2026-04-04T19:40:14Z https://journal.fk.unpad.ac.id/index.php/mkb/oai

oai:ojs.journal.fk.unpad.ac.id:article/3237 2023-02-15T02:10:29Z amj:fbma

oai:ojs.journal.fk.unpad.ac.id:article/3281 2024-10-08T08:39:36Z mkb:ART

Correlation of Hepatocyte Growth Factor Levels with Myopia Degree and Axial Length in Outpatient Myopic Adolescents Aldy, Fithria Yanni, Gema Nazri Siregar, Jelita Opthalmology; Biochemistry; Pediatric Axial length, hepatocyte growth factor, myopia Myopia is the most common ophthalmic condition worldwide, with an estimated 22.9% of the population or 1.406 billion people affected. Studies of candidate gene-associated refraction abnormalities have also identified several genes that cause vulnerability myopia, including the hepatocyte growth factor (HGF) and  hepatocyte growth factor receptor (MET) genes. The purpose of the study was to analyze the correlation between hepatocyte growth factor (HGF) levels, degrees of myopia, and long axial in adolescents with myopia treated as outpatients in Universitas Sumatera Utara Hospital. This study applied the cross-sectional analytical approach. The inclusion criterion for the participants was patients diagnosed as suffering from myopia by the Ophthalmology Outpatient Clinic of the Universitas Sumatera Utara Hospital. Sampling was performed consecutively with a minimum sample size of 25 patients in control group and 25 patients in the case group. This study revealed that the mean axial length of the right eye in the case group was 23.82 mm, with a significant difference in the axial length between the case and control groups. The mean HGF level in the myopia group was 510.49 ng/mL, which was not significantly different from the mean HGF level in the control or emmetropic group. The HGF levels were highest in the group of subjects with moderate myopia, with an average of 551.87 ng/mL, and differences in HGF levels were identified in different degrees of myopia. Thus, no significant correlation is identified between the HGF levels, axial length, and myopia degree. Faculty of Medicine, Universitas Padjadjaran 2024-03-17 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.fk.unpad.ac.id/index.php/mkb/article/view/3281 10.15395/mkb.v56.3281 Majalah Kedokteran Bandung; Vol 56, No 1 (2024); 1-7 Majalah Kedokteran Bandung; Vol 56, No 1 (2024); 1-7 2338-6223 0126-074x 10.15395/mkb.v56n1 eng https://journal.fk.unpad.ac.id/index.php/mkb/article/view/3281/pdf https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/3281/3988 https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/3281/3989 https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/3281/4027 Copyright (c) 2023 Majalah Kedokteran Bandung http://creativecommons.org/licenses/by-nc/4.0

oai:ojs.journal.fk.unpad.ac.id:article/2363 2022-02-04T04:04:21Z mkb:ART

Correlation between Estrogen Receptorβ (ERβ), Neurofilament Protein (NF), and Protein Gene Product 9.5 (PGP9.5) Expressions as a Marker of Pain on Adenomyosis Etiopathogenesis Setiawan, Arief Anwar, Ruswana Husnitawati, Tita Djuwantono, Tono Permadi, Wiryawan Medicine; Obstetric and Gynecology; Endocrinology Reproduction Adenomyosis, estrogen receptors β(ERβ), protein neurofilament (NF), protein gene product 9.5(PGP9.5) Adenomyosis is a pathological condition characterized by the presence of endometrial glands and stroma within the myometrium. Endometrial like cells development was influenced by local inflammatory reactions, increases local estradiol due to asynchromatized estrogen synthesis (ERβ) and then stimulated to proliferation and fibrosis, are also irritation on small nerve fibers in women with painful characterized symptoms on adenomyosis. There are expressions of neurofilament protein (NF) and protein gene product 9.5 (PGP 9.5) is a highly specific pan-neuronal marker for microfilament nerve fibers and is related to presenting pain with adenomyosis symptoms. A retrospective immunohistochemical study of thirty samples histopathological of adenomyosis as study groups and 30 with control groups between 25–49 ages which were established at Dr. Hasan Sadikin General Hospital and the satellites in April 2014–May 2015. This case-control analyzed ERβ, NF, and PGP 9.5 expressions compared and correlation between study groups and controls. The results showed there were significant differences in expression of ERβ, NF, and PGP 9.5 on adenomyosis higher than the control study (p<0.05). The intensity was higher and very strong into the study groups (p<0,001). Cut off point of ERβ was more than>6(sensitivity 66.7%; specificity 70%), NF>3 (sensitivity 93%; specificity 46%), PGP 9.5>4 (sensitivity 90%; specificity 67%). Odds Ratio (CI 95%) ERβ>6= 4.67; NF >3=12.25; PGP 9.5 >4=24.75 (p<0.001). The value of histoscore of ERβ and PGP9.5 have correlates to adenomyosis, the differences were statistically significant (p<0.05). The conclusion were that the adenomyosis had higher ERβ, NF, and PGP 9.5 expressions. There are simultant correlates and positive values between ERβ, NF, and PGP9.5 based on etiophatogenesis of pain on adenomyosis. Faculty of Medicine, Universitas Padjadjaran 2021-12-31 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.fk.unpad.ac.id/index.php/mkb/article/view/2363 10.15395/mkb.v53n4.2363 Majalah Kedokteran Bandung; Vol 53, No 4 (2021); 215-222 Majalah Kedokteran Bandung; Vol 53, No 4 (2021); 215-222 2338-6223 0126-074x 10.15395/mkb.v53n4 eng https://journal.fk.unpad.ac.id/index.php/mkb/article/view/2363/pdf https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/2363/2817 https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/2363/2818 Copyright (c) 2021 Majalah Kedokteran Bandung http://creativecommons.org/licenses/by-nc/4.0

oai:ojs.journal.fk.unpad.ac.id:article/3311 2024-10-10T06:40:37Z mkb:ART

Comparison of Different Cycloplegic Refraction Regimens for Children Irfani, Irawati Gunawan, Fany Satari, Karmelita Sari, Maya Oktarima, Primawita Caesarya, Sesy Karfiati, Feti Medicine, Ophthalmology, Refractive Cyclopentolate, cycloplegic, mydriasis, phenylephrine, tropicamide In the process of a pediatric eye exam, cycloplegic refraction is a crucial step. Since no single cycloplegic drug is ideal, a combination regimen is employed. This study compares the ocular (refractive power and pupil diameter) and systemic (blood pressure and heart rate) effects of administering a combination of 1% cyclopentolate and 2.5% phenylephrine, with or without 1% tropicamide, to children with refractive errors. This study aimed to discover a more feasible regimen for children. This was a single-blind study, a randomized clinical trial conducted from November–December 2020 in children with mild to moderate refractive errors. Group A received 1% cyclopentolate, 2.5% phenylephrine, and 1% tropicamide (SFT), whereas group B received 1% cyclopentolate and 2.5% phenylephrine (SF). The outcomes were measured using an auto refractometer and IOL Master® 700. Before and 60 minutes after medication was administered, blood pressure and heart rate were measured. There were 54 participants (108 eyes) with an average age of 12.85± 2.84 years. Although the SFT group's refractive power and pupil width were greater than those of the SF group, the differences were not statistically significant (p=0.271 and p=0.088). Heart rate (p=0.521) and blood pressure (systolic p=0.201; diastolic p=0.950) did not significantly differ between the two groups. Despite mydriasis manifested more rapidly in the SFT group, there was no discernible difference in the cycloplegic effects between those groups. SF might be a more feasible regimen for cycloplegic refraction in children with refractive errors. Faculty of Medicine, Universitas Padjadjaran 2024-09-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.fk.unpad.ac.id/index.php/mkb/article/view/3311 10.15395/mkb.v56.3311 Majalah Kedokteran Bandung; Vol 56, No 3 (2024); 214-220 Majalah Kedokteran Bandung; Vol 56, No 3 (2024); 214-220 2338-6223 0126-074x 10.15395/mkb.v56.n3 eng https://journal.fk.unpad.ac.id/index.php/mkb/article/view/3311/pdf https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/3311/4046 https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/3311/4047 https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/3311/4048 https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/3311/4049 Copyright (c) 2024 Majalah Kedokteran Bandung http://creativecommons.org/licenses/by-nc/4.0

oai:ojs.journal.fk.unpad.ac.id:article/2615 2023-11-23T03:16:33Z mkb:ART

Association Between Parenting Styles, Children’s Nutritional Status, and Quality of Life among Children Ages 8-12 Years Harsono, Vivian Angelina Surjono, Edward Wijaya, Ellen Setiawan, Andy Medicine; Health Sciences; Public Health Children, nutritional status, parenting styles, parenting styles and dimensions questionnaire, pediatric quality of life inventory, quality of life Nutritional status and parenting styles are two factors that are thought to affect children’s quality of life. This study aimed to assess the relationship between parenting styles, nutritional status, and  quality of life of children aged 8-12 years. This cross-sectional observational analytic study used data collected from November 2020 to January 2021 using the Parenting Styles and Dimensions Questionnaire (PSDQ) and Pediatric Quality of Life Inventory (PedsQL) that were distributed in the form of e-questionnaire . The analysis tests used were the Spearman and logistic regression tests with a level of significance of 0.05. The results of the Spearman test showed that there was no correlation between parenting style and quality of life (p = 0.882) and between the nutritional status and quality of life (p = 0.568). The results of the logistic regression analysis showed that the variables of parenting (p = 0.437; 95% CI = 0.607–3.174; OR = 1.388) and nutritional status (p = 0.432; 95% CI = 0.504–1.341; OR = 0.822) were not associated with quality of life. Thus, there is no significant relationship between parenting patterns and children's nutritional status on the quality of life of children aged 8-12 years. Faculty of Medicine, Universitas Padjadjaran Edward Surjono Ellen Wijaya Andy Setiawan School of Medicine and Health Sciences Catholic University of Indonesia Atma Jaya, Jakarta, Indonesia 2022-09-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.fk.unpad.ac.id/index.php/mkb/article/view/2615 10.15395/mkb.v54n3.2615 Majalah Kedokteran Bandung; Vol 54, No 3 (2022); 136–142 Majalah Kedokteran Bandung; Vol 54, No 3 (2022); 136–142 2338-6223 0126-074x eng https://journal.fk.unpad.ac.id/index.php/mkb/article/view/2615/pdf https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/2615/3055 https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/2615/3056 Copyright (c) 2022 Majalah Kedokteran Bandung http://creativecommons.org/licenses/by-nc/4.0

oai:ojs.journal.fk.unpad.ac.id:article/3870 2025-10-15T07:01:31Z mkb:ART

Workplace Violence Against Doctors and Nurses in Public Healthcare Services in AL- Majmaah City, Saudi Arabia Alfhaid, Fahad Mohammad Loni, Shamshad Begum Aljulifi, Mohammed Zaid Alturki, Raghad Abdulaziz Ahmad AlGhannam, Raghad Ghannam Ibrahim Almutairi, Batool Awn Allah Khalifah Almutairi, Maram Awn Allah Khalifah Al-Majmaah city, healthcare workers, public healthcare facilities, Saudi Arabia, workplace violence Workplace violence raises a significant concern in healthcare settings, with healthcare workers being at risk of physical and emotional harms. This phenomenon is, however, rarely investigated in Al-Majmaah city, Saudi Arabia. This study sought to estimate the prevalence of workplace violence against doctors and nurses working in public healthcare facilities in Al-Majmaah city. A cross-sectional study was conducted in public health facilities in Al-Majmaah city, Saudi Arabia, from June to August 2022. Healthcare workers were recruited to participate in a self-administered online questionnaire, which collected data on sociodemographic information, workplace violence exposure, and attitudes towards violence. Of the total participants, 41.9% reported experiencing workplace violence. The majority of incidents occurred in health institutions, with 92.3% involving verbal abuse, 2.6% physical violence, or both. Patients' families were responsible for 48.7% of the violence, followed by the patients themselves (43.6%). In response to violence, healthcare workers reported various coping mechanisms, including pretending the incident never happened (23.1%), attempting to stop the perpetrator (23.1%), and protecting themselves (18%). Regarding system satisfaction, 14% remained indifferent, 16% were dissatisfied, and 2% were satisfied. Furthermore, 15.1% of participants experienced disturbed thoughts or images of the attack, 14% avoided thinking or talking about incidents, and 11.8% were unaffected. Workplace violence is a significant problem affecting healthcare workers in public healthcare facilities in Al-Majmaah city, Saudi Arabia. The high prevalence of verbal abuse and physical violence highlights the need for effective prevention and intervention strategies to ensure a safe working environment for healthcare workers. Faculty of Medicine, Universitas Padjadjaran 2025-03-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.fk.unpad.ac.id/index.php/mkb/article/view/3870 10.15395/mkb.v57.3870 Majalah Kedokteran Bandung; Vol 57, No 1 (2025); 1-9 Majalah Kedokteran Bandung; Vol 57, No 1 (2025); 1-9 2338-6223 0126-074x 10.15395/mkb.v57n1 eng https://journal.fk.unpad.ac.id/index.php/mkb/article/view/3870/pdf https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/3870/4939 Copyright (c) 2024 Majalah Kedokteran Bandung http://creativecommons.org/licenses/by-nc/4.0

oai:ojs.journal.fk.unpad.ac.id:article/1779 2022-03-21T03:53:24Z mkb:CR

Case Study on Cardiac Decompensation in Patients with Preeclampsia and Peripartum Cardiomyopathy Phanaka, Evelyn Leonie Iqbal, Mohammad Wiwaha, Guswan Cardiac decompensation, peripartum cardiomyopathy, preeclampsia In pregnant women, cardiovascular complications are among the causes of maternal death, one of which is peripartum cardiomyopathy (PPCM). The similarity in the mechanism of PPCM and pre-eclampsia makes preeclampsia a risk factor for PPCM. Preeclampsia, together with PPCM, also contributes to the increasing maternal mortality when most of the causes of maternal death are preventable. This case study aimed to provide descriptions as the basis in education, raising public awareness, early detection, and early treatment, especially for patients at risk. Eight PPCM cases with preeclampsia were identified during the period of 2017–2018 in Dr. Hasan Sadikin General Hospital Bandung, Indonesia (RSHS). Cases of PPCM with preeclampsia are rarely reported in RSHS. Out of 8 patients, 7 experienced severe preeclampsia and 1 had impending eclampsia. Diagnosis in PPCM patients requires a complete history taking, physical examination, and other diagnostic tests such as echocardiography. In this study, all patients (100%) complained of dyspnea on exertion as a chief complaint and, based on the New York Heart Association in 1994, 87.5% were included in functional class III-IV. The average ejection fraction was shown to be 34.6%, indicating a value below normal limit. Studi Kasus Dekompensasi Jantung pada Pasien Preeklampsia dengan Kardiomiopati PeripartumPada wanita hamil, komplikasi kardiovaskular berperan dalam kematian ibu, salah satunya adalah kardiomiopati peripartum (PPCM). Persamaan patogenesis antara PPCM dan pre-eklampsia menjadikan preeklampsia sebagai faktor risiko untuk PPCM. Preeklampsia bersama dengan PPCM berperan dalam peningkatan angka kematian ibu (AKI) ketika sebagian besar penyebab AKI dapat dicegah. Studi kasus ini bertujuan diharapkan untuk memberikan deskripsi sebagai dasar dalam pendidikan, meningkatkan kesadaran masyarakat, deteksi dini, dan perawatan dini, terutama untuk pasien yang berisiko. Pada tahun 2017–2018, terdapat 8 kasus pasien PPCM dengan preeklampsia yang dirawat di RSUP Dr. Hasan Sadikin Bandung (RSHS). Kasus PPCM dengan preeklampsia jarang dilaporkan di RSHS. Dari 8 pasien, 7 mengalami preeklamsia berat dan 1 mengalami eklampsia yang akan datang. Diagnosis pada pasien PPCM memerlukan anamnesis yang lengkap, pemeriksaan fisik, dan pemeriksaan penunjang seperti ekokardiografi. Pada penelitian ini, semua pasien (100%) mengeluhkan sesak nafas sebagai keluhan utama dan berdasar atas klasifikasi New York Heart Association tahun 1994, 87.5% termasuk dalam kelas fungsional III-IV. Rata-rata fraksi ejeksi menunjukkan 34.6% yang menandakan nilai di bawah batas normal. Faculty of Medicine, Universitas Padjadjaran 2020-03-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.fk.unpad.ac.id/index.php/mkb/article/view/1779 10.15395/mkb.v52n1.1779 Majalah Kedokteran Bandung; Vol 52, No 1 (2020); 53-60 Majalah Kedokteran Bandung; Vol 52, No 1 (2020); 53-60 2338-6223 0126-074x eng https://journal.fk.unpad.ac.id/index.php/mkb/article/view/1779/pdf https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/1779/1399 https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/1779/1400 Copyright (c) 2020 Majalah Kedokteran Bandung http://creativecommons.org/licenses/by-nc/4.0

oai:ojs.journal.fk.unpad.ac.id:article/2169 2023-07-17T04:50:42Z mkb:ART

Relationship between Age, Exercise Habits, Cigarette Smoke Duration Exposure, and Lung Vital Capacity in Passive Smokers Puteri, Saskia Oktaviani Ratnawati, Ratnawati Vikawati, Nura Eky Health Sciences; Public Health exposure to cigarette smoke; lung vital capacity; personal characteristics Lung vital capacity of is different for each individual depending on personal characteristics, such as age, body mass index (BMI), and exercise habits or environmental factors, such as exposure to cigarette smoke. This study aimed to determine the relationship between personal characteristics, duration of exposure to cigarette smoke, and lung vital  capacity in passive smokers in one of the areas in Indonesia. This study was a cross-sectional observational analytic study conducted during the period of August to September 2019. Data were collected through interviews and measurements using the Contec SP10BT spirometer. Participants were sampled consecutively with only women who did not smoke but had at least one family member who actively smoked and was over 20 years old participated in this study. Women were selected as the population due to the fact that the proportion of passive smokers among women is higher than men, while the age group of above 20 years old was selected with a consideration of the average age for the optimum lung capacity. The relationship between personal characteristics and a history of exposure to cigarette smoke with lung vital capacity was analyzed using Pearson and Spearman correlation test. There is a significant relationship between age, exercise habits, duration of exposure to cigarette smoke, and vital lung capacity (p=0.000; p=0.018; p=0.000) among the participants of the study. However, further research is still needed to be able to generalize this finding into a broader community. Faculty of Medicine, Universitas Padjadjaran 2023-06-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.fk.unpad.ac.id/index.php/mkb/article/view/2169 10.15395/mkb.v55n2.2169 Majalah Kedokteran Bandung; Vol 55, No 2 (2023); 65-69 Majalah Kedokteran Bandung; Vol 55, No 2 (2023); 65-69 2338-6223 0126-074x eng https://journal.fk.unpad.ac.id/index.php/mkb/article/view/2169/pdf https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/2169/2102 https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/2169/2103 Copyright (c) 2023 Majalah Kedokteran Bandung http://creativecommons.org/licenses/by-nc/4.0

oai:ojs.journal.fk.unpad.ac.id:article/4361 2025-10-02T07:22:23Z mkb:ART

Home Environmental Hazard as Extrinsic Factors For Falls Among Community-Dwelling Elderly Gondodiputro, Sharon Safnul, Farhan Bariq Amelia, Indah Public Health Elderly, extrinsic factors, fall, home environmental hazards Falls among the elderly are a major concern in both clinical practice and public health. Studies have shown that falls occur more frequently at home than outside home.This study aimed to identify the areas and types of home environmental hazards present in the residences elderly individuals. A quantitative descriptive study was conducted from April to May 2024 accross six primary healthcare centers in Bandung, West Java, Indonesia, selected from having the highest number of elderly patients. A total of 100 elderly respondents were recruited using a multistage purposive convenience sampling method. Data collection was carried out using an instrument consisting of two parts: the first part focused on respondent characteristics and the second part on home environmental hazards.The study variables were respondent characteristics and environmental hazards in the terrace, living room, stairs, bedroom, bathroom, kitchen, and garage. Data were analyzed using Microsoft Excel software and presented in tabular form. Results showed that all areas of the home posed potential hazards, with the presence of scattered items on the floor as the commonly identified risk. In specific areas such as the kitchen, high shelves were found, and in the bathroom, there were slippery floors, squat toilets, absence of handrails, and inward-opening bathroom door. Home can be a source of environmental hazards that increase the fall risk among the elderly. It is essential to provide the elderly with adequate information on these risk to encourage preventive actions and, where necessary, home modifications that improve safety and reduce the risk of falls. Faculty of Medicine, Universitas Padjadjaran None 2025-09-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.fk.unpad.ac.id/index.php/mkb/article/view/4361 10.15395/mkb.v57.4361 Majalah Kedokteran Bandung; Vol 57, No 3 (2025); 225-233 Majalah Kedokteran Bandung; Vol 57, No 3 (2025); 225-233 2338-6223 0126-074x 10.15395/mkb.v57n3 eng https://journal.fk.unpad.ac.id/index.php/mkb/article/view/4361/pdf https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/4361/5588 Copyright (c) 2025 Majalah Kedokteran Bandung http://creativecommons.org/licenses/by-nc/4.0

oai:ojs.journal.fk.unpad.ac.id:article/2143 2021-07-01T01:33:41Z mkb:ART

Nuclei DNA Damage Due to Extreme High-Temperature Exposure during Forensic Identification Examination Yudianto, Ahmad Novita, Masniari Wibowo, Ariyanto Setiawan, Fery Costae, DNA level, Extreme high temperature, molar tooth, Short Tandem Repeat Combined DNA Index System Accurate personal identification is important in investigations because an error in the identification process may bring fatal consequences during trial. The most common identification process is the Deoxyribonucleic acid [DNA] analysis. Degraded DNA sample due to extremely high-temperature exposure may limit DNA analysis. This study aimed to analyze DNA damage patterns caused by an extremely high temperature using STR (short tandem repeat) CODIS marker. This study was conducted at the Forensic and Medicolegal Department, Laboratorium Balai Besar Kesehatan Surabaya, Ministry of Health of the Republic of Indonesia, Human Genetic Study Group of Universitas Airlangga, and Faculty of Science and Technology of Universitas Brawijaya Malang from July until October 2009. Results of PCR visualization using STR CODIS for costae demonstrated that the THO1 detection (+) in 1,2500C - 40’: 25% and the TPOX detection (+) in 1,0000C - 30’: 50% whereas the results from molar teeth showed that the THOI locus detection (+) in 1,2500C - 30’: 25% and TPOX in 1,0000C - 40’: 50%. Results for PCR visualization using mini-STR CODIS for the costae presented that the mini-THOI in 1,2500C - 20’: 50% (+) while for the molar tooth the mini-THOI in 1,2500C - 30’ : 25% (+) and mini-TPOX in 1,0000C - 40’ : 50% (+). All loci were detected on costae and second molar teeth samples of the control group. Thus, extreme high-temperature exposure significantly decreased the DNA level of second costae and second molar tooth. Sequence patterns of STR loci successfully detected were TPOX, THO1, and CSF1PO.Kerusakan DNA Inti Karena Paparan Suhu Tinggi Selama Proses Identifikasi ForensikIdentifikasi melalui DNA secara tepat penting dalam penyelidikan karena kesalahan akan berakibat fatal selama proses persidangan. Salah satu keterbatasan adalah DNA yang terdegradasi karena paparan suhu yang sangat tinggi. Penelitian ini bertujuan menganalisis pola kerusakan DNA akibat suhu sangat tinggi menggunakan penanda CODIS STR (short tandem repeat). Penelitian dilakukan di Instalasi Kedokteran Forensik, Laboratorium Kemenkes, Human Genetic Study Group, dan Universitas Brawijaya Malang pada periode Juli sampai Oktober 2009. Visualisasi PCR menggunakan STR CODIS untuk costae adalah sebagai berikut: deteksi THO1 (+) pada 12500C - 40’: 25%, deteksi TPOX (+) pada 10000C - 30’: 50%, sedangkan hasil dari gigi molar adalah sebagai berikut: THOI locus detection (+) di 12500C - 30’: 25% dan TPOX di 10000C - 40’: 50%. Hasil visualisasi PCR menggunakan mini-STR CODIS untuk costae adalah sebagai berikut: mini-THOI pada 12500C - 20’: 50% (+) dan untuk gigi molar: mini-THOI pada 12500C-30': 25% (+ ) dan mini-TPOX di 10000C - 40’ : 50%  (+). Semua lokus terdeteksi pada kelompok kontrol pada sampel costae dan gigi molar kedua. Kesimpulannya, paparan suhu tinggi yang ekstrim secara signifikan menurunkan tingkat DNA kosta dan gigi molar kedua.  Faculty of Medicine, Universitas Padjadjaran 2020-12-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.fk.unpad.ac.id/index.php/mkb/article/view/2143 10.15395/mkb.v52n4.2143 Majalah Kedokteran Bandung; Vol 52, No 4 (2020); 185–192 Majalah Kedokteran Bandung; Vol 52, No 4 (2020); 185–192 2338-6223 0126-074x 10.15395/mkb.v52n4 eng https://journal.fk.unpad.ac.id/index.php/mkb/article/view/2143/pdf https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/2143/2044 https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/2143/2070 https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/2143/2072 https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/2143/2098 Copyright (c) 2020 Majalah Kedokteran Bandung http://creativecommons.org/licenses/by-nc/4.0

oai:ojs.journal.fk.unpad.ac.id:article/3277 2024-10-08T08:40:23Z mkb:ART

Impact of Severe Preeclampsia on the Incidence of Low-Birth-Weight Babies Ferawati, Emi Kuswandi, Kadar Karmila, Nela Medicine; Health Science; Obstetrics ; Midwifery Battaglia and Lubchencho, fetal growth restriction, low birth weight, severe preeclampsia, uteroplacental insufficiency Infant birth weight is an important indicator of survival, growth potential, and developmental capacity. Maternal health plays an important role in determining the well-being of newborns. A complicated pregnancy, inclusive of conditions such as preeclampsia, elevates the risk of giving birth to a low birth weight (LBW) baby. This study aimed to compare the impact of severe preeclampsia on the incidence of LBW babies in Dr. Dradjat Prawiranegara General Hospital Serang, Indonesia. This case-control analysis included 148 parturients recruited randomly from June to October 2022. Logistic regression was used as the analytical tool, with P=0.000 considered as demonstrating a significant association. The incidence rates of LBW and severe preeclampsia in 2018 were 19.84% and 14.15%, respectively. The case group recorded LBW within the weight range of 1,000-2,450 g, with 38% of them were Small for Gestation Age (SGA), while 50% and 12% were Appropriate for Gestational Age (AGA), and Large for Gestational Age (LGA), respectively. In contrast, the control group, with birth weights ranging from 2,600-4,500 g, 13.50% were SGA, while 77% and 9.50% were AGA and LGA, respectively. Parity was a confounding factor influencing the incidence of LBW, while maternal age did not present a significant correlation. Pregnancies with severe preeclampsia were found to have a 29-fold increased likelihood of delivering LBW babies compared to the control group when controlling for parity (P=0.000, CI 95%). Hence, women with severe preeclampsia pregnancies have a higher risk for delivering LBW babies of 29 times higher than the control. Faculty of Medicine, Universitas Padjadjaran 2023-12-31 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.fk.unpad.ac.id/index.php/mkb/article/view/3277 10.15395/mkb.v55n4.3277 Majalah Kedokteran Bandung; Vol 55, No 4 (2023); 227-231 Majalah Kedokteran Bandung; Vol 55, No 4 (2023); 227-231 2338-6223 0126-074x 10.15395/mkb.v55n4 eng https://journal.fk.unpad.ac.id/index.php/mkb/article/view/3277/pdf https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/3277/3991 https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/3277/3992 https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/3277/3993 https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/3277/3996 https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/3277/3997 https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/3277/3998 https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/3277/4000 https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/3277/4001 Copyright (c) 2023 Majalah Kedokteran Bandung http://creativecommons.org/licenses/by-nc/4.0

oai:ojs.journal.fk.unpad.ac.id:article/4164 2026-03-31T15:39:48Z mkb:ART

LRINEC Scoring Accuracy and Its Association with Clinical Outcomes in Necrotizing Fasciitis Patients Ronald, Ronald Djajakusumah, Teguh Marfen Septrina, Rani Medicine;Health Sciences Histopathology; morbidity; mortality, necrotizing fasciitis, sensitivity and specificity Necrotizing Fasciitis (NF) is a soft tissue infection characterized by rapidly progressive necrosis of the fascia and is associated with high morbidity and mortality worldwide. It has atypical clinical symptoms during the early course of the disease, making timely diagnosis challenging. Early and adequate antibiotic therapy combined with timely surgical intervention is essential to reduce morbidity and mortality in NF. Consequently, realiable diagnostic tools are needed for early diagnosis of NF. The LRINEC score is one of the diagnostic tools that is simple and rapidly applicebe; however, its use in diagnosing NF is still under debate. This study aimed to determine the accuracy of LRINEC scoring in diagnosing NF compared to histopathological examination (the gold standard) and to assess its association with morbidity and mortality. This observational prospective cohort study included NF patients presenting to the surgical emergency department throughout 2024. A total of 29 patients were enrolled, with an average age of 53.9 years, dominated by men. Diabetes mellitus was the most common comorbidity, present in 18 patients (72.9%). Death occurred in 1 patient (3.4%). The mean LRINEC score among subjects was 6.3. The LRINEC score demonstrated an accuracy of 89.66% compared to histopathological findings, with a sensitivity of 95% and a specificity of 77.78% for scores >6. Thus, thee LRINEC score demonstrates good diagnostic accuracy for necrotizing fasciitis, despite the lack of statistically significant association between LRINEC score and morbidity or mortality in this study. Faculty of Medicine, Universitas Padjadjaran None 2026-03-31 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.fk.unpad.ac.id/index.php/mkb/article/view/4164 10.15395/mkb.v58.4164 Majalah Kedokteran Bandung; Vol 48, No 1 (2026); 56-62 Majalah Kedokteran Bandung; Vol 48, No 1 (2026); 56-62 2338-6223 0126-074x 10.15395/mkb.v58.n1 eng https://journal.fk.unpad.ac.id/index.php/mkb/article/view/4164/pdf https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/4164/5287 https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/4164/5288 https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/4164/5289 https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/4164/5290 https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/4164/5291 https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/4164/5292 Copyright (c) 2026 Majalah Kedokteran Bandung http://creativecommons.org/licenses/by-nc/4.0

oai:ojs.journal.fk.unpad.ac.id:article/2223 2023-01-13T09:03:19Z mkb:ART

Effect of Mangkokan (Polyscias scutellaria) Leaf Extract on Blood Sugar Levels in Alloxan-Induced Male White Rats Nasution, Sri Lestari Ramadhani Awanis, Awanis Elsafarindo, Stiven Medicine Blood glucose level, mangkokan leaves, metformin, pancreas Type 2 diabetes is a metabolic disorder caused by insulin resistance and is associated with oxidative stress. In Indonesia, the mean prevalence of diabetes ranges from 1.4% to 1.6%; however, some areas have a much higher diabetes prevalence such as Pekajangan (2.3%) and in Manado (6%). The 2013 Indonesian Basic Health Research (IBHR) stated that the number of people with DM in Indonesia has reached an alarming rate. This study aimed to determine the antidiabetic effect of Polyscias scutellaria on alloxan-induced male Wistar. This was an experimental study conducted in July 2020 in the Faculty of Medicine, Prima Indonesia University. This study used 25 rats that were grouped into 5 treatment groups: control group (Na-CMC), standard (Metformin), and 3 extract groups with different doses (125 mg/kg BW, 250 mg/kg BW, and 500 mg/kg BW). Mangkokan leaf extract was obtained through the maceration method. All ratswere induced intraperitoneally using alloxan monohydrate 10% at a dose of 175 mg/kg BW. The parameters used in this study were fasting blood glucose level before induction, after induction, and after treatment and body weight before treatment. It was observed that there was a significant change in blood glucose level between the extract groups. The blood sugar level in the 125 mg/kg BW group was 495.00 mg/dl while in the 250 mg/kg BW and 500 mg/kg BW, the blood glucose levels were 317.00 mg/dl and 126.00 mg/dl, respectively, with the 500 mg/Kg BW dose as the most effective dose (P-value = 0.001). Thus, mangkokan leaves have the potential to reduce blood glucose level but are not as good as the standard group. Faculty of Medicine, Universitas Padjadjaran 2021-09-20 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.fk.unpad.ac.id/index.php/mkb/article/view/2223 10.15395/mkb.v53n3.2223 Majalah Kedokteran Bandung; Vol 53, No 3 (2021); 132–137 Majalah Kedokteran Bandung; Vol 53, No 3 (2021); 132–137 2338-6223 0126-074x 10.15395/mkb.v53n3 eng https://journal.fk.unpad.ac.id/index.php/mkb/article/view/2223/pdf https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/2223/2163 https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/2223/2169 https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/2223/2170 Copyright (c) 2021 Majalah Kedokteran Bandung http://creativecommons.org/licenses/by-nc/4.0

