Characteristics of Neonatal Hyperbilirubinemia at West Java’s Top Referral Hospital, Indonesia.

Nurain Yahya, Tetty Yuniati, Leonardo Lubis


Background: Neonatal hyperbilirubinemia or neonatal jaundice is a common disorder and considered as one of the main problems in neonatal period worldwide with high incidence, especially in Asia and Southeast Asia region. This study was conducted to determine the characteristics of neonatal hyperbilirubinemia including the prevalence and frequency of neonatal hyperbilirubinemia causes at Dr. Hasan Sadikin General Hospital in 2012.

Methods: This descriptive study was conducted at Dr. Hasan Sadikin General Hospital using the cross-sectional method. Four hundred and twenty five cases of neonatal hyperbilirubinemia in hospitalized and outpatients, from 1 January to 31 December 2012 were included in this descriptive study.

Results: The prevalence of neonatal hyperbilirubinemia was about 4.08%. Causes were identified in 95 cases and the most common cause of neonatal hyperbilirubinemia during this period of time was physiological causes (23.2%). Other causes included neonatal hepatitis (14.7%), other hemolytic causes (13.7%), infection (12.6%), ABO incompatibility (11.6%) and breastfeeding (11.6%).

Conclusions: Neonatal hyperbilirubinemia cases are common and remain as one of the neonatal problems in Dr. Hasan Sadikin General Hospital, thus prevention and proper management of neonatal hyperbilirubinemia should be implemented.


DOI: 10.15850/amj.v4n2.1065


Neonatal hyperbilirubinemia, neonatal jaundice, prevalence

Full Text:



aeusch HW, Ballard RA, Gleason CA, Avery ME. Avery’s diseases of the newborn. 9th ed. Philadelphia: Elsevier Saunders; 2012. p. 1129–1148.

Brown AK. Kernicterus: past, present, and future. Pediatrics. 2003;4(2):e33–40.

Kliegman RM, Stanton BMD, Geme JS, Schor NF, Behrman RE. Nelson textbook of pediatrics: expert consult. 19th ed. Philadelphia: Elsevier Health Sciences; 2011. p. 603–8.

Setia S, Villaveces A, Dhillon P, Mueller BA. Neonatal jaundice in Asian, white, and mixed-race infants. Arch Pediatr Adolesc Med. 2002;156(3):276–9.

Du L, Ma X. International perspectives: hyperbilirubinemia and kernicterus in neonates in China. Neoreviews. 2012;13(3):e141–4.

Maisels MJ. Neonatal jaundice. Pediatr Rev. 2006;27(12):443–54.

National Institute for Health and Care Excellence. Neonatal jaundice: NICE clinical guideline 98. Manchester: National Institute for Health and Clinical Excellence. 2010 [cited 2013 March 21]: Available from:

Sgro M, Campbell D, Shah V. Incidence and causes of severe neonatal hyperbilirubinemia in Canada. CMAJ. 2006;175(6):587–90.

Widiasta A, Reniarti L, Sukadi A. Incidence of neonatal hyperbilirubinemia in low, intermediate-low, and intermediate-high risk group infants. Paediatr Indones. 2010;50(6):351–4.

Indriyani SAK, Retayasa IW, Surjono A, Suryantoro P. Percentage birth weight loss and hyperbilirubinemia during the first week of life in term newborns. Paediatr Indones. 2009;49(3):149–54.

Tikmani SS, Warraich HJ, Abbasi F, Rizvi A, Darmstadt GL, Zaidi AK. Incidence of neonatal hyperbilirubinemia: a population-based prospective study in Pakistan. Trop Med Int Health. 2010;15(5):502–7.

Moerschel SK, Cianciaruso LB, Tracy LR. A practical approach to neonatal jaundice. Am Fam Physician. 2008;77(9):1255–62.

Cloherty JP, Eichenwald EC, Hansen AR, Stark AR. Manual of neonatal care. 7th ed. Philadelphia: Wolters Kluwer Health; 2012. p. 304–39

Lazarus C, Avchen RN. Neonatal hyperbilirubinemia management: a model for change. J Perinatol. 2009;29(Suppl 1):S58–60.

Nold JL, Georgieff MK. Infants of diabetic mothers. Pediatr Clin North Am. 2004;51(3):619–37, viii.

Gudmundsson S, Henningsson AC, Lindqvist P. Correlation of birth injury with maternal height and birthweight. BJOG. 2005;112(6):764–7.

AAP Subcommittee on Neonatal Hyperbilirubinemia. Neonatal jaundice and kernicterus. Pediatrics. 2001;108(3):763–5.

Maisels MJ. Neonatal hyperbilirubinemia and kernicterus-not gone but sometimes forgotten. Early Hum Dev. 2009;85(11):727–32.

Manning D, Todd P, Maxwell M, Platt MJ. Prospective surveillance study of severe hyperbilirubinaemia in the newborn in the UK and Ireland. Arch Dis Child Fetal Neonatal Ed. 2007;92(5):F342–6


Article Metrics

Abstract view : 635 times
PDF - 356 times

 This Journal indexed by




Creative Commons License
AMJ is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License


View My Stats