Thyroid Profile and Serum Lipid Level in Women with Normal Pregnancy

Raj Kumar, Sudeep Kumar, Manisha Arora, Dinesh Kumar, Sumesh Prasad Sah, Shivani Sharma

Abstract


Objective: To evaluate the changes in thyroid profile and serum lipid level in normal pregnancy.

Methods: This observational study was conducted at the Department of Biochemistry of Santosh Medical College, Ghaziabad, UP, India, from June 2021 to February 2022. In this study, 200 average pregnant women were enrolled. The thyroid profile was estimated using the ELISA method, and the lipid profile was measured using the enzymatic kit method. All data were expressed as means and standard deviations, and SPSS version 17 was used for statistical analysis.

Results: This observational study observed that the mean T3, T4, and TSH levels increased significantly in the second trimester compared to the first trimester. In contrast, the mean value of T3, T4, and TSH decreased in the third trimester as compared to the second trimester. The mean levels of total cholesterol, triglyceride, and LDL-cholesterol increased significantly, while the mean value of HDL-cholesterol decreased significantly in the second and third trimesters when compared to the first trimester.

Conclusion: This study demonstrated abnormal lipid and thyroid metabolism. Changes in thyroid profile may be associated with adverse obstetric outcomes. The altered lipid parameters, mainly High TG and low HDL-C concentrations, may promote vascular dysfunction and oxidative stress.


Keywords


Pregnancy; Thyroid Hormones; Triglycerides; Trimester.

Full Text:

PDF

References


  1. Moog NK, Entringer S, Heim C, Wadhwa PD, Kathmann N, Buss C. Influence of maternal thyroid hormones during gestation on fetal brain development. Neuroscience. 2017;342:68–100. doi:10.1016/j.neuroscience.2015.09.070.
  2. Soma-Pillay P, Nelson-Piercy C, Tolppanen H, Mebazaa A. Physiological changes in pregnancy. Cardiovasc J Afr. 2016;27(2):89–94. doi:10.5830/CVJA-2016-021.
  3. Jiffri EH. Relationship between lipid profile blood and thyroid hormones in patient with type 2 diabetes mellitus. Adv Obes Weight Manag Control. 2017;6(6):178–82. doi:10.15406/aowmc.2017.06.00176
  4. Abdullah TH, Baqi HR, Karim SH, Ghafor DA. Association of lipid profile with body mass index in Public Employees in Halabja City, Kurdistan Region of Iraq. Polytechnic Journal 2020;30(10):71–80. doi: 10.25156/ptj.v10n2y2020.pp71-80
  5. Sonagra AD, Shylaja TV, Deba Z, Makandar A. Study of serum lipid profile in normal pregnancy. International Journal of Biotechnology and Biochemistry 2017;13(2):175–82.
  6. Kumari K, Sharan S, Kumar R. Assessment of changes in lipid profile of pregnant women during periods of gestation and post partum in Chotanagpur – a descriptive study. International Journal of Contemporary Medical Research 2018;5(5):E4-E7. doi: http://dx.doi.org/10.21276/ijcmr.2018.5.5.14
  7. Parveen S , Zaman I, Noor N , Moin S , Ali SM. Maternal lipid profile and its impact on pregnancy outcome. J South Asian Feder Obs Gynae 2022;14(3):302–6. doi: 10.5005/jp-journals-10006-2051
  8. Chen Q, Chen H, Xi F, Sagnelli M, Zhao B, Chen Y, et al. Association between maternal blood lipids levels during pregnancy and risk of small-for-gestational-age infants. Sci Rep. 2020;10(1):19865. doi:10.1038/s41598-020-76845-1
  9. Cibickova L, Schovanek J, Karasek D. Changes in serum lipid levels during pregnancy in women with gestational diabetes. A narrative review. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2021;165(1):8–12. doi:10.5507/bp.2021.009
  10. Pusukuru R, Shenoi AS, Kyada PK, Ghodke B, Mehta V, Bhuta K, et al. Evaluation of lipid profile in second and third trimester of pregnancy. J Clin Diagn Res. 2016;10(3):QC12-QC16. doi:10.7860/JCDR/2016/17598.7436
  11. Yoganathan T, Hettiarachchi M, Arasaratnam V, Liyanage C. Maternal iodine status and the thyroid function of pregnant mothers and their neonates in Jaffna District of Sri Lanka. Indian J Endocr Metab 2015;19:817–23. doi:10.4103/2230-8210.167563
  12. Mehta V, Pusukuru R, Ghodke B. Association of Thyroid Stimulating Hormone and Lipid Profile in Pregnancy. J Med Res Innov. 2017;1(2):AU1–AU6. doi : 10.15419/jmri.50
  13. Devi RV, Oinam S, Bishwalata RK, Singh NI, Singh TR. A study of association between lipid profile and thyroid hormones in pregnancy. IOSR J Dental Med Sci (IOSRJDMS) 2018;17(9):55–60. doi: 10.9790/0853-1709015560
  14. Hannoush ZC, Weiss RE. Defects of thyroid hormone synthesis and action. Endocrinol Metab Clin North Am. 2017;46(2):375–88. doi:10.1016/j.ecl.2017.01.005
  15. TG thyroglobulin [Homo sapians (human)]- Gene- NCBI. [cited 2019-09-16]. Available from: https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=DetailsSearch&Term=7038.
  16. Lata K, Dutta P, Sridhar S, Rohilla M, Srinivasan A, Prashad GRV, et al. Thyroid autoimmunity and obstetric outcomes in women with recurrent miscarriage: a case–control study. Endocr Connect. 2013;2(2):118–24. doi:10.1530/EC-13-0012
  17. Duntas LH, Brenta G. A Renewed focus on the association between thyroid hormones and lipid metabolism. front endocrinol (Lausanne). 2018;9:511. doi:10.3389/fendo.2018.00511
  18. Sangeeta N, Singh AK, Devi P , Singh RKR, Chubalemla L, Abhishek D, et al. Lipid Profile in thyroid dysfunction patients. IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) 2016;15(12):39–43. doi: 10.9790/0853-1512113943




DOI: https://doi.org/10.15850/ijihs.v11n2.3460

Article Metrics

Abstract view : 474 times
PDF - 131 times


 

This Journal indexed by

                   

 


Creative Commons License
IJIHS is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License



View My Stats