oai:ojs.journal.fk.unpad.ac.id:article/3347 2024-10-08T08:39:10Z mkb:CR

Clinical Profiles of Obstructive Hydrocephalus in Patient with Von Hippel–Lindau Naqeeb, Mohammed R. Abdulmannan, Dina M. Medicine Hemgioblastomas; hydrocephalus; von Hippel-Lindau disease Von-Hippel-Lindau (VHL) is an autosomal dominant disease that affects multiple systems that may result in benign and malignant multisystem tumors. The estimated incidence of VHL is 1 in 36,000 births. Disease incidence ranges from 10 to 40 years, with an average of 26 years, and it impacts diverse ethnic groups. VHL results from mutations in the germ line that have been mapped to chromosome 3P25. Currently, this is the only gene known to cause the syndrome. This study presented a case of obstructive hydrocephalus in a patient with VHL. A 19-year-old female was referred to the Eye Clinic for a diagnosis of papilledema. She began to experience vagal abdominal discomfort for no apparent reason. Per exam, the patient had 20/20 OD and 20/400 OS, with an intraocular pressure of 14 OU. The patient's MRI revealed a posterior fossa cranial cystic brain lesion that was obstructing the fourth ventricle and causing obstructive hydrocephalus. Early detection, management, and focal laser treatment of capillary hemangiomas in the retina's periphery led to favorable visual outcomes. Even after vitreoretinal surgery, the tumors may cause exudative retinal detachment and have an inferior visual prognosis if left untreated. Faculty of Medicine, Universitas Padjadjaran 2024-06-29 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.fk.unpad.ac.id/index.php/mkb/article/view/3347 10.15395/mkb.v56.3347 Majalah Kedokteran Bandung; Vol 56, No 2 (2024); 153-156 Majalah Kedokteran Bandung; Vol 56, No 2 (2024); 153-156 2338-6223 0126-074x 10.15395/mkb.v56n2 eng https://journal.fk.unpad.ac.id/index.php/mkb/article/view/3347/pdf https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/3347/4099 https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/3347/4249 Copyright (c) 2023 Majalah Kedokteran Bandung http://creativecommons.org/licenses/by-nc/4.0

oai:ojs.journal.fk.unpad.ac.id:article/2611 2023-11-23T03:17:47Z mkb:ART

Oral Ulcer Healing Activity of Lemon Pepper Ethanol Extract Gel in Streptozotocin-Induced Diabetic Wistar Rats Chiuman, Veranyca Chiuman, Linda Tanjung, Dian Soraya Miftahulaila, Mourent Erawati, Suci Florenly, Florenly Diabetes mellitus; lemon pepper; oral ulcer; ulcer healing Diabetes mellitus (DM) is a metabolic condition where the body's ability to produce and utilize insulin is impaired; thus, wound healing process is slower than usual in patients with DM. Lemon pepper has both antioxidant and anti-inflammatory properties. This study aimed to investigate the effect of topical application of lemon pepper fruit ethanol extracts on the healing process of oral traumatic ulcers in diabetic rats. This study was performed at the Pharmacology Laboratory, Faculty of Medicine, Universitas Prima Indonesia from September 2021–October 2021. Thirty males diabetic Wistar rats were thermally injured on the lower labial mucosa and divided into five groups: control, standard, and lemon pepper gel 5%, 7.5%, and 10% groups. The ulcer size was measured after injury and on the 7th and 14th day. On the last day, all rats underwent both routine blood count and histology study for oral ulcer tissue. On the 14th day, all treatment groups showed some significant difference wound contraction, with the highest tendency of wound contraction seen in both lemon pepper gel 10% and standard groups (62.50%. p-value =0.001). The improvement of wound contraction was also supported by reduced white blood cell count (p-value<0.05) in routine blood count and regeneration of epidermis and dermis tissues in the histology study. Hence, it can be concluded that the lemon pepper extract gel in all concentrations has good physical stability and the lemon pepper gel with the highest concentration group presents the best ulcer healing activity compared to other concentrations and has similar ulcer healing activity as the standard group that receives Kenalog® in Orabase. Faculty of Medicine, Universitas Padjadjaran 2022-06-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.fk.unpad.ac.id/index.php/mkb/article/view/2611 10.15395/mkb.v54n2.2611 Majalah Kedokteran Bandung; Vol 54, No 2 (2022); 80–88 Majalah Kedokteran Bandung; Vol 54, No 2 (2022); 80–88 2338-6223 0126-074x 10.15395/mkb.v54n2 eng https://journal.fk.unpad.ac.id/index.php/mkb/article/view/2611/pdf https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/2611/2954 https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/2611/2955 Copyright (c) 2022 Majalah Kedokteran Bandung http://creativecommons.org/licenses/by-nc/4.0

oai:ojs.journal.fk.unpad.ac.id:article/1389 2021-12-26T06:47:52Z mkb:CR

Patau Syndrome with Genotype 47,XY, + 13,t(13:18) Sindrom Patau dengan genotipe 47,xy,+13,t(13:18) Elfira, Vanda Kadi, Fiva Aprilia Laksono, Bremmy Effendi, Sjarif Hidajat Medicine Patau syndrome, Trisomy 13, translocation Pediatric Trisomi 13, translokasi, sindrom Patau Trisomy 13 (Patau syndrome) is cytogenetically classified as a 47,XY,+13 or 47,XX,+13, due to nondisjunction at meiosis I or II, or at mitosis (mosaicism), and partial trisomy due to translocation. Patau syndrome is one of the most common chromosomal anomalies with an estimated incidence of about 1/10,000 births characterized by the presence of cleft lip and/or palate, post axial polydactyly, low set ears, rocker-bottom feet, cryptorchidism, and congenital heart disease. This was a case report of a newborn baby in Dr. Hasan Sadikin General Hospital Bandung in January 2016 with translocation of chromosome 13 segment to chromosome 18 or 47,XY,+13,t(13:18). Sindrom Patau dengan Genotype 47,XY,+13,t(13:18)Trisomi 13 (sindrom Patau) secara sitogenetik diklasifikasikan 47,XY,+13 atau 47,XX,+13, disebabkan oleh kegagalan pemisahan pada meiosis I atau II, atau pada mitosis (mosaicism) dan trisomi parsial yang disebabkan oleh translokasi. Sindrom Patau merupakan salah satu anomali kromosom yang paling sering dengan insidensi sekitar 1/10.000 kelahiran, dengan karakteristik fenotipe seperti celah bibir dan atau celah langit-langit, postaxial polydactyly, low set ears, rocker bottom feet, kriptokismus, serta kelainan jantung kongenital. Dilaporkan kasus sindrom Patau pada bayi baru lahir di Rumah Sakit Dr. Hasan Sadikin Bandung pada Januari 2016 yang menunjukkan segmen dari kromosom 13 translokasi ke kromosom 18 atau 47,XY,+13,t(13:18). Trisomi 13 (sindrom Patau) secara sitogenetik diklasifikasikan 47,XY,+13 atau 47,XX,+13, disebabkan oleh gagalnya pemisahan pada meiosis I atau II, atau pada mitosis (mosaicism) dan trisomi parsial yang disebabkan oleh translokasi. Sindrom Patau merupakan salah satu anomali kromosom yang paling sering dengan insidensi sekitar 1/10.000 kelahiran, dengan karakteristik fenotipe seperti celah bibir dan atau celah langit-langit, postaxial polydactyly, low set ears, rocker bottom feet, kriptokismus dan kelainan jantung kongenital. Laporan kasus ini menunjukkan segmen dari kromosom 13 translokasi ke kromosom 18 atau 47,XY,+13,t(13:18). Faculty of Medicine, Universitas Padjadjaran 2019-12-27 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.fk.unpad.ac.id/index.php/mkb/article/view/1389 10.15395/mkb.v51n3.1389 Majalah Kedokteran Bandung; Vol 51, No 3 (2019); 185-188 Majalah Kedokteran Bandung; Vol 51, No 3 (2019); 185-188 2338-6223 0126-074x 10.15395/mkb.v51n3 eng https://journal.fk.unpad.ac.id/index.php/mkb/article/view/1389/pdf https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/1389/2926 Copyright (c) 2019 Majalah Kedokteran Bandung http://creativecommons.org/licenses/by-nc/4.0

oai:ojs.journal.fk.unpad.ac.id:article/2727 2023-05-04T03:43:20Z mkb:CR

Case Report on Painful Patellar Crepitation Following a Knee Replacement with Preserved Patella Butarbutar, John Christian Parsaoran Hananto, Joshua Edward Irvan, Irvan Orthopaedic; Medicine Clunk, crepitation, debridement, knee arthroplasty, knee replacement, patellar resurfacing Patellar clunk crepitation is a well-known complication following knee replacement surgery and is associated with posterior stabilized knee replacement surgery and surgical technique. Currently, patellar clunk or crepitation management following knee replacement surgery with preserved patella remains unclear. The purpose of this case report is to discuss whether patellar clunk or crepitation management should include debridement with patellar resurfacing or debridement alone. This case describes a patellar crepitation after knee replacement surgery with the preserved patella. The surgery went uneventfully using the standard medial parapatellar approach. However, the patient was still unsatisfied with the chronic left knee pain (>3 months) and crepitation that developed following the surgery, and the patient was diagnosed with patellar clunk and crepitation (PCC). A patellar resurfacing procedure was performed with a satisfactory clinical outcome. Replicating the original joint line level and placing the tibial component posteriorly play a pivotal role in preventing PCC. Debridement and patellar resurfacing procedures are recommended in this type of case to overcome the valgus knee alignment and the placement of the tibial component. Faculty of Medicine, Universitas Padjadjaran 2023-03-31 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.fk.unpad.ac.id/index.php/mkb/article/view/2727 10.15395/mkb.v55n1.2727 Majalah Kedokteran Bandung; Vol 55, No 1 (2023); 57–64 Majalah Kedokteran Bandung; Vol 55, No 1 (2023); 57–64 2338-6223 0126-074x 10.15395/mkb.v55n1 eng https://journal.fk.unpad.ac.id/index.php/mkb/article/view/2727/pdf https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/2727/3263 Copyright (c) 2023 Majalah Kedokteran Bandung http://creativecommons.org/licenses/by-nc/4.0

oai:ojs.journal.fk.unpad.ac.id:article/3990 2025-07-08T07:47:54Z mkb:ART

HbA1c Level in Type 2 Diabetes Mellitus Patients With and Without Obesity in An Indonesian Regional Hospital Tinangon, Fritsal Luciana, Linny Sihombing, Martina Rentauli Edward, Harny Medicine HbA1c, Obesity, Type 2 diabetes mellitus Diabetes Mellitus (DM) is a disease characterized by hyperglycemia due to insulin deficiency or impaired insulin function. The International Diabetes Federation (IDF) estimated that approximately 463 million people aged 20 to 79 years old were affected by DM worldwide in 2019. Indonesia is the third highest with a prevalence of 11.3%. More than 90% of diabetic patients are obese which reduced insulin sensitivity. This study aimed to determine the difference in HbA1c levels between obese and non-obese patients with Type 2 Diabetes Mellitus (T2DM) at Tarakan Regional Hospital, Indonesia. Data from medical records of T2DM patients from January to December 2023 were collected based on inclusion and exclusion criteria using consecutive sampling method, resulting in 128 samples. The results of the study, as determined using the Mann Whitney test, indicated a significant difference in the HbA1c levels between T2DM patients with and without obesity (p=0.031), with non-obese T2DM patients tend to have better HbA1c control compared to their obese counterparts. Thus, it can be inferred that obesity affects the blood glucose control in diabetic patients. However, this result needs to be further researched as there are a few limitations inherent to this study, particularly the partial availability of certain medical record information, such as duration of diagnosis and medication adherence. Faculty of Medicine, Universitas Padjadjaran 2025-06-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.fk.unpad.ac.id/index.php/mkb/article/view/3990 10.15395/mkb.v57.3990 Majalah Kedokteran Bandung; Vol 57, No 2 (2025); 99-103 Majalah Kedokteran Bandung; Vol 57, No 2 (2025); 99-103 2338-6223 0126-074x 10.15395/mkb.v57n2 eng https://journal.fk.unpad.ac.id/index.php/mkb/article/view/3990/pdf https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/3990/5007 https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/3990/5009 Copyright (c) 2025 Majalah Kedokteran Bandung http://creativecommons.org/licenses/by-nc/4.0

oai:ojs.journal.fk.unpad.ac.id:article/1563 2021-12-26T05:48:40Z mkb:ART

Association Between Polymorphonuclear Leukocyte Cell Percentage in Cerebrospinal Fluid and Outcome of Tuberculous Meningitis Patients in a Tertiary Hospital in Indonesia Hubungan Persentase Sel Leukosit Polimorfonuklear dalam Cairan Serebrospinal dan Luaran Pasien Meningitis Tuberkulosis di RSUP Dr. Hasan Sadikin Bandung Widayanti, Amanda Ganiem, Ahmad Rizal Parwati, Ida cerebrospinal fluid; tuberculous meningitis; outcome; polymorphonuclear (PMN) cell Tuberculous (TB) meningitis is the most severe type of extrapulmonary TB with high morbidity and mortality rates. Many factors affect patient outcome, including the intracranial inflammation process. In acute inflammation, recruitment of a high number of polymorphonuclear (PMN) cells can cause edema which may eventually increase the intracranial pressure. This increase in intracranial pressure may lead to functional decline, disability, and even death. This study aimed to explore the association between the PMN percentage in cerebrospinal fluid (CSF) and TB meningitis patient outcome as measured by the Glasgow Outcome Scale at Dr. Hasan Sadikin General Hospital Bandung, which is a tertiary hospital in Indonesia. This was a retrospective cohort study using patient medical record data from 2017. All TB meningitis patients over 18 years old were included. Patients with missing PMN results in medical record were excluded, which led to a total 88 subjects participating in this study. Variables analyzed were PMN percentage in CSF and patient outcome that were categorized as poor, moderate, and good. Analysis were performed using theKruskal-wallis test. An increase in PMN median as the patient outcome declined were observed, but the association between the PMN percentage in CSF and patient outcome was insignificant (p=0.186). Hence,  no association between PMN percentage in CSF and TB meningitis patient outcome was identified in this study. Hubungan Persentase Sel Leukosit Polimorfonuklear dalam Cairan Serebrospinal dan Luaran Pasien Meningitis Tuberkulosis di RSUP Dr. Hasan Sadikin BandungMeningitis tuberkulosis (TB) merupakan merupakan jenis TB ekstraparu paling berat dengan morbiditas dan mortalitas tinggi. Berbagai faktor memengaruhi luaran pasien, salah satunya proses inflamasi intrakranial. Pada inflamasi akut, terjadi peningkatan sel polimorfonuklear (PMN) dan bila dalam jumlah tinggi dapat menimbulkan efek edema yang meningkatkan tekanan intrakranial. Peningkatan tekanan intrakranial ini menyebabkan penurunan fungsi otak, disabilitas, bahkan kematian. Penelitian ini bertujuan mengetahui hubungan persentase PMN dalam cairan serebrospinal (CSS) dan luaran Glasgow Outcome Scale pada pasien meningitis TB di RSUP Dr. Hasan Sadikin Bandung. Penelitian ini merupakan studi retrospektif cohort menggunakan data rekam medik tahun 2017. Kriteria inklusi adalah pasien terdiagnosis meningitis TB dan berusia ≥18 tahun. Kriteria eksklusi adalah data rekam medik yang tidak lengkap untuk hasil PMN. Variabel yang diteliti adalah persentase PMN dan luaran pasien yang dikategorikan menjadi GOS buruk, sedang, dan baik kemudian dianalisis dengan uji Kruskal-wallis. Didapatkan 88 subjek yang memenuhi syarat. Terdapat peningkatan median PMN seiring derajat perburukan luaran namun hasil analisis menunjukkan tidak terdapat hubungan yang bermakna antara PMN dan luaran GOS pasien (p=0,186). Simpulan, tidak terdapat hubungan antara persentase PMN dalam CSS dengan luaran GOS pasien meningitis TB. Meningitis TB (MTB) merupakan infeksi selaput otak dan merupakan jenis TB ekstraparu paling berat dengan tingkat morbiditas dan mortalitas tinggi. Berbagai faktor memengaruhi luaran pasien, salah satunya proses inflamasi. Pada inflamasi akut, terjadi rekrutmen dari sel polymorphonuklear (PMN) dan bila dalam jumlah tinggi dapat menimbulkan efek edema yang pada otak dibatasi tengkorak. Hal ini memungkinkan adanya peningkatan tekanan intrakranial yang dikhawatirkan memengaruhi fungsi otak dengan penurunan fungsi, disabilitas, bahkan kematian. Penelitian ini bertujuan untuk mengetahui hubungan PMN dalam cairan serebrospinal dan luaran Glasgow Outcome Scale pada pasien MTB di RSUP Dr. Hasan Sadikin, Bandung. Metode penelitian dengan studi retrospektif cohort menggunakan data rekam medik tahun 2017. Kriteria inklusi adalah pasien terdiagnosis MTB dan berusia ≥18 tahun. Kriteria eksklusi adalah data rekam medik yang tidak lengkap untuk hasil PMN. Variabel yang diteliti adalah PMN dan luaran pasien yang dikategorikan menjadi GOS buruk, sedang, dan baik kemudian dianalisis dengan uji Kruskal-wallis. Didapatkan 88 subjek yang memenuhi kriteria inklusi. Ditemukan bahwa terdapat peningkatan median PMN seiring penurunan luaran namun hasil analisis menunjukkan tidak terdapat hubungan yang bermakna secara statistik antara PMN dan luaran GOS pasien (p=0,186). Kesimpulan penelitian adalah tidak terdapat hubungan antara PMN dalam CSS dengan luaran GOS pasien MTB. Faculty of Medicine, Universitas Padjadjaran 2020-12-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.fk.unpad.ac.id/index.php/mkb/article/view/1563 10.15395/mkb.v52n4.1563 Majalah Kedokteran Bandung; Vol 52, No 4 (2020); 220–226 Majalah Kedokteran Bandung; Vol 52, No 4 (2020); 220–226 2338-6223 0126-074x 10.15395/mkb.v52n4 eng https://journal.fk.unpad.ac.id/index.php/mkb/article/view/1563/pdf https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/1563/1066 https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/1563/1067 https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/1563/1069 https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/1563/1070 https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/1563/2887 https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/1563/2888 Copyright (c) 2020 Majalah Kedokteran Bandung http://creativecommons.org/licenses/by-nc/4.0

oai:ojs.journal.fk.unpad.ac.id:article/2208 2021-12-26T04:09:46Z mkb:ART

Parental Knowledge, Attitude, and Behavior towards Basic Immunization Hanka, Vicky Sagita Surjono, Edward Public Health; attitude;behavior;complete basic immunization; knowledge Immunization, which is usually done by giving vaccinations, is the process of forming immunity in individuals against infectious diseases. The target in the Strategic Plan of the Ministry of Healht of the Republic of Indonesia in 2015-2019 aimed for 93 % of coverage. However, according to the report of the Indonesian Basic Health Survey (IBHR), there is actually a decrease in basic immunization coverage for the period of 2012–2015 when compared to the previous period. This study aimed to determine the correlation between parental knowledge, attitudes, and behavior towards complete course of basic immunization among parents of an elementary school in North Jakarta, Indonesia, in 2018 and 2019. This was a cross-sectional analytical descriptive study involving 110 respondents. Data were obtained through a questionnaire that was distributed to parents that included questions on knowledge, attitude, and behavior towards complete basic immunization. Out of 110 respondents, 70% stated that their child received the full basic immunization course while the remaining 30% stated that their child only received some of the vaccines required in the basic immunization course. There was no correlation, based on the bivariate analytical test, between parental behavior (p = 0.868), parental attitude (p = 0.647), and full course of basic immunization. In contrast, parental knowledge influences whether the child will receive the full course of basic immunization or not (p=0.000). Faculty of Medicine, Universitas Padjadjaran 2021-06-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.fk.unpad.ac.id/index.php/mkb/article/view/2208 10.15395/mkb.v53n2.2208 Majalah Kedokteran Bandung; Vol 53, No 2 (2021); 73-77 Majalah Kedokteran Bandung; Vol 53, No 2 (2021); 73-77 2338-6223 0126-074x 10.15395/mkb.v53n2 eng https://journal.fk.unpad.ac.id/index.php/mkb/article/view/2208/pdf https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/2208/2147 Copyright (c) 2021 Majalah Kedokteran Bandung http://creativecommons.org/licenses/by-nc/4.0

oai:ojs.journal.fk.unpad.ac.id:article/3323 2024-10-08T08:39:10Z mkb:ART

Antioxidant and Antimicrobial Potential of Sappan Wood Extract against Porphyromonas gingivalis Sugiaman, Vinna Kurniawati Jeffrey, Jeffrey Widowati, Wahyu Ferdiansyah, Rival Novianto, Agung Antimicrobial, antioxidant, brazilin, periodontal diseases, sappan wood Gingivitis inflammation triggered by microbial biofilms is one of the detrimental causes of periodontal diseases. When a periodontal disease occurs, tooth decay becomes inevitable, and can pose a serious threat to oral health, requiring appropriate treatment. Inflammation in periodontitis is mainly caused by oxidative stress; hence, antimicrobial and antioxidant-based therapies are suggested for periodontitis. Sappan wood is well-known for its brazilin compounds, which have the potential as herbal medicines and antibacterial agents to fight oral pathogens with minimal side effects. This study aimed to examine the antimicrobial and antioxidant activities of sappan wood extract (SE) as a candidate agent for preventing periodontal diseases. This study was conducted at Maranatha Christian University, Sekolah Tinggi Farmasi Indonesia, and Aretha Medika Utama from January-April 2023. The sappan wood was extracted using ethanol 96% and the antimicrobial evaluation was done by calculating the total colony of P. gingivalis while the antioxidant activity was evaluated by ABTS, H2O2, and FRAP Assays. This study revealed that SE was significantly effective in reducing the total colony of P. gingivalis up to 0 CFU/mL. The highest antioxidant activity of SE was found in 100 µg/mL with IC50 19.06 µg/mL for ABTS, 90.99 µg/mL for H2O2, and 564 µM Fe (II) for FRAP. Thus, SE presents its strong antimicrobial and antioxidant activity potentials by in vitro evaluation that could be analyzed further for its utilization as a periodontal-preventing agent. This study also provides basic information for future implication of sappan wood extract as ingredients for dental care products. Faculty of Medicine, Universitas Padjadjaran 2024-06-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.fk.unpad.ac.id/index.php/mkb/article/view/3323 10.15395/mkb.v56.3323 Majalah Kedokteran Bandung; Vol 56, No 2 (2024); 80-87 Majalah Kedokteran Bandung; Vol 56, No 2 (2024); 80-87 2338-6223 0126-074x 10.15395/mkb.v56n2 eng https://journal.fk.unpad.ac.id/index.php/mkb/article/view/3323/pdf https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/3323/4065 Copyright (c) 2024 Majalah Kedokteran Bandung http://creativecommons.org/licenses/by-nc/4.0

oai:ojs.journal.fk.unpad.ac.id:article/2629 2023-11-23T03:19:13Z mkb:ART

Use of Herb Combination (Jamu Atoke) Before Mating to Improve Rat Pup Health Andriyanto, Andriyanto Widi, Leliana Nugrahaning Yendri, Hamdika Mardathilah, Kharisma Yuliansah, Diky Agustin, Firda Mustika, Aulia Andi Manalu, Wasmen Avocado, holy basil, Jamu ATOKE, maternal problems, mung bean sprouts Mortality and health disturbances in children often correlate with maternal health and fertility. Avocado, mung bean sprouts, and holy basil have been traditionally used to improve maternal health, before and during pregnancy. This study was aimed to assess the efficacy of herbal combination of avocado, mung bean sprouts, and holy basil (Jamu ATOKE) in optimizing reproductive health. Eighteen female Sprague Dawley rats (9–10 weeks old, BW: 180–250 g) were randomly divided into 3 treatment groups (n=6 rats for each group) of control, group I and II. ATOKE were added into rats drinking water and consumed for 30 days before pregnancy. After the rats were pregnant and gave birth, pup per parent ratio, pup mortality, and pup health performance (body weight gain, feed and drink consumption, motor activity, pup speed in finding light and feed, red blood cell (RBC) count, white blood cell (WBC) count and differential, SGPT, SGOT, blood urea nitrogen (BUN), creatinine, and proinflammatory mediators (TNF-α and IL-6) were analyzed. Pups born to in group I had a generally better health performance compared to the control group. There was a 100% mortality in the litter of group II due to the excessive aggressive behavior of the dams as a sign of toxicity. Administration of 2.5% Jamu ATOKE showed the best effects on the health and intelligence of the rat pup. Faculty of Medicine, Universitas Padjadjaran 2022-03-31 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.fk.unpad.ac.id/index.php/mkb/article/view/2629 10.15395/mkb.v52n4.2629 Majalah Kedokteran Bandung; Vol 54, No 1 (2022); 7-13 Majalah Kedokteran Bandung; Vol 54, No 1 (2022); 7-13 2338-6223 0126-074x 10.15395/mkb.v54n1 eng https://journal.fk.unpad.ac.id/index.php/mkb/article/view/2629/pdf https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/2629/3069 https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/2629/3070 Copyright (c) 2022 Majalah Kedokteran Bandung http://creativecommons.org/licenses/by-nc/4.0

oai:ojs.journal.fk.unpad.ac.id:article/3823 2025-10-15T07:09:04Z mkb:ART

Vitamin D Supplementation and Colorectal Cancer Patients Outcomes Mulyadi, Noeray Pratiwi Rudiman, Reno Purnama, Andriana Medicine; Surgery; Oncology Colorectal neoplasms, neoplasm metastasis, mortality, vitamin D, supplementation Colorectal cancer is the third most encountered malignancy worldwide in 2018. Some earlier studies indicate a significant influence of vitamin D supplementation on the 5-year survival rate and the rate of metastasis progression in colorectal cancer patients. Studies investigating the effects of vitamin D supplementation on the outcomes of colorectal cancer patients are limited in Indonesia. Therefore, a double-blinded Randomized Controlled Trial (RCT) of the effect of vitamin D supplementation on the outcome of colorectal cancer patients was conducted from April 2022 to March 2023 at the digestive surgery outpatient clinic of Dr. Hasan Sadikin General Hospital Bandung, Indonesia. In this study, 36 patients received vitamin D and 34 patients received a placebo. Data analysis performed using the multivariate analysis with multiple regression revealed no significant relationship between vitamin D supplementation and colorectal cancer patient outcomes. Furthermore, ANOVA analysis indicated no relationship between the analyzed independent and dependent variables in this study.  No relationship was found between vitamin D supplementation and the outcomes of metastasis, mortality, and Karnofsky scores in colorectal cancer patients. Further research with a larger population is still needed to determine the benefits of vitamin D supplementation on the outcomes of colorectal cancer patients. Faculty of Medicine, Universitas Padjadjaran 2024-12-31 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.fk.unpad.ac.id/index.php/mkb/article/view/3823 10.15395/mkb.v56.3823 Majalah Kedokteran Bandung; Vol 56, No 4 (2024); 292-302 Majalah Kedokteran Bandung; Vol 56, No 4 (2024); 292-302 2338-6223 0126-074x 10.15395/mkb.v56.n4 eng https://journal.fk.unpad.ac.id/index.php/mkb/article/view/3823/pdf https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/3823/4742 https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/3823/4786 https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/3823/4787 https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/3823/4788 https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/3823/4789 https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/3823/4805 https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/3823/4806 Copyright (c) 2024 Majalah Kedokteran Bandung http://creativecommons.org/licenses/by-nc/4.0

oai:ojs.journal.fk.unpad.ac.id:article/2930 2023-02-15T02:48:57Z mkb:ART

Nutmeg Extract Alters Mitochondrial Genes Regulation of Skeletal Muscle Fibers in Aging Rats Setiawan, Setiawan Pratiwi, Yuni Susanti Lesmana, Ronny Sari, Galuga Sinalusur Ramdan, Ahmad Hartono, Aldo Fathurachman, Fathurachman Supratman, Unang Aging, mitochondria, nutmeg, sarcopenia Nutmeg as one of Indonesia native plants has already been used widely in herbal treatment. It has been demonstrated that nutmeg presents activities related to mitochondria functions. Nutmeg potentially has the effect of peroxisome proliferator activated receptors Υ (PPAR Υ) which contributes to myogenesis, and may alters mitochondrial homeostasis in respiration and biogenesis. In this study, how nutmeg extract alters oxidative process in skeletal muscle of aging rats was explored. Twenty aging Wistar male rats aged 80 weeks old were divided into two groups (control and nutmeg treatment). Nutmeg extract was administered for 12 weeks using a gavage. After that, the soleus muscles were collected, weighted, frozen, and stored at -800C until used. Nutmeg was observed to increase the COX1 (1.9 folds, p<0.01), COX2 (1.6 folds, p<0.05), and COXIV (2.8 folds, p<0.01) gene expressions, in parallel with increased protein carbonyl levels (1.5 folds, p<0,01). Nutmeg treatment also significantly increased the expressions of antioxidant endogen COQ7 (2 folds, p<0,01) and PDSS2 (2 folds, p<0,01) in the soleus muscle. Taken together, nutmeg extract may improve mitochondrial respiratory oxidative activities in type I aging skeletal muscle. Faculty of Medicine, Universitas Padjadjaran 2022-12-31 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.fk.unpad.ac.id/index.php/mkb/article/view/2930 10.15395/mkb.v54n4.2930 Majalah Kedokteran Bandung; Vol 54, No 4 (2022); 242-248 Majalah Kedokteran Bandung; Vol 54, No 4 (2022); 242-248 2338-6223 0126-074x 10.15395/mkb.v54n4 eng https://journal.fk.unpad.ac.id/index.php/mkb/article/view/2930/pdf https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/2930/3524 Copyright (c) 2022 Majalah Kedokteran Bandung http://creativecommons.org/licenses/by-nc/4.0

oai:ojs.journal.fk.unpad.ac.id:article/3952 2025-07-08T07:45:47Z mkb:ART

Prevalence, Severity, and Self-Medication for Dysmenorrhea among Female Adolescents in Indonesia Zulimartin, Handika Harzif, Achmad Kemal Shadrina, Amalia Harahap, Juliana Sari Tanjung, Anton Muharam, R. Medicine; Health Sciences; Gynecology Dysmenorrhea, Indonesia, self-medication, traditional medicine Dysmenorrhea, commonly referred to as menstrual pain, is a prevalent condition affecting many reproductive-aged women, particularly female adolescents, with varying degrees of intensity. Dysmenorrhea affects 64.5% of female adolescents in Indonesia, with the highest prevalence rates found in West Java (98.8%) and Jakarta (87.5%). Over the years, various therapy modalities have been developed for treating this condition based on its pathophysiology. However, in Indonesia, a country renowned for its rich natural resources and medicinal herbs, there is a prevailing belief in the efficacy of traditional medicine. Female adolescents in Indonesia are often engaged in self-medication practices, combining traditional medicine with nonsteroidal anti-inflammatory drugs (NSAIDs). This study aimed to analyze the prevalence, severity, and self- medication practices for dysmenorrhea among female adolescents in Indonesia. The study was conducted from January to December 2020 using an online survey that included questions about menstrual pain, family history, and the use of traditional medicine and NSAIDs. This study comprised 362 participants recruited through convenience sampling. Results showed that 92.5% of participants experienced dysmenorrhea with varying degrees of pain. A total of 216 (59.9%) female adolescents experienced frequent dysmenorrhea, while 118 (32.6%) reported experiencing this condition every menstrual cycle. Of all participants, 33.1% used traditional medicine as a treatment option, and 16.9% used NSAIDs. According to the self-reported visual analog scale (VAS), the use of natural remedies, such as traditional medicine, was associated with lower pain levels, suggesting their potential benefits in healthcare services for dysmenorrhea. Faculty of Medicine, Universitas Padjadjaran 2025-06-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.fk.unpad.ac.id/index.php/mkb/article/view/3952 Majalah Kedokteran Bandung; Vol 57, No 2 (2025); 104-110 Majalah Kedokteran Bandung; Vol 57, No 2 (2025); 104-110 2338-6223 0126-074x 10.15395/mkb.v57n2 eng https://journal.fk.unpad.ac.id/index.php/mkb/article/view/3952/pdf https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/3952/4947 https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/3952/4949 https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/3952/4950 Copyright (c) 2024 Majalah Kedokteran Bandung http://creativecommons.org/licenses/by-nc/4.0

