Clinicopathological Characteristics of Cervical Carcinoma with Pelvic Lymph Node Metastases in Dr. Hasan Sadikin General Hospital, Bandung 2013-2021

Henny Sri Rejeki, Sri Suryanti, Anglita Yantisetiasti, Kemala I. Mantilidewi, Gatot Nyarumenteng Adhipurnawan Winarno

Abstract


Background: Carcinoma of the cervix is the most common gynecological malignancy, which ranks first among carcinomas in Indonesia. Lymph node metastasis is a risk of recurrence, affecting survival and therapy. The purpose of this study was to determine the clinicopathological characteristics of cervical carcinoma with pelvic lymph node metastasis that had undergone radical hysterectomy and lymphadenectomy at Dr. Hasan Sadikin General Hospital, Bandung.

Methods: This study used a cross-sectional retrospective descriptive study. Data on the clinical stage I-II cervical cancer patients with pelvic lymph node metastasis were collected  from the archives of the pathological anatomy  laboratory during period from 2013 to 2021. Data were presented in percentage.

Results: There were 64 data patients, and the most common age of cervical carcinoma ranged from 40 to 50 years old (52%), the most common stage was stage II (66%), and the most frequent histopathological type was squamous cell carcinoma (70%). The highest degree of differentiation was moderate differentiation (50%). There was no difference in tumor size between sizes <4 cm and ≥4 cm.

Conclusion: The cases of cervical carcinoma at Dr. Hasan Sadikin General Hospital Bandung are treated with radical hysterectomy and lymphadenectomy. The patients generally aged between 41–50 years old, stage II, and squamous cell carcinoma with a moderate degree of differentiation.


Keywords


Cervical carcinoma; metastases; pelvic lymph node

Full Text:

