Correlation Between Serum Ferritin and Testosterone Level in Adolescent Male with Transfusion Dependent Thalassemia

Raja Iqbal Mulya Harahap, Nina Tristina, Delita Prihatni, Dewi Kartika Turbawaty

Abstract


Transfusion-dependent thalassemia (TDT) is a type of beta-thalassemia that needs regular and long-term blood transfusions. Complications can occur due to the deposition of iron in TDT patients, including endocrine complications causing deficiency of testosterone that plays a role in the secondary sexual development in males. The objective of this study was to understand the correlation between ferritin and testosterone level in male adolescences with transfusion-dependent thalassemia. This cross-sectional observational correlative study was conducted from April to August 2019 on 74 males aged 12-18 years old who were presented to the Thalassemia Outpatient clinic, Dr. Hasan Sadikin General Hospital, Bandung. Blood was collected using phlebotomy for ferritin and total testosterone serum examination. Data were then analyzed using SPSS version 17.0. Low testosterone level (<3.0 ng/mL) was found in 63.5% of subjects. Results of the Spearmen correlation test demonstrated a negative correlation with r: -0,699 and p-value <0.001, showing a negative, strong, and significant correlation among those variables. The higher ferritin level in TDT patients indicates a high level of the free iron level in the body that can destroy the endocrine organs and cause deprivation of testosterone secretion, leading to hypogonadism in transfusion dependent thalassemia patients.


Keywords


ferritin, iron, transfusion dependent thalassemia, total testosterone

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References


Keohane EM. Thalassemia. Dalam: Keohane EM, Smith LJ, Walenga JM, editor. Rodak’s Hematology: Clinical Principles and Applications. 6th ed. New Jersey: Elsevier; 2018.

Galanello R, Origa R. Beta-thalassemia. Orphanet J Rare Dis. 2010;5:11.

Mishra AK, Tiwari A. Iron overload in beta thalassaemia major and intermedia patients. Maedica (Bucur). 2013;8(4):328–2.

Maggio M, De Vita F, Fisichella A, Lauretani F, Ticinesi A, Ceresini G, et al. The role of the multiple hormonal dysregulation in the onset of “anemia of aging”: focus on testosterone, IGF-1, and thyroid hormones. Int J Endocrinol. 2015;3(3):226–35.

Mula-Abed W-A, Hashmi HA, Mushlahi MA, Muslahi HA, Lamki MA. Prevalence of endocrinopathies in patients with beta-thalassaemia major -a cross-sectional study in Oman. Oman Medical Journal. 2014;23(4):1–6.

Saliba AN, Harb AR, Taher AT. Iron chelation therapy in transfusion-dependent thalassemia patients: current strategies and future directions. Blood Med. 2015;6:197–209.

De Sanctis V, Soliman AT, Elsedfy H, Di Maio S, Canatan D, Soliman N, et al. Gonadal dysfunction in adult male patients with thalassemia major: an update for clinicians caring for thalassemia. Expert Rev Hematol. 2017;10(12):1095–106.

Siripunthana S, Sahakitrurungruang T, Wacharasindhu S, Sosothikul D, Supornsilchai V. Testicular function in patients with regular blood transfusion for thalassemia major. Asian Biomedicine. 2015;9(2):185–91.

Huda Tutor, Al-Ali Zainal. Evaluation of reproductive hormones in patients with β-thalassemia major in Misan Province, Iraq. Medicolegal Update. 2020;20(2):274–83.

Sinharay M, Mitra S, Dasgupta A. Effect of iron overload on gonadotrophins and organ sex steroids in pubertal thalassemia patients. Int J Cur Res Rev. 2017;9(23):15–21.

Dumaidi K, Al-Jawabreh A, Al-Assi S. Assessment of gonadal and thyroid function for adult transfusion - dependent - β-thalassemic patients in Palestine. Jordan Medical Journal. 2015;49(1):17–26.

Paduch DA, Brannigan RE, Fuchs EF, Kim ED, Marmar JL, Sandlow JI. The Laboratory diagnosis of testosterone deficiency. Urology. 2014;83(5):980–8.

Yaghobi M, Miri-Moghaddam E, Majid N, Bazi A, Navidian A, Kalkali A. Complications of transfusion-dependent β-thalassemia patients in Sistan and Baluchistan, South-East of Iran. Int J Hematol Oncol Stem Cell Res. 2017;11(4):268–72.

Sleiman J, Tarhini A, Bou-Fakhredin R, Saliba AN, Cappellini MD, Taher AT. Non-transfusion-dependent thalassemia: an update on complications and management. Int J Mol Sci. 2018;19(1):182

Saffari F, Mahyar A, Jalilolgadr S. Endocrine and metabolic disorders in β-thalassemia major patients. Caspian J Internal Med. 2012;3(3):466–72.




DOI: https://doi.org/10.15395/mkb.v53n3.2389

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