oai:ojs.journal.fk.unpad.ac.id:article/2013 2021-03-02T05:05:43Z mkb:ART

Correlation Between HbA1c and Albuminuria in Type 2 Diabetes Mellitus Merlin, Jesika Pusparini, Pusparini Medicine; Clinical Pathology Albuminuria, diabetic nephropathy, HbA1c, type 2 diabetes mellitus In patients with type 2 diabetes mellitus (Type 2 DM), glycemic control plays an essential role in reducing macro- and microvascular complications. The earliest marker for diabetic nephropathy is the presence of albuminuria. Meanwhile, HbA1c  has been recognized as a marker of glycemic control in the blood. This study aimed to identify the correlation between HbA1c and albuminuria in type 2 DM. This was a cross-sectional study involving 100 patients with type 2 DM aged 40–70 years visiting Dr. Soetomo Hospital, Surabaya, Indonesia. Secondary data from medical records of type 2 DM patients undergoing HbA1c and albuminuria examinations from January to December 2015 were used. The mean age of subjects was 55.4 ±8.7 years, with the majority (55%) being of female gender. The mean HbA1c concentration was 9.8±2.4%. Most subjects (83%) had an HbA1c level of ≥7 %. Albuminuria was found in the majority of the subjects (78%), where 33% of them had positive  1 albuminuria. The Spearman correlation test showed a positive strong significant correlation between HbA1c and albuminuria, with r=0.865 and p<0.001. Thus, it can be concluded that there is a significant correlation between HbA1c and albuminuria in type 2 DM.Korelasi HbA1c dan Albuminuria pada Diabetes Melitus Tipe 2 Pada penderita diabetes melitus tipe 2 (DM tipe 2), kontrol glikemik memegang peranan penting untuk menurunkan komplikasi makrovaskular dan mikrovaskular. Petanda awal terjadinya nefropati diabetik adalah adanya albuminuria. HBA1c merupakan petanda untuk mengetahui kontrol glikemik didalam darah. Tujuan penelitian ini untuk mengetahui korelasi antara HbA1c dengan albuminuria pada  DM tipe 2. Penelitian ini menggunakan desain potong lintang, mengikutsertakan 100 penderita DM tipe 2 berusia 40–70 tahun di Rumah Sakit Dr. Soetomo Surabaya. Data yang digunakan adalah data sekunder dari rekam medis penderita DM tipe 2 yang melakukan pemeriksaan HbA1c dan albuminuria pada bulan Januari 2015 sampai dengan Desember 2015. Rerata usia subjek adalah 55,47±8,7 tahun dengan subjek terbanyak berjenis kelamin perempuan (55%). Rerata kadar HbA1c berkisar 9,8±2,4 %. Sebagian besar subjek mempunyai kadar HbA1c ≥7 % yaitu 83%. Albuminuria dijumpai pada sebagian besar subjek yaitu 78% dan sebagian besar subjek mempunyai albuminuria positif 1, yaitu 33 %. Hasil uji korelasi Spearman menunjukkan terdapat korelasi positif kuat yang bermakna antara HbA1c dengan albuminuria dengan nilai r=0,865 dan p<0,001. Dengan demikian, dapat disimpulkan terdapat korelasi yang bermakna antara HbA1c dan albuminuria pada DM tipe 2. Faculty of Medicine, Universitas Padjadjaran 2020-09-28 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.fk.unpad.ac.id/index.php/mkb/article/view/2013 10.15395/mkb.v52n3.2013 Majalah Kedokteran Bandung; Vol 52, No 3 (2020); 125-130 Majalah Kedokteran Bandung; Vol 52, No 3 (2020); 125-130 2338-6223 0126-074x 10.15395/mkb.v52n3 eng https://journal.fk.unpad.ac.id/index.php/mkb/article/view/2013/pdf https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/2013/1856 https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/2013/1857 Copyright (c) 2020 Majalah Kedokteran Bandung http://creativecommons.org/licenses/by-nc/4.0

oai:ojs.journal.fk.unpad.ac.id:article/3047 2024-03-14T03:01:06Z mkb:ART

Comparison of Preemptive Post-Intubation 15 Mg/KgBW Paracetamol to 0.35 Mg/KgBW Meperidine in Incidence of Post-Anesthetic Shivering Nataputra, Mario Bisri, Dewi Yulianti Budipratama, Dhany Medicine;Anesthesiology General anesthesia, meperidine, paracetamol, preemptive, shivering Post anesthesia shivering (PAS) is a repetitive involuntary movement of one or more muscle groups as a result of a decrease in core body temperature. Pharmacological therapy in preventing PAS may include meperidine and paracetamol. This study compared the effectiveness of paracetamol to meperidine in reducing the incidence of post-anesthesia shivering. This study used an experimental randomized double-blind comparative analytic design on patients underwent exploratory laparotomy surgery under general anesthesia at Dr. Hasan Sadikin General Hospital Bandung, Indonesia, from September 2021 to August 2022. Patients with 50 ASA 1-2 physical status were included and divided into two groups. One group received 15 mg/kg group paracetamol and the other received 0.35 mg/kg meperidine. Data on tympanic membrane temperature and hemodynamics before and after induction and after extubating were collected. Furthermore, data on the results of the assessment of the incidence and grade of shivering in each treatment group were also collected. The results of this study showed that there was a decrease in the frequency of PAS in patients receiving intravenous 15 mg/kg paracetamol (p<0.05), as well as less side effects in the form of nausea and vomiting (p < 0.05). The incidence and degree of shivering after general anesthesia using intravenous 15 mg/kg paracetamol was lower compared to the use of 0.35 mg/kg meperidine. In the meperidine group, the decrease in body temperature was lower than in the paracetamol group, while the incidence of nausea and vomiting in the paracetamol group was lower than in the meperidine group. In conclusion, paracetamol reduces the incidence of post-anesthesia shivering better than meperidine. Faculty of Medicine, Universitas Padjadjaran 2023-09-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.fk.unpad.ac.id/index.php/mkb/article/view/3047 10.15395/mkb.v55n3.3047 Majalah Kedokteran Bandung; Vol 55, No 3 (2023); 176-180 Majalah Kedokteran Bandung; Vol 55, No 3 (2023); 176-180 2338-6223 0126-074x 10.15395/mkb.v55n3 eng https://journal.fk.unpad.ac.id/index.php/mkb/article/view/3047/pdf https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/3047/3667 https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/3047/3668 Copyright (c) 2023 Majalah Kedokteran Bandung http://creativecommons.org/licenses/by-nc/4.0

oai:ojs.journal.fk.unpad.ac.id:article/4193 2026-01-21T05:05:08Z mkb:CR

Rare Eccrine Porocarcinoma of The Eyelid in A Non-Caucasian Patient Boesoirie, Shanti F. Mardianty, Friska Wahyu, Tri Dewi, Niluh Putu Ayu Nursalamah, Mia Dahlan, Mohamad Rinaldi Kartiwa, Raden Angga Medicine; Ophthalmology; Ophthalmic Oncology eyelid tumor, palpebral defects, periosteal flap, porocarcinoma, rare tumor Eccrine porocarcinoma of the eyelid is a rare and locally aggressive tumor with a significant risk of metastasis and recurrence after surgical excision. There are only eight cases of eyelid porocarcinoma reported in the literature, most involve Caucasian patients. A 58-year-old non-Caucasian male had a recurrent mass of the left upper eyelid for a year. He underwent two prior mass removal procedures in the same location of the upper eyelid. At the time of this study, the patient underwent full-thickness excision, and a lateral canthal defect with superior palpebral involvement was sacrificed. The periosteal flap from the lateral orbital rim was attached to the edge of the intact tarsal plate of the upper eyelid as a part of the defect reconstruction. Good outcomes in terms of tumor recurrences, cosmesis, and upper eyelid functionality were observed one month following surgery. According to the histopathology, the tumor was identified as eccrine porocarcinoma, and the patient was recommended for chemotherapy. The 4-month follow-up showed no recurrence or metastasis. Eccrine porocarcinoma is a rare condition that should be taken into account when making a differential diagnosis for patient with malignant eyelid tumors. Wide excision is still a treatment of choice.  Faculty of Medicine, Universitas Padjadjaran 2025-12-31 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.fk.unpad.ac.id/index.php/mkb/article/view/4193 10.15395/mkb.v57.4193 Majalah Kedokteran Bandung; Vol 57, No 4 (2025); 354-358 Majalah Kedokteran Bandung; Vol 57, No 4 (2025); 354-358 2338-6223 0126-074x 10.15395/mkb.v57n4 eng https://journal.fk.unpad.ac.id/index.php/mkb/article/view/4193/pdf https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/4193/5439 Copyright (c) 2025 Majalah Kedokteran Bandung http://creativecommons.org/licenses/by-nc/4.0

oai:ojs.journal.fk.unpad.ac.id:article/2230 2021-08-11T04:57:47Z mkb:ART

Mutation and Phylogenetic Analysis of Spike Glycoprotein of Indonesian Isolates of Severe-Acute-Respiratory-Syndrome-Coronavirus-2 (SARS-CoV-2) Gaffar, Shabarni Rahmani, Syifa Al Fauziah Hardianto, Ari Chemistry Mutation, phylogenetic analysis, SARS-CoV-2, Spike Coronavirus disease-2019 (COVID-19) is an infectious acute respiratory disease caused by SARS-CoV-2. The protein that plays a role in the entry of SARS-CoV-2 into human cells is the surface protein, or the Spike, which is thought to be the effective vaccine target to prevent SARS-CoV-2 infection. Until December 2020, Indonesia has reported 106 SARS-CoV-2 genome sequences identified from COVID-19 positive patients. The purpose of this study was to analyze the phylogenetic relationship of the Spike protein of the Indonesian isolates of SARS-CoV-2 Indonesian, as well as the virus mutations and their effects on changes in the amino acid. The 106 Indonesian SARS-CoV-2 genomes were downloaded from GISAID and  the Spike nucleotide and amino acid sequences were analyzed by multiple sequence alignment (MSA) and mutation analysis using the ClustalW method. Phylogenetic trees were created using the Neighbor-Joining method in MEGA-X software. The results showed that 30 of the 106 Indonesian isolate SARS-CoV-2 Spike were 100% identical to the Wuhan-Hu-1, while the remaining 76 had experienced mutations at 1-4 sites. There were 43-point mutations in the Spike gene, 27 of which led to amino acid changes and four had not been reported in other countries. The global mutation D614G was found in 60 Indonesian isolates , of which West Java was the province with the most reports. The phylogenetic of Spike showed that the Indonesian samples have been divided into several branches that are far from Wuhan-Hu-1. This study indicates the possibility of differences in the protein structure of Indonesian isolate SARS-CoV-2 Spike that need to be further studied to manufacture a vaccine against the Indonesian strain of SARS-CoV-2. Faculty of Medicine, Universitas Padjadjaran 2021-03-31 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.fk.unpad.ac.id/index.php/mkb/article/view/2230 10.15395/mkb.v53n1.2230 Majalah Kedokteran Bandung; Vol 53, No 1 (2021); 38–47 Majalah Kedokteran Bandung; Vol 53, No 1 (2021); 38–47 2338-6223 0126-074x 10.15395/mkb.v53n1 eng https://journal.fk.unpad.ac.id/index.php/mkb/article/view/2230/pdf https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/2230/2171 https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/2230/2187 https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/2230/2188 https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/2230/2189 Copyright (c) 2021 Majalah Kedokteran Bandung http://creativecommons.org/licenses/by-nc/4.0

oai:ojs.journal.fk.unpad.ac.id:article/3346 2024-10-08T08:39:36Z mkb:ART

Association Between Screen Time, Vitamin A Consumption Behavior, and Computer Vision Syndrome in Preclinical Medical Students Prasetya, Harka Rahmawati, Atik Andira, Aisyah Putri Suparmi, Suparmi Medicine; Opthalmology Computer vision syndrome (CVS), consumption behavior, screen time, vitamin A Computer Visual Syndrome (CVS) refers to visual disturbances induced by electronic media such as computers, laptops, tablets, and smartphones. This research aimed to determine the association between screen time, vitamin A consumption behavior, and CVS symptoms among preclinical medical students. Ninety-five students from a single class at the Faculty of Medicine, Universitas Islam Sultan Agung, Indonesia, participated in this cross-sectional study. Data were collected using an online survey platform in February 2022. The screen time, vitamin A consumption behavior, and CVS were measured using a validated questionnaire. The average daily screen time of the respondents was more than 10 h, with the majority having a moderate vitamin A consumption patterns (66.3%) and experienced CVS (63.2%). The most prevalent CVS symptom identified among these respondents was eye fatigue (62.1%), while double vision and inflamed or watery eyes were the least reported CVS symptoms (9.5% and 8.4%, respectively). The Chi-Square test revealed that there was no correlation between screen time and CVS (p > 0.05), but there was a significant correlation between vitamin A consumption and CVS (p < 0.05). In conclusion, CVS is observed among preclinical medical students due to increased screen time and decreased vitamin A consumption. Therefore, there is a need to develop strategies to manage screen time and vitamin A consumption among students at risk for developing a CVS during their academic careers. Faculty of Medicine, Universitas Padjadjaran 2024-03-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.fk.unpad.ac.id/index.php/mkb/article/view/3346 10.15395/mkb.v56.3346 Majalah Kedokteran Bandung; Vol 56, No 1 (2024); 29-34 Majalah Kedokteran Bandung; Vol 56, No 1 (2024); 29-34 2338-6223 0126-074x 10.15395/mkb.v56n1 eng https://journal.fk.unpad.ac.id/index.php/mkb/article/view/3346/pdf https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/3346/4111 https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/3346/4112 Copyright (c) 2023 Majalah Kedokteran Bandung http://creativecommons.org/licenses/by-nc/4.0

oai:ojs.journal.fk.unpad.ac.id:article/2444 2022-02-04T04:04:23Z mkb:ART

Validity and Reliability Test of Four-Meter Gait Speed on Six Meter Track for Indonesian Adults Nusdwinuringtyas, Nury Fransiska, Tresia Sunarjo, Peggy Triangto, Kevin Dahlan, Sopiyudin Medicine; Rehabiltation; Cardiorespiratory 4MGS; 6 meters track; mongoloid race Walking is an essential component of daily life and studies have shown the growing number of clinicians performing walking tests in their daily practice. This study is aimed to assess the validity and reliability of the Four-Meter Gait Speed (4MGS) test for healthy Indonesian adults (Mongoloid race). Data collection were conducted at the Rehabilitation Department of Dr. Cipto Mangunkusumo General Hospital during the period of August 2016 to March 2017. Two observers and two trials were involved in measuring the gait speed in the 4MGS test with a 6 meter track. All accumulated data were analyzed for validity using the Bland-Altman test, while test re-test reliability was done using Cronbach's alpha for internal consistency. Sixty-one subjects were involved in this study. There were no significant differences in inter-trial comparison from both observers (P=0.262 and P=0.954). Similarly, intra-observer walking speed comparison in both trials were also not significantly different (P=0.117 and P=0.869). The intraclass correlation coefficient (ICC) value between the first and second tests from observer I was 0.839 (Cronbach Alpha,0.911) while the value for observer II was 0.902 (Cronbach Alpha, 0.948). The ICC value between observer I and II in the first trial was 0.906 (Cronbach Alpha, 0.950); whereas the second trial demonstrated a value of 0.890 (Cronbach Alpha, 0.941). Thus, the 6 meter track 4MGS has a good validity and reliability for healthy Indonesian adults. It is expected that the walking speed from this study can be used for Mongoloid race living in other countries and the 4MGS can become an alternative speed-based walk test, especially during COVID-19 pandemic, due to its practicality in measuring functional capacity in a shorter duration. Faculty of Medicine, Universitas Padjadjaran 2021-12-31 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.fk.unpad.ac.id/index.php/mkb/article/view/2444 10.15395/mkb.v53n4.2444 Majalah Kedokteran Bandung; Vol 53, No 4 (2021); 179-185 Majalah Kedokteran Bandung; Vol 53, No 4 (2021); 179-185 2338-6223 0126-074x 10.15395/mkb.v53n4 eng https://journal.fk.unpad.ac.id/index.php/mkb/article/view/2444/pdf https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/2444/2617 https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/2444/2618 https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/2444/2619 Copyright (c) 2021 Majalah Kedokteran Bandung http://creativecommons.org/licenses/by-nc/4.0

oai:ojs.journal.fk.unpad.ac.id:article/4140 2024-10-14T09:04:45Z mkb:FBM

Front Cover, Editorial Team, Table of Contents, and Back Cover back, front Faculty of Medicine, Universitas Padjadjaran 2024-03-31 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.fk.unpad.ac.id/index.php/mkb/article/view/4140 Majalah Kedokteran Bandung; Vol 56, No 1 (2024) Majalah Kedokteran Bandung; Vol 56, No 1 (2024) 2338-6223 0126-074x 10.15395/mkb.v56n1 eng https://journal.fk.unpad.ac.id/index.php/mkb/article/view/4140/1994 Copyright (c) 2024 Majalah Kedokteran Bandung http://creativecommons.org/licenses/by-nc/4.0

oai:ojs.journal.fk.unpad.ac.id:article/2701 2023-11-23T03:16:33Z mkb:ART

Association Between Maternal Mid-Upper Arm Circumference and Baby's Birth Weight Yosefinata, Kelly Zuhairini, Yenni Luftimas, Dimas E. Medicine; Public Health birth weight, chronic energy malnutrition, MUAC, Tanjungsari Birth weight can be a potential predictor for short-term and long-term health outcomes. Low birth weight can be an output from maternal malnutrition. Mothers' chronic energy malnutrition risk is detected by measuring maternal mid-upper arm circumference (MUAC). This study aimed to analyze the correlation of maternal MUAC with a baby's birth weight. This study was an analytic observational study that used secondary data from October 2021 to January 2022. Data were obtained from Tanjungsari Intergenerational Study Nutrition Working Group from 2014 to 2016. Subjects were 124 pairs of mother and baby who were recruited using total sampling. Data were analyzed using t-test and logistic regression. A significant association of maternal MUAC and the baby's birth weight (t (122) = 3.75, 95% CI 174.5, 564.0, p=0.000) was detected. Underweight (OR 23.3, 95% CI 2.6, 209.0, p=0.005), overweight, and obese (OR 0.05, 95% CI 0.01, 0.42, p=0.006) status was shown to have an association with MUAC. Education level and occupation status had no associations with MUAC. In conclusion, maternal MUAC is associated with baby's birth weight. The determinant factors of maternal MUAC were underweight, overweight, and obese status. Faculty of Medicine, Universitas Padjadjaran 2022-09-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.fk.unpad.ac.id/index.php/mkb/article/view/2701 10.15395/mkb.v54n3.2701 Majalah Kedokteran Bandung; Vol 54, No 3 (2022); 172–176 Majalah Kedokteran Bandung; Vol 54, No 3 (2022); 172–176 2338-6223 0126-074x eng https://journal.fk.unpad.ac.id/index.php/mkb/article/view/2701/pdf https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/2701/3224 https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/2701/3225 Copyright (c) 2022 Majalah Kedokteran Bandung http://creativecommons.org/licenses/by-nc/4.0

oai:ojs.journal.fk.unpad.ac.id:article/3834 2025-10-15T07:01:31Z mkb:ART

Sexual Violence among University Medical Students in Sumatera, Indonesia Windasari, Noverika Fadila, Zurayya Medicine; Forensic; Medical student, sexual violence, Universities Sexual violence is a pervasive issue affecting both adults and children globally, resulting in severe trauma for victims. Due to the power dynamics, this problem also extends to educational institutions, including universities. Therefore, this study aimed to investigate incidents of sexual violence among medical students at a state university in West Sumatra, Indonesia in 2023. A descriptive cross-sectional survey was conducted using a questionnaire distributed to pre-clinical and clinical medical students. A total of 1,170 students were included as respondents, of which 9.66% of them reported experiencing sexual violence. Specifically, 46.% of respondents had previous experience of sexual violence, and 42.5% of these occurred during their time as university students. The most common forms were non-physical sexual violence, accounting for 35% of reported cases, with 30.3% of the perpetrators being strangers. Over half of the victims experienced sexual violence more than once, and only 46.2% of victims reported their experience. This study showed that sexual violence affected medical students, mainly in non-physical forms, with a low reporting rate. Consequently, collaboration between campus leaders and the academic community is crucial to empower victims in participating and creating an environment that is free from sexual violence. Preventive efforts must also be comprehensive, engaging multiple sectors and community, to effectively combat sexual violence in universities. Faculty of Medicine, Universitas Padjadjaran Faculty of Medicine Universitas Andalas 2025-03-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.fk.unpad.ac.id/index.php/mkb/article/view/3834 10.15395/mkb.v57.3834 Majalah Kedokteran Bandung; Vol 57, No 1 (2025); 36-42 Majalah Kedokteran Bandung; Vol 57, No 1 (2025); 36-42 2338-6223 0126-074x 10.15395/mkb.v57n1 eng https://journal.fk.unpad.ac.id/index.php/mkb/article/view/3834/pdf https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/3834/4764 https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/3834/4765 https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/3834/4766 https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/3834/4767 https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/3834/4808 https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/3834/5185 Copyright (c) 2024 Majalah Kedokteran Bandung http://creativecommons.org/licenses/by-nc/4.0

oai:ojs.journal.fk.unpad.ac.id:article/1863 2022-03-21T03:53:21Z mkb:ART

DNA Methylation from Bloodstain as a Forensic Age Estimation Method Yudianto, Ahmad Novita, Masniari Jauhani, Muhammad Afiful Binarsa, Deka Bagus Forensic Medicine and Medicolegal Age, bloodstain, DNA methylation, estimation, forensic Forensic identification is an effort to help law enforcement officers to reveal a person's identity. Personal identity is often a problem in criminal and civil cases as well as  cases related to death without identity and mass disasters. Age estimation is very important in forensic identification. DNA methylation is a potential epigenetic modification for age estimation because the aging process of DNA resembles the developments regulated in processes that are tightly controlled by specific epigenetic modifications. In most cases of violent crime, bloodstains can be found at the crime scene. Bloodstain may come from victims, perpetrators of crime, or both. Bloodstain can be used to scientifically reveal the correlation between DNA methylation from bloodstain and the age of unknown person. This study aimed to determine the correlation betweeen DNA methylation from bloodstain and a person's age. The study was conducted at the Institute of Tropical Disease of Universitas Airlangga from July to October 2019 using the analytic observational approach on 10 samples consisting of 5 male and 5 female samples. It was discovered that the correlation coefficient between DNA methylation and age in male subjects was 0.888 with a significance value of 0.04 and 0.834 in female subjects with a significance value of 0.079. In conclusion, there is a significant correlation between percent methylation and age in male subjects. However, this correlation is not statistically significant in female subjects. Metilasi DNA pada Bercak Darah sebagai Metode Forensik untuk Perkiraan UmurIdentifikasi dalam bidang kedokteran forensik adalah upaya untuk membantu penegak hukum dalam menentukan identitas seseorang. Identitas personal sering menjadi masalah dalam kasus pidana, kasus perdata, kematian tanpa identitas, dan bencana massal. Estimasi umur sangat penting dalam identifikasi forensik. Metilasi DNA merupakan suatu modifikasi epigenetik yang potensial untuk memperkirakan umur. Hal ini dikarenakan, DNA pada individu yang mengalami penuaan menyerupai perkembangan yang diatur dalam proses yang dikontrol ketat oleh modifikasi epigenetik khusus. Pada kebanyakan kasus kriminal dengan tindak kekerasan, bercak darah dapat ditemukan pada tempat kejadian perkara. Bercak darah tersebut mungkin berasal dari korban, pelaku kejahatan, atau bahkan dari keduanya. Bercak darah dapat digunakan untuk membantu mengungkap peristiwa tersebut secara ilmiah Sejauh ini korelasi metilasi DNA dari bercak darah dengan umur seseorang belum banyak diketahui. Penelitian ini bertujuan mengetahui korelasi metilasi DNA dari bercak darah dengan umur seseorang. Penelitian dilakukan di Institute of Tropical Disease Universitas Airlangga periode Juli sampai Oktober 2019. Metode penelitian yang digunakan observasional analitik yang dilakukan pada 10 sampel dengan rincian 5 sampel pria dan 5 sampel wanita. Hasil penelitian, korelasi metilasi DNA dengan umur pada subyek laki-laki didapatkan nilai r adalah 0.888 dengan nilai signifikansi 0.04 dan pada subyek perempuan didapatkan r adalah 0.834 dengan nilai signifikansi 0.079. Simpulan, ditemukan korelasi signifikan antara persen metilasi dengan umur pada laki-laki, sedangkan pada perempuan tidak terdapat korelasi yang signifikan secara statistik. Faculty of Medicine, Universitas Padjadjaran SIMLITABMAS KEMRISTEKDIKTI 2018 2020-03-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.fk.unpad.ac.id/index.php/mkb/article/view/1863 10.15395/mkb.v52n1.1863 Majalah Kedokteran Bandung; Vol 52, No 1 (2020); 11-15 Majalah Kedokteran Bandung; Vol 52, No 1 (2020); 11-15 2338-6223 0126-074x eng https://journal.fk.unpad.ac.id/index.php/mkb/article/view/1863/pdf https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/1863/1570 https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/1863/2880 Copyright (c) 2020 Majalah Kedokteran Bandung http://creativecommons.org/licenses/by-nc/4.0

oai:ojs.journal.fk.unpad.ac.id:article/2934 2023-07-17T05:41:52Z mkb:ART

Anxiety (DASS21) and the Quality of Life (FertiQol) of Infertile Women Underwent In Vitro Fertilization Tjahyadi, Dian Irsyad, Bayu Indrayana Pramatirta, Ahmad Yogi Andayani, Santi medicine; reproductive health; psychiatry Anxiety; infertility; quality of life Infertility affects physical and mental health and has various consequences. In vitro fertilization (IVF) is one of the Assisted Reproductive Technology (ART) programs that include several phases, requiring longer time, more patience, and is expensive. This may make women who undergo the ART program to have higher stress level, especially anxiety. This study aimed to determine the relationship between anxiety and quality of life in infertile patients undergoing assisted reproductive technology programs. This was a cross-sectional observational analytic study performed at Aster Fertility Clinic, Dr. Hasan Sadikin General Hospital and Bandung Fertility Center, Limijati Hospital Bandung, Indonesia, from February until April 2020. The analysis was performed using the DASS21 scale and FertiQol count on 27 subjects undergoing the IVF program and 30 control subjects who were pregnant without IVF program. The statistical analyses used to determine the condition of anxiety and the condition of quality of life were the Chi-square and the Mann-Whitney tests, while the relationship between anxiety and quality of life as the main subject was measured using the Spearman correlation test. The anxiety level as measured with the DASS21 instrument in the subject and control groups was 6.2 vs 0.7 with p<0.001. From the analysis of the FertiQol instrument in the subject and control groups, the scores were 79.6 vs. 98.9 for the mind-body domain (p<0.001); 68.8 vs 98.5 for the emotional domain (p < 0.001); 83.2 vs 95.7 for the relational domain (p<0.001); and 77.6 vs 97.6 for the social domain (p<0.001). For the overall FertiQol core domains, the score was 77.3 vs 97.7 (p<0.001). The correlation between anxiety and the FertiQol total core domains were evident from the results of the Spearman correlation test, with an r-value of -0.479 (p<0.001). Therefore, there is a significant negative correlation between anxiety and quality of life. Faculty of Medicine, Universitas Padjadjaran 2023-06-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.fk.unpad.ac.id/index.php/mkb/article/view/2934 10.15395/mkb.v55n2.2934 Majalah Kedokteran Bandung; Vol 55, No 2 (2023); 98–105 Majalah Kedokteran Bandung; Vol 55, No 2 (2023); 98–105 2338-6223 0126-074x eng https://journal.fk.unpad.ac.id/index.php/mkb/article/view/2934/pdf https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/2934/3528 Copyright (c) 2022 Majalah Kedokteran Bandung http://creativecommons.org/licenses/by-nc/4.0

oai:ojs.journal.fk.unpad.ac.id:article/4196 2026-01-21T05:05:08Z mkb:ART

Heat Stress Exposure and Chronic Kidney Disease in Indonesian Rayon Factory Workers Suraya, Anna Ningsih, Sri Utami Lelitasari, Lelitasari Sulandari, Uci Shanmugam, Rekha Venugopal, Vidhya Public Health; Occupational Health Chronic kidney diseases, heat stress, Indonesia, workers Chronic kidney disease (CKD) has become an emerging occupational health concern, particularly among workers exposed to high temperatures. This study aimed to determine the prevalence of CKD among workers in a rayon factory in West Java, Indonesia, and evaluate its association with occupational heat exposure. A retrospective cohort study was conducted using secondary data from the company’s annual medical check-up records (2022–2023) and workplace heat stress measurements obtained in 2017 using the Quest Temp Wet-Bulb Globe Temperature monitor. Workers who completed medical examinations in both years and gave written informed consent to participate in the study were included. CKD was defined as a serum creatinine level >1.2 mg/dL and an estimated glomerular filtration rate <60 mL/min/1.73 m² in two consecutive years. Chi-square tests were used for bivariate analysis, and multivariate logistic regression was performed to obtain adjusted odds ratios (ORs). Of 675 eligible workers, male constituted the majority (99.7%) and 49% were older than 40 years. Most workers (96.1%) were exposed to workplace temperatures above 28°C, and obesity (47%), hypertension (16.7%), and diabetes mellitus (5.5%) were common comorbidities. The prevalence of reduced kidney function was 5.5%, with heat exposure of 28.2–30°C associated with an OR of 4.5 (95% CI: 1.372–14.792). The prevalence of CKD was 0.9%, and heat exposure in the same temperature range demonstrated an OR of 8.958 (95% CI: 1.207–66.515). However, the association was not statistically significant after adjusting for age, obesity, and hypertension. These findings suggest that occupational heat exposure may contribute to early kidney impairment, highlighting the need for heat mitigation strategies and routine worker health monitoring in industries where workers are at risk of heat exposure. Faculty of Medicine, Universitas Padjadjaran 2025-12-31 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.fk.unpad.ac.id/index.php/mkb/article/view/4196 10.15395/mkb.v57.4169 Majalah Kedokteran Bandung; Vol 57, No 4 (2025); 267-275 Majalah Kedokteran Bandung; Vol 57, No 4 (2025); 267-275 2338-6223 0126-074x 10.15395/mkb.v57n4 eng https://journal.fk.unpad.ac.id/index.php/mkb/article/view/4196/pdf https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/4196/5347 https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/4196/5348 https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/4196/5349 Copyright (c) 2025 Majalah Kedokteran Bandung http://creativecommons.org/licenses/by-nc/4.0

oai:ojs.journal.fk.unpad.ac.id:article/2985 2024-10-08T08:40:23Z mkb:CR

Giant Pyonephrosis Due to Calculus of Ureter: A Case Report Singgih, Nicholas Andrian Lionardi, Stevan Kristian Mintardi, Mintardi Abdominal mass, case report, giant pyonephrosis, ureteropelvic junction obstruction Giant pyonephrosis (GP) is a rare and severe form of pyonephrosis characterized by a massive enlargement of the affected kidney due to the accumulation of infected fluid. This study presents case of a 51-year-old male patient with giant pyonephrosis who underwent nephrectomy as treatment. The clinical manifestations of giant pyonephrosis are nonspecific, necessitating the use of imaging and laboratory techniques to aid in diagnosis. Nephrectomy is the preferred treatment option for these patients. One week after nephrectomy, the laboratory results showed improvements. Making the right treatment decision is challenging in this particular case. Faculty of Medicine, Universitas Padjadjaran 2023-12-31 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.fk.unpad.ac.id/index.php/mkb/article/view/2985 10.15395/mkb.v55n4.2985 Majalah Kedokteran Bandung; Vol 55, No 4 (2023); 264-268 Majalah Kedokteran Bandung; Vol 55, No 4 (2023); 264-268 2338-6223 0126-074x 10.15395/mkb.v55n4 eng https://journal.fk.unpad.ac.id/index.php/mkb/article/view/2985/pdf https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/2985/3578 https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/2985/3579 Copyright (c) 2023 Majalah Kedokteran Bandung http://creativecommons.org/licenses/by-nc/4.0

