2026-04-04T19:40:14Z https://journal.fk.unpad.ac.id/index.php/ijihs/oai

oai:ojs.journal.fk.unpad.ac.id:article/2757 2022-03-21T03:53:24Z mkb:FBM

oai:ojs.journal.fk.unpad.ac.id:article/2774 2022-04-08T04:00:10Z mkb:FBM

oai:ojs.journal.fk.unpad.ac.id:article/3237 2023-02-15T02:10:29Z amj:fbma

oai:ojs.journal.fk.unpad.ac.id:article/4565 2025-12-04T07:27:55Z ijihs:ART

Arterial Blood Gas Analysis and Dyselectrolytemia in Acute Exacerbation of Chronic Obstructive Pulmonary Disease (COPD) Reddy, Nivedita Tayamgol Patil, Sachin Reddy, Kailash Chronic obstructive pulmonary disease; electrolyte imbalance; hypokalemia; hyponatremia; respiratory acidosis Background: Acute exacerbations of chronic obstructive pulmonary disease (AECOPD) is one of the important causes of  morbidity, mortality, and healthcare burden. Electrolyte disturbances and acid–base imbalances are frequent but under-recognized complications that may worsen outcomes in cases of AECOPD.Objective: To understand the prevalence of serum electrolyte abnormalities and arterial blood gas (ABG) parameters in patients admitted with AECOPD.Methods: This prospective observational study enrolled 200 patients with confirmed AECOPD admitted to a tertiary care hospital in Kalaburagi, India, over an 18 month period. The ABG analysis and serum electrolytes (sodium, potassium, magnesium, chloride) measurement were performed at admission. Demographic, clinical, and radiological data were also collected. Data were then analyzed using SSPS 23.0, with a P value of < 0.05 considered statistically significant.Results: Abnormalities related to sodium (91.5%), potassium (90.5%), magnesium (80.5%), and chloride (56%) were common in cases admitted with AECOPD. In 45% cases, the PaO₂ <50 mmHg  was seen whereas PaCO₂ >45 mmHg was found in 43%. Acid–base imbalance was seen  in 35% cases, with 4.5% showing severe acidosis (pH ≤7.1). Cough (72.5%) and breathlessness (60.5%) were most common symptoms. The majority were elderly males (65%) whereas 57% were smokers. Diabetes was the most common comorbidity (30.5%).Conclusion: Electrolyte abnormalities and ABG derangements are nearly universal in AECOPD and have important prognostic implications. Routine metabolic profiling should be integrated into the acute management of COPD to improve outcomes, particularly in resource-constrained settings. Faculty of Medicine Universitas Padjadjaran 2025-10-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.fk.unpad.ac.id/index.php/ijihs/article/view/4565 10.15850/ijihs.v13n2.4565 International Journal of Integrated Health Sciences; Vol 13, No 2 (2025); 89-95 International Journal of Integrated Health Sciences; Vol 13, No 2 (2025); 89-95 2338-4506 2302-1381 10.15850/ijihs.v13n2 eng https://journal.fk.unpad.ac.id/index.php/ijihs/article/view/4565/2152 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/4565/5891 Copyright (c) 2025 International Journal of Integrated Health Sciences http://creativecommons.org/licenses/by-nc/4.0

