Perbandingan Anestesi Spinal Menggunakan Ropivakain Hiperbarik 13,5 mg dengan Ropivakain Isobarik 13,5 mg terhadap Mula dan Lama Kerja Blokade Sensorik

Hunter D. Nainggolan, Iwan Fuadi, Ike Sri Redjeki

Abstract


Penyebaran obat anestesi lokal pada anestesi spinal terutama ditentukan oleh barisitas dan posisi. Penelitian ini bertujuan membandingkan mula dan lama kerja blokade sensorik antara anestesi spinal menggunakan ropivakain hiperbarik 13,5 mg dan ropivakain isobarik 13,5 mg. Penelitian dilakukan dengan uji acak terkontrol buta ganda mengikutsertakan 32 pasien usia 50–70 tahun, ASA I–II yang menjalani transurethral resection of prostate (TURP) dengan anestesi spinal di Rumah Sakit Dr. Hasan Sadikin Bandung pada April– Juli 2012. Data hasil penelitian dianalisis menggunakan Uji Mann-Whitney dengan tingkat kepercayaan 95% dan dianggap bermakna bila p<0,05. Hasil penelitian didapatkan mula kerja blokade sensorik pada ropivakain hiperbarik 5,00 (SB 1,03) menit lebih cepat secara bermakna dibandingkan dengan ropivakain isobarik 10,25 (SB 1,23) menit dan terdapat perbedaan lama kerja blokade sensorik secara bermakna, dengan lama kerja ropivakain hiperbarik adalah 89,38 (SB 5,12) menit dibandingkan dengan ropivakain isobarik 125,94 (SB 7,57) menit. Simpulan penelitian ini adalah anestesi spinal menggunakan ropivakain hiperbarik menghasilkan mula kerja blokade sensorik yang lebih cepat dan lama kerja blokade sensorik yang lebih pendek bila dibandingkan dengan ropivakain isobarik pada pasien yang menjalani operasi TURP.

Kata kunci: Anestesi spinal, barisitas, lama kerja, mula kerja, ropivakain, transurethral resection of prostate


Comparison of Onset and Sensory Blockade Duration of Spinal Anesthesia between 13.5 mg Hyperbaric Ropivacaine and 13.5 mg Isobaric Ropivacaine

The spread of the local anesthetic drug in spinal anesthesia is primarily determined by baricity and position. The aim of this study was to compare the onset and duration of sensoric blockade in spinal anaesthesia using 13.5 mg hyperbaric ropivacaine and 13.5 mg isobaric ropivacaine. This was a double blind randomized trial involving 32 patients aged between 50–70 years with ASA I–II whom underwent TURP surgery with spinal anesthesia at Dr. Hasan Sadikin Hospital Bandung within April–July 2012. Data was analyzed using Mann-Whitney Test with level of confidence 95% and p<0.05 was significant. The result showed that onset of sensory blockade in hyperbaric ropivacaine 5.00 (SB 1.03) minutes was significantly faster compared to isobaric ropivacaine 10.25 (SB 1,23) minutes and there was significant difference on sensory blockade duration, where hyperbaric ropivacaine 89.38 (SB 5.12) minutes was shorter than isobaric ropivacaine 125.94 (SB 7.57) minutes. The conclusions of this study shown spinal anesthesia using hyperbaric ropivacaine produced faster onset and shorter duration of sensory block compared to isobaric ropivacaine in TURP surgery.

Key words: Baricity, duration, onset, spinal anesthesia, ropivacaine, transurethral resection of prostate

 

DOI: 10.15851/jap.v2n1.232


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