oai:ojs.journal.fk.unpad.ac.id:article/2389 2023-01-13T09:03:21Z mkb:ART

Correlation Between Serum Ferritin and Testosterone Level in Adolescent Male with Transfusion Dependent Thalassemia Harahap, Raja Iqbal Mulya Tristina, Nina Prihatni, Delita Turbawaty, Dewi Kartika Medicine; Health Science; Clinical Pathology ferritin, iron, transfusion dependent thalassemia, total testosterone Transfusion-dependent thalassemia (TDT) is a type of beta-thalassemia that needs regular and long-term blood transfusions. Complications can occur due to the deposition of iron in TDT patients, including endocrine complications causing deficiency of testosterone that plays a role in the secondary sexual development in males. The objective of this study was to understand the correlation between ferritin and testosterone level in male adolescences with transfusion-dependent thalassemia. This cross-sectional observational correlative study was conducted from April to August 2019 on 74 males aged 12-18 years old who were presented to the Thalassemia Outpatient clinic, Dr. Hasan Sadikin General Hospital, Bandung. Blood was collected using phlebotomy for ferritin and total testosterone serum examination. Data were then analyzed using SPSS version 17.0. Low testosterone level (<3.0 ng/mL) was found in 63.5% of subjects. Results of the Spearmen correlation test demonstrated a negative correlation with r: -0,699 and p-value <0.001, showing a negative, strong, and significant correlation among those variables. The higher ferritin level in TDT patients indicates a high level of the free iron level in the body that can destroy the endocrine organs and cause deprivation of testosterone secretion, leading to hypogonadism in transfusion dependent thalassemia patients. Faculty of Medicine, Universitas Padjadjaran 2021-09-26 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.fk.unpad.ac.id/index.php/mkb/article/view/2389 10.15395/mkb.v53n3.2389 Majalah Kedokteran Bandung; Vol 53, No 3 (2021); 163-168 Majalah Kedokteran Bandung; Vol 53, No 3 (2021); 163-168 2338-6223 0126-074x 10.15395/mkb.v53n3 eng https://journal.fk.unpad.ac.id/index.php/mkb/article/view/2389/pdf https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/2389/2498 https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/2389/2499 https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/2389/2500 Copyright (c) 2021 Majalah Kedokteran Bandung http://creativecommons.org/licenses/by-nc/4.0

oai:ojs.journal.fk.unpad.ac.id:article/3496 2024-10-10T06:36:48Z mkb:ART

Nephroprotective Effects of Sunkist Peel Ethanol Extract on Diabetic Nephropathy Mutia, Maya Sari Ginting, Chrismis Novalinda Yulizal, OK Suhartomi, Suhartomi Sihotang, Widya Yanti Medicine; Health Science; Public Health Diabetic, nephropathy, Sunkist peel, vascular endothelial growth factor The most common long-term diabetic complication is diabetic nephropathy which, in most cases, falls into the End-Stage Kidney Disease. Numerous studies on the nephroprotective effects of citrus fruit have been conducted recently. This study was performed to investigate the phytochemical properties of Sunkist peel ethanol extract and their possible effects on improving diabetic nephropathy. To get the extract, the Sunkist peels were macerated and the extract was analyzed by GC-MS. An in vivo assay of five different groups of 25 male Wistar rats was then performed using the extracts. The groups included control, standard, 500 mg/kg extract, 750 mg/kg extract, and 1,500 mg/kg BW extract. All rats were sacrificed after 28 days of treatment and VEGF level serum and kidney histology analysis were performed. The VEGF data were first analyzed descriptively, followed by one-way ANOVA or Kruskal-Wallis test based on the data distribution. Meanwhile, the kidney histology was observed and narratively described. Results showed that the Sunkist peel ethanol extract has a potential effect to suppress the VEGF level (p-value < 0.05). The extract at the highest dose revealed the mildest pathology damage in the form of tubular structure degeneration without any glomerular damage. This study indicates that Sunkist peel extract has nephroprotective effects from its various phytochemical compounds that work as antioxidants and anti-inflammation. Faculty of Medicine, Universitas Padjadjaran 2024-09-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.fk.unpad.ac.id/index.php/mkb/article/view/3496 10.15395/mkb.v56.3496 Majalah Kedokteran Bandung; Vol 56, No 3 (2024); 190-196 Majalah Kedokteran Bandung; Vol 56, No 3 (2024); 190-196 2338-6223 0126-074x 10.15395/mkb.v56.n3 eng https://journal.fk.unpad.ac.id/index.php/mkb/article/view/3496/pdf https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/3496/4321 https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/3496/4322 Copyright (c) 2024 Majalah Kedokteran Bandung http://creativecommons.org/licenses/by-nc/4.0

oai:ojs.journal.fk.unpad.ac.id:article/2656 2023-11-23T03:17:47Z mkb:ART

Protein and Phosphate Intakes are Associated with Hyperphosphatemia in Hemodialysis Patients at Sanglah Hospital, Bali, Indonesia Duarsa, Made Dyah Vismita Indramila Kandarini, Yenny Mahadita, Gede Wira Sari, Ni Nyoman Shinta Prasista Medicine; internal medicine; nephrology Chronic kidney disease; hemodialysis, hyperphosphatemia; phosphorus intake; protein intake Increased chronic kidney disease (CKD) mortality rate is significantly associated with increased blood phosphate levels. Hyperphosphatemia control is one of the main focuses in the management of hemodialysis (HD) patients. A high protein diet has been suggested to prevent malnutrition in hemodialysis patients. However, a high protein and phosphorus diet has the risk of increasing the phosphate level in the blood circulation, leading to a higher mortality rate of hemodialysis patients. This study aimed to prove that the level of protein and phosphate intake is associated with hyperphosphatemia in CKD patients with routine HD. This was cross-sectional analytical study conducted from September to October 2020 on 66 CKD patients who underwent hemodialysis. Subject characteristics and phosphorus and protein intake data were obtained from a questionnaire food recall adapted from the Food and Agriculture Organization of the United Nations. Data consumption patterns were processed using the nutritional survey software to obtain the nutritional values. Data were analyzed using the Chi-Square test to identify the relationship and risk between hyperphosphatemia and diet protein, phosphorus, and protein-phosphorus ratio. The confidence level in this study was 95%. There was a significant relationship between protein and phosphorus intake in hyperphosphatemia in CKD patients. The risk factors for hyperphosphatemia were high phosphorus intake (p=0.018; OR=3.886;95% CI: 1.212–12.460) and adequate protein intake (p=0.035; OR=3.674; 95% CI: 1.049-12.865). This study showed no significant relationship between phosphorus-protein ratio, protein-phosphorus ratio, and hyperphosphatemia incidence. In conclusion, high protein intake and excessive phosphorus intake provide a significant relationship to the incidence of hyperphosphatemia in CKD patients undergoing routine hemodialysis. Faculty of Medicine, Universitas Padjadjaran 2022-06-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.fk.unpad.ac.id/index.php/mkb/article/view/2656 10.15395/mkb.v54n2.2656 Majalah Kedokteran Bandung; Vol 54, No 2 (2022); 89–95 Majalah Kedokteran Bandung; Vol 54, No 2 (2022); 89–95 2338-6223 0126-074x 10.15395/mkb.v54n2 eng https://journal.fk.unpad.ac.id/index.php/mkb/article/view/2656/pdf https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/2656/3146 https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/2656/3149 https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/2656/3150 Copyright (c) 2022 Majalah Kedokteran Bandung http://creativecommons.org/licenses/by-nc/4.0

oai:ojs.journal.fk.unpad.ac.id:article/1715 2021-12-26T06:40:42Z mkb:ART

Comparison of Antioxidant and Antiaging Activities Between Dragon Fruit (Hyloceureus polyrhizus (F.A.C. Weber) Britton & Rose) Rind Extract and Kaempferol Viany, Lisma Rizal, Rizal Widowati, Wahyu Samin, Buter Kusuma, Rita Fachrial, Edy I Nyoman, Lister Ehrich Medicine Antiaging, antioxidant, anti-tyrosinase, DFRE, DPPH Aging involves progressive physiological changes of the body, including skin dysfunction and death which can be accelerated by the presence of free radicals. Compounds with potential antioxidants and antiaging are contained in various fruits, including dragon fruit (Hyloceureus polyrhizus (F.A.C. Weber) Britton & Rose). This study aimed to compare the antioxidant and antiaging activities of dragon fruit rind extract (DFRE) and Kaempferol. The antioxidant and antiaging activities were measured by 2,2-diphenyl-1-picrylhydrazyl (DPPH) scavenger and inhibitory activity assay of tyrosinase, respectively and was conducted at the Biomolecular and Biomedicine Research Center, Aretha Medika Utama, from August to November 2018. Data acquired were then analyzed using ANOVA, followed by Post Hoc Test using Turkey HSD test with a confidence level of 95% (α=0.05). Phytochemical assay was also conducted to determine the content of active ingredients in thedragon fruit rind extract. Phytochemical test result showed that DFRE contained flavonoids, tannins, phenols, triterpenoids, and alkaloids compounds. Both DPPH scavenging and tyrosine inhibition assay indicated that Kaempferol compound also had antioxidant and antiaging activities. The IC50 values of DFRE and Kaempferol antioxidant activities were 164.98 μg/mL and 83.30 μg/mL, respectively, while the IC50 values of tyrosinase inhibition activity of DFRE and Kaemferol were 88.46 μg/mL and 59.34 μg/mL, respectively. DFRE had antioxidant activities and tyrosinase inhibition activities thus can be used as an alternative antiaging and antioxidant agents. Perbandingan Aktivitas Antioksidan dengan Antitirosinase Ekstrak Etanol Kulit Buah Naga (Hyloceureus polyrhizus (F.A.C. Weber) Britton & Rose)Aging atau penuaan adalah proses kompleks yang ditandai dengan penurunan progresif fungsi fisiologis tubuh, termasuk kulit yang diikuti oleh disfungsi dan kematian kulit. Faktor-faktor yang dapat mempercepat proses penuaan dini di antaranya radikal bebas dan gaya hidup yang tidak sehat. Buah-buahan banyak mengandung senyawa yang berpotensi sebagai antioksidan dan antiaging, salah satu di antaranya adalah buah naga. Penelitian ini bertujuan mengetahui potensi antioksidan dan antiaging ekstrak kulit buah naga (EKBN) yang dibandingkan dengan senyawa kaempferol (SK) sebagai pembanding. Penelitian yang dilakukan meliputi uji fitokimia untuk mengetahui kandungan bahan aktif pada kulit buah naga, uji pemerangkapan DPPH, dan uji penghambatan tirosinase dan dilakukan di Pusat Penelitian Biomolekul dan Biomedis, Aretha Medika Utama, dari Agustus hingga November 2018. Data lalu dianalisis menggunakan analisis varians (ANOVA) satu arah (one way) Hasil penelitian uji fitokimia menunjukkan EKBN mengandung golongan senyawa, flavonoid, tanin, fenol, triterpenoid, dan alkaloid serta tidak mengandung golongan senyawa saponin, steroid, dan terpenoid. Senyawa kaempferol memiliki aktivitas antioksidan melalui pemerangkapan DPPH dan aktivitas antiaging melalui penghambatan tirosinase yang lebih baik dibanding dengan EKBN. Aktivitas antioksidan dilihat dari nilai IC50 EKBN sebesar 164.98 μg/ml dan SK sebesar 83.30 μg/mL. Aktivitas penghambatan tirosinase memiliki nilai IC50 EKBN masing-masing sebesar 88.46 μg/mL dan IC50 SK sebesar 59.34 μg/mL. EKBN memiliki aktivitas antioksidan dan penghambatan tirosinase sehigga dapat dimanfaatkan sebagai alternatif bahan antiaging dan antioksidan.  Faculty of Medicine, Universitas Padjadjaran 2019-12-27 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.fk.unpad.ac.id/index.php/mkb/article/view/1715 10.15395/mkb.v51n3.1715 Majalah Kedokteran Bandung; Vol 51, No 3 (2019); 147-153 Majalah Kedokteran Bandung; Vol 51, No 3 (2019); 147-153 2338-6223 0126-074x 10.15395/mkb.v51n3 eng https://journal.fk.unpad.ac.id/index.php/mkb/article/view/1715/pdf https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/1715/2922 Copyright (c) 2019 Majalah Kedokteran Bandung http://creativecommons.org/licenses/by-nc/4.0

oai:ojs.journal.fk.unpad.ac.id:article/2966 2023-05-04T03:43:22Z mkb:ART

Pneumonia Clinical Features in Under-Five Children Treated in Atma Jaya Hospital in 2017-2020 Roselany, Rachel Surjono, Edward Medicine; Health Sciences; Pediatric Health Clinical features, pneumonia, under five Pneumonia is the leading cause of infection-related death among children and still remains a global health problem, especially for children under five. This study aimed to identify the clinical features of pneumonia in under-five chilren treated at Atma Jaya Hospital during the period of 2017-2020. This was a cross-sectional retrospective descriptive study on all under-five patients diagnosed with pneumonia treated in Atma Jaya Hospital. Data were collected from November 2021-January 2022 from the medical records of these children (n=148) and analyzed using the univariate analysis.  Results showed that most subjects of this study were boys (60.8%), in the age group of 1-4 years old (62.2%), with fever as the most common pnemonia clinical symptom (93.9%). Physical examinations revealed that the average pulse of the subjects were 131.2 beats/minute and the average temperature was 37.1°C. Other signs and symptoms identified during physical examinations were tachypnea (20,3%), retractions (56.1%), crackles (82.4%), and wheezing (22,3%). The laboratory findings presented a mean hemoglobin of 11.0 g/dL, a mean hematocrit of 32.5%, and a mean CRP of 13.2 mg/dL, while most subjects had normal leukocyte (58.1%) and platelet counts (52.0%). The most common chest X-ray finding of pneumonia in these children was infiltrate (92.6%) and the average length of stay was 4 days. Most under-five children experiencing pneumonia recovered after treatment (97.3%). Faculty of Medicine, Universitas Padjadjaran 2023-03-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.fk.unpad.ac.id/index.php/mkb/article/view/2966 10.15395/mkb.v55n1.2966 Majalah Kedokteran Bandung; Vol 55, No 1 (2023); 21–26 Majalah Kedokteran Bandung; Vol 55, No 1 (2023); 21–26 2338-6223 0126-074x 10.15395/mkb.v55n1 eng https://journal.fk.unpad.ac.id/index.php/mkb/article/view/2966/pdf https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/2966/3556 https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/2966/3557 https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/2966/3558 Copyright (c) 2023 Majalah Kedokteran Bandung http://creativecommons.org/licenses/by-nc/4.0

oai:ojs.journal.fk.unpad.ac.id:article/4004 2025-10-02T07:29:09Z mkb:ART

Family Support and Medication Adherence in Patients in Prolanis Program Aini, Zahratul Suardi, Hijra Novia Dewi, Fitria Meutia Ibrahim, Tilaili Waraztuty, Ika Mulia, Vera Dewi Medicine; Health Sciences; Public Health Chronic disease, family support, medication adherence, prolanis The Chronic Disease Management Program, or Program Pengelolaan Penyakit Kronis (Prolanis), is a disease management program designed for individuals with chronic illnesses. It aims to maintain health and improve quality of life. The success of Prolanis depends not only on patient adherence to medication but also on family involvement as the primary source of support. This study aimed to examine the relationship between family support and medication adherence among Prolanis patients at Batoh Public Health Center, Banda Aceh, Indonesia. An observational analytic study with a cross-sectional design was conducted using consecutive sampling of 74 Prolanis participants. Data were collected through guided interviews. Among the participants, 33 individuals (44.5%) exhibited low medication adherence, while 41 individuals (55.5%) demonstrated high adherence. Additionally, 8 participants (10.8%) reported poor family support, whereas 66 participants (89.2%) received good family support. Data analysis using the chi-square test revealed a significant relationship (p=0.009) between family support and medication adherence. Therefore, it can be concluded that family support is significantly associated with medication adherence in Prolanis patients.  Families are the main supporters in maintaining the health of their family members, with an important role in encouraging, supporting, and supervising patients' treatment. Good support and constant encouragement and attention can increase patients' confidence, which in turn will affect their adherence to treatment. Faculty of Medicine, Universitas Padjadjaran 2025-09-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.fk.unpad.ac.id/index.php/mkb/article/view/4004 10.15395/mkb.v57.4004 Majalah Kedokteran Bandung; Vol 57, No 3 (2025); 203-211 Majalah Kedokteran Bandung; Vol 57, No 3 (2025); 203-211 2338-6223 0126-074x 10.15395/mkb.v57n3 eng https://journal.fk.unpad.ac.id/index.php/mkb/article/view/4004/pdf https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/4004/5042 https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/4004/5043 https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/4004/5044 Copyright (c) 2024 Majalah Kedokteran Bandung http://creativecommons.org/licenses/by-nc/4.0

oai:ojs.journal.fk.unpad.ac.id:article/2121 2021-07-01T01:45:43Z mkb:ART

Effects of Ethanolic Extract of Curcuma Longa on Cardiac Biomarkers of Doxorubicin-Induced Rats Rahayu, Lydia Ernawati Chiuman, Linda Ginting, Chrismis Novalinda Ginting, Sahna Ferdinand Medicine Cardiotoxicity; CK-MB; LDH Cardiotoxicity is a condition where damages caused by toxic chemical exposure are observed in heart and blood vessels. Doxorubicin is the most common chemotherapy agents for various types of cancer therapy. However, doxorubicin is converted into doxorubicinol known to trigger cardiac disfunctions and release of several cardiac biomarkers, such as CK-MB and LDH. Turmeric is known to be an alternative medical treatment that has the effect of neutralizing oxidative stress. This study aimed to evaluate CK-MB and LDH levels in doxorubicin-induced rats (20 mg/kgBW) that received turmeric ethanolic extract from curcuma. This was an experimental study conducted in February 2020 in the Faculty of Pharmacy Universitas Sumatera Utara. The rats were divided into six group and each group consisted of wistar albino male rats. The groups were normal (CMC-Na), positive control (Vitamin E 1%+Dox 20 mg/kgBW), negative control (Dox 20 mg/kgBW), treatment I (EEC 100 mg/kgBW+Dox 20 mg/kgBW), treatment II (EEC 300 mg/kgBW+Dox 20 mg/kgBW), and treatment III (EEC 500 mg/kgBW+Dox 15 mg/kgBW). Doxorubicin was given 5 mg/kgBW once a week for four weeks. Results showed that the groups that received 100 mg/kg BW, 300 mg/kgBW, and 500 mg/kgBW of turmeric ethanol extract demonstrated a reducing effect on the biomarkers of cardiac damage, i.e. CK-MB and LDH. Statistically, serum CK-MB and LDH levels at dose 500 mg/kgBW showed no significant differences (p>0.05) with the normal and positive treatment group. In conclusion, turmeric has a cardioprotective effect. Pengaruh Kardioprotektif Ekstrak Etanol Curcuma Longa pada Tikus yang Diinduksi DoxorubicinKardiotoksisitas adalah kondisi terjadinya jantung dan pembuluh darah akibat paparan kimia. Doxorubicin diubah menjadi doxorubicinol yang diketahui menyebabkan gangguan fungsi jantung dan pelepasan biomarker jantung sseperti CK-MB dan LDH. Kunyit dikenal sebagai pengobatan alternatif yang memiliki efek menetralkan stres oksidatif. Penelitian ini dilakukan pada Februari 2020 di Fakultas Farmasi Universitas Sumatera Utara. Tujuan penelitian ini adalah mengevaluasi kadar CK-MB dan LDH pada tikus yang diberi ekstrak etanol kunyit yang diinduksi doksorubisin (20 mg/kgbb). Penelitian dibagi menjadi enam kelompok dan tiap-tiap kelompok terdiri atas 4 ekor tikus wistar albino jantan: normal (CMC-Na), kontrol positif (Vitamin E 1%+Dox 20 mg/kgBB), kontrol negatif (Dox 20 mg/kgBB), group I (EEC 100 mg/kgBB+Dox 20 mg/kgBB), group II (EEC 300 mg/kgBB+Dox 20 mg/kgBB), dan group III (EEC 500 mg/kgBB+Dox 15 mg/kgBB). Doxorubicin 5 mg/kgBB diberikan 4 kali. Hasil penelitian menunjukkan bahwa kelompok yang diberi ekstrak etanol kunyit dengan dosis 100 mg/kgBB, 300 mg/kgbb, 500 mg/kgBB memiliki efek penurunan biomarker kerusakan jantung yaitu CK-MB dan LDH. Berdasar atas hasil uji statistik kadar CK-MB dan LDH serum pada dosis 500 mg/kgBB tidak terdapat perbedaan yang bermakna (p>0,05) dengan kelompok normal dan positif, dapat disimpulkan bahwa kunyit memiliki efek kardioprotektif. Faculty of Medicine, Universitas Padjadjaran 2020-12-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.fk.unpad.ac.id/index.php/mkb/article/view/2121 10.15395/mkb.v52n4.2121 Majalah Kedokteran Bandung; Vol 52, No 4 (2020); 199–204 Majalah Kedokteran Bandung; Vol 52, No 4 (2020); 199–204 2338-6223 0126-074x 10.15395/mkb.v52n4 eng https://journal.fk.unpad.ac.id/index.php/mkb/article/view/2121/pdf https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/2121/2018 https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/2121/2022 Copyright (c) 2020 Majalah Kedokteran Bandung http://creativecommons.org/licenses/by-nc/4.0

oai:ojs.journal.fk.unpad.ac.id:article/2303 2021-12-26T04:08:05Z mkb:ART

Gestational Monosodium Glutamate Exposure Effects on Anogenital Distance of Male Rat Pups Sari, Amelya Permata Ilmiawati, Cimi Reza, Mohamad Medicine; Health Sciences; Reproductive Health Anogenital distance, estrogen, gestation, male, monosodium glutamate High-dose Monosodium Glutamate (MSG) expo sure increases the estrogen level in pregnant rats. However, there are limited data available on whether the MSG-related maternal hormonal effects can affect male litters' genitalia phenotype. This study aimed to analyze the impact of MSG on estrogen level in pregnant rats and anogenital distance in male pups. Experiment for this study was performed at the animal facility of Biomedical Laboratory at the Faculty of Medicine, Universitas Andalas, from April 2019 to February 2020. Pregnant Wistar rats were given MSG orally at 2 and 4 mg/g body weight (BW) for 20 days. On day 21, pregnant rats were sacrificed and blood was drawn intracardially. Estradiol serum level was measured by ELISA. Male pups were counted, and the anogenital distance (AGD) was measured. Maternal serum estradiol levels were statistically analyzed by One-Way ANOVA and the AGD of male litters were analyzed by the Kruskal-Wallis test. Results showed that perinatal MSG exposure increased the estradiol level (26.3±4.5 pg/ml; 37.5±6.7 pg/ml; 62.1±8.2 pg/ml in control, 2 mg/g BW, and 4 mg/g BW group, respectively [mean±SD; p=<0.001]) and decreased the AGD (4 mm; 3 mm; 1.5 mm in control, 2 mg/g BW, and 4 mg/gBW group, respectively [median; p=<0.01]) in a dose-dependent manner. Thus, MSG exposure during pregnancy is a risk factor for male rat feminization.  Faculty of Medicine, Universitas Padjadjaran 2021-06-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.fk.unpad.ac.id/index.php/mkb/article/view/2303 10.15395/mkb.v53n2.2302 Majalah Kedokteran Bandung; Vol 53, No 2 (2021); 67-72 Majalah Kedokteran Bandung; Vol 53, No 2 (2021); 67-72 2338-6223 0126-074x 10.15395/mkb.v53n2 eng https://journal.fk.unpad.ac.id/index.php/mkb/article/view/2303/pdf https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/2303/2333 https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/2303/2396 Copyright (c) 2021 Majalah Kedokteran Bandung http://creativecommons.org/licenses/by-nc/4.0

oai:ojs.journal.fk.unpad.ac.id:article/3145 2024-10-08T08:39:10Z mkb:ART

Correlation Between CA 15-3 And Miller Payne Histopathological Response In Locally Advanced Breast Cancer Undergoing FAC Regiment Neoadjuvant Chemotherapy Rizki, Kiki Akhmad Azhar, Raden Yohana Dewayani, Birgitta Fahman, Aulia Novariza Breast cancer, chemotherapy, histopathology Response to chemotherapy for breast cancer can be assessed using the CA 15-3 tumor marker, or through histopathological means such as Miller Payne assessment. This study aimed to explore the correlation between CA 15-3 level and histopathological response in locally advanced breast cancer. This is a cross-sectional study measuring CA 15-3 before and after neoadjuvant chemotherapy using the FAC regiment. This study took place in Dr. Hasan Sadikin Hospital Bandung, Indonesia, from January to August 2022. Data on histopathological responses before chemotherapy and after surgery were also collected. Thirty-nine patients were admitted as subjects. Most patients had invasive carcinoma of no special type (79.5%) and luminal B HER 2 molecular subtype (38.5%). A significant decrease in CA 15-3 level after chemotherapy (from 23.54±18.38 ng/ml to 16.30±6.51 ng/mL) was observed. No significant correlation between CA 15-3 level and Miller Payne histopathological responses were found in the subjects. Faculty of Medicine, Universitas Padjadjaran 2024-06-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.fk.unpad.ac.id/index.php/mkb/article/view/3145 10.15395/mkb.v56.3145 Majalah Kedokteran Bandung; Vol 56, No 2 (2024); 117-122 Majalah Kedokteran Bandung; Vol 56, No 2 (2024); 117-122 2338-6223 0126-074x 10.15395/mkb.v56n2 eng https://journal.fk.unpad.ac.id/index.php/mkb/article/view/3145/pdf https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/3145/3798 https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/3145/3818 https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/3145/3914 Copyright (c) 2024 Majalah Kedokteran Bandung http://creativecommons.org/licenses/by-nc/4.0

oai:ojs.journal.fk.unpad.ac.id:article/2775 2023-11-23T03:19:13Z mkb:FBM

Front Cover, Editorial Team, Table of Contents, and Back Cover Back, Front Faculty of Medicine, Universitas Padjadjaran 2022-03-31 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.fk.unpad.ac.id/index.php/mkb/article/view/2775 Majalah Kedokteran Bandung; Vol 54, No 1 (2022) Majalah Kedokteran Bandung; Vol 54, No 1 (2022) 2338-6223 0126-074x 10.15395/mkb.v54n1 eng https://journal.fk.unpad.ac.id/index.php/mkb/article/view/2775/1637 Copyright (c) 2022 Majalah Kedokteran Bandung http://creativecommons.org/licenses/by-nc/4.0

oai:ojs.journal.fk.unpad.ac.id:article/25 2023-07-10T08:52:15Z mkb:CR

Tuberkulosis Perinatal Bermanifestasi sebagai Tuberkulosis Milier dan Meningitis Nataprawira, Heda Melinda D. Faisal, Faisal Tuberkulosis (TB) perinatal adalah kasus TB yang jarang dilaporkan karena manifestasi klinis tidak spesifik, serta terdapat permasalahan dalam pemeriksaan laboratorium dan radiologis sehingga tidak terdiagnosis. Istilah TB perinatal menjelaskan adanya infeksi Mycobacterium tuberculosis yang terjadi pada masa perinatal baik selama kehamilan, persalinan, maupun pascapersalinan dalam masa neonatus. Seorang bayi laki-laki usia tiga bulan dirujuk ke Emergensi Anak Rumah Sakit Hasan Sadikin dengan riwayat demam lama dan tidak mau menetek. Proses kelahiran tidak ada masalah. Pada pemeriksaan fisis ditemukan letargis, febris, takipnea, dan hepatosplenomegali. Pewarnaan Ziehl Neelsen aspirat lambung menunjukkan basil tahan asam positif. Uji kulit tuberkulin menunjukkan nonreaktif, foto toraks memperlihatkan gambaran milier, dan fungsi lumbal memberikan interpretasi TB meningitis. Berdasarkan penelusuran aktif sumber penularan TB serumah, ternyata ayah dan kakek bayi merupakan sumber penularan. Selain diberikan paduan oral antituberkulosis standar, juga diberikan antibiotik dan prednison. Dalam perjalanan penyakitnya, terjadi syok sepsis serta koagulasi intravaskular diseminata dan bayi meninggal. Dari kultur darah teridentifikasi Staphylococcus haemolyticus. Disimpulkan bahwa walaupun tidak terdapat permasalahan saat kelahiran bayi, diperlukan penelusuran aktif kemungkinan TB perinatal pada keluarga dengan sumber penularan TB positif. Diperlukan kewaspadaan terdapatnya TB pada wanita hamil di negara berkembang dengan jumlah kasus TB tinggi. [MKB. 2010;42(3):135-9].Kata kunci: tuberkulosis perinatal Perinatal Tuberculosis Presenting as Miliary Tuberculosis and MeningitisPerinatal tuberculosis (TB) is rarely reported, because the clinical manifestations are not specific and there is a problem in its laboratory and radiology examination which caused undiagnosed. Perinatal TB is the preferred description that encompasses TB acquired either intra uterine, during or post delivery in early newborn period. A-3- month old baby was transferred to Pediatric Emergency Hasan Sadikin Hospital because of prolong fever and unable to breastfeed. There was no problem with delivery. Lethargic, fever, tachypnea, and hepatosphlenomegali were found on physical examination. Ziehl Neelsen smear of gastric lavage yielded positive acid fast bacilli. Tuberculine test was non reactive, chest x-ray showed a miliary pattern, and cerebral spinal fluid analysis gave tuberculous meningitis interpretation. By active finding, his father and grandfather were detected as a source of TB transmission. In additon to oral antituberculosis regimen, antibiotics and prednison were also given. Septic shock and disseminated intravascular coagulation were occurred during his illness and the baby died. Staphylococcus haemolyticus was identified from blood culture. In conclusion, although there were no problems during labor, active investigation of perinatal TB possibility is required on the family with a source of TB. Caution on TB in pregnant women is necessary at developing country with high rates of TB. [MKB. 2010;42(3):135-9].Key words: Disseminated intravascular coagulation, miliary, meningitis, perinatal tuberculosis DOI: http://dx.doi.org/10.15395/mkb.v42n3.25 Faculty of Medicine, Universitas Padjadjaran 2013-05-01 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.fk.unpad.ac.id/index.php/mkb/article/view/25 Majalah Kedokteran Bandung; Vol 42, No 3; 135-139 Majalah Kedokteran Bandung; Vol 42, No 3; 135-139 2338-6223 0126-074x eng https://journal.fk.unpad.ac.id/index.php/mkb/article/view/25/26

oai:ojs.journal.fk.unpad.ac.id:article/3240 2023-11-23T03:16:33Z mkb:FBM

Front Cover, Editorial Team, Table of Contents, and Back Cover back cover, front Faculty of Medicine, Universitas Padjadjaran 2022-09-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.fk.unpad.ac.id/index.php/mkb/article/view/3240 Majalah Kedokteran Bandung; Vol 54, No 3 (2022) Majalah Kedokteran Bandung; Vol 54, No 3 (2022) 2338-6223 0126-074x eng https://journal.fk.unpad.ac.id/index.php/mkb/article/view/3240/1761 Copyright (c) 2023 Majalah Kedokteran Bandung http://creativecommons.org/licenses/by-nc/4.0

oai:ojs.journal.fk.unpad.ac.id:article/4066 2025-07-08T07:48:31Z mkb:ART

Comparison of ABO Blood Group Antibody Titers in Elderly and Young Adult Patients Dianawati, Dina Asri Lismayanti, Leni Wasilah, Fajar Clinical Pathology ABO blood group; aged; antibodies; young adults Immunosenescence in the elderly decreases their antibodies, which may lead to weaker degree of agglutination formation that potentially causes ABO discrepancies. This may lead to misinterpretation of blood group in this group. This study aimed to determine whether there are differences in antibody titer levels and degree of agglutination formed when examining ABO blood groups in the elderly as compared to young adults. This was a cross-sectional study employing analytical observational methods. Data were collected prospectively from the Blood Services Unit of Dr. Hasan Sadikin General Hospital Bandung, Indonesia, between May 2022 and July 2022. The subjects included were 42 elderly participants and 42 young adults, grouped accordingly. The ABO blood typing was performed using the slide method, while anti-A and anti-B titers were measured by serial two-fold dilution using the tube method. A significant difference in ABO blood group antibody titer levels was observed between elderly and young adult groups (median: 6 vs 64, p<0.001). Antibody titers were lower in the elderly across blood groups A (median: 8 vs 64, p<0.001), B (median: 8 vs 64, p<0.001), and O (median: 4 vs 64, p<0.001). The degree of agglutination was lower in the elderly (2+) compared to young adults (4+). On average, antibody titers in elderly individuals were approximately tenfold lower than those in young adults across all three blood groups. The reduced degree of agglutination further supports the diminished antibody response in the elderly group. Faculty of Medicine, Universitas Padjadjaran 2025-06-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.fk.unpad.ac.id/index.php/mkb/article/view/4066 10.15395/mkb.v57.4066 Majalah Kedokteran Bandung; Vol 57, No 2 (2025); 143-147 Majalah Kedokteran Bandung; Vol 57, No 2 (2025); 143-147 2338-6223 0126-074x 10.15395/mkb.v57n2 eng https://journal.fk.unpad.ac.id/index.php/mkb/article/view/4066/pdf https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/4066/5151 https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/4066/5189 Copyright (c) 2024 Majalah Kedokteran Bandung http://creativecommons.org/licenses/by-nc/4.0