oai:ojs.journal.fk.unpad.ac.id:article/399 2023-11-02T04:53:25Z ijihs:ART

Eicosapentaenoic Acid as Adjuvant for Cachexia in Cancer’s Patients Hadi, Soeseno Kurniawan, Cynthia Budiono, Jansen Cachexia, cancer, EPA Cachexia is a frequent problem in cancer patients associated with mortality and morbidity since it causes death, reduced therapy effectiveness, as well as decreased quality of life. Cachexia emerges from interactions of several factors, namely metabolic effect of cancer cells, factors released by cancer cells, cytokines release from host cell in response to tumors, and side effects of therapies. Combination of these factors contributes to anorexia, decreased body fat and muscle, and weight loss. Unfortunately, there is no gold standard for treatment of cachexia. Several studies found that eicosapentaenoic acid (EPA) might improve cancer cachexia. It has potential blocking effects on several cachexia underlying factors. It may reverse weight loss, increase lean body mass, and improve the efficacy of therapy and the quality of life. The objective of this literature review is to describe and give basic understanding of EPA as adjuvant for cancer cachexia. Keywords: Cachexia, cancer, EPADOI: 10.15850/ijihs.v3n1.399 Faculty of Medicine Universitas Padjadjaran 2015-04-06 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.fk.unpad.ac.id/index.php/ijihs/article/view/399 International Journal of Integrated Health Sciences; Vol 3, No 1 (2015); 1-6 International Journal of Integrated Health Sciences; Vol 3, No 1 (2015); 1-6 2338-4506 2302-1381 10.15850/ijihs.v3n1 eng https://journal.fk.unpad.ac.id/index.php/ijihs/article/view/399/363 Copyright (c) 2014 International Journal of Integrated Health Sciences http://creativecommons.org/licenses/by-nc/4.0

oai:ojs.journal.fk.unpad.ac.id:article/2603 2023-11-02T04:48:58Z ijihs:CR

Secondary Chronic Immune Thrombocytopenia in Diffuse Large B-cell Lymphoma: A Rare Case Report Vidyaniati, Putri Fransisca, Fransisca Rizki, Kiki Akhmad Oehadian, Amaylia Diffuse Large B-Cell Lymphoma; refractory; secondary immune thrombocytopenia; splenectomy Objective: To present a case of rare secondary chronic immune thrombocytopenia in diffuse large B-cell lymphoma.Methods: A case of secondary ITP associated with diffuse large B-cell lymphoma (DLBCL) in a 58-year-old woman suffering from hemorrhagic tendencies that was refractory to conventional treatments of ITP was reported. This case is a rarity because there are not many cases of secondary chronic ITP due to DLBCL have been reported to date.Results: A 58-year-old woman was diagnosed with ITP around 11 months before she was admitted to the Emergency Room with bleeding. Previous treatment with steroid and azathioprine was only temporarily effective. During the course of treatment, splenomegaly and lymphadenopathy were identified, but lymph node biopsy was delayed by the thrombocytopenia. The drug was then replaced to the eltrombopag, which showed good response. However, the patient had to undergo splenectomy because of the mechanical effect of splenomegaly, with the biopsy result showed DLBCL. Immune thrombocytopenia then went into a complete remission after splenectomy.Conclusion: In cases of ITP that are refractory to conventional treatments, a thorough search for secondary ITP might be helpful, even if no underlying disorder is detected at the initial presentation. Faculty of Medicine Universitas Padjadjaran 2022-03-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.fk.unpad.ac.id/index.php/ijihs/article/view/2603 10.15850/ijihs.v10n1.2603 International Journal of Integrated Health Sciences; Vol 10, No 1 (2022); 46-50 International Journal of Integrated Health Sciences; Vol 10, No 1 (2022); 46-50 2338-4506 2302-1381 eng https://journal.fk.unpad.ac.id/index.php/ijihs/article/view/2603/1653 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/2603/2869 Copyright (c) 2022 International Journal of Integrated Health Sciences http://creativecommons.org/licenses/by-nc/4.0

