Perbandingan Efek Induksi Propofol dengan Ketamin terhadap Penurunan Nilai Neutrofil pada Pasien dengan Tindakan Anestesi Umum

Angga Permana Putra, Hasanul Arifin, Chairul M. Mursin

Abstract


Leukosit merupakan bagian dari imunitas bawaan. Penurunan nilai neutrofil dapat dipakai sebagai parameter yang sederhana untuk mengukur berat ringannya stres dan inflamasi sistemik pada pasien. Beberapa penelitian mengemukakan pengaruh obat-obat anestesi terhadap leukosit dan penelitian yang lain melihat dari pengaruh obat-obat anestesi terhadap fungsi dari subset leukosit terutama neutrofil. Tujuan penelitian ini mengetahui perbedaan efek induksi propofol dengan ketamin terhadap penurunan nilai neutrofil pada pasien dengan tindakan anestesi umum di Instalasi Bedah Pusat RSUP H. Adam Malik
Medan mulai Mei–Juni 2016. Penelitian uji klinis dengan  randomized control trial double blind dilakukan pada 32 pasien ASA I dan II dibagi dalam 2 kelompok yang menjalani operasi dengan anestesi umum. Pasien pada kelompok propofol (A) diberikan induksi dengan propofol 2 mg/kgBB. Kelompok ketamin diinduksi ketamin 2 mg/kgBB. Kemudian diukur nilai neutrofil (%) pada saat sebelum induksi (T1), 10 menit setelah intubasi (T2), dan 60 menit setelah insisi kulit (T3). Dengan SPSS ver.23, Uji T-independen dan Mann-Whitney U didapatkan hasil T1 neutrofil nilai p=0,636, T2 neutrofil nilai p=0,846, T3 neutrofil nilai p=0,403. Simpulan, terdapat perbedaan efek induksi antara propofol dan ketamin terhadap penurunan nilai neutrofil. Terdapat pengaruh ketamin terhadap penurunan nilai neutrofil, tetapi tidak ada pengaruh propofol terhadap penurunan nilai neutrofil.


Kata kunci: Ketamin, leukosit, neutrofil, propofol


Comparison of Induction Effect between Propofol and Ketamine against Impairment of Neutrophils in Patient with General Anesthesia

Leukocyte is a part of innate immunity elements. Neutrophil impairment of can be used as a simple parameter to measure the severity of stress and systemic inflammation in patients. Some research suggests the influence of anesthetic drugs on leukocytes and other studies look at the effect of anesthetic drugs on leukocyte subset functions, especially neutrophils. This study aimed to reveal the difference in the induction effect of propofol and ketamine against impairment of neutrophils in patients with general anesthesia. This was a double blind randomized control trial conducted in 32 patients ASA I and II who were divided into two groups. These patients underwent general anesthesia at the Central Operating Theater of H. Adam Malik General Hospital during May–June 2016. Group propofol (A) received 2 mg/kgBW propofol, while group ketamine (B) received 2 mg/kgBW ketamine. Neutrophils were measured before induction (T1), 10 minutes after intubation (T2), and 60 minutes after intubation (T3). By using T-independent and Mann-Whitney U test in SPSS ver.23, it was found that the the p-values for T1. T2, and T3 neutrophils were 0.636,0.846, and 0.403. respectively. In conclusion, there is a difference in induction effect between propofol and ketamine against impairment of neutrophils with no effect is found for propofol.

Key words: Ketamine, leukocyte, neutrophils, propofol

 

DOI: 10.15851/jap.v5n1.999


Keywords


Ketamin, leukosit, neutrofil, propofol

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