Comparison of Cognitive Function of Ischemic Stroke Patients with and without Pneumonia
Abstract
Background: Pneumonia is a common complication of ischemic stroke that may worsens brain injury, leading to cognitive impairment as well as patient outcome. The aim of this study was to compare cognitive function in ischemic stroke patients with and without pneumonia.
Methods: This study was a comparative numerical analytic retrospective cross-sectional study that was conducted from September 2020 to February 2021. This study used data from ischemic stroke patients treated at Dr. Hasan Sadikin General Hospital in 2019 with the total sampling method. Data were stratified into patients with pneumonia and without pneumonia. The mini mental state examination (MMSE) was used to measure cognitive function in both groups and scores were compared using the Mann-Whitney Test.
Result: Of the 164 data, 25 were patients with pneumonia and 139 without pneumonia. Male patients were predominantly prevalent in the pneumonia and non-pneumonia groups. Hemiparesis was the most common neurological deficit. The MMSE score was significantly lower in the pneumonia group (22.6 ± 5.4 vs. 24.7 ± 4.8, respectively; p-value=0.032).
Conclusion: Cognitive function is more prevalent in ischemic stroke patient with pneumonia compared to non-pneumonia. However, other factors such as recurrent stroke and possible vascular risk factors should be considered for future studies to better identify the relationship between ischemic stroke and pneumonia.
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of ischemic stroke. US Pharm. 2013;38(1):HS1–5
Kalaria RN, Akinyemi R, Ihara M. Stroke injury, cognitive impairment and vascular dementia. Biochim Biophys Acta. 2016;1862(5):915–25.
Sun JH, Tan L, Yu JT. Post-stroke cognitive impairment: Epidemiology, mechanisms and management. Ann Transl Med. 2014;2(8):80.
Nam KW, Kwon HM, Lim JS, Lee YS. Leukoaraiosis is associated with pneumonia after acute ischemic stroke. BMC Neurol. 2017;17(1):51.
de Castillo LLC, Sumalapao DEP, Pascual JLR. Risk factors for pneumonia in acute stroke patients admitted to the Emergency Department of a Tertiary Government Hospital. Natl J Physiol Pharm Pharmacol. 2017;7(8):855–9.
Winklewski PJ, Radkowski M, Demkow U. Cross-talk between the inflammatory response, sympathetic activation and pulmonary infection in the ischemic stroke. J Neuroinflammation. 2014;11:213.
Davydow DS, Hough CL, Levine DA, Langa KM, Iwashyna TJ. Functional disability, cognitive impairment, and depression after hospitalization for pneumonia. Am J Med. 2013;126(7):615–24.e5.
Bour A, Rasquin S, Boreas A, Limburg M, Verhey F. How predictive is the MMSE for cognitive performance after stroke? J Neurol 2010;257(4):630–7.
Habibi-Koolaee M, Shahmoradi L, Kalhori SRN, Ghannadan H, Younesi E. Prevalence of stroke risk factors and their distribution based on stroke subtypes in Gorgan: a retrospective hospital-based study-2015–2016. Neurol Res Int. 2018;2018:2709654.
Haast RAM, Gustafson DR, Kiliaan AJ. Sex differences in stroke. J Cereb Blood Flow Metab. 2012;32(12):2100–7.
Wang S, Shen B, Wu M, Chen C, Wang J. Effects of socioeconomic status on risk of ischemic stroke: a case-control study in the Guangzhou population. BMC Public Health. 2019;19(1):648.
Jackson CA, Sudlow CLM, Mishra GD. Education, sex and risk of stroke: aprospective cohort study in New South Wales, Australia. BMJ Open. 2018;8:e024070.
Wandira RD, Amalia L, Fuadi I. Hubungan antara derajat keparahan stroke dengan kejadian stroke-associated pneumonia. Neurona. 2018;35(2):116–20.
Hannawi Y, Hannawi B, Rao CPV, Suarez JI, Bershad EM. Stroke-associated pneumonia: major advances and obstacles. Cerebrovasc Dis. 2013;35(5):430–43.
Liu DD, Chu SF, Chen C, Yang PF, Chen NH, He X. Research progress in stroke-induced immunodepression syndrome (SIDS) and stroke-associated pneumonia (SAP). Neurochem Int. 2018;114:42–54.
Hui C, Tadi P, Patti L. Ischemic Stroke. [Updated 2020 Aug 10]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2020 [cited 2020 Dec 5]Available from: https://www.ncbi.nlm.nih.gov/books/NBK499997/
Jaillard A, Grand S, Le Bas JF, Hommel M. Predicting cognitive dysfunctioning in nondemented patients early after stroke. Cerebrovasc Dis. 2010;29(5):415–23.
Squire L, Berg D,Bloom FE, du Lac S, Ghosh A, Spitzer NC. Fundamental Neuroscience. 3 rd Ed, Cambridge, Massachusetts: Academic Press Elsevier; 2008. p.1277
Shah FA, Pike F, Alvarez K, Angus D, Newman AB, Lopez O, et al. Bidirectional relationship between cognitive function and pneumonia. Am J Respir Crit Care Med. 2013;188(5):586–92.
Lakhan SE, Kirchgessner A, Hofer M. Inflammatory mechanisms in ischemic stroke: therapeutic approaches. J Transl Med. 2009;7:97.
DOI: https://doi.org/10.15850/amj.v8n3.2356
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