oai:ojs.journal.fk.unpad.ac.id:article/3359 2024-06-11T07:30:01Z ijihs:CR

Case Series on Imaging Features of Trilateral and Quadrilateral Retinoblastoma: What Radiologists Need to Know Fiona, Fiona Yuli Anandasari, Pande Putu Margiani, Ni Nyoman Pineal Gland; Quadrilateral; Retinoblastoma; Suprasellar; Trilateral Objective: To identify the differences between trilateral and quadrilateral retinoblastoma based on radiologic imaging.Case: We found three cases of retinoblastoma at Sanglah General Hospital. The retinoblastoma patients we found were boys under the age of 5. The first patient presented with swelling, pain, and impaired vision in the right eye. The second and third patients presented with eye protrusion and leukocoria. Computed tomography (CT) imaging revealed a calcified mass in the intraorbital region that extended to the cerebral hemispheres. It may be accompanied by hair-on-end periosteal reaction. In the first patient, the mass extended to the pineal gland. In the second and third patients, the mass extended to the suprasellar and pineal regions.  Trilateral retinoblastoma consists of a primordial midline neuroectodermal tumor that originates in the pineal or suprasellar region. It is an uncommon combination of unilateral or bilateral retinoblastomas. Quadrilateral retinoblastoma, on the other hand, presents with bilateral retinoblastoma and tumors in both the suprasellar and pineal regions. The histopathology of trilateral and quadrilateral retinoblastoma shows a different pattern from retinoblastoma.Conclusion: Retinoblastoma poses one of the most challenging problems due to its distinct patterns of growth, extension, and recurrence. Intracranial metastasis of trilateral and quadrilateral retinoblastoma exhibits a different pattern. The prognosis and diagnosis of retinoblastoma are significantly influenced by clinical examination, radiologic imaging, and histopathology. Faculty of Medicine Universitas Padjadjaran 2024-03-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.fk.unpad.ac.id/index.php/ijihs/article/view/3359 10.15850/ijihs.v12.n1.3359 International Journal of Integrated Health Sciences; Vol 12, No 1 (2024); 65-72 International Journal of Integrated Health Sciences; Vol 12, No 1 (2024); 65-72 2338-4506 2302-1381 10.15850/ijihs.v12.n1 eng https://journal.fk.unpad.ac.id/index.php/ijihs/article/view/3359/1942 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/3359/4124 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/3359/4223 Copyright (c) 2024 International Journal of Integrated Health Sciences http://creativecommons.org/licenses/by-nc/4.0

oai:ojs.journal.fk.unpad.ac.id:article/100 2024-03-27T08:38:05Z ijihs:LR

Integrating Basic Sciences into Global Health by Implementing the Translational Research Shahib, Muhamad Nurhalim Dhyanawati, Diah Rofaani, Elrade An emphasize on herbal medicine in cancer therapy is also included as an example of translational research implementation. A translational research in Faculty of Medicine, Universitas Padjajaran, has been conducted to develop a novel genomic approach (herbal genomic) on herbal crude extracts. This study focuses on the effects of the extracts on specific gene expressions. In this aspect, the concept of molecular targets is slightly different from pharmaceutical approaches  that aim to find compounds that interact with a specific molecule or macromolecule with known function. In this research strategy, the herbal genomic approaches involve screening of herbal extracts that affect particular gene expression related to cell responses rather than a single proteins. The determination of herbal concentration is based on differential gene expression before and after treatment which is analyzed by real time PCR. The results are being compared to the existing small molecule (active molecule) on the gene expressions. All these academic activities require biomedical research workforce to implement the translational research which, in the Faculty of Medicine, Universitas Padjadjaran, is fulfilled by involving the postgraduate students. New crude extract formulation plus specific gene expression profile is a concept required for developing chemotherapeutic agent in Indonesia. Hopefully, this review can support increased cooperation between hospital and academic institutions in implementing translational research in Indonesia.    DOI: 10.15850/ijihs.v1n1.86 Faculty of Medicine Universitas Padjadjaran 2013-08-02 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.fk.unpad.ac.id/index.php/ijihs/article/view/100 International Journal of Integrated Health Sciences; Vol 1, No 1 (2013); 1-7 International Journal of Integrated Health Sciences; Vol 1, No 1 (2013); 1-7 2338-4506 2302-1381 eng https://journal.fk.unpad.ac.id/index.php/ijihs/article/view/100/86

