Pengaruh Puguntano terhadap HOMA-IR Pada Pasien Diabetes Melitus yang Baru Didiagnosis
Abstract
Kata kunci: Diabetes melitus, HOMA-IR, puguntano
Effect of Puguntano on HOMA-IR in Newly Diagnosed Type 2 Diabetes Mellitus
Insulin resistance is important not only as a powerful predictor of future development of type 2 diabetes mellitus but also as a therapeutic target once hyperglycemia is present. HOMA-IR is a method for assessing insulin resistance that has been validated worldwide. Puguntano is one of the traditional plants found in North Sumatera that has been recognized for its anti-diabetic effect. Samples were taken from 2015–2016 at H. Adam Malik General Hospital Medan. This study tried to assess the effect of puguntano as a traditional plant in North Sumatera on insulin resistance in type 2 diabetes melitus patients and aimed to determine the effect of puguntano treatment on HOMA-IR in newly diagnosed type 2 diabetes mellitus patients. This was a randomized open clinical trial on 24 newly diagnosed type 2 diabetes mellitus patients (12 patients and 12 controls) divided into 2 groups who were assigned to receive puguntano or Metformin for 12 weeks. HOMA-IR and Hba1c were determined at baseline and at the end of 12 weeks. In puguntano group, the mean decrease of HOMA-IR was 1.71 (± 2.29) (p=0.034). There was no difference in terms of the mean decrease of HOMA-IR between the puguntano and Metformin group, which was 1.71 (±2.29) vs 0.80 (±1.47) (p=0.402). There was a decrease mean of HOMA-IR level with puguntano treatment in newly diagnosed type 2 diabetes mellitus patients which was statistically significant. In conclusions, the effect of puguntano in controlling blood sugar especially in its role of improving insulin sensitivity is not much different from metformin which has become a standard drug in the first-line treatment of type 2 diabetes mellitus. [MKB. 2017;49(2):67–72]
Key words: Diabetes mellitus, HOMA-IR, puguntano
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Okita K, Iwahashi H, Kozawa J, Okauchi Y, Funahashi T, Imagawa A, dkk. Homeostasis model assessment of insulin resistance for evaluating insulin sensitivity in patients with type 2 diabetes on insulin therapy. Endocr J. 2013;60(3):283–90.
Taylor R. Insulin Resistance and Type 2 Diabetes. Diabetes. 2012;61(4):776–9.
Harfina F, Bahri S, Saragih A. Pengaruh serbuk daun puguntano (Curanga fel-terrae Merr) pada pasien diabetes melitus. J Pharmaceutics Pharmacol. 2012;1(2):112–8.
Sitorus P, Harahap U, Pandapotan M, Barus T. Isolation of β-sitosterol from n-Hexane extract of picria fel-terrae lour leave and study of its antidiabetic effect in alloxan induced diabetic mice. Int J PharmTech Res. 2014;6(1):137–41.
Juwita NA. Pengujian efek antiinflamasi ekstrak etanol daun pugun tano (Curanga fel-terrae Merr) terhadap mencit putih [skripsi]. Medan: Fakultas Farmasi USU; 2009.
Saha PK, Reddy VT, Konopleva M, Andreeff M, Chan L. The Triterpenoid 2-Cyano-3,12-dioxooleana-1,9-dien-28-oic-acid methyl ester has potent anti-diabetic effects in diet-induced diabetic mice and Leprdb/db mice. J Biol Chem. 2010;285(52):40581–92.
Rojas LBA, Gomes MB. Metformin: an old but still the best treatment for type 2 diabetes. Diabetol Metab Syndr. 2013;5(1):6.
Iliadis F, Kadoglou NP, Hatzitolios A, Karamouzis M, Alevizos M, Karamitsos D. Metabolic effects of rosiglitazone and metformin in Greek patients with recently diagnosed type 2 diabetes. In Vivo. 2007; 21(6):1107–14.
Ma J, Liu LY, Wu PH, Liao Y, Tao T, Liu W. Comparison of metformin and repaglinide monotherapy in the Treatment of new onset type 2 diabetes melitus in china. J Diabetes Res. 2014;2014:294017.
Krysiak R, Gdula-Dymek A, Okopien B. Effect of metformin on selected parameters of hemostasis in fenofibrate-treated patients with impaired glucose tolerance. Pharmacol Rep. 2013;65(1):208–13.
Kadhim KA, Ismael DK, Khalaf BH, Husseiun KL, Zalzala MH, Hussain SA. Dose-dependent relationship between serum metformin levels and glycemic control, insulin resistance and leptin levels in females newly diagnosed with type 2 diabetes melitus. J Diabetes melitus. 2012;2(2):179–85.
Frid A, Sterner GN, Londahl M, Wiklander C, Cato A, Vinge E, dkk. Novel assay of met-formin levels in patients with type 2 diabetes and varying levels of renal function. Diabetes Care. 2010;33(6):1291–3.
DOI: https://doi.org/10.15395/mkb.v49n2.1051
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