oai:ojs.journal.fk.unpad.ac.id:article/2042 2021-12-26T05:57:46Z mkb:ART

Antihyperglycemic Effectiveness Test of 96% Ethanol Extract of Soursop Leaves on Mus musculus Induced by Streptozotocin Khalid, Nur Fadhillah Kabo, Peter Djide, Natsir Medicine Antihyperglycemic, ethanol extract, soursop leaves (Annona muricata L.), streptozotocin Annona muricata L. is widely known throughout Indonesia as having great potentials as an antidiabetic agent. This study aimed to evaluate the antihyperglycemic effectiveness of ethanol extract 96% from soursop leaves and to compare its effects to metformin and insulin aspart injection as antidiabetic agents. This was a cross-sectional experimental study with random sampling approach which was performed at Phytochemistry and Biopharmacy Laboratory, Faculty of Pharmacy, Hasannudin University, Indonesia, from February 17 to March 3, 2020. Twenty-four Mus musculus subjects induced by streptozotocin were divided into six groups, which received 96% ethanol extract from Annona muricata in various doses. The extract was produced using the maceration process. The fasting blood sugar level was measured using the point of care testing (POCT) method, and data collected were then analyzed using a univariate approach. Results showed that the average fasting blood glucose level (FBG) was decreasing with increasing doses (5 g/kgBW=127 mg/dL, 10 g/kgBW =114 mg/dL, and 15 g/kg BW=97.75 mg/dl with a p-value of 0.000 based on repeated ANOVA. When compared to the positive control 1 (metformin), the decrease in FBG level in this control group (70.67 mg/dL) was better than in the group that received ethanol extract from Annona muricata L. In subjects in positive control 2 (insulin aspart), the average FBG level remained high, which was 473 mg/dL. Hence, 96% ethanol extract of Annona muricata L. can effectively lower fasting blood glucose in Mus musculus. Uji Efektivitas Antihiperglikemik Ekstrak Ethanol 96% Daun Sirsak pada Mus musculus yang diinduksi dengan Streptozotocin Tanaman sirsak menyebar di pelosok Indonesia serta banyak dimanfaatkan masyarakat sebagai obat herbal untuk berbagai macam penyakit, diantaranya  sebagai antidiabetes. Tujuan penelitian ini adalah mengetahui efektivitas antihiperglikemik ekstrak ethanol 96% daun sirsak pada mencit yang diinduksi dengan streptozotocin dan membandingkan efeknya  dengan metformin dan insulin aspart. Penelitian ini adalah penelitian eksperimental dengan desain cross-sectional dan teknik sampling secara acak yang dilakukan di Laboratorium Fitokimia dan Biofarmasi Fakultas Farmasi Universitas Hasanuddin pada 17 Februari–3 Maret 2020. Sebanyak 24 ekor mencit yang diinduksi streptozotocin dibagi menjadi enam kelompok yang menerima ekstrak etanol 96% dari daun sirsak dalam berbagai dosis. Pembuatan ekstrak menggunakan proses maserasi dan untuk mendapatkan gula darah puasa (GDP) menggunakan metode point of care testing (POCT). Hasil penelitian menunjukkan bahwa rata-rata kadar GDP menurun dengan peningkatan dosis pada dosis 5 g/kgBB=127 mg/dL, 10 g/kgBB=114 mg/dL, 15 g/kgBB=97,75 mg/dL dengan nilai p=0,000 berdasar atas uji ANOVA. Jika dibanding dengan kontrol positif 1 (metformin) penurunan nilai GDP jauh lebih baik pada kelompok kontrol 70,67 mg/dL lebih baik dibandingkan pada kelompok yang mendapat ekstrak etanol dari daun sirsak. Pada subjek kontrol positif 2 (insulin aspart) nilai kadar GDP tetap tinggi, yaitu 473 mg/dL. Simpulan, ekstrak ethanol 96% daun sirsak efektif menurunkan kadar glukosa darah puasa pada mencit. Faculty of Medicine, Universitas Padjadjaran 2020-09-28 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.fk.unpad.ac.id/index.php/mkb/article/view/2042 10.15395/mkb.v52n3.2042 Majalah Kedokteran Bandung; Vol 52, No 3 (2020); 131-138 Majalah Kedokteran Bandung; Vol 52, No 3 (2020); 131-138 2338-6223 0126-074x 10.15395/mkb.v52n3 eng https://journal.fk.unpad.ac.id/index.php/mkb/article/view/2042/pdf https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/2042/1889 https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/2042/2891 https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/2042/2892 Copyright (c) 2020 Majalah Kedokteran Bandung http://creativecommons.org/licenses/by-nc/4.0

oai:ojs.journal.fk.unpad.ac.id:article/3664 2023-11-20T02:20:14Z mkb:FBM

Front Cover, Editorial Team, Table of Contents, and Back Cover back cover, front Faculty of Medicine, Universitas Padjadjaran 2023-06-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.fk.unpad.ac.id/index.php/mkb/article/view/3664 Majalah Kedokteran Bandung; Vol 55, No 2 (2023) Majalah Kedokteran Bandung; Vol 55, No 2 (2023) 2338-6223 0126-074x eng https://journal.fk.unpad.ac.id/index.php/mkb/article/view/3664/1849 Copyright (c) 2023 Majalah Kedokteran Bandung http://creativecommons.org/licenses/by-nc/4.0

oai:ojs.journal.fk.unpad.ac.id:article/4397 2026-03-31T15:39:48Z mkb:ART

Correlation Between Pre-Transplant Anemia and Mortality After Kidney Transplantation in Diabetic and Non-Diabetic Patients Partiningrum, Dwi Lestari Putra, Nusa Purnawan Lestariningsih, Lestariningsih Nephrology; Internal Medicine; Health Sciences anemia, diabetes mellitus, kidney transplantation, mortality Anemia is an established risk factor for mortality and graft failure among kidney transplant recipients, particularly those with diabetes mellitus; however, the combined effects of these conditions remains poorly understood. Regular anemia evaluation is important for patients with End-Stage Kidney Disease (ESKD), especially after transplantation. This retrospective study aimed to analyze 40 kidney transplant recipients with anemia to investigate the correlation between pre-transplant anemia and post-transplant mortality in diabetic and non-diabetic patients at Dr. Kariadi National General Hospital between 2014 and 2020. Data on patient demographics and comorbidities, as well as laboratory data were collected and analyzed. The mean patient age was 41.9±12.4 years, with male constituted 52.5%. The average pre-transplant hemoglobin and serum creatinine levels were 9.4±1.4 mg/dL and 12.4±18.9 g/dL, respectively. Diabetes mellitus was present in 12.5% of patients. Overall, the one-year and three-year post-transplant mortality rates were 20% and 22.5%, respectively. One-year post-transplant mortality occurred in 80% of diabetic patients and 11.4% of non-diabetic patients (p=0.003). At three years, mortality reached 80% in diabetic patients and 14.3% in non-diabetic patients (p=0.006). Pre-transplant anemia significantly increases the risk of post-transplant mortality, especially among diabetic patients, highlighting the need for optimal anemia management before kidney transplantation to enhance long-term patient outcomes. Faculty of Medicine, Universitas Padjadjaran 2026-03-31 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.fk.unpad.ac.id/index.php/mkb/article/view/4397 10.15395/mkb.v58.4397 Majalah Kedokteran Bandung; Vol 48, No 1 (2026); 26-31 Majalah Kedokteran Bandung; Vol 48, No 1 (2026); 26-31 2338-6223 0126-074x 10.15395/mkb.v58.n1 eng https://journal.fk.unpad.ac.id/index.php/mkb/article/view/4397/pdf https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/4397/5630 https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/4397/5631 https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/4397/5632 Copyright (c) 2026 Majalah Kedokteran Bandung http://creativecommons.org/licenses/by-nc/4.0

oai:ojs.journal.fk.unpad.ac.id:article/2161 2021-12-26T05:09:25Z mkb:ART

IP-10 as a Non Sputum Biomarker in TB Treatment Monitoring Efriyani, Yuhpita Indah Parwati, Ida Tristina, Nina Tjandrawati, Anna Medicine IP-10, Tuberculosis, Tuberculosis treatment monitoring. There are currently still limitations in the diagnosis of tuberculosis (TB). Sputum collection as specimen for diagnosis is not only difficult but also has low sensitivity.In blood, IP-10/CXCL-10 chemokine plays a role in inducing the movements of chemotactic inflammatory cells towards the sites of inflammation. A high level of IP-10 is found in active pulmonary TB patients and significantly decline after the patients have completed the TB treatments. The aim of this study was to analyze the decline of the IP-10 level before and after 2 months of TB treatment. This study was conducted from March­ toJuni 2020. This was a comparative observational cohort study on active pulmonary TB patients who were >18 years old at the DOTS Clinic of Dr. Hasan Sadikin General Hospital Bandung. Thirty patients who met the inclusion criteria were followed up until 2 months of TB treatment. Serum of  these patients were collected and examined for the IP-10 level before and after 2 months of TB treatment. It was demonstrated that the median IP-10 level in new active pulmonary TB patients was 384.1 pg/mL (136.70–779.80) and dropped to 251.85 pg/mL (91.10–698.30) (p<0l001) two months of TB treatment. Thus, the IP-10 level in the active pulmonary TB patients is significantly declined (p<0.001) after 2 months of TB treatment and that serum IP-10 level could be considered as a non-sputum-based marker to monitor TB treatment. Faculty of Medicine, Universitas Padjadjaran 2021-03-31 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.fk.unpad.ac.id/index.php/mkb/article/view/2161 10.15395/mkb.v53n1.2161 Majalah Kedokteran Bandung; Vol 53, No 1 (2021); 52-56 Majalah Kedokteran Bandung; Vol 53, No 1 (2021); 52-56 2338-6223 0126-074x 10.15395/mkb.v53n1 eng https://journal.fk.unpad.ac.id/index.php/mkb/article/view/2161/pdf https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/2161/2086 https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/2161/2087 https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/2161/2088 https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/2161/2089 https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/2161/2090 https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/2161/2886 Copyright (c) 2021 Majalah Kedokteran Bandung http://creativecommons.org/licenses/by-nc/4.0

oai:ojs.journal.fk.unpad.ac.id:article/3039 2024-10-08T08:39:36Z mkb:ART

Interleukin-6 Level and Neutrophil-Lymphocytes Ratio and Severity of Coronavirus Disease 19 Latifah, Armina Parwati, Ida Tjandrawati, Anna Suraya, Nida Medicine COVID-19, disease severity, IL-6, NRL Interleukin-6 (IL-6) is a proinflammatory cytokine that plays an important role in hyperinflammation and cytokine storm in Coronavirus Disease 19 (COVID-19) patients. The neutrophil-lymphocyte ratio (NRL) describes the innate and adaptive immune responses. Elevated IL-6 and NLR levels usually indicate a severe clinical condition in COVID-19 patients. Aim of this study was to determine the correlation of IL-6 and NLR with the severity of illness in COVID-19 hospitalized patients. This was a descriptive correlative observational study with a cross-sectional design using secondary data from COVID-19 patients treated in Dr. Hasan Sadikin General Hospital, Bandung, Indonesia, from November 2020 to October 2021. There were 225 subjects who were classified by the severity and analyzed for IL-6 levels and NLR. Median levels of IL-6 at moderate, severe, and critical levels were 4.1 pg/mL, 20.4 pg/mL, and 38.8 pg/mL, respectively. The median NLR at moderate, severe, and critical grades were respectively 4.41, 9.65, and 17.79. The correlation between IL-6, NLR, and severity was 0.441 (p<0.001) and 0.408 (p<0.001). Meanwhile, the correlation between IL-6 levels and NLR in COVID-19 was 0.230 (p<0.001). Thus, IL-6 and NRL levels have a moderate positive correlation with the severity of COVID-19, while IL-6 and NRL have a weak correlation because IL-6 is not the only factor that affects the NRL. Faculty of Medicine, Universitas Padjadjaran 2024-03-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.fk.unpad.ac.id/index.php/mkb/article/view/3039 10.15395/mkb.v56.3039 Majalah Kedokteran Bandung; Vol 56, No 1 (2024); 62-68 Majalah Kedokteran Bandung; Vol 56, No 1 (2024); 62-68 2338-6223 0126-074x 10.15395/mkb.v56n1 eng https://journal.fk.unpad.ac.id/index.php/mkb/article/view/3039/pdf https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/3039/3657 https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/3039/3658 Copyright (c) 2022 Majalah Kedokteran Bandung http://creativecommons.org/licenses/by-nc/4.0

oai:ojs.journal.fk.unpad.ac.id:article/2449 2023-11-23T03:19:13Z mkb:ART

Four-Meter Gait Speed Cut-off and Correlation with 6-Minute Walk Test in Adults Nusdwinuringtyas, Nury Fransiska, Tresia Sunarjo, Peggy Triangto, Kevin Santausa, Febrian Dahlan, M. Sopiyudin Medicine; Rehabiltation; Cardiorespiratory Four-meter gait speed test (4MGS), cut-off values, healthy adults, Indonesia, six-minute walk test (6MWT) In facilities where a track required is not available for gait speed test, a simpler method using a shorter track and test duration is needed. One of such methods is the 4-meter gait speed. This study aimed to determine the cut off values for 4MGS and its correlation with the 6-minute walk test (6MWT), a more common functional performance test with shorter track and time. Data for this study were collected at the Department of Rehabilitation of Dr. Cipto Mangunkusumo General Hospital during the period of August 2016 to March 2017. The consecutive sampling approach was used to recruit healthy Indonesian adults (n=61) aged 18–50 years into this cross sectional study. The anthropometric and respiratory variables were measured as descriptive data and the cut-off values were determined by calculating the mean 4-meter gait speed (4MGS)-2SD for each gender. The 6MWT was performed afterwards to assess the correlation between 4MGS and 6-minute walk distance (6MWD). Results presented a mean 4MGS value of 2.114±0.309 m/s (male) and 1.908±0.227m/s (female) with the cut-off values for normal gait speed of 1.496 m/s and 1.454m/s for male and female, respectively. Factors affecting 4MGS were body height, body weight, forced vital capacity (FVC), and forced expiratory volume in 1 second (FEV1). The 4MGS is only shown to be weakly correlated with 6MWD (r=0.314, p=0.014). The cut-off values for 4MGS can be used as a reference to assess the normality of gait speed as a parameter of functional mobility in healthy Indonesian adults and should be used in adjunct to 6MWT to represent a comprehensive functional capacity status. Faculty of Medicine, Universitas Padjadjaran 2022-03-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.fk.unpad.ac.id/index.php/mkb/article/view/2449 10.15395/mkb.v52n4.2449 Majalah Kedokteran Bandung; Vol 54, No 1 (2022); 20-23 Majalah Kedokteran Bandung; Vol 54, No 1 (2022); 20-23 2338-6223 0126-074x 10.15395/mkb.v54n1 eng https://journal.fk.unpad.ac.id/index.php/mkb/article/view/2449/pdf https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/2449/2620 https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/2449/2621 https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/2449/2622 Copyright (c) 2022 Majalah Kedokteran Bandung http://creativecommons.org/licenses/by-nc/4.0

oai:ojs.journal.fk.unpad.ac.id:article/3700 2025-10-15T07:09:04Z mkb:ART

Effect of Curcumin on Nitric Oxide and Endothelin-1 Levels in L-NAME-Induced Preeclamptic Wistar Rat Rahardjo, Bambang Dewi, Ratih Frastika Wiyasa, I Wayan Arsana Handayani, Puspita Prasetyorini, Nugrahanti Wibisono, Hermawan Medicine; Health Sciences; obstetric and gynecology Curcumin, endothelin-1, nitric oxide, preeclampsia Preeclampsia is a pregnancy disorder marked by the onset of hypertension after the 20th week, posing risks such as cardiovascular disease. Curcumin, a commonly consumed herbal medicine, has been investigated as a potential antihypertensive agent in mouse models of preeclampsia. This study took place in the Bioscience Laboratory of Universitas Brawijaya from March to August 2023, employing a true experimental design with various groups of mice receiving different treatments. Nitric oxide (NO) and endothelin-1 (ET-1) levels were measured using calorimetry and ELISA. The rats were divided into five groups: positive control, negative control and P1, P2, and P3 as the treatment groups. Treatment grups received fifferent curcumin doses of 30mg/kgBW/day, 50mg/kgBW/day, and 100mg/kgBW/day for P1, P2, and P3, respectively. Data analysis using the One-Way ANOVA and Post Hoc LSD revealed that curcumin at 100mg/kgBW/day significantly increased the NO level of 47.75±22.6 and decreased the ET-1 level of 67.03±24.47 when compared to the positive control (p<0.05). However, the 30mg/kgBW/day and 50mg/kgBW/day doses did not significantly affect the NO and ET levels. In conclusion, curcumin supplementation shows positive effects on NO and ET-1 levels in L-NAME-induced preeclamptic Wistar rats, highlighting its potential as an effective intervention for managing this pregnancy-related disorder. Faculty of Medicine, Universitas Padjadjaran 2024-12-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.fk.unpad.ac.id/index.php/mkb/article/view/3700 10.15395/mkb.v56.3700 Majalah Kedokteran Bandung; Vol 56, No 4 (2024); 263-271 Majalah Kedokteran Bandung; Vol 56, No 4 (2024); 263-271 2338-6223 0126-074x 10.15395/mkb.v56.n4 eng https://journal.fk.unpad.ac.id/index.php/mkb/article/view/3700/pdf https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/3700/4578 https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/3700/4745 https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/3700/4746 https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/3700/4747 Copyright (c) 2024 Majalah Kedokteran Bandung http://creativecommons.org/licenses/by-nc/4.0

oai:ojs.journal.fk.unpad.ac.id:article/2749 2023-02-15T02:48:57Z mkb:ART

Neurotoxicity of Chlorpyrifos, Carbofuran, and Cypermethrin in Adolescent Rats’ Brain Narwanto, Muhammad Ihwan Purwandhono, Azham Sofiana, Kristianningrum Febianti, Zahrah putri, Elvia Rahmi Marga Jauhani, Muhammad Afiful medicine; biomedicine; neuroscience Hippocampus, insecticide, memory, oxidative stress Chronic exposure to insecticides, even at low levels, has led to chronic neurotoxicity. Adolescent brain is still undergoing important developments, including in the hippocampus. This study investigated neurotoxicity effects of subacute exposure to chlorpyrifos, carbofuran and cypermethrin in the brain of adolescent rats. This study was performed at the Histology, Biochemistry, and Animal House Laboratory of Jember University from November to December 2021. Subjects were divided into five groups: normal, control, chlorpyrifos, carbofuran, and cypermethrin. Short-term memory was evaluated by Y maze test and tissue damage was evaluated by histological examination. Brain MDA levels were determined by thiobarbituric acid reactive substance method to evaluate the oxidative stress effect on the organ. This study showed spontaneous alternation in the Y maze test and the number of pyramidal neurons in hippocampus decreased in the cypermethrin group. There was a significant elevation of brain MDA level in carbofuran and cypermethrin groups. Thus, cypermethrin causes more severe neurotoxicity than carbofuran and chlorpyrifos. Improvements in the insecticide application management are urgently needed to prevent neurotoxicity. Faculty of Medicine, Universitas Padjadjaran university of jember 2022-12-31 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.fk.unpad.ac.id/index.php/mkb/article/view/2749 10.15395/mkb.v54n4.2749 Majalah Kedokteran Bandung; Vol 54, No 4 (2022); 202-207 Majalah Kedokteran Bandung; Vol 54, No 4 (2022); 202-207 2338-6223 0126-074x 10.15395/mkb.v54n4 eng https://journal.fk.unpad.ac.id/index.php/mkb/article/view/2749/pdf https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/2749/3285 https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/2749/3286 Copyright (c) 2022 Majalah Kedokteran Bandung http://creativecommons.org/licenses/by-nc/4.0

oai:ojs.journal.fk.unpad.ac.id:article/3809 2025-10-15T07:01:31Z mkb:ART

Success Rate and Complications of Percutaneous Nephrolithotomy (PCNL) in Nephrolithiasis Patients Stein, Lambok Kevin Safriadi, Ferry Complication, nephrolithiasis, percutaneous nephrolithotomy, success rate Percutaneous Nephrolithotomy (PCNL) is the standard management method for kidney stones due to its high success rates. This process is associated with risks, including complications such as infection and bleeding. This study aimed to evaluate the complications and success rates of PCNL in nephrolithiasis patients and provide important insights for clinical decision-making. Data were collected from patients undergoing PCNL for nephrolithiasis at Dr. Hasan Sadikin General Hospital Bandung, Indonesia, in the form of demographic data, stone parameters, and postoperative complications. Data were then analyzed statistically to identify the associated factors. This study was conducted at the Urology Department of the hospital from January to December 2023, involving 80 nephrolithiasis cases. Predominantly, 67.5% of patients were males, with 63.7% in the age group of above 50 years. Multiple stones were the most common (55%), with stone sizes of ≥1.5 cm prevalent in 95% of cases. Left-sided stones (43.75%) were most frequent, followed by right-sided (36.25%) and bilateral stones (20%). Hydronephrosis complications were present in 36.25% of cases, with 100% stone clearance found in Guy Stone Score (GSS) grade 1 cases, while GSS grade 4 cases exhibited the lowest stone clearance rate at 45.45%. This study provided insights into nephrolithiasis demographics, stone characteristics, and postoperative outcomes. Male predominance, multiple stones, high rates of stone clearance, and postoperative complications, particularly in the Guy's score system, underscore the need for proper management strategies and further research in this field. Faculty of Medicine, Universitas Padjadjaran 2025-03-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.fk.unpad.ac.id/index.php/mkb/article/view/3809 10.15395/mkb.v57.3809 Majalah Kedokteran Bandung; Vol 57, No 1 (2025); 74-80 Majalah Kedokteran Bandung; Vol 57, No 1 (2025); 74-80 2338-6223 0126-074x 10.15395/mkb.v57n1 eng https://journal.fk.unpad.ac.id/index.php/mkb/article/view/3809/pdf https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/3809/4724 https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/3809/4725 https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/3809/4726 Copyright (c) 2024 Majalah Kedokteran Bandung http://creativecommons.org/licenses/by-nc/4.0

oai:ojs.journal.fk.unpad.ac.id:article/1970 2021-12-26T06:13:00Z mkb:ART

Comparison of Antibacterial Efficacy between 96% Ethanolic Extracts from Abrus precatorius L. and Piper betle L. Leaves against Escherichia coli Saraswati, Felicia Angelina, Yohanna Kurniawan, Sandy Vitria Medicine ; Herbal Medicine Abrus precatorius L., disc diffusion, Escherichia coli, Piper betle L. Escherichia coli (E.coli) is a frequently found infectious pathogen commonly transmitted through water. In Indonesia, the level of this pathogen exceeds the accepted standard. Several studies have shown the presence of antibiotic-resistant E.coli, making studies on alternative treatments for E.coli necessary. Abrus precatorius L. and Piper betle L. leaves are among herbs that have herbal antibacterial properties. This study observed and compared the antibacterial effects of Abrus precatorius L. and Piper betle L. leaves against E.coli. This was an in vitro experimental study performed at the Laboratory of the Department of Microbiology, Faculty of Medicine and Health Science, Atma Jaya Catholic University, from August to November 2019. Abrus precatorius L. and Piper betle L. leaves were extracted by maceration in 96% Ethanol, and further processed into concentrations of 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, 90%, and 100%. Disc-diffusion on Mueller-Hinton Agar was used to identify the inhibition zones of the extracts against E.coli ATCC 25922. Ciprofloxacin disc and 96% ethanol impregnated-discs were used as positive and negative controls, respectively. Independent t-test results showed a significant difference between Abrus precatorius L. and Piper betle L. leaves effects against E.coli with p=0.044 and p=0.045 (p<0.05), respectively. In conclusion, Abrus precatorius L. and Piper betle L. leaves have antibacterial effects against E.coli ATCC 25922, albeit less sensitivity than Ciprofloxacin, with Piper betle L. presents a greater effect than Abrus precatorius L.Perbandingan Efektivitas Antibakteri Ekstrak Etanol 96% Daun Abrus precatorius L. dan Daun Piper betle L. Terhadap Escherichia coliEscherichia coli (E.coli) adalah patogen infeksius yang sering ditemukan dan ditularkan melalui air. Di Indonesia, tingkat patogen ini melebihi standar yang diterima. Beberapa penelitian telah menunjukkan ada E.coli yang kebal antibiotik, membuat penelitian tentang pengobatan alternatif untuk E.coli diperlukan. Daun Abrus precatorius L. dan Piper betle L. berpotensi sebagai pengobatan herbal antibakteri. Penelitian ini bertujuan melihat dan membandingkan efek antimikroba kedua daun tersebut terhadap E.coli. Penelitian eksperimental in vitro ini dilakukan di Laboratorium Mikrobiologi Fakultas Kedokteran dan Ilmu Kesehatan Atma Jaya mulai dari Agustus sampai November 2019. Daun  Abrus precatorius L. dan Piper betle L.  dimaserasi menggunakan etanol 96%, lalu dibentuk konsentrasi 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, 90%, dan 100%. Difusi cakram pada agar Mueller-Hinton dilakukan untuk menguji zona hambat kedua ekstrak terhadap bakteri E.coli ATCC 25922. Cakram ciprofloksasin merupakan kontrol positif, dan kontrol negatif adalah cakram yang direndam etanol 96%. Hasil uji independent t-test didapatkan perbedaan bermakna antara efektivitas ekstrak kedua daun terhadap E.coli, yaitu daun Abrus precatorius L. p=0.044 dan daun Piper betle L. p=0.045 (p<0.05). Simpulan, daun  Abrus precatorius L. dan Piper betle L. memiliki efek antibakteri terhadap E.coli ATCC 25922 walaupun tidak lebih sensitif dari Ciprofloksasin dengan Piper betle L. memiliki efek yang lebih besar dibanding dengan Abrus precatorius L. Faculty of Medicine, Universitas Padjadjaran 2020-06-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.fk.unpad.ac.id/index.php/mkb/article/view/1970 10.15395/mkb.v51n2.1970 Majalah Kedokteran Bandung; Vol 52, No 2 (2020); 69-73 Majalah Kedokteran Bandung; Vol 52, No 2 (2020); 69-73 2338-6223 0126-074x 10.15395/mkb.v52n2 eng https://journal.fk.unpad.ac.id/index.php/mkb/article/view/1970/pdf https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/1970/2899 https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/1970/2900 https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/1970/2902 Copyright (c) 2020 Majalah Kedokteran Bandung http://creativecommons.org/licenses/by-nc/4.0

oai:ojs.journal.fk.unpad.ac.id:article/3287 2024-03-14T03:01:05Z mkb:ART

In-silico study of the Effectiveness of Allium sativum L. extract as an Angiotensin-Converting Enzyme (ACE) Inhibitor in Hypertension Limanto, Agus Husain, Elma Eka Fitra Dewajanti, Anna Maria Medicine, Biomedic, Biochemistry ACE inhibitors, cheminformatics, garlic, hypertension Over the last decade, the global prevalence of hypertension rate has increased by 5.2% and, in Indonesia, the prevalence rate has increased significantly from 25.8% in 2013 to 34.1% in 2018. Hypertension treatments using blood pressure-lowering drugs, such as angiotensin-converting enzyme (ACE) inhibitors, often cause unpleasant side effects. These side effects increase the interest in using potentially effective natural remedies, such as garlic. This study aimed to determine which organosulfur compounds in garlic can act as an ACE inhibitor to reduce blood pressure in hypertension using a cheminformatics approach. Eighteen organosulfur compounds of Allium sativum L. were screened based on Lipinski’s rules and ADMET evaluation. Seven compounds passed the screening and were subjected to QSAR analysis, molecular docking analysis, and molecular dynamics simulations to assess the stability of the protein. The seven compounds then underwent molecular docking and QSAR analysis. Ajoene (4,5,9-trithiadodeca-1,6,11-triene-9-oxide) and S-allylmercaptocysteine (SAMC) were two compounds with better docking values compared to the positive control compound. The QSAR analysis also showed that SAMC had an activity as an ACE inhibitor. The ADMET evaluation showed that Ajoene and SAMC had good absorption and could not penetrate the blood-brain barrier. Molecular dynamics simulation of ACE complexes Ajoene, SAMC, and Captopril ranged from 0.05 to 5.61 Å but exhibited a pattern of synonymous fluctuations for most residues. Based on the simulation data, the organosulfur compounds from garlic, Ajoene, and SAMC are proven to have a mechanism of action as ACE inhibitors to reduce blood pressure in hypertension. Faculty of Medicine, Universitas Padjadjaran 2023-09-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.fk.unpad.ac.id/index.php/mkb/article/view/3287 10.15395/mkb.v55n3.3287 Majalah Kedokteran Bandung; Vol 55, No 3 (2023); 161-170 Majalah Kedokteran Bandung; Vol 55, No 3 (2023); 161-170 2338-6223 0126-074x 10.15395/mkb.v55n3 eng https://journal.fk.unpad.ac.id/index.php/mkb/article/view/3287/pdf https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/3287/4012 https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/3287/4013 https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/3287/4039 https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/3287/4040 https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/3287/4041 https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/3287/4055 https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/3287/4147 https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/3287/4148 https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/3287/4149 Copyright (c) 2023 Majalah Kedokteran Bandung http://creativecommons.org/licenses/by-nc/4.0

oai:ojs.journal.fk.unpad.ac.id:article/4364 2026-01-21T05:05:08Z mkb:ART

Changes in Astigmatism After Phacoemulsification with a Superior Incision Pritasari, Alteriana Mydriati Sita Giza, Putri Arifkha Fatmawati, Dina Suparmi, Suparmi Medicine; Ophalmology phacoemulsification, senile cataracts, superior corneal incision, surgically induced astigmatism Surgically induced astigmatism (SIA) is a common phacoemulsification procedure for senile cataracts. The size, location, and incision type significantly influence the SIA degree. This study aimed to evaluate the effect of a superior incision on astigmatism levels in patients both before and after phacoemulsification for senile cataracts. This retrospective analytical observational study utilized a cohort at Sultan Agung Islamic Hospital, Semarang, Indonesia, between November 2023 and May 2024. The accessible population consisted of patients treated during the study period. A total of 65 eyes from patients who underwent phacoemulsification with a superior incision were included in the study. Twenty-five patients (38.5%) exhibited against-the-rule (ATR) astigmatism before the surgical procedure, which decreased to 16 patients (24.6%) following surgery. In contrast, after phacoemulsification with a superior incision, the number of patients with with-the-rule (WTR) astigmatism increased from 61.5% to 75.4%. The astigmatism value before phacoemulsification with a superior incision was 1.274±1.02, while the value was 0.945±1,02 afterwards. The Wilcoxon Test revealed a significant difference (p<0.05) in the mean of astigmatism values before and after the procedure with a superior incision, indicating the surgical effect on reducing astigmatism. This study confirms that phacoemulsification using a superior incision significantly reduces postoperative astigmatism, particularly in patients with WTR astigmatism. Combining small incisions and sutureless techniques enhances corneal stability, accelerates healing, and improves surgical outcomes. Faculty of Medicine, Universitas Padjadjaran 2025-12-31 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.fk.unpad.ac.id/index.php/mkb/article/view/4364 10.15395/mkb.v57.4364 Majalah Kedokteran Bandung; Vol 57, No 4 (2025); 313-318 Majalah Kedokteran Bandung; Vol 57, No 4 (2025); 313-318 2338-6223 0126-074x 10.15395/mkb.v57n4 eng https://journal.fk.unpad.ac.id/index.php/mkb/article/view/4364/pdf https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/4364/5594 https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/4364/5677 Copyright (c) 2025 Majalah Kedokteran Bandung http://creativecommons.org/licenses/by-nc/4.0