oai:ojs.journal.fk.unpad.ac.id:article/2243 2023-11-02T04:49:52Z ijihs:ART

Effectiveness of Multimedia and Education using Lecturing Method on Role of Vitamin D for Health Cadres Dewi, Sumartini Sulistyo, Adityana Sumardi, Erwin Puji Lestari, Eka Sulay Wijaya, Kevin Kusuma, Paramitha Dewi, Theresia Agraini, Agraini Sauma, Eldi Kurniati, Winda Triandari, Francisca Nungki Iskandar, Shelly Kurnianingsih, Tuti Pandia, Veranita Education; lectures; multimedia; vitamin D Objective: To investigate the differences in the effectiveness of learning methods between multimedia and lecture methods on benefits of vitamin D for health from the perspective of health cadres' knowledge,. Methods: This study was an experimental study with a pre-and post-test design. The knowledge of health cadres was assessed using a questionnaire. The questionnaire was distributed before and after the health cadres received vitamin D education by two different methods. Data analysis was conducted using paired and independent t-test with a significance level of p <0.05. Results: A total of 59 health cadres participated in this study. Prior to education, the median test score for the multimedia group was 9.45, while the median test score for the lecture group was 82.70. After the education, the multimedia group and the lecture group got a median test score of 10.84. The multimedia method and lecture method significantly increased health cadres' knowledge with p-values of <0.02 and 0.003, respectively. There was no difference in the multimedia method's effectiveness compared to the lecture method in increasing the knowledge of health workers about vitamin D's role in health (p=0.62). Conclusion: The multimedia education method is as effective as the lecture method in increasing health cadres' knowledge about the role of vitamin D in health.  Faculty of Medicine Universitas Padjadjaran Universitas Padjadjaran Internal Grant 2021-10-19 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.fk.unpad.ac.id/index.php/ijihs/article/view/2243 10.15850/ijihs.v9n2.2243 International Journal of Integrated Health Sciences; Vol 9, No 2 (2021); 55-59 International Journal of Integrated Health Sciences; Vol 9, No 2 (2021); 55-59 2338-4506 2302-1381 10.15850/ijihs.v9n2 eng https://journal.fk.unpad.ac.id/index.php/ijihs/article/view/2243/1639 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/2243/2194 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/2243/2195 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/2243/2196 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/2243/2197 Copyright (c) 2021 International Journal of Integrated Health Sciences http://creativecommons.org/licenses/by-nc/4.0

oai:ojs.journal.fk.unpad.ac.id:article/3460 2025-05-20T08:19:17Z ijihs:ART

Thyroid Profile and Serum Lipid Level in Women with Normal Pregnancy Kumar, Raj Kumar, Sudeep Arora, Manisha Kumar, Dinesh Sah, Sumesh Prasad Sharma, Shivani Pregnancy; Thyroid Hormones; Triglycerides; Trimester. Objective: To evaluate the changes in thyroid profile and serum lipid level in normal pregnancy.Methods: This observational study was conducted at the Department of Biochemistry of Santosh Medical College, Ghaziabad, UP, India, from June 2021 to February 2022. In this study, 200 average pregnant women were enrolled. The thyroid profile was estimated using the ELISA method, and the lipid profile was measured using the enzymatic kit method. All data were expressed as means and standard deviations, and SPSS version 17 was used for statistical analysis.Results: This observational study observed that the mean T3, T4, and TSH levels increased significantly in the second trimester compared to the first trimester. In contrast, the mean value of T3, T4, and TSH decreased in the third trimester as compared to the second trimester. The mean levels of total cholesterol, triglyceride, and LDL-cholesterol increased significantly, while the mean value of HDL-cholesterol decreased significantly in the second and third trimesters when compared to the first trimester.Conclusion: This study demonstrated abnormal lipid and thyroid metabolism. Changes in thyroid profile may be associated with adverse obstetric outcomes. The altered lipid parameters, mainly High TG and low HDL-C concentrations, may promote vascular dysfunction and oxidative stress. Faculty of Medicine Universitas Padjadjaran 2023-09-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.fk.unpad.ac.id/index.php/ijihs/article/view/3460 10.15850/ijihs.v11n2.3460 International Journal of Integrated Health Sciences; Vol 11, No 2 (2023); 79-84 International Journal of Integrated Health Sciences; Vol 11, No 2 (2023); 79-84 2338-4506 2302-1381 10.15850/ijihs.v11n2 eng https://journal.fk.unpad.ac.id/index.php/ijihs/article/view/3460/1852 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/3460/4236 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/3460/4237 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/3460/4238 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/3460/4239 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/3460/4240 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/3460/4241 Copyright (c) 2023 International Journal of Integrated Health Sciences http://creativecommons.org/licenses/by-nc/4.0

