvi A, Bibliowicz N, Yungmann M, Camner S, Leavitt M, Solomon JA. Surgical wound dehiscence following cutaneous excisions: A retrospective study and review of the literature. Journal of Dermatology and Dermatologic Surgery. 2020;24(2):93–8.
  13. Njoku CO, Njoku AN. Microbiological pattern of surgical site infection following caesarean section at The University of Calabar Teaching Hospital. Open Access Maced J Med Sci. 2019;7(9):1430–35. doi:10.3889/oamjms.2019.286
  14. Ntambi S, Sutiningsih D, Hussein MA, Laksono B. Distribution and Prevalence of Multidrug-Resistant Organisms (MDROs) Among MDRO-Positive Individuals at Dr. Kariadi Hospital. J Epidemiol Kesehat Komunitas. 2023;8(2):103–9.
  15. Liana P, Patricia V, Agatha C. Multidrug-resistant organisms (MDRO) patterns of GICU patients in Dr Mohammad Hoesin Hospital Palembang. J Phys Conf Ser. 2019;1246(1):2.
  16. Saffanah NI, Agustina D, Sutejo IR. Postoperative Orthopedic Surgical Site Infection Antibiogram of dr. Soebandi Hospital Jember in 2019. J Pharm Sci Clin Res. 2020;5(2):110–20.
  17. Islam MH, Mishu MP, Afroze N, Mahmud MH, Islam MS, Shah MS. Bacteriological study on surgical site infection in Rangpur Medical College and Hospital. J Rang Med Col. 2022;7(2):12–9.
  18. Singh V, Khyriem AB, Lyngdoh WV, Lyngdoh CJ. Surgical site infections - a hospital havoc: retrospective study of surgical site infections in Tertiary Health Care Centre in North East India. IJIRMS. 2018;3(1):1639–43.




DOI: https://doi.org/10.15395/mkb.v56.3422

Article Metrics

Abstract view : 121 times
PDF - 57 times

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.


 


Creative Commons License
MKB is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License

 


View My Stats