Korelasi Skor Modified Sequensial Organ Failure Assesment dengan Kadar Superoksida Dismutase dan Vitamin D Serum pada Pasien Sepsis

Cut Meliza Zainumi, Raka Jati Prasetya

Abstract


Sepsis adalah disfungsi organ yang mengancam jiwa yang disebabkan oleh disregulasi antara respons tubuh dan infeksi. Penilaian tingkat keparahan sepsis berdasar atas derajat disfungsi organ dapat digunakan skor modified sequential organ failure assesment (MSOFA). Beberapa penelitian terdahulu menemukan hubungan rendahnya kadar vitamin D dan peningkatan kadar superoxide dismutase (SOD) pada sepsis. Tujuan penelitian ini mengetahui korelasi skor MSOFA dengan kadar SOD dan vitamin D serum pada sepsis. Penelitian ini adalah penelitian potong lintang pada 61 pasien sepsis yang dirawat di ruang terapi intensif pada bulan Juli sampai Oktober 2017. Penilaian Skor MSOFA dan pengambilan sampel darah dilakukan saat pasien masuk ruang intensif dengan metode enzim linked immunosorbent assay (ELISA). Analisis statistik menggunakan korelasi Spearman dengan p<0,05, hasil yang diperoleh terdapat korelasi skor MSOFA dengan kadar vitamin D serum (p 0,169 dan nilai r 0,179). Korelasi skor MSOFA dengan kadar SOD tidak bermakna dan kekuatan korelasinya juga sangat lemah (p=0,793; r=0,034). Simpulan penelitian ini adalah pada pasien sepsis skor MSOFA tidak mempunyai korelasi dengan kadar SOD dan vitamin D serum sehingga kadar vitamin D dan SOD tidak dapat digunakan sebagai prediksi morbiditas dan mortalitas sepsis.

Kata kunci: Sepsis, skor MSOFA, superoksida dismutase, vitamin D


Keywords


Sepsis, skor MSOFA, superoksida dismutase, vitamin D

Full Text:

PDF

References


Lever A, Mackenzie I. Sepsis: definition, epidemiology, and diagnosis. BMJ. 2007;335(7625):879–83.

Breu F, Guggenbichler S, Wollmann J. World Health Statistics 2013. Vasa. 2013;168:3.

Azim A, Ahmed A, Yadav S, Baronia AK, Gurjar M, Godbole MM, dkk. Prevalence of vitamin D deficiency in critically ill patients and its influence on outcome: experience from a tertiary care centre in North India (an observational study). J Intens Care. 2013;1(1):14.

Upala S, Sanguankeo A, Permpalung N. Significant association between vitamin D deficiency and sepsis: a systematic review and meta-analysis. BMC Anesthesiol. 2015;15(1):84.

Lorente L, Martin MM, Almeida T, Abreu-Gonzalez P, Ferreres J, Sole-Violan J, dkk. Association between serum total antioxidant capacity and mortality in severe septic patients. J Crit Care. 2015;30(1):217.e7–217.e12.

Paludo FJO, Bristot IJ, Alho CS, Gelain DP, Moreira JCF. Effects of 47C allele (rs4880) of the SOD2 gene in the production of intracellular reactive species in peripheral blood mononuclear cells with and without lipopolysaccharides induction. Free Radic Res. 2014;48(2):190–9.

Vincent J-L, Moreno R, Takala J, Willatts S, De Mendonca A, Bruining H, dkk. The SOFA (sepsis-related organ failure assessment) score to describe organ dysfunction/failure. On behalf of the Working Group on Sepsis-Related Problems of the European Society of Intensive Care Medicine. Intens Care Med. 1996;22(7):707–10.

Grissom CK, Brown SM, Kuttler KG, Boltax JP, Jones J, Jephson AR, dkk. A modified sequential organ failure assessment score for critical care triage. Disaster Med Public Health Prep. 2010;4(4):277–84.

Briassouli E, Briassoulis G. Glutamine randomized studies in early life: The unsolved riddle of experimental and clinical studies. Clin Dev Immunol. 2012;2012:749189.

Parekh D, Patel JM, Scott A, Lax S, Dancer RCA, D’Souza V, dkk. Vitamin D deficiency in human and murine sepsis. Crit Care Med. 2016;45(2):1.

Kempker JA, Han JE, Tangpricha V, Ziegler TR, Martin GS. Vitamin D and sepsis: an emerging relationship. Dermatoendocrinology. 2012;4(2):101–8.

Hewison M. Antibacterial effects of vitamin D. Nat Rev Endocrinol. 2011;7:337.

Higgins DM, Wischmeyer PE, Queensland KM, Sillau SH, Sufit AJ, Heyland DK. Relationship of vitamin D deficiency to clinical outcomes in critically ill patients. J Parenter Enter Nutr. 2012;36(6):713–20.

Jeng L, Yamshchikov AV, Judd SE, Blumberg HM, Martin GS, Ziegler TR, dkk. Alterations in vitamin D status and anti-microbial peptide levels in patients in the intensive care unit with sepsis. J Transl Med. 2009;7(1):28.

Alizadeh N, Khalili H, Mohammadi M, Abdollahi A. Serum vitamin D levels at admission predict the length of intensive care unit stay but not in-hospital mortality of critically ill surgical patients. J Res Pharm Pract. 2015;4(4):193.

Vipul P, Shuchi C, Avinash A, Manish G, Sukriti K, Ved P. Correlation of serum vitamin d level with mortality in patients with sepsis. Indian J Crit Care Med. 2017;21(4):199–204.

Miller AF. Superoxide dismutases: active sites that save, but a protein that kills. Curr Opin Chem Biol. 2004;8(2):162–8.

Rosario AL, Azevedo LCP. Therapeutic use of antioxidants in sepsis. Recent Pat Endocr Metab Immune Drug Discov. 2007;1:210–23.

Abreu IA, Cabelli DE. Superoxide dismutases-a review of the metal-associated mechanistic variations. Biochim Biophys Acta-Proteins Proteomics. 2010;1804(2):263–74.

Kawaguchi T, Suzuki K, Matsuda Y, Nishiura T, Uda T, Ono M, dkk. Serum-manganese-superoxide dismutase: normal values and increased levels in patients with acute myocardial infarction and several malignant diseases determined by an enzyme-linked immunosorbent assay using a monoclonal antibody. J Immunol Methods. 1990;127(2):249–54.


Refbacks

  • There are currently no refbacks.



 

This Journal indexed by:

               

 
Creative Commons License
JAP is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License

 


View My Stats