oai:ojs.journal.fk.unpad.ac.id:article/4326 2025-08-01T02:32:08Z ijihs:ART

Role Of High-Resolution CT Thorax in Interstitial Lung Disease Evaluation Singh, Surinder Jain, Tripti Kaur, Amarjit Chhabra, Harinder Singh HRCT; hypersensitivity pneumonitis; interstitial lung disease; NSIP; usual interstitial pneumonia Background: High-Resolution Computed Tomography (HRCT) plays a crucial role in the evaluation of interstitial lung diseases, offering detailed imaging for accurate diagnosis.Objective: To evaluate diagnostic precision and clinical relevance of High-Resolution Computed Tomography (HRCT) in evaluating Interstitial Lung Diseases (ILDs).Methods: This observational study analyzed HRCT images from 30 patients using a multi-detector CT scanner. The study was conducted at the Department of Radiodiagnosis of Gian Sagar Medical College and Hospital, India, in a period of one year (January 2024 to December 2024). Images were reviewed by two radiologists for various features, including ground-glass opacities, reticulations, honeycombing, and traction bronchiectasis. The patterns were classified as definite UIP, probable UIP, or suggestive of chronic HP or NSIP.Results: Eighteen patients (60%) showed basal-predominant honeycombing, reticulations, and traction bronchiectasis consistent with definite UIP. Six of these also exhibited upper lobar emphysema, categorized as Combined Pulmonary Emphysema and Fibrosis (CPFE). Another six patients with NSIP displayed subpleural curvilinear opacities, fine reticulations, and ground-glass abnormalities. Six (20%) patients with chronic HP showed diffuse ground-glass opacities and traction bronchiectasis, primarily in the upper lobes with air trapping on expiratory scans.Conclusion: This case series demonstrates the diverse HRCT findings in ILD, underscoring the importance of HRCT in diagnosis and prognosis. Larger studies with histopathological confirmations are needed to refine these diagnostic insights. Faculty of Medicine Universitas Padjadjaran 2025-04-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.fk.unpad.ac.id/index.php/ijihs/article/view/4326 10.15850/ijihs.v13n1.4326 International Journal of Integrated Health Sciences; Vol 13, No 1 (2025); 29-36 International Journal of Integrated Health Sciences; Vol 13, No 1 (2025); 29-36 2338-4506 2302-1381 10.15850/ijihs.v13.n1 eng https://journal.fk.unpad.ac.id/index.php/ijihs/article/view/4326/2077 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/4326/5552 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/4326/5553 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/4326/5554 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/4326/5555 Copyright (c) 2025 International Journal of Integrated Health Sciences http://creativecommons.org/licenses/by-nc/4.0

