Congenital Heart Disease among Down Syndrome Children at Dr. Hasan Sadikin General Hospital from 2008 to 2013

Thyviyaa Rajamany, Rahmat Budi Kuswiyanto, Leonardo Lubis

Abstract


Background: Children with Down syndrome are more prone to congenital heart disease due to the consequences of trisomy chromosomal 21 on gene expression. The aim of this study was to determine the pattern of congenital heart disease in children with Down syndrome.

Methods: This was a retrospective study of reviewed children with Down syndrome from January 2008 to January 2013 at Dr. Hasan Sadikin General Hospital, Bandung, Indonesia. This study was conducted from August until October 2014. Patients under the age of 15 years and diagnosed having congenital heart disease from 2008 to 2013 were enrolled in this study by using the total sampling method. Incomplete medical records and children who had not performed an echocardiogram were excluded. Sex, age at diagnosis for congenital heart disease, nutritional status and other comorbidities were also examined.

Results: Congenital heart disease occurred in 28 children with Down Syndrome. Patent ductus arteriosus (PDA) was the most common and found in 11 patients followed by a combination of congenital heart diseases in 5 patients. Other 3 patients had Atrioventricular septal defect (AVSD), and Tetralogy of fallot (TOF) was found in 3 patients, 2 patients had Atrial septal defect (ASD) and 1 patient had miscellaneous cardiac defect.

Conclusions: The most common CHD in Down syndrome is PDA.


Keywords


Children, congenital heart disease, Down syndrome

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References


WHO. Genes and human disease.2013. [Cited 2014 November 10] Available from: http://www.who.int/genomics/public/geneticdiseases/en/index.html.

Freeman SB, Bean LH, Allen EG, Tinker SW, Locke AE, Druschel C, et al. Ethnicity, sex, and the incidence of congenital heart defects: a report from the National Down Syndrome Project. Genet Med. 2008;10(3):173–80.

Nisli K, Oner N, Candan S, Kayserili H, Tansel T, Tireli E, et al. Congenital heart disease in children with Down’s syndrome: Turkish experience of 13 years. Acta Cardiol. 2008;63(5):585–9.

Irving CA, Chaudhari MP. Cardiovascular abnormalities in Down’s syndrome: spectrum, management and survival over 22 years. Arch Dis Child. 2012;97(4):326–30.

Wiseman FK, Alford KA, Tybulewicz VL, Fisher EM. Down syndrome–recent progress and future prospects. Hum Mol Genet. 2009;18(R1):R75–R83.

Joziasse IC, Smith KA, Chocron S, van Dinther M, Guryev V, van de Smagt JJ, et al. ALK2 mutation in a patient with Down’s syndrome and a congenital heart defect. Eur J Hum Genet. 2011;19(4):389–93.

Blom HJ, Smulders Y. Overview of homocysteine and folate metabolism. With special references to cardiovascular disease and neural tube defects. J Inherit Metab Dis. 2011;34(1):75–81.

Stanton B, Berhman K, Stanton J. Nelson textbook of Pediatrics. 19th ed. Philadelphia: Elsevier, pg; 2007. p. 29–39.

De Onis M, Mercedes, WHO. WHO child growth standards: length/height–for–age, weight–for–age, weight–for–length, weight–for–height and body mass index–for–age: methods and development. Geneva: WHO; 2006 [Cited 2014 November 3]. Available from: http://apps.who.int/iris/handle/10665/43413

Mogra R, Zidere V, Allan L. Prenatally detectable congenital heart defects in fetuses with Down syndrome. Ultrasound Obstet Gynecol. 2011;38(3):320–4.

Forsey JT, Elmasry OA, Martin RP. Patent arterial duct. Orphanet J Rare Dis. 2009;4(1):17.

Abbag FI. Congenital heart diseases and other major anomalies in patients with Down syndrome. Saudi Med J. 2006;27(2):219–22.

Okoromah CA, Ekure EN, Lesi FE, Okunowo WO, Tijani BO, Okeiyi JC. Prevalence, profile and predictors of malnutrition in children with congenital heart defects: a case–control observational study. Arch Dis Child. 2011; 96(4):354-60

Jadcherla S, Vijayapal A, Leuthner S. Feeding abilities in neonates with congenital heart disease: a retrospective study. J Perinatol. 2008;29(2):112–8.

Pemberton VL, McCrindle BW, Barkin S, Daniels SR, Barlow SE, Binns HJ, et al. Report of the National Heart, Lung, and Blood Institute’s Working Group on obesity and other cardiovascular risk factors in congenital heart disease. Circulation. 2010;121(9):1153–9.

Gibson P, Newton R, Selby K, Price D, Leyland K, Addison G. Longitudinal study of thyroid function in Down’s syndrome in the first two decades. Arch Dis Child. 2005;90(6):574–8.

Klein I, Danzi S. Thyroid disease and the heart. Circulation. 2007;116(15):1725–35.

Park S, Chatterjee V. Genetics of congenital hypothyroidism. J Med Genet. 2005;42(5):379–89.

D’Alto M, Mahadevan VS. Pulmonary arterial hypertension associated with congenital heart disease. Eur Respir Rev. 2012;21(126):328–37.


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