oai:ojs.journal.fk.unpad.ac.id:article/2167 2021-08-09T04:53:29Z mkb:ART

Effects of Ethanol Extract from Sunkist (Citrus sinensis L. Osbeck) Peels on Rat’s Estrus Cycle Mutia, Maya Sari Suhartina, Suhartina estrus, ethinyl estradiol, Sunkist peels, vaginal swab Kuhnle et al. has reported that Sunkist peels contain 36 µg/100 g wet weight of phytoesterogen. This study was designed to explore Sunkist peels' potential to recover the infertility due to ovulation failure. This study was performed in June 2020 at the Pharmacology Laboratory, Universitas Prima Indonesia, on 25 rats. These rats were divided into five groups: Control, Standard, and Sunkist Peels Extract-I, II, and III that received 1 ml of 0.5% Sodium Carboxymethyl cellulose suspension, ethinyl estradiol 50 g/kgBW, 300 mg/kgBW, 450 mg/k BW, and 600 mg/kgBW of ethanol extract from Sunkist peel, respectively. Every 8-12 hours, the rat’s vagina were swabbed and smear into on object glass to be stained by 10% Giemsa and viewed at 40x and 100x magnifications. The leucocytes, especially neutrophils, epithelial cells, cornified and epithelial cells as well as the density of cells in vaginal swab were evaluated to determine the estrus cycle of the rats. The length of estrus phases was express as median (IQR) and analyzed using the Kruskall-Wallis test. The result of this study showed that the standard and highest dosage extract showed a significant extending of estrus and metestrus phases compared to the control group and significantly shortened diestrus phases. Hence, the highest dosage of Sunkist extract can prevent infertility by increasing the period of estrus cycle (ovulation) at the same level as the standard group. Faculty of Medicine, Universitas Padjadjaran 2021-03-31 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.fk.unpad.ac.id/index.php/mkb/article/view/2167 10.15395/mkb.v53n1.2167 Majalah Kedokteran Bandung; Vol 53, No 1 (2021); 32–37 Majalah Kedokteran Bandung; Vol 53, No 1 (2021); 32–37 2338-6223 0126-074x 10.15395/mkb.v53n1 eng https://journal.fk.unpad.ac.id/index.php/mkb/article/view/2167/pdf https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/2167/2096 https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/2167/2097 Copyright (c) 2021 Majalah Kedokteran Bandung http://creativecommons.org/licenses/by-nc/4.0

oai:ojs.journal.fk.unpad.ac.id:article/3307 2024-10-08T08:39:36Z mkb:ART

Shallot (Allium cepa L.) Peel Infusion Ameliorates Kidney Histopathological Damages in Diazinon-Induced Wistar Rats Bi’izzyk, Avie Baldana Helianti, Dina Wahyudi, Septa Surya Dewi, Rosita Biomedicine; Histopathology Flavonoid, kidney, oxidative stress, pesticide, red onion Diazinon, an organophosphate pesticide, is used extensively in agricultural sector. Consumption of agricultural products containing diazinon residue may lead to harmful health consequences. Among these is nephrotoxicity, which includes lipid peroxidation, that can damage the kidney. Flavonoids in shallot peel can scavenge free radicals, inhibit necrosis, and activate bone marrow-derived cells for cell regeneration. This study aimed to determine the correlation between shallot peel infusion (SPI) dose and kidney damage amelioration to establish the maximum effective dose of SPI to ameliorate kidney histopathological damage in diazinon-induced rats. This study was performed at the Pharmacology Laboratory, Faculty of Medicine, University of Jember, Indonesia, in April 2021, on 35 rats that were divided into 7 groups—normal, diazinon, and five treatment groups. Diazinon 40 mg/kgBW was administered on day 1-7, while SPI 125, 250, 500, 1,000, 2,000 mg/kgBW were administered on day 8–14 according to the treatment group. Kidney histopathological slides with hematoxylin-eosin (H.E.) staining were assessed using Kocoglu scoring and Kidney damage scores of the treatment groups were analyzed using Pearson test. The maximum effective dose was determined using regression test. The damages found in diazinon-induced rats were tubular degeneration, necrosis, and inflammation with a higher damage score than normal rats (p<0.05). Pearson test showed moderate correlation (coefficient -0.594). Higher SPI doses presented lower kidney damage scores, with 1,359 mg/kgBW being the maximum effective dose. SPI dose and the kidney damage amelioration are moderately correlated with a SPI maximum effective dose to ameliorate kidney damage in diazinon-induced rats of 1,359 mg/kgBW. Faculty of Medicine, Universitas Padjadjaran 2024-03-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.fk.unpad.ac.id/index.php/mkb/article/view/3307 10.15395/mkb.v56.3307 Majalah Kedokteran Bandung; Vol 56, No 1 (2024); 8-14 Majalah Kedokteran Bandung; Vol 56, No 1 (2024); 8-14 2338-6223 0126-074x 10.15395/mkb.v56n1 eng https://journal.fk.unpad.ac.id/index.php/mkb/article/view/3307/pdf https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/3307/4038 https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/3307/4056 Copyright (c) 2024 Majalah Kedokteran Bandung http://creativecommons.org/licenses/by-nc/4.0

oai:ojs.journal.fk.unpad.ac.id:article/2393 2022-02-04T04:04:21Z mkb:ART

Knowledge of Helminthiasis of People Living in Slum Areas of Bandung District, Indonesia Faridah, Lia Fauziah, Nisa Adrizain, Riyadi Public Health Helminthiasis, knowledge, population Among the most prevalent infections worldwide, Soil-Transmitted Helminth (STH) infection is the one that affects the poorest and most deprived populations. Data from the WHO shows that more than 1.5 billion people are affected by soil-transmitted helminth diseases globally. In 2010, it was estimated that 819.0 million, 464.6 million, and 438.9 million people around the world were infected with Ascaris lumbricoides, Trichuris trichiura, and hookworms (Ancylostoma duodenale and Necator americanus), respectively, with the Southeast Asia as the region with the highest prevalence of STH. Children’s awareness and knowledge of helminthiasis are essential to reduce the STH infection prevalence. Unfortunately, evaluation on children’s understanding of helminthiasis is still scarce. This study was intended to measure children's knowledge of STH infections and its prevention, especially prevention measures at home, in Bandung District, Indonesia. This study was conducted in March 2021 on 506 children who lived in 15 different subdistricts in Bandung District. Data were collected through a questionnaire that was used for face-to-face interviews with the children. All data were recorded in RedCap apps for further analysis. It was demonstrated in this study that children in Bandung District generally have low-to-medium knowledge on helminthiasis prevention, symptoms, and treatment (85%). Thus, there is an urgent need for an education program on helminthiasis to complement the deworming measures conducted by the local government. Faculty of Medicine, Universitas Padjadjaran This study was funded by Simlitabmas grants from the Ministry of Education and Culture and JPSP/DG-RSTHE Bilateral Joint Research Projects. 2021-12-31 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.fk.unpad.ac.id/index.php/mkb/article/view/2393 10.15395/mkb.v53n4.2393 Majalah Kedokteran Bandung; Vol 53, No 4 (2021); 223-228 Majalah Kedokteran Bandung; Vol 53, No 4 (2021); 223-228 2338-6223 0126-074x 10.15395/mkb.v53n4 eng https://journal.fk.unpad.ac.id/index.php/mkb/article/view/2393/pdf https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/2393/2512 https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/2393/2513 https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/2393/2514 Copyright (c) 2021 Majalah Kedokteran Bandung http://creativecommons.org/licenses/by-nc/4.0

oai:ojs.journal.fk.unpad.ac.id:article/3355 2024-10-10T06:34:50Z mkb:CR

Management of Stage-4 HIV with Cerebral Toxoplasmosis Coinfection and SIADH Complication Laksono, Pandu Oktavia, Erlin Putri, Hidayati Adi Herawati, Fauna Clinical Pharmacy HIV, acquired immunodeficiency syndrome, cerebral toxoplasmosis, inappropriate ADH syndrome, anti-retroviral agents, antiparasitic agents, hypertonic sodium chloride solution HIV/AIDS stage 4 is the stage where the HIV/AIDS patients have low immunity protection against infections, which can led to coinfections and complications. This case report presented an evaluation of the diagnosis and treatment of an HIV/AIDS stage 4 patient with cerebral toxoplasmosis coinfection and SIADH complications. A man (47 years, 35 kg), married with two children, complaining of weakness, nausea, vomiting, weight loss, and low appetite. Sodium level were measured, showing a 117 mg/dL level that continued to decrease throughout the patient's treatment. Five days later, the patient lost his consciousness with a GCS score of 224, indicating severe brain injury, and was diagnosed with cerebral toxoplasmosis based on the result of head CT-SCAN with contrast. On day 6, the patient was tested positive for HIV and diagnosed with stage 4 with an absolute CD4 count of 4 cells/μl. Therapy was provided by giving pyrimethamine-clindamycin therapy for cerebral toxoplasmosis, followed by Tenofovir, Lamivudine, and Evafirenz as antiretroviral therapy. Treatment for hyponatremia was done by administration of 3% NaCl and tolvaptan. The patient started experiencing an improvement in consciousness after the 10th day of medication, and sodium levels fluctuated throughout the treatments. Patient was discharged after 15 days with clinical improvements. Faculty of Medicine, Universitas Padjadjaran 2024-09-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.fk.unpad.ac.id/index.php/mkb/article/view/3355 10.15395/mkb.v56.3355 Majalah Kedokteran Bandung; Vol 56, No 3 (2024); 221-227 Majalah Kedokteran Bandung; Vol 56, No 3 (2024); 221-227 2338-6223 0126-074x 10.15395/mkb.v56.n3 eng https://journal.fk.unpad.ac.id/index.php/mkb/article/view/3355/pdf https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/3355/4116 https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/3355/4117 Copyright (c) 2024 Majalah Kedokteran Bandung http://creativecommons.org/licenses/by-nc/4.0

oai:ojs.journal.fk.unpad.ac.id:article/2690 2023-11-23T03:16:33Z mkb:ART

Pili Protein 65.5 kDa of Klebsiella pneumoniae Induced a Decrease in IL-10 in Mice Agustina, Dini Wati, Mei Liana Wisudanti, Desie Dwi Shodikin, Muhammad Ali Mufida, Diana Chusna Suswati, Enny Medicine; Microbiology; Immunology Interleukin-10, immune response, Klebsiella pneumoniae, pili protein Klebsiella pneumoniae is one of the leading cause of nosocomial infection worldwide with clinical isolates mostly found in Multi-Drug Resistant (MDR) or Extensively Drug-Resistant (XDR). This makes therapeutic options due to this bacteria limited. Several studies have shown that the pili protein of K. pneumoniae with different molecular weights plays a role in the virulence factor, as they are hemagglutinin and adhesin proteins. Pili protein 65.5 kDa of K. pneumoniae can be considered as the antigen candidate for vaccines. This study aimed to determine the immune response based on the IL-10 level as induced by pili protein 65.5 kDa K. pneumoniae. This study was conducted from October 2020 to March 2021 at the Faculty of Mathematics and Natural Sciences and Faculty of Medicine of Jember University. This was true experimental with post-test only controlled group design on 27 male BALB/c mice which divided into 3 groups: K1, K2, and K3. The groups were induced with sterile PBS, pili protein and Freund’s adjuvant, and Freund’s adjuvant only, respectively. Samples were drawn through cardiac puncture, then serum was taken to measure the IL-10 levels using the ELISA method. Hemagglutination test showed a positive result with 1/8 as the highest titer. Results showed that the mean IL-10 levels were 290.92±45.33; 235.05±44.53; 218.54±64,81 for K1, K2, and K3, respectively. One-way ANOVA test results showed a statistical difference between groups (p=0,019). This research shows that pili protein 65.5 kDa K. pneumoniae decreases the IL-10 level. However, when it is provided with the Freund’s Adjuvant, there is no proof of the immunogenicity when compared to the control group. Faculty of Medicine, Universitas Padjadjaran 2022-09-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.fk.unpad.ac.id/index.php/mkb/article/view/2690 10.15395/mkb.v54n3.2690 Majalah Kedokteran Bandung; Vol 54, No 3 (2022); 143–147 Majalah Kedokteran Bandung; Vol 54, No 3 (2022); 143–147 2338-6223 0126-074x eng https://journal.fk.unpad.ac.id/index.php/mkb/article/view/2690/pdf https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/2690/3203 https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/2690/3204 Copyright (c) 2022 Majalah Kedokteran Bandung http://creativecommons.org/licenses/by-nc/4.0

oai:ojs.journal.fk.unpad.ac.id:article/3887 2025-10-15T07:01:31Z mkb:ART

Characteristics of Patients with Anterior Cruciate Ligament Injury at Ulin Hospital Banjarmasin, Indonesia Damayanthi, Essy Dwi Hosea, Nathania Medicine Anterior cruciate ligament, arthroscopy, knee injuries Knee injuries are one of the common injuries, especially among athletes. Many studies have concluded that the main cause of these injuries were sudden movements while doing sports. The incidence of the knee joint injury in Indonesia was 38 to 78 per 100,000 patients with the prevalence of Anterior Cruciate Ligament (ACL) injuries of 16%. Recently, an increasing number of ACL injury patients was observed to be treated at the Ulin Hospital, Banjarmasin, Indonesia, when compared to the number of the previous years, making it important to understand the characteristics of patients experiencing these injuries. This study aimed to explore the characteristics of patients with ACL injuries in the hospital. Data for this retrospective descriptive study were collected from medical records during the period of  March 2022 to June 2023 from Ulin Hospital, Banjarmasin. The inclusion criteria were patients diagnosed with an ACL injury with or without meniscus tear. From a total of 95 patients with ACL injuries,  30 (32%) were below 20 years old,   42 (44%) were 20-30 years old, 18 (19%) were 31-40 years old, 3 (3%) were 41-50 years old, and 2 (2%) were above 50 years old.  The ratio between men and women was 11:1. There were 74 patients who had sports-related injuries while the remaining 21 patients experienced the injury due to other activities.  Of the total 95 cases, 59 (62%) were treated nonoperatively and 36 (38%) received arthroscopy surgery. The arthroscopy was mostly performed to patients who also experienced a meniscus injury and in the chronic phase, with an average length of stay at the hospital of 2.6 days. Faculty of Medicine, Universitas Padjadjaran - 2025-03-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.fk.unpad.ac.id/index.php/mkb/article/view/3887 10.15395/mkb.v57.3887 Majalah Kedokteran Bandung; Vol 57, No 1 (2025); 10-15 Majalah Kedokteran Bandung; Vol 57, No 1 (2025); 10-15 2338-6223 0126-074x 10.15395/mkb.v57n1 eng https://journal.fk.unpad.ac.id/index.php/mkb/article/view/3887/pdf https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/3887/4847 https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/3887/4889 https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/3887/4902 https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/3887/4945 Copyright (c) 2024 Majalah Kedokteran Bandung http://creativecommons.org/licenses/by-nc/4.0

oai:ojs.journal.fk.unpad.ac.id:article/1792 2022-03-21T03:53:22Z mkb:ART

Elderly Quality of Life and Its Predictors in Chronic Disease Management Program: Indonesian Version of WHOQOL-BREF and WHOQOL-OLD Lionthina, Melly Wiwaha, Guswan Gondodiputro, Sharon Sukandar, Hadyana Arya, Insi Farida Desy Sunjaya, Deni K. Public Health Elderly, PROLANIS, QoL, WHOQOL-BREF, WHOQOL-OLD Indonesia is currently experiencing increasing proportion of older population, which also increases the prevalence of chronic diseases that may decrease the quality of life (QoL). The Indonesian Social Security Agency develops a program to control chronic diseases, which is referred to as the Chronic Disease Management Program (Program Pengelolaan Penyakit Kronis, PROLANIS) for the National Health Insurance participants. Its goals is to control chronic diseases in order to improve participants’ QoL. To evaluate the QoL of the elderly, the World Health Organization (WHO) has developed two questionnaires, namely WHOQOL-BREF and WHOQOL-OLD. The objective of this study was to analyze the differences in the QoL of the elderly between PROLANIS and non-PROLANIS participants using the Indonesian-verson of WHOQOL-BREF and WHOQOL-OLD as well as the QoL predictors. A  cross-sectional study was carried out to 84 elderly  PROLANIS participants (n=42) and non-PROLANIS participants (n=42).  Respondents were sampled consecutively from 6 public health health centers (Pusat Kesehatan Masyarakat, Puskesmas) in Bangka District, Indonesia in 2018. Mann Whitney test or the unpaired T test were used to statistically analyze the difference between the two groups. A multiple linear regression test was then carried out to determine the predictors of the QoL.  This study discovered that no difference was observed in the QoL of the elderly between PROLANIS and non-PROLANIS participants. Disease status and depression were the predictors of the QoL. Therefore, PROLANIS has not been proven to be able to improve the QoL of the elderly. Kualitas Hidup Lanjut Usia dan Prediktornya pada Program Pengelolaan Penyakit Kronis: Versi Indonesia dari WHOQOL-BREF dan WHOQOL-OLD  Peningkatan proporsi penduduk lanjut usia (lansia) di Indonesia meningkatkan prevalensi penyakit kronis sehingga dapat menyebabkan penurunan kualitas hidup. Badan Penyelenggara Jaminan Sosial mengembangkan Program Pengelolaan Penyakit Kronis (PROLANIS) bagi peserta Jaminan Kesehatan Nasional dengan tujuan agar penyakit kronis tersebut terkontrol dan lansia dapat hidup berkualitas. World Health Organization (WHO) mengembangkan instrumen untuk mengukur kualitas hidup, yaitu WHOQOL-BREF dan WHOQOL-OLD. Penelitian ini bertujuan menganalisis adanya perbedaan kualitas hidup lanjut usia antara bukan peserta PROLANIS dan peserta PROLANIS menggunakan kuesioner WHOQOL-BREF dan WHOQOL-OLD versi Bahasa Indonesia dan faktor yang berpengaruh. Penelitian potong lintang dilakukan pada 84 lansia yang terbagi menjadi 2 grup masing-masing 42 responden, yaitu bukan peserta PROLANIS danpeserta PROLANIS. Responden berasal dari 6 Puskesmas di Kabupaten Bangka Provinsi Bangka Belitung Indonesia pada tahun 2018 yang dipilih sesuai kriteria inklusi dan dengan metode consecutive sampling. Data yang terkumpul dilakukan analisis menggunakan Uji Mann Whitney atau uji T tidak berpasangan. Uji regresi linier multipel dilakukan untuk menentukan prediktor dari kualitas hidup. Hasil penelitian  menunjukkan bahwa tidak ada perbedaan kualitas hidup lansia antara bukan peserta PROLANIS dan peserta PROLANIS. Status penyakit dan depresi merupakan prediktor kualitas hidup. Simpulan, PROLANIS belum terbukti dapat meningkatkan kualitas hidup lansia. Faculty of Medicine, Universitas Padjadjaran None 2020-03-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.fk.unpad.ac.id/index.php/mkb/article/view/1792 Majalah Kedokteran Bandung; Vol 52, No 1 (2020); 28-34 Majalah Kedokteran Bandung; Vol 52, No 1 (2020); 28-34 2338-6223 0126-074x eng https://journal.fk.unpad.ac.id/index.php/mkb/article/view/1792/pdf https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/1792/2914 https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/1792/2915 Copyright (c) 2020 Majalah Kedokteran Bandung http://creativecommons.org/licenses/by-nc/4.0

oai:ojs.journal.fk.unpad.ac.id:article/2753 2023-07-17T06:46:55Z mkb:ART

Effectiveness of WHO Stress Management for Improving Insomnia Severity Index Score in Telegram’s Self-Isolated Online Group Population Octaviani, Ines Damayanti Maharatih, Gusti Ayu Herdaetha, Adriesti Medicine; Psychiatry; Psychotherapy Insomnia; post covid syndrome; WHO stress management Insomnia is one of the various symptoms frequently found in patients with post-covid syndrome (PCS) (19.1%). The WHO Stress Management (WSM) is an eclectic psychotherapy that combines mindfulness and relaxation which, theoretically, can be effective in treating insomnia due to PCS. This study aimed to explore the effectiveness of WSM in improving the Insomnia Severity Index Score for people with PCS. This was a quasi-experimental pre-test-post-test control study on 18 participants in the population of online self-isolation group in the Telegram who experienced insomnia. The intervention applied was WSM. These participants were compared to 18 controls who only received psychoeducation. Clinical insomnia symptoms were examined using the Insomnia Severity Index (ISI) before the intervention, then the control group was given sleep hygiene psychoeducation, and the treatment group was given WSM in 5 Zoom on-cam meetings once a week for 30-60 minutes. A re-assessment using the ISI post-test was then performed, and data were analyzed statistically. There was a change in score for insomnia symptoms in the treatment group (delta score 27.50) compared to the control group (delta score 9.50, p=0.00; OR 0.00, p=0,99, 95% CI). Thus, WSM can improve the insomnia score in the population with PCS. Faculty of Medicine, Universitas Padjadjaran 2023-06-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.fk.unpad.ac.id/index.php/mkb/article/view/2753 10.15395/mkb.v55n2.2753 Majalah Kedokteran Bandung; Vol 55, No 2 (2023); 77–84 Majalah Kedokteran Bandung; Vol 55, No 2 (2023); 77–84 2338-6223 0126-074x eng https://journal.fk.unpad.ac.id/index.php/mkb/article/view/2753/pdf https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/2753/3298 Copyright (c) 2022 Majalah Kedokteran Bandung http://creativecommons.org/licenses/by-nc/4.0

oai:ojs.journal.fk.unpad.ac.id:article/4046 2025-11-19T07:16:03Z mkb:ART

Skinfold Thickness and Mid-upper Arm Circumference in Pediatric Patients with Chronic Kidney Disease Suriadiredja, Siti Saqinah Widiasta, Ahmedz Rossanti, Rini Chronic kidney disease, mid-upper arm circumference, nutritional status, pediatric, skinfold thickness Chronic kidney disease (CKD) can impair the kidneys' capacity to manage nutrition, and any nutritional imbalances in CKD may affect the disease's progression. This study evaluated triceps skinfold (TSF) thickness and mid-upper arm circumference (MUAC) as indicators of nutritional status in children with early- and late-stage CKD at Dr. Hasan Sadikin General Hospital, Bandung, Indonesia. A descriptive cross-sectional design was used with secondary data from the nephrology division registry collected between August 2021 and August 2022. Data analysis was conducted with Microsoft Excel. The study involved 65 participants, with 32 in the early stage and 33 in the late stage. For early-stage patients, the average TSF was 13.75 mm and the MUAC was 12 cm, while, the average TSF an MUAC in the late stage were  11.39 mm and 11.70 cm, respectively. Based on TSF percentiles, most patients fell within the normal range, whereas MUAC measurements indicated that the majority were below normal. In terms of %TSF, most early-stage patients had above-average values, whereas late-stage patients were below average. All MUAC measurements indicated below-average values for both stages. Overall, TSF percentiles suggested that most patients had adequate nutritional status; however, %TSF revealed excess adiposity in early-stage patients and deficits in late-stage patients. MUAC consistently indicated deficits across both groups. Faculty of Medicine, Universitas Padjadjaran 2025-09-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.fk.unpad.ac.id/index.php/mkb/article/view/4046 10.15395/mkb.v57.4046 Majalah Kedokteran Bandung; Vol 57, No 3 (2025); 234-240 Majalah Kedokteran Bandung; Vol 57, No 3 (2025); 234-240 2338-6223 0126-074x 10.15395/mkb.v57n3 eng https://journal.fk.unpad.ac.id/index.php/mkb/article/view/4046/pdf https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/4046/5126 https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/4046/5127 https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/4046/5264 Copyright (c) 2024 Majalah Kedokteran Bandung http://creativecommons.org/licenses/by-nc/4.0

oai:ojs.journal.fk.unpad.ac.id:article/2372 2024-10-08T08:40:23Z mkb:ART

Continuous Ambulatory Peritoneal Dialysis Cost-Effectiveness in National Health Insurance Era of Indonesia Tjahjodjati, Tjahjodjati Kuddah, Yasser Wijayanti, Zola Urology; Medicine; Chronic Kidney Disease Chronic kidney disease, continuous ambulatory peritoneal dialysis, cost-effectiveness analysis, hemodialysis national health insurance Essential treatments for patients with end-stage renal disease include Renal Replacement Therapy (RRT) consisting of hemodialysis, peritoneal dialysis, and kidney transplantation. In 2014, dialysis coverage in Indonesia was more than 1.5 trillion, making it the second highest expense in the National Health Insurance (BPJS) expenses. This study compared the cost-effectiveness between Continuous Ambulatory Peritoneal Dialysis (CAPD) and Hemodialysis (HD) in  patients treated in Dr. Hasan Sadikin General Hospital. Data were collected from the Urology Department from 2014 to 2017. This was a retrospective observational study on 3 groups of patients: patients with effective CAPD each year as the first group; patients who had experienced repair of CAPD and continued to use it as the second group; and patients who discontinued CAPD due to complications and returned to hemodialysis as the third group. Each group expense was calculated with standard cost insurance for one year in  the hospital. The expense was then be compared to the expense of hemodialysis for one year. A total of 89 patients in the CAPD program from 2014–2017 were treated at the department. When compared to HD, the first, second, and third group of CAPD patients experienced a cost reduction of IDR 23.227.857/person, IDR 18.127.857/person, and IDR 1.661.972.000, respectively. Total savings from the CAPD program in the hospital was IDR 1.661.972.000 from 2014. It is then concluded that CAPD could reduce the burden of government insurance in a cost-effective manner and is considered a treatment of choice in the National Health Insurance Era. Faculty of Medicine, Universitas Padjadjaran 2023-12-31 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.fk.unpad.ac.id/index.php/mkb/article/view/2372 10.15395/mkb.v55n4.2372 Majalah Kedokteran Bandung; Vol 55, No 4 (2023); 260-263 Majalah Kedokteran Bandung; Vol 55, No 4 (2023); 260-263 2338-6223 0126-074x 10.15395/mkb.v55n4 eng https://journal.fk.unpad.ac.id/index.php/mkb/article/view/2372/pdf https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/2372/2450 https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/2372/2451 Copyright (c) 2021 Majalah Kedokteran Bandung http://creativecommons.org/licenses/by-nc/4.0

oai:ojs.journal.fk.unpad.ac.id:article/4376 2026-03-31T15:39:48Z mkb:ART

Types of Social Participation among the Elderly in Bandung City, Indonesia Gondodiputro, Sharon Fauzan, Yusuf Naufal Athaya Widjajakusuma, Anggraini Public Health Elderly, religious activities, social participation, neighborhood cleaning activities Elderly individuals are at increased risk of experiencing various health problems associated with isolation and loneliness. Social participation with family, friends, neighbors, and engagement in community activities has been proven to reduce these risks. This study aimed to identify the types of social participation activities undertaken by elderly residents in Bandung City, Indonesia. A quantitative descriptive study was conducted involving 100 elderly individuals who visited Community Health Centers in Bandung City, using multistage purposive convenience sampling. The study variables were respondent characteristics and types of social participation at the family, friend, neighbor, and community levels.The most common forms of social participation with family and neighbors involved direct conversations. Religious activities and cleaning up the neighborhood (kerja bakti in local language) were the most frequently reported types of social participation with neighbors and the broader community. Based on these findings, it is necessary to develop various structured and easily accessible community activities to provide the elderly with more opportunities for meaningful social participation. Faculty of Medicine, Universitas Padjadjaran None 2026-03-31 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.fk.unpad.ac.id/index.php/mkb/article/view/4376 10.15395/mkb.v58.4376 Majalah Kedokteran Bandung; Vol 48, No 1 (2026); 70-82 Majalah Kedokteran Bandung; Vol 48, No 1 (2026); 70-82 2338-6223 0126-074x 10.15395/mkb.v58.n1 eng https://journal.fk.unpad.ac.id/index.php/mkb/article/view/4376/pdf https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/4376/5606 https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/4376/5607 Copyright (c) 2026 Majalah Kedokteran Bandung http://creativecommons.org/licenses/by-nc/4.0

oai:ojs.journal.fk.unpad.ac.id:article/2310 2023-01-13T09:03:20Z mkb:ART

Knowledge and Severity of Female Urinary Incontinence and Reasons for Not Seeking Treatment Susiarno, Hadi Prakasa, Ryandra Handono, Budi Medicine; Obstetrics and Gynecology Knowledge; treatment-seeking; urinary incontinence Urinary incontinence (UI) is a commonly overlooked problem in women, particularly women of post-menopausal age. Despite the medical, social, and hygiene burdens conferred by UI to its sufferers, past studies have shown that only a few among women afflicted with UI sought treatment. This may be due to various reasons: lack of knowledge and awareness of UI or a wrong belief of UI as a natural part of aging. This study aimed to investigate the association between knowledge and severity of UI and reasons for not seeking treatment among post-menopausal women in Bandung, Indonesia. This was an analytic cross-sectional study conducted at the Geriatric and Gynecology Clinic, Dr. Hasan Sadikin General Hospital, in September 2013. Ninety-one women who met the inclusion criteria were interviewed to assess their knowledge of UI. The severity of UI was assessed using Urinary Distress Inventory 6 (UDI-6). Data were analyzed using the chi-square test. Sixty-five respondents (70.7%) had poor knowledge of UI. Knowledge of UI was not associated with awareness of UI as a medical condition (p=0.633). The difference in UI severity was associated with the perception of UI as a normal part of aging (p=0.008). Post-menopausal women are poorly informed regarding urinary incontinence. However, knowledge alone might not be adequate to encourage women to seek treatment. Further studies are needed to investigate women’s reasons for not seeking treatment for UI. Faculty of Medicine, Universitas Padjadjaran 2021-09-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.fk.unpad.ac.id/index.php/mkb/article/view/2310 10.15395/mkb.v53n3.2310 Majalah Kedokteran Bandung; Vol 53, No 3 (2021); 138–142 Majalah Kedokteran Bandung; Vol 53, No 3 (2021); 138–142 2338-6223 0126-074x 10.15395/mkb.v53n3 eng https://journal.fk.unpad.ac.id/index.php/mkb/article/view/2310/pdf https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/2310/2493 https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/2310/2494 Copyright (c) 2021 Majalah Kedokteran Bandung http://creativecommons.org/licenses/by-nc/4.0

oai:ojs.journal.fk.unpad.ac.id:article/3184 2024-10-08T08:39:10Z mkb:ART

Comparison of Phaco-Chop versus Stop-and-Chop Nucletomy Techniques in Patients with Soft to Moderate Nucleus Cataracts Budiman, Budiman Knoch, Andrew M. H. Sugiarti, Emmy Dwi Tjokrovonco, Ludwig Melino Cataract and Refractive Surgery; Medicine; Ophthalmology Anterior chamber depth, cataract, endothelial cell, phacoemulsification Various phacoemulsification techniques are commonly used, with phaco-chop and stop-and-chop techniques as the most popular ones. Phacoemulsification inevitably leads to endothelial cell destruction, which, in severe cases, might result in vision impairment. This study aimed to compare endothelial cell characteristics between two phacoemulsification procedures, phaco-chop, and stop-and-chop, in patients with soft to moderate nucleus cataracts. This study was conducted on 142 patients at the National Eye Center of Cicendo Hospital between April and August 2018. Of those, 66 patients underwent the phaco-chop technique, while 76 patients underwent the stop-and-chop technique. Intraoperative parameters such as effective phaco time (EPT), phaco time, average power, and duration were recorded. Endothelial density, hexagonality, coefficient of variation (CV), and central cornea thickness (CCT) were also recorded before surgery, as well as one week and four weeks after surgery. Mean power, EPT, phaco time, and duration in the phaco-chop group were significantly lower than in the stop-and-chop group. Mean (SD) endothelial density at one-week and four-week evaluation in the phaco-chop group were considerably lower than in the stop-and-chop group (p-value=0.024 and p-value=0.000, respectively). Mean (SD) CV at one-week evaluation in the phaco-chop group was significantly higher compared to a stop-and-chop group, 43.3 (8.0) versus 40.0 (6.7) % (p-value=0.009). Mean (SD) hexagonality at four-week evaluation in the phaco-chop group was significantly higher compared to a stop-and-chop group (43.1 (17.6) versus 48.7 (13.2) respectively, p-value=0.045). Phaco-chop technique have significantly lower EPT, average power, phaco time, and surgery duration than stop-and-chop techniques at one-week and four-week evaluation after phacoemulsification. Faculty of Medicine, Universitas Padjadjaran 2024-06-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.fk.unpad.ac.id/index.php/mkb/article/view/3184 10.15395/mkb.v56.3184 Majalah Kedokteran Bandung; Vol 56, No 2 (2024); 129-134 Majalah Kedokteran Bandung; Vol 56, No 2 (2024); 129-134 2338-6223 0126-074x 10.15395/mkb.v56n2 eng https://journal.fk.unpad.ac.id/index.php/mkb/article/view/3184/pdf https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/3184/3852 https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/3184/3853 https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/3184/3904 Copyright (c) 2023 Majalah Kedokteran Bandung http://creativecommons.org/licenses/by-nc/4.0