oai:ojs.journal.fk.unpad.ac.id:article/2175 2022-04-11T03:03:33Z ijihs:ART

Correlation between MMP-9 Level and Diastolic Dysfunction in Concentric Left Ventricular Hypertrophy Patients Pramudyo, Miftah Jungjunan, Ridho Martanto, Erwan Achmad, Chaerul Diastolic dysfunction; Hypertensive Heart Disease; Left Ventricular Hypertrophy; Matrix Metalloproteinase-9 Objective: To establish the relationship between plasma matrix metalloproteinase (MMP)-9 levels and diastolic functional abnormalities using the E/e’ measurement in concentric type Hypertensive Heart Disease (HHD) patients.Methods: A cross-sectional study was conducted from November 2014 to January 2015 in population with hypertension and concentric Left Ventricular Hypertrophy (LVH). Diastolic function was assessed with E/e’ measurement using echocardiography. The relationship between the two variables was analyzed using Spearman correlation.Results: Thirty-nine subjects (14 males, 35.9%) with the average relative wall thickness of 0.7(±0.15), average body weight of 63.45 (±12.97) kg, average height of 155.51 (±7.12) cm, average body mass index of 26.23 (±5.08) kg/m2, and mean age of 55 (±10) years were fit to be included in the analysis. The median systolic blood pressure was 140 (110-220) mmHg while the median diastolic blood pressure and median left ventricular mass index were 80 (70-110) mmHg and 119.24 (103.05-205.69) g/m2, respectively. The median MMP-9 was measured at 108 (4-460) ng/mL and the median E/e' was 10.99 (6.2-20.42). There was a significant positive correlation between MMP-9 and E/e' (r = 0.416, p = 0.004).Conclusion: There is a significant moderate positive correlation between the MMP-9 level and diastolic dysfunction in concentric LVH patients.  Faculty of Medicine Universitas Padjadjaran 2021-03-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.fk.unpad.ac.id/index.php/ijihs/article/view/2175 10.15850/ijihs.v9n1.2175 International Journal of Integrated Health Sciences; Vol 9, No 1 (2021); 1-6 International Journal of Integrated Health Sciences; Vol 9, No 1 (2021); 1-6 2338-4506 2302-1381 10.15850/ijihs.v9n1 eng https://journal.fk.unpad.ac.id/index.php/ijihs/article/view/2175/1599 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/2175/2482 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/2175/2483 Copyright (c) 2021 International Journal of Integrated Health Sciences http://creativecommons.org/licenses/by-nc/4.0

oai:ojs.journal.fk.unpad.ac.id:article/3020 2024-01-05T03:40:37Z ijihs:ART

Autoantibody Profile and Lung HRCT Scan in Systemic Sclerosis with Restrictive Lung Disease Saragih, Winda Agnestia Maranna Dewi, Sumartini Wachjudi, Rachmat Gunadi Logito, Verina Tjandrawati, Anna Autoantibodies; Diffuse Cutaneous; Lung Fibrosis; Restrictive Lung Disease; Systemic Sclerosis. Objective: To identify auto-antibodies in systemic sclerosis with interstitial lung disease (ILD). Method: This was a descriptive categorical study on auto-antibody profile in systemic sclerosis patients visiting the Rheumatology Clinic of Dr. Hasan Sadikin General Hospital, West Java, and Bandung during the period of January 2018 to December 2019 who were registered in the West Java Systemic Sclerosis Registry. Auto-antibody identification was performed using the Euroline immunoblot assays.Results: Thirty six cases were identified during the study period with most of the cases involved women (n=35, 97.2%). The average age of patients participating in this study was 40 years, with an average duration of disease of 18 months. Diffuse cutaneous systemic sclerosis was found in 22 (61.1%) cases and limited cutaneous systemic sclerosis was observed in 14 (38.9%) cases. Specific autoantibodies were positive in 33 (91.6%) cases, with anti-topoisomerase I as the largest group, positive in 22 (52.9.3%) cases. This was followed by anti-Th/To in eight (15.7%) cases; anti-Ro52 in four (7.8%) cases; anti-centromere in three (5.9%) cases; anti-RNA polymerase in three (5.9%) cases; anti-fibrillarin in three (5.9%) cases; anti-Ku in two (3.9%) cases; and anti-PDGF in one (2.0%) case. High-resolution computed tomography of the lung showed 34 (94.4%) cases with ILD and 22 (61.1%) cases with severe lung fibrosis. Usual interstitial pneumonia was seen in 19 (52.8%) cases and non-specific interstitial pneumonia in 15 (41.7%) cases.Conclusion: Anti-topoisomerase I, anti-Th/To, and anti-Ro52 are the most common autoantibodies observed in systemic sclerosis patients with ILD as the most prevalent feature detected with lung HRCT. Faculty of Medicine Universitas Padjadjaran 2023-03-31 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.fk.unpad.ac.id/index.php/ijihs/article/view/3020 10.15850/ijihs.v11n1.3020 International Journal of Integrated Health Sciences; Vol 11, No 1 (2023); 42-49 International Journal of Integrated Health Sciences; Vol 11, No 1 (2023); 42-49 2338-4506 2302-1381 10.15850/ijihs.v11n1 eng https://journal.fk.unpad.ac.id/index.php/ijihs/article/view/3020/1801 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/3020/3612 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/3020/3615 Copyright (c) 2023 International Journal of Integrated Health Sciences http://creativecommons.org/licenses/by-nc/4.0