PDF

References


  1. Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worlwide for 36 cancers in 185 countries. CA Cancer J Clin. 2021;71(3):209–49.
  2. Indonesian Society of Gynecologic Oncology. National data of cervical cancer.Jakarta: The Institute; 2020
  3. Himpunan Onkologi Ginekologi Indonesia. Panduan penatalaksanaan kanker serviks Kementerian Kesehatan Republik Indonesia. Jakarta: The Institute; 2018.
  4. Carneiro SR, Fagundes MdA, Rosario PdJO, Neves LMT, Souza GS, Pinheiro MCN. Five-year survival and associated factors in women treated for cervical cancer at a reference hospital in the Brazilian Amazon. PLoS One. 2017;12(11):e0187579.
  5. Lorin L, Bertaut A, Hudry D, Beltjens F, Roignot P, Lepinoy MCB, et al. About invasive cervical cancer: a French population based study between 1998 and 2010. Eur J Obstet Gynecol Reprod Biol. 2015;191:1–6.
  6. Li D, Xu X, Yan D, Yuan S, Ni J, Lou H. Prognostic factors affecting survival and recurrence in patient with early cervical squamous cell cancer following radical hysterectomy. J Int Med Res. 2019;48(4): 1–13.
  7. Ferdous J, Khatun S, Akhter S, Chowdhury S, Pervin S, Amir M, et al. Evaluation of the risk factors for pelvic lymph node metastasis in early stage cervical cancer.J Cancer Ther. 2018;9(12):1011–26.
  8. Herrington CS, Bray F, Ordi J. Tumours of the uterine cervix. In: Kurman RJ, Carcangiu ML, Herrington CS, Young RH, editors. WHO classification of tumours of the female reproductive Organs. Lyon; IARC; 2020. p. 335.
  9. Lu X, Zhou Y, Meng J, Jiang L, Gao J, Fan X, et al. Epigenetic age acceleration of cervical squamous cell carcinoma converged to human papillomavirus 16/18 expression, immunoactivattion, and favourable prognosis. Clin Epigenetics. 2020;12:23.
  10. Biewenga P, Velden JVD, Mol BW, Stalpers LJA, Schilthuis MS, Steeg JW, et al. Prognostic model for survival in patients with early stage cervical cancer. Cancer. 2011;117(4):768–76.
  11. Tricia D. Distribution of age, stage, and histopathology of cervical cancer: a retrospective study on patients at Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia 2006–2010. J Obstet Gynecol. 2011;35(1):21–4.
  12. Lin AJ, Wright JW, Dehdasti F, Siegel B, Markovina S, Schwarz J, et al. Impact of tumor histology on detection of pelvic and para-aortic nodal metastasis with FDG-PET in stage IB cervical cancer. Int J Gynecol Cancer. 2019;29(9):1351–4.
  13. Mabuchi S, Okazawa M, Matsuo K, Kawano M, Suzuki O, Miyatake T, et al. Impact of histological subtype on survival of patients with surgically-treated stage IA2-IIB cervical cancer: adenocarcinoma versus squamous cell carcinoma. Gynecol Oncol. 2012;127(1):114–20.
  14. Kato T, Watari H, Takeda M, Hosaka M, Mitamura T, Kobayashi N, et al. Multivariate prognostic analysis of adenocarcinoma of the uterine cervix with radical hysterectomy and systemic lymphadenectomy. J Gynecol Oncol. 2013;24(3):222–8.
  15. Huang YT, Wang CC, Tsai CS, Lai CH, Chang TC, Chou HH, et al. Clinical behaviors and outcomes for adenocarcinoma or adenosquamous carcinoma of cervix treated by radical hysterectomy and adjuvant radiotherapy or chemoradiotherapy. Int J Radiat Oncol Biol Phys. 2012;84(2):420–7.
  16. Xie L, Chu R, Wang K, Zhang X, Li J, Zhao Z, et al. Prognostic assessment of cervical cancer patients by clinical staging and surgical-pathological factor: a support vector machine-based approach. Front Oncol. 2020;10:1353.
  17. Andrijono. Kanker serviks. 4th ed. Jakarta: Divisi Onkologi Departemen Obstetri-Ginekologi Fakultas Kedokteran Universitas Indonesia, 2012. p. 77–112.
  18. Widhiarta PK, Mahendra IN, Aryana MBD, Megaputra IG. Faktor-faktor klinikopatologi kekambuhan kanker serviks stadium 0–IIA2 pasca histerektomi radikal di RSUP Sanglah periode 2019–2020. Intisari Sains Medis. 2021;12(1):196–200.
  19. Stoller M BC CT, Ferenczy AS. Tumours of the uterine cervix. In: Kurman RJ HC, Young R, editor. WHO classification of tumours of the female reproductive organs. Lyons; WHO; 2014. p. 172–80.
  20. Hacker NF, Vermoken JB. Cervical cancer. In: Berek JS, Hacker NF, editors. Berek & Hacker’s gynecologic oncology. 7th ed. Philadelphia: Wolter Kluwers; 2021. p. 247–49.
  21. Witkiewicz AK, Wright TC, Ferenczy AS, Ronnet BM, Kurman RJ. Carcinoma anad other tumors of the cervix. In: Kurman RJ, Elleson LH, Ronnet BM, editors. Blaustein’s pathology of the female genital tract. 6th ed. New York: Springer Science & Business Media; 2013. p. 253–72.
  22. Feng M, Xu L, He Y, Sun L, Zhang Z, et al. Elevated PD-L1 expression (CD274) enhanced expression in cervical squamous cell carcinoma. Int J Clin Exp Pathol. 2018;11(11):5370–8.
  23. Chen Z, Pang N, Du R, Zhu Y, Fan L, Cai D, et al. Elevated expression of progammed death-1 and programmed death ligand-1 negatively regulates immune response againt cervical cancer servik. Mediators Inflamm. 2016;2016:6891482




DOI: https://doi.org/10.15850/amj.v10n2.2776

Article Metrics

Abstract view : 542 times
PDF - 283 times



 This Journal indexed by

                  

          

 

Creative Commons License
AMJ is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License

 


View My Stats