oai:ojs.journal.fk.unpad.ac.id:article/2636 2023-11-23T03:17:47Z mkb:ART

Profile and Frequency of One Hundred Ankle Osteoarthritis Cases in an Indonesian Tertiary Hospital Ibrahim, Muhammad Farhan Wahyudi, Kurnia Primadhi, Raden Andri Orthopaedics; Arthritis; Ankle Ankle; frequency; osteoarthritis Osteoarthritis is one of the most common cases in orthopedics and traumatology clinic. Ankle osteoarthritis is less common than osteoarthritis of hip and knee. Limited data and literature resulted in suboptimal treatment strategy. The purpose of this study was to describe the profile and frequency of ankle osteoarthritis at Dr. Hasan Sadikin General Hospital Bandung, a tertiary referral hospital in Indonesia. A cross-sectional descriptive observational study was conducted on all patients diagnosed with ankle osteoarthritis enrolled in the medical record database at Dr. Hasan Sadikin General Hospital Bandung, Indonesia in November 2020–November 2021. Results showed that the majority of the patients were female (52%), aged ≥60 years old (44%), graduated from senior high school education (56%), and housewives (30%). The 100 patients were proportionally distributed with most of them were categorized as suffering from secondary osteoarthritis with post-trauma predominance. From the perspective of body mass index, 85% patients were classified as above normal. As many as 76% of patients presented to the hospital in an advanced stage. With the high rate of posttraumatic ankle osteoarthritis, concerns should be given more to the ankle trauma management, as well as to the population with high body mass index. Increased health promotion for general population and health care providers is also needed to reduce the tendency of late presentation at the health care facility. Faculty of Medicine, Universitas Padjadjaran 2022-06-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.fk.unpad.ac.id/index.php/mkb/article/view/2636 10.15395/mkb.v54n2.2636 Majalah Kedokteran Bandung; Vol 54, No 2 (2022); 109–115 Majalah Kedokteran Bandung; Vol 54, No 2 (2022); 109–115 2338-6223 0126-074x 10.15395/mkb.v54n2 eng https://journal.fk.unpad.ac.id/index.php/mkb/article/view/2636/pdf https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/2636/3095 https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/2636/3096 Copyright (c) 2022 Majalah Kedokteran Bandung http://creativecommons.org/licenses/by-nc/4.0

oai:ojs.journal.fk.unpad.ac.id:article/1652 2021-12-26T04:58:45Z mkb:ART

Histopathological Effects of Ageratum Leaf Extract (Ageratum Conyzoides) on Wound Healing Acceleration After Acute Excisional Wound on Epidermis in Type 2 Diabetes Mellitus Model of Sprague Dawley Rats (Rattus norvegicus) Yudhantoro, Liliek Hidajat, Nucki Nursjamsi Ismiarto, Yoyos Dias Ismono, Darmadji Ageratum leaves, diabetic wound, wound healing Diabetic wound healing problem often occurs if proper care is not given which will lead to the development of a chronic wound. Ageratum (Ageratum conyzoides L.) leaves is one of the most common plants in tropical areas, including Indonesia, which are frequently used in traditional treatment due to its anti-bacterial properties. This experimental study aimed to identify the effects of topical application of Ageratum leaf extract on wound healing based on histopathological examination of the reepithelization, ulceration, neovascularization, and the presence of inflammatory cells. This study was performed in the period of September to December 2017 at the Pharmacology and Pathology Anatomy laboratories of Dr. Hasan Sadikin General Hospital Bandung, Indonesia. Excisions were made on the back of the 36 rats that were divided into control and test groups. The test group then received a topical application of Ageratum leaf extract. The resulting histopathologic appearance of the wound was then examined. The test group showed better wound healing in all parameters inspected when compared to the control group. Mann-Whitney Test with 95% confidence interval (p<0.05) showed that the re-epithelialization, ulceration, neovascularization, and presence of inflammatory cells reflected a statistically significant improvement in the test group (p=0.319, p=0.290, p=0.251, and p=0.245, respectively). This study concludes that the topical application of Ageratum leaf extract has a statistically significant benefit on diabetic wound healing.Pengaruh Histopatologis Ekstrak Daun Ageratum (Ageratum Conyzoides) terhadap Akselerasi Penyembuhan Luka Setelah Luka Eksisi Akut pada Epidermis pada Model 2 Diabetes Mellitus Tikus Sprague Dawley (Rattus norvegicus) Luka diabetes sering menyebabkan luka kronik jika tidak mendapat penanganan yang tepat. Ageratum (Ageratum conyzoides) merupakan tanaman khas daerah tropis termasuk Indonesia, yang daunnya digunakan untuk pengobatan tradisional karena mengandung zat anti bakteri. Penelitian eksperimental ini menggunakan desain kelompok kontrol post-test untuk mengidentifikasi efek aplikasi topical dari ekstrak daun Ageratum pada penyembuhan luka dengan pemeriksaan histopatologis dari reepitelialisasi, ulserasi, neovaskularisasi, dan sel radang. Penelitian ini dilakukan antara September hingga Desember 2017 di laboratorium Farmakologi dan Patologi Anatomi Rumah Sakit Umum Dr. Hasan Sadikin Bandung. Eksisi dilakukan pada tiap-tiap tikus dari 36 tikus yang dibagi menjadi kelompok kontrol dan kelompok uji di mana kelompok uji dilakukan perawatan dengan ekstrak etanol daun ageratum secara topikal. Setelah diaplikasikan ekstrak daun Ageratum, luka diperiksa secara histopatologi. Observasi pada kelompok uji menunjukkan penyembuhan luka eksisional tikus diabetes yang lebih baik daripada kelompok control untuk semua parameter. Uji Mann-Whitney dengan interval kepercayaan 95% (p <0,05) menunjukkan bahwa nilai p untuk reepitelisasi, ulserasi, neovaskularisasi, dan sel radang adalah p=0,319, p=0,290, p=0,251, dan p=0,245. Aplikasi topikal dari ekstrak daun Ageratum memiliki manfaat pada penyembuhan luka diabetes dan hasilnya signifikan secara statistik.  Faculty of Medicine, Universitas Padjadjaran 2019-12-27 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.fk.unpad.ac.id/index.php/mkb/article/view/1652 10.15395/mkb.v51n3.1652 Majalah Kedokteran Bandung; Vol 51, No 3 (2019); 172-178 Majalah Kedokteran Bandung; Vol 51, No 3 (2019); 172-178 2338-6223 0126-074x 10.15395/mkb.v51n3 eng https://journal.fk.unpad.ac.id/index.php/mkb/article/view/1652/pdf https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/1652/2882 Copyright (c) 2019 Majalah Kedokteran Bandung http://creativecommons.org/licenses/by-nc/4.0

oai:ojs.journal.fk.unpad.ac.id:article/2808 2023-05-04T03:43:20Z mkb:ART

Hospital Management Information System Implementation Assessment Using HOT-FIT Model in Langsa General Hospital Aceh, Indonesia Nasution, Sri Wahyuni Chairunnisa, Chairunnisa Medicine; Public Health HOT-FIT, Hospital, HIMS In providing the best health care to the community, hospitals as health care facilities utilize technologies that are influenced by developments and advances in medical sciences and technologies. One of such technologies is the information management technology. Since the quality of information processing is an essential factor for succesful medical care of patients, Regulation of the Minister of Health of the Republic of Indonesia Number 82 of 2013 requires all hospitals to implement a hospital information management system (HIMS). To assess the successful implementation of HIMS, various models and frameworks have been developed, including the HOT-FIT model. This study aimed to analyze the implementation of the hospital management information system at Langsa General Hospital, Aceh, Indonesia, using the HOT-FIT model which applied the SEM-PLS method. This quantitative study was performed in approximately three months using the HOT-FIT (company, technology-FIT human,) framework that includes nine variables of system quality, information quality, service quality, organization structure, facility situations, support from leadership, system usage, user satisfaction, and net benefits. Data analysis was performed using the SEM-PLS analysis in SmartPLS application (V.3.2.9). Results showed that human, organization, and technology supports were factors that influence the successful implementation of HIMS. To conclude, the HOT-FIT model can be used to identify the factors that influence the successful implementation of HIMS to inform the HIMS improvement in the hospital that will eventually improve the hospital’s quality system, information, service quality, and user satisfaction. Faculty of Medicine, Universitas Padjadjaran 2023-03-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.fk.unpad.ac.id/index.php/mkb/article/view/2808 10.15395/mkb.v55n1.280 Majalah Kedokteran Bandung; Vol 55, No 1 (2023); 13–20 Majalah Kedokteran Bandung; Vol 55, No 1 (2023); 13–20 2338-6223 0126-074x 10.15395/mkb.v55n1 eng https://journal.fk.unpad.ac.id/index.php/mkb/article/view/2808/1773 https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/2808/3415 https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/2808/3416 https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/2808/3436 https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/2808/3437 Copyright (c) 2023 Majalah Kedokteran Bandung http://creativecommons.org/licenses/by-nc/4.0

oai:ojs.journal.fk.unpad.ac.id:article/3928 2025-10-02T07:33:21Z mkb:ART

Tummy Time and Development of 6- to 12-Month-Old Infants Titah, Marvella Graceria Surjono, Edward Prabowo, Johanes A. C. Setiawan, Andy Dewi, Rita Infant development, sensory stimulation, tummy time Early childhood development, particularly within the first 1,000 days of life, is a critical period. Globally, 5–16% of children experience developmental delays. This figure is higher in Indonesia with approximately 13–18% of children under five are facing growth and developmental issues. Adequate stimulation, including activities like tummy time, plays a vital role in a child's growth and development. This study aimed to investigate the correlation between tummy time and the developmental outcomes of infants aged 6–12 months. An analytical descriptive design with a cross-sectional approach was employed in this study that was conducted at Public Health Centers in North Sulawesi Province, Indonesia. Data collection involved questionnaires assessing the onset, frequency, and duration of tummy time, alongside the use of the Child Development Pre-Screening Questionnaire. With a minimum sample size of 96 respondents, data were analyzed using Spearman’s correlation. Findings indicated that performing tummy time more than 1–2 times per week, with each session lasting 6–20 minutes, was significantly associated with better developmental outcomes. However, no significant relationship was observed between early initiation of tummy time or the number of daily sessions with infant development. The study concluded that engaging in tummy time more than 1-2 times per week for 6-20 minutes per session can promote optimal infant development. Faculty of Medicine, Universitas Padjadjaran 2025-09-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.fk.unpad.ac.id/index.php/mkb/article/view/3928 10.15395/mkb.v57.3928 Majalah Kedokteran Bandung; Vol 57, No 3 (2025); 175-180 Majalah Kedokteran Bandung; Vol 57, No 3 (2025); 175-180 2338-6223 0126-074x 10.15395/mkb.v57n3 eng https://journal.fk.unpad.ac.id/index.php/mkb/article/view/3928/pdf https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/3928/4909 https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/3928/4937 https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/3928/4938 Copyright (c) 2025 Majalah Kedokteran Bandung http://creativecommons.org/licenses/by-nc/4.0

oai:ojs.journal.fk.unpad.ac.id:article/2028 2021-07-01T02:01:22Z mkb:ART

Correlation Between Tumor Cell Differentiation and CEA Levels in Patients with Adenocarcinoma of the Rectum Rudiman, Reno Lukman, Kiki Barr, Tubagus Izzul Adenocarcinoma of the Rectum, carcinoembryonic antigen (CEA), tumor cell differentiation Adenocarcinoma of the rectum is the most common colorectal cancer in Indonesia. This cancer has the highest recurrence after curative surgical therapy with or without adjuvant therapy. With the advancing modern histopathology and molecular biology, the prognosis after therapy can be predicted through surveillance using tumor cell differentiation and carcinoembryonic antigen (CEA). The aim of this study was to analyze the correlation between tumor cell differentiation and serum CEA level in patients with adenocarcinoma of the rectum in Dr. Hasan Sadikin General Hospital Bandung, Indonesia. This was a retrospective observational analytic study conducted from January 2018- January 2019. There were 36 patients involved in this study consisting of 3 patients (8.3%) diagnosed with Stage II, 10 patients (27.7%) with Stage IIIA, 20 patients (55.5%) with stage IIIB, and 3 patients (8.3%) with stage IIIC. On histopathological examination, it was demonstrated that19 patients (52.8%) were well-differentiated, 15 patients (41.7%) were moderately differentiated, and 2 patients (5.6%) were poorly differentiated. The mean CEA level (CI 95%) for well-differentiated patients before surgery was 138.18 (15.99-260.38) ng/ml while the same level for the moderately differentiated patients was 64.34 (34.34-163.02) ng/ml. The mean CEA level for poorly differentiated patients was 1.55 (6.71-9.81) ng / ml. The result of the Kruskal Wallis test showed a p-value of 0.004. There is a strong correlation between the level of tumor cell differentiation and CEA level. Hubungan Tingkat Diferensiasi Sel Tumor dengan Kadar Ekspresi CEA Pada Pasien Adenokarsinoma Rektum Di Indonesia adenokarsinoma rektum memiliki rekurensi yang tinggi setelah terapi bedah kuratif dengan atau tanpa terapi adjuvan. Prognosisnya setelah terapi dapat  diketahui melalui surveilens dengan menggunakan Tingkat diferensiasi sel tumor dan carcinoembryonic antigen (CEA). Penelitian ini bertujuan menilai hubungan diferensiasi sel tumor dengan tingkat ekspresi CEA pada pasien adenokarsinoma rektum di RSUP Dr. Hasan Sadikin Bandung. Penelitian ini merupakan penelitian analitik observasional secara retrospektif. Pengambilan data dilakukan dari rekam medik Poliklinik Bedah Digestif dengan diagnosa adenokarsinoma rektum. Dari 36 pasien, 3 pasien (8,3%) stadium II, 10 pasien (27.7%) Stadium IIIA, 20 pasien (55,5%) stadium IIIB dan 3 pasien (8,3%) sisanya stadium IIIC. Sebanyak 19 pasien (52.8%) memiliki hasil histopatologi well differentiated, 15 pasien (41.7%) moderately differentiated dan 2 pasien (5.6%) poorly differentiated. Mean (CI 95%) kadar CEA sebelum operasi untuk well differentiated adalah 138.18(15.99-260.38) ng/mL, moderately differentiated 64.34(34.34-163.02)ng/ml, poorly differentiated 1.55(6.71-9.81)ng/mL. Uji Kruskal Wallis didapatkan nilai p=0,004 sehingga dapat disimpulkan bahwa terdapat hubungan antara tingkat diferensiasi sel tumor dengan kadar CEA  serum sebelum terapi pada pasien adenokarsinoma rektum di RSUP Hasan Sadikin Bandung. Pasien adenokarsinoma rektum preoperatif di RSUP Hasan Sadikin Bandung menunjukkan bahwa semakin baik tingkat diferensiasi sel tumornya semakin tinggi kadar CEAnya di dalam serum. Faculty of Medicine, Universitas Padjadjaran 2020-12-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.fk.unpad.ac.id/index.php/mkb/article/view/2028 10.15395/mkb.v52n4.2028 Majalah Kedokteran Bandung; Vol 52, No 4 (2020); 233–237 Majalah Kedokteran Bandung; Vol 52, No 4 (2020); 233–237 2338-6223 0126-074x 10.15395/mkb.v52n4 eng https://journal.fk.unpad.ac.id/index.php/mkb/article/view/2028/pdf https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/2028/1874 https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/2028/1897 https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/2028/1904 Copyright (c) 2020 Majalah Kedokteran Bandung http://creativecommons.org/licenses/by-nc/4.0

oai:ojs.journal.fk.unpad.ac.id:article/2245 2022-04-26T08:29:46Z mkb:ART

Three-Month Iron Supplementation as Treatment for Microcytic Hypochromic Anemia in Pregnancy Donel, Donel Novri, Dhini Aiyulie Rustam, Ruza Prima Savira, Maya Iron supplementation, microcytic hypochromic anemia, pregnancy In pregnant women there is a twofold increase in iron requirements due to increased blood volume without the expansion of plasma volume. Pregnant women are very prone to suffering from iron deficiency anemia. Iron deficiency anemia generally has an erythrocyte index which represents  hypochromic microcytic. This study aimed to determine the effect of three-month iron tablet supplementation as a therapy against microcytic hypochromic anemia in pregnancy. This was a quantitative quasi-experimental study using pre-test and post-test design. The study was conducted in May-September 2020 at the Arifin Achmad Regional General Hospital, Riau Province, Indonesia. Subjects were 30 pregnant women with microcytic hypochromic anemia. Primary data were analyzed using statistical paired sample t-tests. Results showed that there was an increase in hemoglobin levels after the supplementation of iron tablet from an average of 9.1 ± 1.2 gr/dl to 11.8 ± 1.0 g/dl. This change was significant based on the results of the T-test (p-0.003) Thus, iron supplementation for three month significantly increases hemoglobin levels in pregnant women. Faculty of Medicine, Universitas Padjadjaran 2021-06-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.fk.unpad.ac.id/index.php/mkb/article/view/2245 10.15395/mkb.v53n2.2245 Majalah Kedokteran Bandung; Vol 53, No 2 (2021); 83-86 Majalah Kedokteran Bandung; Vol 53, No 2 (2021); 83-86 2338-6223 0126-074x 10.15395/mkb.v53n2 eng https://journal.fk.unpad.ac.id/index.php/mkb/article/view/2245/pdf https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/2245/2202 https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/2245/2203 https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/2245/2204 Copyright (c) 2021 Majalah Kedokteran Bandung http://creativecommons.org/licenses/by-nc/4.0

oai:ojs.journal.fk.unpad.ac.id:article/3508 2024-10-08T08:39:10Z mkb:ART

Neurodegenerative and Neurobehavioral Symptoms in Jember Agricultural Workers Caused by Oxidative Stress and Neurotransmitter Disturbance Narwanto, Muhammad Ihwan Purwandhono, Azham Sofiana, Kristianningrum Dian Febianti, Zahrah Jauhani, Muhammad Afiful Kusumastuti, Inke Putri, Elvia Rahmi Marga medicine, biomedic, community Cholinesterase, cognitive, depression, malondialdehyde, pesticides Increased use of pesticides can have detrimental health consequences, one of which is chronic neurotoxicity. The symptoms include degenerative and neurobehavioral issues. Chronic neurotoxicity occurs through oxidative stress, inflammation, and neurotransmitter disturbances. This study aimed to determine chronic neurotoxicity and test malondialdehyde and cholinesterase levels as neurotoxicity biomarkers among agricultural workers in Wuluhan, Jember, Indonesia. The 60-person research sample was divided into two groups: agricultural and non-agricultural workers. The interview utilized a mini-mental score examination, Chan's questionnaire, and the Patient Health Questionnaire to analyze the cognitive impairment, Parkinsonism, and depressive symptoms. The examination of serum malondialdehyde levels was performed using the TBARS method and cholinesterase levels by photometric kinetic method at a biochemistry laboratory from October to November 2022. Results showed cognitive impairment and depressive symptoms in agricultural workers, as well as high levels of malondialdehyde and low cholinesterase levels. This study concludes the presence of chronic pesticide neurotoxicity among agricultural workers in Jember, Indonesia, and that malondialdehyde and cholinesterase levels might serve as biomarkers of pesticide-induced neurotoxicity. Faculty of Medicine, Universitas Padjadjaran Jember University 2024-06-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.fk.unpad.ac.id/index.php/mkb/article/view/3508 10.15395/mkb.v56.3508 Majalah Kedokteran Bandung; Vol 56, No 2 (2024); 88-94 Majalah Kedokteran Bandung; Vol 56, No 2 (2024); 88-94 2338-6223 0126-074x 10.15395/mkb.v56n2 eng https://journal.fk.unpad.ac.id/index.php/mkb/article/view/3508/pdf https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/3508/4313 https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/3508/4314 Copyright (c) 2024 Majalah Kedokteran Bandung http://creativecommons.org/licenses/by-nc/4.0

oai:ojs.journal.fk.unpad.ac.id:article/2687 2023-11-23T03:19:13Z mkb:ART

Laparoscopic Ventral Mesh Fixation in Patients with Pelvic Organ Prolapse Imanova, Solmaz Zeynalov, B. M. Akyol, Cihangir Laparoscopic sacrocolpopexy, laparoscopic sacrocolporectopexy, pelvic organ, prolapse, vaginal plastic surgery Pelvic organ prolapse (POP) is a condition with a high incidence rate and often creates difficulties in surgical coloproctology and gynecology. The aim of this study was to evaluate the effectiveness of laparoscopic ventral reticular sacrocolporectopexy and sacrorectopexi in women and men with POP, respectively. This study was conducted at the Educational-Surgical Clinic of Azerbaijan Medical University and Department of Surgery of the Faculty of Medicine of Ankara University (2016-2019) on 21 patients with POP (15 women and 6 men). Results of diagnostics and surgical treatment of POP were studied with preferences towards endoscopic, radiation, and functional methods. The surgical methods used in these patients included laparoscopic fixation methods (sacrocolpopexy, sacrocolporectopexy) of protruding organs (uterus, vaginal vault/vaginal cuff, rectum) and simultaneous vaginal (colporrhaphy, colpolevatoroplasty, vaginal plastic surgery) and proctological surgeries (circulatory resection, hemorrhoidectomy, sphincteroplasty). The findings demonstrated that the most progressive POP mostly occurred in women of premenopausal age and during menopause. Based on the results of the long-term evaluation of the surgical treatment (6-12 months), the rates of recurrence of prolapse and complications were low (up to 4.8% and 9.5%, respectively) with favorable long-term functional results,  such as a decrease in the degree of fecal incontinence and constipation, observed in the evaluation. Due to the concomitant weakness of the ligamentous apparatus of the pelvic floor in these patients, there is the need for intra-abdominal apical support of organs. In conclusion, that laparoscopic sacrocolpopexy in women and sacrorectopexy in men are reliable surgical method to treat POP. However, specific skills need to be acquired by both gynecologist and coloproctologist to be able to do these laparoscopic surgery techniques. Faculty of Medicine, Universitas Padjadjaran 2022-03-31 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.fk.unpad.ac.id/index.php/mkb/article/view/2687 10.15395/mkb.v54n1.2687 Majalah Kedokteran Bandung; Vol 54, No 1 (2022); 1-6 Majalah Kedokteran Bandung; Vol 54, No 1 (2022); 1-6 2338-6223 0126-074x 10.15395/mkb.v54n1 eng https://journal.fk.unpad.ac.id/index.php/mkb/article/view/2687/pdf https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/2687/3198 https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/2687/3199 Copyright (c) 2022 Majalah Kedokteran Bandung http://creativecommons.org/licenses/by-nc/4.0

oai:ojs.journal.fk.unpad.ac.id:article/3412 2025-10-15T07:09:04Z mkb:ART

Characteristics and Risk Factors of Diabetic Retinopathy Patients in West Java, Indonesia Setiawan, Grace Rini, Mayang Ratnaningsih, Nina Memed, Feti Karfiati Dahlan, Muhammad Rinaldi Medicine; Ophthalmology; Public Health Diabetic retinopathy, public health, screening program Diabetic retinopathy (DR) is the major microvascular complication of diabetes mellitus (DM) and responsible as the leading cause of vision loss among working-age adults. With the estimated DM cases reaching 578 million in 2030, public health systems are faced with challenges of increasing costs of implementation and maintenance of DR screening program in people with DM. This study aimed to describe characteristics and risk factors of DR among patients of a Primary Health Care Center in West Java, Indonesia. This was a cross-sectional study during the period of March 2021 until June 2022 on 1,080 participants. Among these participants with DM, 28.89% (25.16–33.12% [95% CI]) were classified to have DR. A total of 32.69% (28.14–36.71 [95% CI]) participants with DR had vision threatening DR (VTDR). The prevalence of DR in this study was higher in women (77.23%) with a mean age of 57.26 ± 9.17 and duration of DM of ≥5-years (56.01%), blood glucose level <200 mg/dL (63.79%), high systolic blood pressure (52.03%), high diastolic blood pressure (39.07%), normal BMI (55.5%), high waist circumference (43.7%), and high HbA1C (3.42%). A total of 1,041 (96.39%) participants were using antidiabetic drugs, and 9.63% of them were currently smoking. This study showed that diastolic blood pressure, abnormal abdominal circumference, and high HbA1C levels were more prevalent in DR and VTDR groups. The findings of this study represent the current characteristics of DR patients in West Java and can be used as a baseline or comparison data for other regions in Indonesia. Faculty of Medicine, Universitas Padjadjaran 2024-12-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.fk.unpad.ac.id/index.php/mkb/article/view/3412 10.15395/mkb.v56.3412 Majalah Kedokteran Bandung; Vol 56, No 4 (2024); 303-308 Majalah Kedokteran Bandung; Vol 56, No 4 (2024); 303-308 2338-6223 0126-074x 10.15395/mkb.v56.n4 eng https://journal.fk.unpad.ac.id/index.php/mkb/article/view/3412/pdf https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/3412/4188 https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/3412/4289 Copyright (c) 2024 Majalah Kedokteran Bandung http://creativecommons.org/licenses/by-nc/4.0

oai:ojs.journal.fk.unpad.ac.id:article/2666 2023-02-15T02:48:57Z mkb:ART

Correlation between Albumin, Colon Leakage Score (CLS), and Anastomotic Leakage after Colorectal Cancer Resection Rudiman, Reno Hapsari, Putie Indrajaya, Novi Christina Medicine anastomotic leakage, anastomotic resection, albumin, colorectal cancer, colon leakage score Anastomotic leakage is still the most undesirable complication of colorectal surgery. The reported incidence of anastomotic leakage after colorectal surgery varies from 1.8% to 15.9%. The impact of anastomotic leakage is increased morbidity, mortality (12–30%), length of stay, and cost of hospitalization; hence, this complication should be prevented as much as possible.Several studies have shown a correlation between low albumin levels and increased anastomotic leakage.The Colon Leakage Score (CLS) is a standard score for predicting anastomotic leakage, but this score does not include the albumin level as a parameter of anastomotic leakage despite the importance of the albumin level’s contribution on the anastomotic leakage. Therefore, this study sought to analyze the correlation between the albumin level, CLS, and the incidence of anastomotic leakage after anastomotic resection surgery in colorectal cancer (CRC) patients at Dr. Hasan Sadikin General Hospital Bandung, Indonesia. This study was a cross-sectional retrospective analytical study on medical records of CRC patients over the age of 18 who underwent intestinal anastomotic resection surgery between 2016–2020. There were thirty-two patients with colorectal cancer underwent anastomotic resection during the study period, with two patients experienced anastomotic leakage. Correlation analysis showed that the correlation coefficient for the albumin level and anastomotic leakage was 0.209, while the correlation coefficient between CLS and anastomotic leakage was 0.110. There is no correlation between albumin level, CLS, and the incidence of anastomotic leakage after anastomotic resection surgery in CRC patients treated at Dr. Hasan Sadikin General Hospital Bandung, Indonesia Faculty of Medicine, Universitas Padjadjaran 2022-12-31 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.fk.unpad.ac.id/index.php/mkb/article/view/2666 10.15395/mkb.v54n4.2666 Majalah Kedokteran Bandung; Vol 54, No 4 (2022); 228-234 Majalah Kedokteran Bandung; Vol 54, No 4 (2022); 228-234 2338-6223 0126-074x 10.15395/mkb.v54n4 eng https://journal.fk.unpad.ac.id/index.php/mkb/article/view/2666/pdf https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/2666/3159 https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/2666/3160 Copyright (c) 2022 Majalah Kedokteran Bandung http://creativecommons.org/licenses/by-nc/4.0

oai:ojs.journal.fk.unpad.ac.id:article/3919 2025-07-08T07:46:25Z mkb:ART

Acute Toxicity (LD50 value) of Peppermint (Mentha piperita) Suspension in Female Mice Andriyanto, Andriyanto Aurelia, Sharon Zilviana, Tengku Hibban, Muhammad Farhan Ibnu Putra, Hamdika Yendri animal science; herbs; toxicity Acute toxicity, Alternative medicine, Herbs, Mice, Peppermint Peppermint has several benefits, such as antibacterial, anti-inflammatory, and antifungal properties, that leads to its use in various products, especially in herbal medicine. This study aimed to evaluate the LD50 value of peppermint suspension through an acute toxicity test. This study was conducted at the Animal Laboratory Management Unit of the School of Veterinary Medicine and Biomedical Sciences, IPB University, from October 9 to 30, 2024. A total of 25 female mice were divided into 5 groups, and given different doses of peppermint suspension of 0, 0.5, 1, 1.5, and 2.0 g/kgBW. Observations were then carried out for 14 days on the parameters of body weight, physiological responses, clinical symptoms, absolute and relative organ weight, body weight, and number of mortalities per day. Results showed that the highest mortality was found in the groups administered with a 1.5 and 2.0 g/kgBW of peppermint suspension. Clinical symptoms, such as hair standing, lethargies, and decreased locomotor activity were also observed in these groups. In addition, the administration of peppermint suspension in mice had no significant effect on body weight, as well as on absolute and relative organ weight, It was also demonstrated that organs collected did not present any significant lesion. Thus, the acute toxicity test of peppermint suspension  showed no macroscopic lesion or changes in organs and body weight. The LD50 value suggested that the is in the moderate toxicity category, with an LD50 value of 1.92 g/kgBW. Faculty of Medicine, Universitas Padjadjaran 2025-06-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.fk.unpad.ac.id/index.php/mkb/article/view/3919 10.15395/mkb.v57.3919 Majalah Kedokteran Bandung; Vol 57, No 2 (2025); 128-135 Majalah Kedokteran Bandung; Vol 57, No 2 (2025); 128-135 2338-6223 0126-074x 10.15395/mkb.v57n2 eng https://journal.fk.unpad.ac.id/index.php/mkb/article/view/3919/pdf https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/3919/4890 https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/3919/4891 Copyright (c) 2024 Majalah Kedokteran Bandung http://creativecommons.org/licenses/by-nc/4.0

oai:ojs.journal.fk.unpad.ac.id:article/1712 2021-12-26T06:04:25Z mkb:ART

Effect of Iron Supplementation in Anti-Tuberculosis Drug Treatment on Interferon-γ Level in Tuberculosis Spondylitis Patients Perdana, M. F. Nanda Rasyid, Hermawan Nagar Ramdan, Ahmad Ismiarto, Yoyos Dias Medicine; Orthopaedic and Traumatology nterferon-γ, iron supplementation, spondylitis TB Tuberculosis (TB) is still one of the major health problems in the community. Micronutrients, including iron, are crucial in the body's defense mechanism. Iron modulates the activation of IFN-γ, which in turn will activate the macrophages. This study explores the effect of iron supplementation given with anti-tuberculosis drug therapy on the IFN-γ level in tuberculosis spondylitis patients. This was a single-blind randomized control trial study at Dr. Hasan Sadikin General Hospital Bandung, from December 2018 to March 2019, using the consecutive sampling approach. Thirty-four respondents with category 1 TB spondylitis and an sTfR level of> 21.7 pg /µL were recruited and randomized into control and experimental groups. The control group (n=17) was treated with 2 RHZE for 2 months while the experimental group (n=17) received 2 RHZE and iron tablet for 2 months. An increase in the IFN-γ level of the experimental group was observed from an average of 21.7 pg/ml before therapy to an average of 72.39 pg/mL after therapy. Meanwhile, the IFN-γ level in the control group increases from an average of 22.5 pg/mL to an average of 35.35 pg/mL. This difference was statistically significant based on the analysis using the independent t-test (p-value <0.05). Therefore, the administration of anti-tuberculosis drugs with the addition of iron can increase the body's immune response, which is indicated by the increasing level of IFN-γ.Pengaruh Penambahan Zat Besi Pada Pengobatan Obat Anti Tuberkulosis Terhadap Kadar Interferon-γ Pada Pasien Spondilitis Tuberkulosis Tuberkulosis (TB) masih merupakan salah satu masalah kesehatan yang cukup besar di masyarakat. Gangguan imunitas tubuh penderita berperan dalam proses terjadinya infeksi tuberculosis. Mikronutrient yang penting dalam pertahanan tubuh salah satunya adalah zat besi. Pada penelitian ini akan dipelajari mengenai pengaruh penambahan zat besi pada terapi OAT terhadap kadar IFN-γ pada pasien spondilitis tuberkulosis. Penelitian ini merupakan penelitian dengan metode single blind randomized control trial di Rumah Sakit Dr. Hasan Sadikin Bandung pada Desember 2018 hingga Maret 2019, dengan metode pengambilan sampel consecutive sampling. Dilakukan randomisasi pada 34 responden. Responden yaitu: penderita spondilitis TB kategori 1 dengan kadar sTfR >21,7 pg/µL. Kelompok kontrol 17 responden diterapi 2 RHZE. Kelompok eksperimen 17 responden diterapi 2 RHZE dengan tablet besi selama 2 bulan. Pada penelitian ini didapatkan peningkatan kadar IFN-γ rata-rata kelompok eksperimen (pemberian obat anti tuberkulosis dengan penambahan zat besi) dari 21,7 pg/mL sebelum dilakukan pemberian terapi menjadi rata-rata 72,39 pg/mL setelah dilakukan pemberian terapi diuji dengan uji t sampel independen (nilai p<0,05), secara statistik berbeda signifikan dengan kelompok kontrol (pemberian obat anti tuberkulosis), yaitu dari 22,5 pg/mL sebelum dilakukan pemberian terapi menjadi rata-rata 35,35 pg/mL setelah dilakukan pemberian terapi.  Simpulan, pemberian obat anti tuberkulosis dengan penambahan zat besi dapat meningkatkan respon imun tubuh, yang ditandai dengan meningkatnya kadar IFN-γ. Faculty of Medicine, Universitas Padjadjaran 2020-09-28 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.fk.unpad.ac.id/index.php/mkb/article/view/1712 10.15395/mkb.v52n3.1712 Majalah Kedokteran Bandung; Vol 52, No 3 (2020); 154-159 Majalah Kedokteran Bandung; Vol 52, No 3 (2020); 154-159 2338-6223 0126-074x 10.15395/mkb.v52n3 eng https://journal.fk.unpad.ac.id/index.php/mkb/article/view/1712/pdf https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/1712/1259 https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/1712/2897 Copyright (c) 2020 Majalah Kedokteran Bandung http://creativecommons.org/licenses/by-nc/4.0