oai:ojs.journal.fk.unpad.ac.id:article/4100 2024-11-25T05:49:23Z ijihs:ART

Role of Ultrasound Imaging in Children with Dengue Fever: A Retrospective Study Sean Martin, Juliet Anitha Annadurai, Karthikeyan Ascites, dengue, gall bladder wall edema, pleural effusion, ultrasound Objective: To study ultrasound findings of children with dengue and analyze the possible correlation between ultrasound findings  and severity of dengue in children.Methods: This retrospective study, which was conducted over one year, analyzed 50 pediatric dengue patients. Ultrasound findings such as gallbladder wall edema, pleural effusion and ascites were assessed. Cases were categorized into dengue without warning signs, dengue with warning signs, and severe dengue according to the World Health Organization's classification of dengue. Correlation between ultrasound abnormalities,  severity of dengue, and  thrombocytopenia were analyses. A p-value of less than 0.05 was taken as statistically significant.Results: Of 50 pediatric patients diagnosed with dengue participated in this study, 72% were boys, and 28% were girls with a male-to-female ratio of 1:0.38. Fever was the most frequent symptom (100%), followed by nausea/vomiting (84%) and body ache/myalgia (78%). Ultrasound findings revealed that gallbladder wall edema (48%), pleural effusion (44%), and ascites (50%) were significantly associated with severe dengue and dengue with warning signs (p<0.001). Thrombocytopenia was documented in 58% of cases and correlated significantly with ultrasound abnormalities such as gallbladder wall edema, ascites, and pleural effusion (p=0.0017).Conclusion: Ultrasound findings, such as gallbladder wall edema, pleural effusion and ascites, are significantly associated with severe dengue and dengue with warning signs. These features aid in early identification of high-risk patients. Faculty of Medicine Universitas Padjadjaran 2024-09-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.fk.unpad.ac.id/index.php/ijihs/article/view/4100 10.15850/ijihs.v12.n2.4100 International Journal of Integrated Health Sciences; Vol 12, No 2 (2024); 109-116 International Journal of Integrated Health Sciences; Vol 12, No 2 (2024); 109-116 2338-4506 2302-1381 10.15850/ijihs.v12.n2 eng https://journal.fk.unpad.ac.id/index.php/ijihs/article/view/4100/2000 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/4100/5217 Copyright (c) 2024 International Journal of Integrated Health Sciences http://creativecommons.org/licenses/by-nc/4.0

