Intralesional Triamcinolone Acetonide and 5-Fluorouracil Combination in Keloid

Jono Hadi Agusni, Eva Krishna Sutedja, Franky Chandra

Abstract


Objective: Corticosteroid injection has always remained the first line treatment for keloid.Although it is effective for recent keloid lesions, the response often limited for the old ones. Meanwhile, 5-fluorouracil (5-FU) is a chemotherapy agent which inhibits collagen production in keloid and has been reported  effective both as single and combination injection  in keloid. This report aimed to evaluate the effectiveness of steroid and 5-FU injection combination for keloid management.

Method: A case of keloid on a 22-year-old woman whose skin lesions first appeared 10 years prior to consultation was presented. Lesions had been surgically excised and given triamcinolone acetonide injection, but there were no improvements. Authors decided  to use and evaluate treatment using intralesional  4 mg (0.1 ml of 40 mg/ml) triamcinolone acetonide and 45 mg (0.9 ml of 50 mg/ml ) 5-FU injection combination for 5 weeks.

Result: Clinical improvements were observed in the third week as the lesions softened and pruritic sensation dinimished. At the end of fifth week, there were improvements with flattening and size reduction of the keloid lesions.

Conclusion: Intralesional triamcinolone acetonide & 5-fluorouracil combination is effective for  keloid lesion treatment

Key words: 5-fluorouracil, intralesional injection, keloid, triamcinolone acetonide

 

DOI: 10.15850/ijihs.v5n1.


Keywords


5-fluorouracil, intralesional injection, keloid, triamcinolone acetonide

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