oai:ojs.journal.fk.unpad.ac.id:article/3134 2024-03-14T03:01:06Z mkb:ART

Correlation Between Pre-Chemotherapy AMH Level, Menstrual Status, and Prediction of Ovarian Function Recovery after FAC Chemotherapy AMH in Breast Cancer Patients Abdurahman, Maman Rizki, Kiki Ahmad Pringadi, Adi Zufron Anti-Mullerian hormone, breast neoplasms, chemotherapy Around 52.6% of women aged <50 years in Indonesia are diagnosed with breast cancer. One of the chemotherapy regimens with a toxicity effect on reproductive function, especially ovarian follicles, is 5-fluorouracil-doxorubicin-cyclophosphamide (FAC). Anti-Mullerian Hormone (AMH) is a biomarker that can be used to assess the ovarian function. This study aimed to determine the correlation between pre-chemotherapy AMH serum level, menstrual status, and whether the AMH serum level can predict ovarian function recovery in pre-menopausal women receiving FAC chemotherapy. This was an analytical observational study with a prospective cohort design performed in Dr. Hasan Sadikin General Hospital, Bandung, Indonesia, during 2021-2022. Data were analyzed using correlation analysis. Subjects were breast cancer patients aged ≤45 years, still of reproductive age, with no prior history of chemotherapy, and were undergoing the FAC chemotherapy. All 32 patients who met the inclusion criteria were included in this study. There was a significant difference (p 0.0001) between pre- and post-6 cycles of chemotherapy AMH levels. Post-6 cycles of chemotherapy showed lower AMH levels. There was a high correlation (p 0.0034) between pre-chemotherapy AMH level and menstrual status six months after six cycles of chemotherapy. The correlation test between post-chemotherapy AMH level and menstrual status showed a non-significant result. Thus, there is a high statistical correlation between pre-chemotherapy anti-Mullerian hormone levels in pre-menopausal women with breast cancer and the menstrual status after FAC chemotherapy which demonstrates that the AMH level could also be used to predict ovarian function recovery. Faculty of Medicine, Universitas Padjadjaran 2023-09-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.fk.unpad.ac.id/index.php/mkb/article/view/3134 10.15395/mkb.v55n3.3134 Majalah Kedokteran Bandung; Vol 55, No 3 (2023); 181-185 Majalah Kedokteran Bandung; Vol 55, No 3 (2023); 181-185 2338-6223 0126-074x 10.15395/mkb.v55n3 eng https://journal.fk.unpad.ac.id/index.php/mkb/article/view/3134/pdf https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/3134/3788 https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/3134/3816 Copyright (c) 2022 Majalah Kedokteran Bandung http://creativecommons.org/licenses/by-nc/4.0

oai:ojs.journal.fk.unpad.ac.id:article/4283 2026-01-21T05:05:08Z mkb:ART

Effects of Propofol and Thiopental on Brain Relaxation and Hemodynamic Response to Craniotomy Supratentorial Tumors Removal Valentino, Andrea Wijaya, Wan Novriza Anggraeni, Novita Sony, Sony medicine, Anesthesiology Brain relaxation, craniotomy, hemodynamics, neuroanesthetics, supratentorial tumors Surgical procedures for brain tumors, particularly supratentorial tumor removal via craniotomy, present challenges related to brain relaxation and maintaining hemodynamic stability. The choice of intravenous anesthetics, such as Propofol and Thiopental, is crucial due to their distinct effects on intracranial pressure (ICP), cerebral blood flow (CBF), and hemodynamic parameters. This study aimed to compare the effects of Propofol and Thiopental on brain relaxation and hemodynamic responses during supratentorial tumor removal. A randomized experimental study was conducted at Arifin Achmad General Hospital, Riau, Indonesia, from May to September 2024 involving patients undergoing elective craniotomy for supratentorial tumors. Patients were divided into two groups: the Propofol group (1-3 mg/kg body weight, with maintenance of 50-100 µg/kg/min) and the Thiopental group (4-6 mg/kg body weight, with maintenance of 100-200 µg/kg/min), both receiving continuous infusion until a bispectral index of 40-60 was achieved. Hemodynamic parameters, including systolic blood pressure, diastolic blood pressure, mean arterial pressure (MAP), and heart rate, were measured at various stages: before induction, during surgery, and at multiple intervals. Brain relaxation was subjectively assessed by a neurosurgeon using a four-point scale. Results showed that 90% of subjects receiving Thiopental experienced good brain relaxation during duramater opening, compared to 70% in the Propofol group, though this difference was not statistically significant (p=0.118). Hemodynamically, the Thiopental group exhibited higher diastolic blood pressure and MAP at induction (p<0.05). In conclusion, Thiopental demonstrated superior hemodynamic stability, albeit both agents provided equally effective brain relaxation. Faculty of Medicine, Universitas Padjadjaran 2025-12-31 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.fk.unpad.ac.id/index.php/mkb/article/view/4283 10.15395/mkb.v57.4283 Majalah Kedokteran Bandung; Vol 57, No 4 (2025); 319-327 Majalah Kedokteran Bandung; Vol 57, No 4 (2025); 319-327 2338-6223 0126-074x 10.15395/mkb.v57n4 eng https://journal.fk.unpad.ac.id/index.php/mkb/article/view/4283/pdf https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/4283/5452 https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/4283/5453 https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/4283/5454 https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/4283/5455 https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/4283/5456 https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/4283/5531 Copyright (c) 2025 Majalah Kedokteran Bandung http://creativecommons.org/licenses/by-nc/4.0

oai:ojs.journal.fk.unpad.ac.id:article/1988 2021-08-30T12:43:38Z mkb:CR

Rare Case of Periampullary Duodenal Carcinoma Maghfirah, Desi Abubakar, Azzaki Yusuf, Fauzi Riswan, Muhammad Internal medicine Adenocarninoma, duodenal carcinoma periampullary, whipple Periampullary carcinoma is a malignancy that appears around the vatteri ampulla. This malignancy can originate from the pancreas, duodenum, and distal choledochal duct. Duodenal cancer is a very rare case, only about 0.3% of the gastrointestinal malignancies. Reported cases are increasing with the increasing use of esophagogastroduodenoscopy. The most frequently found carcinomas of the duodenum include adenocarcinoma, carcinoid, lymphoma, and leiomyosarcoma. The symptoms of these carcinomas are often not specific so the diagnosis is often late, leading to a poor prognosis. Early diagnosis and proper therapy provide a good prognosis.  The case reported here representeda 52-year-old woman presented with hematemesis melena, anemia, jaundice, epigastric mass, right hypochondrial pain, and weight loss. From the esophagogastroduodenoscopy, the mass was found to obstruct half of the duodenum lumen and bleeding, which was easily triggered, was observed in the second part of the duodenum. CT scan revealed a mass in the head of the pancreas with gall bladder hydrops and obstruction of the intra and extra-hepatic billier system. After a Whipple operation Laparotomy, the histology showed papillary adenocarcinoma duodenum. Patients then underwen chemotherapy with 5 fluorouracil regimen. Patient's clinical condition is currently improving and no complaint is conveyed by the patient. Faculty of Medicine, Universitas Padjadjaran 2021-03-31 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.fk.unpad.ac.id/index.php/mkb/article/view/1988 10.15395/mkb.v53n1.1988 Majalah Kedokteran Bandung; Vol 53, No 1 (2021); 57–62 Majalah Kedokteran Bandung; Vol 53, No 1 (2021); 57–62 2338-6223 0126-074x 10.15395/mkb.v53n1 eng https://journal.fk.unpad.ac.id/index.php/mkb/article/view/1988/pdf https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/1988/1842 Copyright (c) 2021 Majalah Kedokteran Bandung http://creativecommons.org/licenses/by-nc/4.0

oai:ojs.journal.fk.unpad.ac.id:article/3334 2024-10-08T08:39:36Z mkb:CR

Bilateral Optic Nerve Atrophy Case Report Naqeeb, Mohammed R. Abdulmannan, Dina M Medicine Atrophy, optic nerve, wolfram syndrome, Saudi Arabia Wolfram syndrome, also known as DIDMOAD or juvenile onset diabetes mellitus, optic nerve atrophy, diabetes insipidus, and deafness, is a genetic neurological condition. This case report provides a description on the first instance of Wolfram syndrome in a Saudi family, which manifested as proliferative diabetic retinopathy and a powder-like cataract, among the other unusual ophthalmological findings. This case involved a 27-year-old Saudi woman with bilateral optic nerve atrophy who was first diagnosed with diabetes mellitus at the age of 8 years. At the age of 18, bilateral optic nerve atrophy was identified. At the age of 27, diabetes insipidus and hearing loss were verified. There were no signs of renal, neurological, or psychiatric issues. Atypical ophthalmological traits were examined and addressed in this study. Any individual with bilateral optic nerve atrophy and insulin-dependent diabetes mellitus within the first 30 years of life should be evaluated for the possibility of Wolfram syndrome. Microvascular diabetes is an incredibly rare complication of Wolfram syndrome. Early diagnosis, treatment, and prevention of severe consequences can result in improved survival rates and quality of life. Faculty of Medicine, Universitas Padjadjaran 2024-03-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.fk.unpad.ac.id/index.php/mkb/article/view/3334 10.15395/mkb.v56.3334 Majalah Kedokteran Bandung; Vol 56, No 1 (2024); 69-72 Majalah Kedokteran Bandung; Vol 56, No 1 (2024); 69-72 2338-6223 0126-074x 10.15395/mkb.v56n1 eng https://journal.fk.unpad.ac.id/index.php/mkb/article/view/3334/pdf https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/3334/4076 https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/3334/4098 Copyright (c) 2023 Majalah Kedokteran Bandung http://creativecommons.org/licenses/by-nc/4.0

oai:ojs.journal.fk.unpad.ac.id:article/2460 2022-02-04T04:04:23Z mkb:ART

Accuracy of Urine Cytology In Detecting Bladder Cancer Syahreza, Ahlan Safriadi, Ferry Medicine; Urology bladder cancer; diagnostic; histopathology; sensitivity; urine cytology One of the most prevalent and deadly cancers in men is bladder cancer. To achieve the best possible outcome, physicians need to diagnose it promptly. The gold standard for diagnosis is tissue biopsy, but this method is invasive. There is another option for non-invasive diagnostic using urine cytology. The purpose of this study was to measure the accuracy of urine cytology in diagnosed bladder cancer patients. This study extracted data from patients medical records in a tertiary hospital in Indonesia from 2009–2019. The diagnostic accuracy was then compared between urine cytology and biopsy as the gold standard. Data on subjects’ baseline characteristics and diagnostic accuracy (sensitivity, specificity, PPV, and NPV) were collected. Results were then stratified according to the American Joint Committee on Cancer pathology staging for bladder cancer. Of 124 study subjects, male was more dominant (male,88% versus female, 12%) Seventy-five patients had a T1-tumor stage. Overall, the diagnostic accuracy was as follows:sensitivity, 47.8%; specificity, 90.9%; PPV, 98.2%; and NPV, 14.5%. High-grade tumors were shown to have a higher sensitivity. The highest accuracy was found in the MIBC grade T3, which was 90.68%. For diagnostic accuracy, urine cytology offered high specificity, but low sensitivity. The exploration of other markers is needed to establish a non-invasive but accurate method to diagnose bladder cancer. Faculty of Medicine, Universitas Padjadjaran 2021-12-31 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.fk.unpad.ac.id/index.php/mkb/article/view/2460 10.15395/mkb.v53n4.2460 Majalah Kedokteran Bandung; Vol 53, No 4 (2021); 240-244 Majalah Kedokteran Bandung; Vol 53, No 4 (2021); 240-244 2338-6223 0126-074x 10.15395/mkb.v53n4 eng https://journal.fk.unpad.ac.id/index.php/mkb/article/view/2460/pdf https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/2460/2643 https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/2460/2647 https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/2460/2648 https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/2460/2775 Copyright (c) 2021 Majalah Kedokteran Bandung http://creativecommons.org/licenses/by-nc/4.0

oai:ojs.journal.fk.unpad.ac.id:article/3794 2025-10-15T07:09:04Z mkb:ART

Phenotypic and Molecular Detection of Carbapenemase-Producing Acinetobacter baumannii Strains from Clinical Specimens in Dezful Teaching Hospital Behnaz, Deihim Khorramizadeh, Maryam A. baumannii; Carbapenem resistance; Carbapenemase; Genotyping Nowadays, antibiotic resistance in bacteria has become a global problem. Therefore, the identification of resistant strains of bacteria has attracted special attention in a pursue to choose more effective treatment solutions. One of the most common mechanisms of resistance is the production of carbapenemase enzyme in Acinetobacter baumannii. This present study aimed to detect carbapenemase-producing strains by phenotypic and molecular methods in clinical specimens collected in Ganjavian Hospital of Dezful between June 2021 and May 2022. Antimicrobial susceptibility testing was performed using the Kirby-Bauer disk diffusion and Etest assay, while the extended-spectrum beta-lactamase production (ESBLs) and Metalobetalactamases (MBLs) were detected by combined disk method using ceftazidime and ceftazidime/clavulanic acid disks and imipenem and imipenem /EDTA disks, respectively. Molecular detection of blaIMP, blaSPM, blaOXA-23, and blaOXA-24, blaOXA-58, blaGES genes was performed. Of a total of 54 strains, the highest resistance rate was for cephalosporins (98.1%), and ciprofloxacin (94.2%), in contrast to minocycline (13%). ESBL and MBL producers were 26% and 80%, respectively. All isolates had intermediate resistance against colistin. The most prevalent gene in the carbapenem-resistant A. baumannii (CRAB) was blaOXA-23, followed by blaOXA-24, blaGES, blaIMP, and blaOXA-58 genes. Present report highlights the existence of CRAB and intermediate resistance to colistin and also the co-existence of several genes from different carbapenemase classes in this region. Therefore, resistant strains should be identified promptly and specific treatment protocols should be devised to control the dissemination of resistance genes in therapeutic settings. Faculty of Medicine, Universitas Padjadjaran 2024-12-31 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.fk.unpad.ac.id/index.php/mkb/article/view/3794 10.15395/mkb.v56.3794 Majalah Kedokteran Bandung; Vol 56, No 4 (2024); 235-243 Majalah Kedokteran Bandung; Vol 56, No 4 (2024); 235-243 2338-6223 0126-074x 10.15395/mkb.v56.n4 eng https://journal.fk.unpad.ac.id/index.php/mkb/article/view/3794/pdf https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/3794/4748 https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/3794/4749 Copyright (c) 2024 Majalah Kedokteran Bandung http://creativecommons.org/licenses/by-nc/4.0

oai:ojs.journal.fk.unpad.ac.id:article/2648 2023-11-23T03:16:33Z mkb:ART

Efficacy and Safety of Micropulse Transscleral Cyclophotocoagulation Use in Refractory Glaucoma Patients Gustianty, Elsa Prahasta, Andika Rifada, R. Maula Tjokrovonco, Ludwig Melino Medicine Glaucoma, laser, micropulse transscleral cyclophotocoagulation Glaucoma is the leading cause of irreversible blindness worldwide. Micropulse Transscleral Cyclophotocoagulation (MP-TSCPC) is a new method for treatment for refractory glaucoma with lesser complications than coventional TSCPC. This study aimed to evaluate the effectiveness and safety of MP-TSCPC (IRIDEX IQ810 Laser systems, CA) for refractory glaucoma treatment. This was a retrospective study using data obtained from the medical records of patients who underwent a MP-TSCPC procedure at Cicendo National Eye Hospital from July 2018 to September 2019. The outcomes measured were success rate (IOP decreased ≥30% from baseline with or without anti glaucoma medication at first month follow up) and post-operative complications. Fifty-seven eyes from 56 patients with a mean age of 57 years old underwent MP-TSCPC with 3 month follow up. The mean pre-operative intraocular pressure (IOP) dropped from 51.8 mmHg to 36.0 mmHg at 1 month follow up and 36.8 mmHg at the final follow up, representing an IOP decrease of 31% (1 month) and 28% (3 month). There was also a decrease of anti glaucoma medication usage from 2.51 to 2.16. The overall success rate at 1 month follow up was 49% and only 5% complication were found in this study. MP-TSCPC is safe and effective for lowering IOP and decreasing the need of anti glaucoma -medications in refractory glaucoma case. Further long-term evaluation and comparison to conventional TSCPC are still necessary. Faculty of Medicine, Universitas Padjadjaran 2022-09-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.fk.unpad.ac.id/index.php/mkb/article/view/2648 10.15395/mkb.v54n3.2648 Majalah Kedokteran Bandung; Vol 54, No 3 (2022); 166–171 Majalah Kedokteran Bandung; Vol 54, No 3 (2022); 166–171 2338-6223 0126-074x eng https://journal.fk.unpad.ac.id/index.php/mkb/article/view/2648/pdf https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/2648/3129 https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/2648/3130 https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/2648/3131 https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/2648/3132 https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/2648/3170 Copyright (c) 2022 Majalah Kedokteran Bandung http://creativecommons.org/licenses/by-nc/4.0

oai:ojs.journal.fk.unpad.ac.id:article/3854 2025-10-15T07:01:31Z mkb:ART

Acid-Base and Electrolytes Profile in Critically Ill Pediatric Patients Admitted to Pediatric Intensive Care Unit (PICU) Khairunnisa, Alya Roosrahima Peryoga, Stanza Uga Widiasta, Ahmedz Medicine;Health Sciences acid-base, critically ill, electrolyte, pediatric intensive care units Critically ill pediatric patients are known to experience more frequent episodes of acid-base and electrolyte imbalances when compared to adults, which can significantly impact morbidity and mortality with higher mortality rates and longer hospital stays. Data on the profile of acid-base and electrolyte imbalances in critically ill pediatric patients is very limited in Indonesia. This study was conducted to describe the electrolytes and acid-base profile of critically ill pediatric patients admitted to the Pediatric Intensive Care Unit (PICU). This was a cross-sectional study using secondary data from medical records of critically ill pediatric patients aged 1 month to 18 years admitted to the PICU of Dr. Hasan Sadikin General Hospital, Bandung, Indonesia, from January 1 to December 31, 2021. Results indicated that 131 (50.8%) of 258 patients experienced electrolytes and acid-base imbalances. The majority of patients were boys (53.0%) and infants (32.8%). The most common primary diagnosis was respiratory (28.2%), central nervous system (19.8%), and gastrointestinal disorders (15.3%). A total of 366 electrolyte imbalance events and 111 acid-base imbalance events were recorded. The most common electrolyte imbalance events were hyponatremia (75.6%), hypocalcemia (48.9%), and hypokalemia (42.7%), respectively, while the most frequent acid-base imbalance events were respiratory alkalosis (33.6%) and metabolic acidosis (21.4%). Electrolyte and acid-base imbalances are common among critically ill pediatric patients in PICU. Thus, early evaluation and recognition of acid-base and electrolyte imbalances are crucial in order to prevent poor outcomes in these patients. Faculty of Medicine, Universitas Padjadjaran 2025-03-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.fk.unpad.ac.id/index.php/mkb/article/view/3854 10.15395/mkb.v57.3854 Majalah Kedokteran Bandung; Vol 57, No 1 (2025); 43-52 Majalah Kedokteran Bandung; Vol 57, No 1 (2025); 43-52 2338-6223 0126-074x 10.15395/mkb.v57n1 eng https://journal.fk.unpad.ac.id/index.php/mkb/article/view/3854/pdf https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/3854/4794 https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/3854/4798 Copyright (c) 2024 Majalah Kedokteran Bandung http://creativecommons.org/licenses/by-nc/4.0

oai:ojs.journal.fk.unpad.ac.id:article/2004 2022-03-21T03:53:23Z mkb:ART

Translation and Validation of Indonesian Version of Scleroderma Health Assessment Questionnaire Defi, Irma Ruslina Jennie, Jennie Vitriana, Vitriana Arisanti, Farida Rehabilitation Medicine, Health Science SHAQ; Short Form 36; Systemic sclerosis; VAS Systemic sclerosis (SSc) or Scleroderma is a chronic autoimmune disease characterized by vasculopathy, fibrosis, and autoimmunity. Scleroderma Health Assessment Questionnare (SHAQ) is a measurement of SSc that is more specific than Health Assessment Questionnaire (HAQ) disability index(DI) to measure disability and function.The aim of this study was to translate SHAQ into Indonesian language and assess its validity and reability. The SHAQ was translated into Indonesian language and then back translated to ensure the meaning. The Indonesian version was then applied to the SSc outpatients. The validity of HAQ-DI and VAS scores was assessed using Pearson Product Moment Correlation and Cronbach’s alpha for the reability test of SSc HAQ score. To determine the convergent validity, comparisons were made between HAQ-DI, Scleroderma Visual Analog Scale (VAS), and Short Form 36 (SF 36). Eighteen females, ranging between 42 to 66 years old, were included in this study from Desember 2019 to February 2020. The results of the validity test in all variables of HAQ-DI and SSc-VAS were valid (r-count >0.361). Cronbach’s alpha for these variables were higher than the standardized items (r > 0.700), reflecting very good reability and acceptable. There was a statistically significant correlation between SSc HAQ score and HAQ-DI with most of SF-36 physical domains, except for general health.The Indonesian version of SHAQ demonstrates a good construct and discriminant validity as well as the reproducibility. Thus, it can be used for measuring disability in systemic sclerosis patients. Translasi  dan Validasi  Scleroderma Health Assessment Questionnaire versi  Bahasa IndonesiaSklerosis sistemik atau skleroderma merupakan penyakit autoimun kronik dengan vaskulopati, fibrosis dan autoimunitas. Scleroderma Health Assessment Questionnaire (SHAQ)menilai disabilitas dan fungsi pada pasien sklerosis sistemiklebih spesifik dibandingkan Health Assessment Questionnaire (HAQ) Disability Index (DI). Tujuan dari penelitian ini adalah menerjemahkan SHAQ ke dalam bahasa Indonesia dan menilai validitas serta relialibilitasnya. Scleroderma Health Assessment Questionnaire diterjemahkan ke dalam bahasa Indonesia dan kemudian dilakukan translasi balik lalu kuesioner diisi oleh pasien sklerosis sistemik rawat jalan. Tes validitas HAQ-DI dan Visual Analog Scale (VAS) dinilai menggunakan korelasi Pearson dan reliabilitas menggunakan Cronbach’s alpha. Perbandingan antara HAQ-DI, Scleroderma-VAS, dan Short Form 36 (SF 36) dilakukan untuk menilai validitas konvergen. Subjek terdiri dari 18 orang wanita yang berusia antara 42 sampai 66 tahun dari Desember 2019 sampai Februari 2020. Hasil validitas pada semua parameter HAQ-DI dan SSc-VAS ditemukan valid (r hitung>0,361). Terdapat reliabilitas yang baik dilihat dari nilai Cronbach’s alpha yang lebih tinggi dari nilai r tabel (r>0,700). Terdapat korelasi yang signifikan antara Skleroderma-HAQ dan HAQ-DI dengan domain SF-36 kecuali domain kesehatan umum. Simpulan, bahwa SHAQ versi Indonesia memiliki konstruk dan validitas diskriminan serta reproduktifitas yang baik sehingga dapat digunakan untuk menilai disabilitas pada pasien sklerosis sistemik. Faculty of Medicine, Universitas Padjadjaran 2020-03-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.fk.unpad.ac.id/index.php/mkb/article/view/2004 10.15395/mkb.v52n1.2004 Majalah Kedokteran Bandung; Vol 52, No 1 (2020); 45-52 Majalah Kedokteran Bandung; Vol 52, No 1 (2020); 45-52 2338-6223 0126-074x eng https://journal.fk.unpad.ac.id/index.php/mkb/article/view/2004/pdf https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/2004/1843 https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/2004/2920 Copyright (c) 2020 Majalah Kedokteran Bandung http://creativecommons.org/licenses/by-nc/4.0

oai:ojs.journal.fk.unpad.ac.id:article/2961 2023-07-17T06:59:14Z mkb:ART

Comparison of Several Indonesian Medicinal Plants Effects on LDL-C and IL-6 Levels in Wistar Rats After High Fat Feeding Martioso, Penny Setyawati Jasaputra, Diana Krisanti Gunadi, Julia Windi Lesmana, Ronny Shabrina, Pinkan Al Medicine Garlic, Java ginger, high-fat feeding, IL-6, pomegranate flowers, turmeric High-fat diet habits lead to an increase in LDL-C levels that eventually influence the atherosclerotic plaque formation and progression, causing coronary heart disease. Atherosclerosis is a chronic inflammatory process that releases various pro-inflammatory cytokines, including IL-6. Indonesians often use medicinal plants to decrease cholesterol levels. This study aimed to compare the LDL-C and IL-6 levels after treatments of ethanol extracts from Java ginger (EEJG), turmeric (EET), garlic (EEG), and pomegranate flowers (EEPF) in a hypercholesterolemia animal model. This study was conducted at the Maranatha Biomedical Research Laboratory from June–December 2020. Male Wistar rats were divided into six groups (n=5 per group) and received high-fat feeding and 0.01% propylthiouracil. The following treatments were given for 28 days: oral carboxymethylcellulose 1% for negative control; 35 mg/200g of oral  EEJG, EET, EEG, EEPF for respective treatment groups (n=5 groups); and 0.36 mg/200 g of oral Rosuvastatin for positive control. It was demonstrated that the mean  LDL-C levels were 65.75 mg/dL, 55.25 mg/dL, 56.75 mg/dL, and 59.60 mg/dL for EEJG, EET, EEG, EEPF groups, respectively, which were significantly different from that of the negative control (81.73 mg/dL). The IL-6 levels of the EEJG (27.55 pg./mL) and EEG (27.54 pg./mL) group were significantly different from the EEPF group (24.5 pg./mL) but not significantly different from the negative control (25.58 pg./mL), EET (25.60 pg./mL), and rosuvastatin (26.09 pg./mL) groups. The administration of ethanol extracts of Java ginger, turmeric, garlic, and pomegranate flower decreases the C-LDL levels; however, only the ethanol extract of pomegranate flowers administered for 28 days decreases the IL-6 levels of Wistar rat hypercholesterolemia model, albeit insignificantly. Faculty of Medicine, Universitas Padjadjaran This study is supported by Hibah Internal Skema B from Maranatha Christian University to DKJ and PSM with number 038/SK/ADD/UKM/VIII/2020 2023-06-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.fk.unpad.ac.id/index.php/mkb/article/view/2961 Majalah Kedokteran Bandung; Vol 55, No 2 (2023); 92–97 Majalah Kedokteran Bandung; Vol 55, No 2 (2023); 92–97 2338-6223 0126-074x eng https://journal.fk.unpad.ac.id/index.php/mkb/article/view/2961/pdf https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/2961/3551 https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/2961/3552 Copyright (c) 2023 Majalah Kedokteran Bandung http://creativecommons.org/licenses/by-nc/4.0

oai:ojs.journal.fk.unpad.ac.id:article/4299 2026-01-21T05:05:08Z mkb:ART

Avicenna Perpective of Learning-Difficulties, Screen-Time, and Emotional-Behavioral Issues in Children with Tuberculosis Nisaa', Defa Rahmatun Dz, Abdus Salam Karim, Abdul Sambas, Dedi Rachmadi Ramadhan, Muhammad Fachdi Medicine Avicenna, childhood tuberculosis, emotional-behavioral issues, learning-difficulties, screen-time Pediatric tuberculosis has become a significant issue in Indonesia, affecting physical, mental, social, and educational aspects of the child. This correlational quantitative study aimed to analyze the correlation between learning-difficulties, screen-time, and emotional-behavioral issues of children with tuberculosis from the perspective of Avicenna. Data collection was performed on 68 children aged 5–12 years in Cirebon, Indonesia, during December 2024. Learning-difficulties were assessed using the Collorado Learning Difficulties Questionnaire in mathematics and language proficiency tests, while emotional-behavioral issues were measured using the Pediatric Symptom Checklist-17. Data analysis was then performed using the Spearman-Rank correlation test. Results showed that there was no significant relationship between learning-difficulties and children's emotional-behavioral issues in either language (r=0.56, p>0.05) or mathematics (r=0.212, p>0.05). However, excessive screen-time was significantly associated with emotional-behavioral issues (r=0.63, p<0.05). Avicenna's perspective shows the importance of balancing physical, mental, and spiritual health to support children's development. This study recommends reducing screen-time, providing family support, and integrating spiritual values into health interventions for children with tuberculosis to mitigate the psychosocial impacts of the disease. Thus, a holistic approach grounded in cultural and spiritual values for managing the condition is crucial. Faculty of Medicine, Universitas Padjadjaran 2025-12-31 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.fk.unpad.ac.id/index.php/mkb/article/view/4299 10.15395/mkb.v57.4299 Majalah Kedokteran Bandung; Vol 57, No 4 (2025); 276-283 Majalah Kedokteran Bandung; Vol 57, No 4 (2025); 276-283 2338-6223 0126-074x 10.15395/mkb.v57n4 eng https://journal.fk.unpad.ac.id/index.php/mkb/article/view/4299/pdf https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/4299/5474 https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/4299/5475 https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/4299/5476 Copyright (c) 2025 Majalah Kedokteran Bandung http://creativecommons.org/licenses/by-nc/4.0

oai:ojs.journal.fk.unpad.ac.id:article/3150 2024-10-08T08:40:23Z mkb:ART

Use of sEMG for Swallowing Muscles Activity Quantification in Acute Phase of Stroke Biben, Vitriana Tanuwijaya, Andre Wardhani, Ildzamar Haifa Amalia, Lisda Medicine Deglutition, electromyography, stroke Early diagnosis of dysphagia and aspiration risk is very important in minimizing the risk of various medical consequences. This study aimed to establish a scientific database for future sEMG-based dysphagia screening investigations by examining the electrical activity of swallowing muscles in acute stroke cases. A quantitative cross-sectional study was conducted on 61 stroke inpatients admitted to Dr. Hasan Sadikin General Hospital, Bandung, Indonesia, from July to November 2019. The objective of this study was to quantify electrical activities of the suprahyoid (SH) and infrahyoid (IH) muscles during swallowing. Patients participated in both dry swallowing and a 3 mL water swallowing task, with the sEMG used to measure electrical activity parameters (duration, swallowing initiation, time-to-peak, and amplitude) on both paretic and normal sides. The Wilcoxon test was used to compare the electrical activity parameters between the patients paretic and normal sides. Only amplitude showed a significant difference between the paretic and normal side (p=0.023) when performing the 3 mL water swallowing test. Other parameters did not exhibit significant differences in activity between muscle groups during both swallowing tests (p>0.05),  although varying water volumes led to distinct activities in both muscles. Despite the absence of a clear pattern in SH and IH contractions during swallowing, the result showed that the sEMG quantification method might become a promising method for screening dysphagia, complementary to FEES and VFSS. The non-invasive and cost-effective sEMG method can serve as an early screening tool for dysphagia in stroke patients. This study underscores the importance of further investigation on sEMG use, incorporating a larger sample size and diverse cohort results with various swallowing exercises (varying in volume and viscosity) to validate the use of sEMG in dysphagia screening. Faculty of Medicine, Universitas Padjadjaran 2023-12-31 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.fk.unpad.ac.id/index.php/mkb/article/view/3150 10.15395/mkb.v55n4.3150 Majalah Kedokteran Bandung; Vol 55, No 4 (2023); 232-239 Majalah Kedokteran Bandung; Vol 55, No 4 (2023); 232-239 2338-6223 0126-074x 10.15395/mkb.v55n4 eng https://journal.fk.unpad.ac.id/index.php/mkb/article/view/3150/pdf https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/3150/3810 https://journal.fk.unpad.ac.id/index.php/mkb/article/downloadSuppFile/3150/3811 Copyright (c) 2023 Majalah Kedokteran Bandung http://creativecommons.org/licenses/by-nc/4.0 543dd9e8c10501b1332fd3ae87a4c721