Association between Patient’s Basic Characteristic and Clark Level in Cutaneous Malignant Melanoma

Egie Rahmalaelani, Hermin Aminah Usman, Jono Hadi Agusni

Abstract


Background: Malignant melanoma is  a cancer that begins in the melanocytes. Melanoma is commonly happened on older people, male and located on sun exposure body area, such as face, neck and lower limb. Melanoma cases occur less than 5% of skin cancer but cause a majority of skin cancer deaths because melanoma has an aggressive behavior. Age, sex, location of lesion, and type of melanoma influences the melanoma invasion. The cutaneous melanoma invasion could be assessed with the Clark level. This study is aimed to determine the association between patient’s basic characteristic and Clark level in cutaneous malignant melanoma.
Methods: This study used cross sectional analytic design. The medical records and histopathology slide from the Department of Anatomic Pathology Dr. Hasan Sadikin General Hospital from 2008−2012 took as a sample. Forty one data were meet the inclusion criteria.  Furthermore, those data were analyzed using chi-square test.
Result: Overall, patient’s characteristic in this study, commonly occurred on female (66%), 50−59 years group age (35%), non-cephalic/acral location (71%), and the level V in Clark level (73%). Location of lesion showed an association with Clark level (p=0.023), whereas, age and sex was not significant (p=0.679 and p=0.389).
Conclusions: There is an association between location of lesion and Clark level [AMJ.2017;4(1):25–9] DOI: 10.15850/amj.v4n1.1015 

Keywords


Basic characteristic, cutaneous melanoma, Clark level, malignant melanoma

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References


American Cancer Society. Melanoma skin cancer. 2012. p. 1−11. [Cited 2013 9 February]. Available from: https://www.cancer.org.

Yaar M, Gilchrest BA. Aging of skin. In: Wolff K, Goldsmith L, Gilchrest B, Paller A, Leffell D, Katz S, et al., editors. Fitzpatrick’s dermatology in general medicine. 7th ed. New York: McGraw-Hill; 2008. p. 963−72.

World Health Organization. Pathology and genetic of skin tumors: melanocytic tumors. Lyon: International Agency for Research on Cancer (IARC); 2006. p. 51−77.

Markovic SN, Erickson LA, Rao RD, Weening RH, Pockaj BA, Bardia A, et al. Malignant melanoma in the 21st century, part 1: epidemiology, risk factors, screening, prevention, and diagnosis. Mayo Clin Proc. 2007;82(3):364−74.

Buchan J, Roberts DL. Pocket guide to malignant melanoma. Oxford, UK: Blackwell Science Ltd; 2008. p.1−5.

Markovic SN, Erickson LA, Rao RD, Weening RH, Pockaj BA, Bardia A, et al. Malignant melanoma in the 21st century, part 2: staging, prognosis, and treatment. Mayo Clin Proc. 2007;82(4):490−513.

Homsi J, Kashani-Sabet M, Messina JL, Daud A. Cutaneous melanoma: prognostic factors. Cancer Control. 2005;12(4):223−9.

Kabigting FD, Nelson FP, Kauffman CL, Popoveniuc G, Dasanu CA, Alexandrescu DT. Malignant melanoma in African-Americans. Dermatol Online J. 2009;15(2):3.

Anger M, Friedhoper H, Fukutaki MF, Ferreira MC, Landman G. Primary cutaneous melanoma: an 18-year study. Clinics (Sao Paulo). 2010;65(3):257−63.

Pailoor J, Mun KS, Leow M. Cutaneous malignant melanoma: clinical and histopathological review of cases in a Malaysian tertiary referral centre. Malays J Pathol. 2012;34(2):97−101.

Káram-Orantes M, Toussaint-Caire S, Domínguez-Cherit J, Veja-Memije E. Clinical and histopathological characteristics of malignant melanoma cases seen at “Dr. Manuel Gea González” General Hospital. Gac Med Mex. 2008;144(3):19−23.

Roche LM, Xiao-Cheng W, Vivien C, Elizabeth HB, Frank DG, Ahmedin J, et al. Cutaneous melanoma incidence and survival among Black, Asian, Pacific Islander and White populations in the United State. Clinical Medicine Insights. 2010;(3):15−24.

Takata M. Acral melanoma: clinical, biologic and molecular genetic characteristic. In: Murph M, editor. Melanoma in the clinic-diagnosis, management and complications of malignancy. Rijeka: InTech; 2011. p. 3−14.

Park HS, Cho KH. Acral lentiginous melanoma in situ: a diagnostic and management challenge. Cancers (Basel). 2010;(2):642−52.

Melanoma molecular map project. Melanoma: an introduction. [cited 2013 May 15] Available from: http://www.mmmp.org.


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