Role of Ultrasound Imaging in Children with Dengue Fever: A Retrospective Study
Abstract
Objective: To study ultrasound findings of children with dengue and analyze the possible correlation between ultrasound findings and severity of dengue in children.
Methods: This retrospective study, which was conducted over one year, analyzed 50 pediatric dengue patients. Ultrasound findings such as gallbladder wall edema, pleural effusion and ascites were assessed. Cases were categorized into dengue without warning signs, dengue with warning signs, and severe dengue according to the World Health Organization's classification of dengue. Correlation between ultrasound abnormalities, severity of dengue, and thrombocytopenia were analyses. A p-value of less than 0.05 was taken as statistically significant.
Results: Of 50 pediatric patients diagnosed with dengue participated in this study, 72% were boys, and 28% were girls with a male-to-female ratio of 1:0.38. Fever was the most frequent symptom (100%), followed by nausea/vomiting (84%) and body ache/myalgia (78%). Ultrasound findings revealed that gallbladder wall edema (48%), pleural effusion (44%), and ascites (50%) were significantly associated with severe dengue and dengue with warning signs (p<0.001). Thrombocytopenia was documented in 58% of cases and correlated significantly with ultrasound abnormalities such as gallbladder wall edema, ascites, and pleural effusion (p=0.0017).
Conclusion: Ultrasound findings, such as gallbladder wall edema, pleural effusion and ascites, are significantly associated with severe dengue and dengue with warning signs. These features aid in early identification of high-risk patients.
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- Zeng Z, Zhan J, Chen L, Chen H, Cheng S. Global, regional, and national dengue burden from 1990 to 2017: A systematic analysis based on the global burden of disease study 2017. EClinicalMedicine. 2021;32:100712. doi: 10.1016/j.eclinm.2020.100712. PMID: 33681736; PMCID: PMC7910667.
- Alejandria MM. Dengue haemorrhagic fever or dengue shock syndrome in children. BMJ Clin Evid. 2015;2015:0917.
- Islam S, Hasan MN, Kalam SB, Islam MS, Hasan MJ, Sami CA, Chowdhury FR. Clinical Profile, Severity Spectrum, and Hospital Outcome of Dengue Patients in a Tertiary Care Hospital in Dhaka City. Cureus. 2022;14(9):e28843. doi: 10.7759/cureus.28843.
- Wakimoto MD, Camacho LA, Guaraldo L, Damasceno LS, Brasil P. Dengue in children: a systematic review of clinical and laboratory factors associated with severity. Expert Rev Anti Infect Ther. 2015;13(12):1441–56. doi:10.1586/14787210.2015.1100534
- Sachdev A, Pathak D, Gupta N, Simalti A, Gupta D, Gupta S, Chugh P. Early Predictors of Mortality in Children with Severe Dengue Fever: A Prospective Study. Pediatr Infect Dis J. 2021 Sep 1;40(9):797–801. doi: 10.1097/INF.0000000000003179.
- Uthraraj NS, Sriraam LM, Hiriyur Prakash M, Kumar M, Palanisamy U, Chettiakkapalayam Venkatachalam KU. Predictive factors for the complications of dengue fever in children: a retrospective analysis. Cureus. 2022;14(12):e33027. doi: 10.7759/cureus.33027.
- Faridah IN, Dania H, Chen YH, Supadmi W, Purwanto BD, Heriyanto MJ, Aufa MA, Chang WC, Perwitasari DA. Dynamic changes of platelet and factors related dengue haemorrhagic fever: a retrospective study in Indonesian. Diagnostics (Basel). 2022;12(4):950. doi: 10.3390/diagnostics12040950.
- Ren ZZ, Zheng Y, Sun T, Wang GY, Chen XM, Zhou YM. A survey of clinical and laboratory characteristics of the dengue fever epidemic from 2017 to 2019 in Zhejiang, China. Medicine (Baltimore). 2022;101(42):e31143. doi:10.1097/MD.0000000000031143
- Hadinegoro SR. The revised WHO dengue case classification: does the system need to be modified?. Paediatr Int Child Health. 2012;32 Suppl 1(s1):33–38. doi:10.1179/2046904712Z.00000000052
- McGregor BL, Connelly CR. A Review of the Control of Aedes aegypti (Diptera: Culicidae) in the Continental United States. J Med Entomol. 2021;58(1):10–25. doi:10.1093/jme/tjaa157
- Uzair H, Waseem R, Kumar N, Hussain MS, Shah HH. Fatal outcome of dengue fever with multi-organ failure and hemorrhage: A case report. SAGE Open Med Case Rep. 2023;11:2050313X231220808. doi:10.1177/2050313X231220808
- Rao SM. Correlation of clinical and laboratory parameters in dengue fever patients and its usefulness as bedside markers. Indian J Crit Care Med. 2014;18(3):183–4. doi:10.4103/0972-5229.128713
- Kaagaard MD, Matos LO, Evangelista MVP, Wegener A, Holm AE, Vestergaard LS, et al. Frequency of pleural effusion in dengue patients by severity, age and imaging modality: a systematic review and meta-analysis. BMC Infect Dis. 2023;23(1):327. doi:10.1186/s12879-023-08311-y
- Sami CA, Tasnim R, Hassan SS, Khan AH, Yasmin R, Monir-Uz-Zaman M, et al. Clinical profile and early severity predictors of dengue fever: Current trends for the deadliest dengue infection in Bangladesh in 2022. IJID Reg. 2023;9:42–8. doi:10.1016/j.ijregi.2023.09.001
- Santhosh VR, Patil PG, Srinath MG, Kumar A, Jain A, Archana M. Sonography in the diagnosis and assessment of dengue Fever. J Clin Imaging Sci. 2014;4:14. doi:10.4103/2156-7514.129260
- Dewan N, Zuluaga D, Osorio L, Krienke ME, Bakker C, Kirsch J. Ultrasound in dengue: a scoping review. Am J Trop Med Hyg. 2021;104(3):826–35. doi: 10.4269/ajtmh.20-0103.
- Colbert J, Gordon A, Roxelin R, Silva S, Silva J, Rocha C et al. Ultrasound measurement of gallbladder wall thickening as a diagnostic test and prognostic indicator for severe dengue in pediatric patients. Pediatr Infect Dis J. 2007;26:850–2.
- Donaldson CD, de Mel S, Clarice CSH, et al. Admission ultrasonography as a predictive tool for thrombocytopenia and disease severity in dengue infection. Trans R Soc Trop Med Hyg. 2021;115(12):1396–402. doi:10.1093/trstmh/trab064
- Pothapregada S, Kullu P, Kamalakannan B, Thulasingam M. Is Ultrasound a Useful Tool to Predict Severe Dengue Infection?. Indian J Pediatr. 2016;83(6):500–4. doi:10.1007/s12098-015-2013-y
- Sharma G.K, Ajmera M, Gurjar R.S, Bairwa A.L. Role of ultra sonography (chest and abdomen) in diagnosis and early prediction of severity of dengue fever. Int J Pediatr Res. 2019;6(05):201–6. doi:10.17511/ijpr.2019.i05.02
DOI: https://doi.org/10.15850/ijihs.v12.n2.4100
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