oai:ojs.journal.fk.unpad.ac.id:article/4210 2025-12-04T07:27:57Z ijihs:ART

Gastrointestinal Manifestations and Neutrophil-to-Lymphocyte Ratio as Marker of Occult Bleeding in COVID -19 Maghfirah, Desi Yusuf, Fauzi Marisa, Marisa Eljatin, Muhammad Ridho Akbar COVID-19; gastrointestinal manifestation; occult bleeding; the neutrophil-to-lymphocyte ratio Background: Coronavirus disease 2019 (COVID-19) was initially recognized as a respiratory illness; however, it has been gradually recognized as a disease that affects multiple organ systems, including the gastrointestinal (GI) tract. GI involvement ranges from mild symptoms, such as nausea and diarrhea, to complications like gastrointestinal bleeding. The neutrophil-to-lymphocyte ratio (NLR) has been proposed as a simple biomarker of inflammation and disease severity in COVID-19.Objective: To describe gastrointestinal manifestations of COVID-19 and examine the association between NLR levels and occult gastrointestinal bleeding.Methods: This cross-sectional study was conducted in 2021 at the New-Emerging and Re-Emerging Infectious Diseases inpatient unit of Dr. Zainoel Abidin General Hospital, Banda Aceh, Indonesia. COVID-19-positive patients aged ≥18 years with gastrointestinal symptoms were included, excluding those who were pregnant or had pre-existing GI disorders. Data were collected from medical records and patient interviews. Statistical analysis was performed using the Mann–Whitney U test, with p < 0.05 considered significantResults: The most frequent symptoms were appetite loss and nausea (93%), bloating and vomiting (87%), and diarrhea (57%). Occult GI bleeding occurred in seven patients (23.3%) who had significantly higher NLR values than those without bleeding (p = 0.041).Conclusion: The most frequent GI manifestations of COVID-19 are loss of appetite, nausea, bloating, vomiting, and diarrhea, while occult gastrointestinal bleeding occurs in about one-fourth of cases. Elevated NLR levels are associated with occult bleeding, suggesting its potential role as a simple and accessible biomarker of intestinal inflammation and disease severity. Faculty of Medicine Universitas Padjadjaran Universitas Syiah Kuala 2025-10-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.fk.unpad.ac.id/index.php/ijihs/article/view/4210 10.15850/ijihs.v13n2.4210 International Journal of Integrated Health Sciences; Vol 13, No 2 (2025); 131-137 International Journal of Integrated Health Sciences; Vol 13, No 2 (2025); 131-137 2338-4506 2302-1381 10.15850/ijihs.v13n2 eng https://journal.fk.unpad.ac.id/index.php/ijihs/article/view/4210/2157 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/4210/5364 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/4210/5365 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/4210/5366 Copyright (c) 2025 International Journal of Integrated Health Sciences http://creativecommons.org/licenses/by-nc/4.0

oai:ojs.journal.fk.unpad.ac.id:article/404 2024-06-11T05:10:21Z ijihs:ART

Effectiveness in Dynamic Balance: a Comparison between Foot Muscle Strengthening Using Elastic Band and without Elastic Band in Children Aged 8–12 with Flexible Flatfeet Listyorini, Indri Shanti, Marietta Prabowo, Tertianto Flexible flatfeet, strengthening exercises, elastic band, dynamic balance, star excursion balance test Objective: To compare the effects of foot muscle strengthening exercises with and without elastic band to the dynamic balance function in children aged 8–12 years with flexible flatfeet.Methods: Forty-one children (aged 8–12 years) with flexible flatfeet and dynamic balance problem were randomly allocated into either the intervention or control group. Both groups received thrice weekly training for 6 weeks. The foot strengthening exercise regimens consisted of pronation, supination, short foot, and tiptoeing using elastic band for the intervention group and without elastic band for the control group. Star Excursion Balance Test (SEBT) was tested before and after 6 weeks of training. Results: A statistically significant difference of normalized SEBT scores was found for both groups in both legs (p=0.00, p<0.05). The intervention group was significantly better than the control group for both right and left legs (p=0.00, p<0.05). Conclusions: Foot muscle strengthening either with or without elastic band improves dynamic balance in children aged 8–12 years with flexible flatfeet. Exercise given with elastic band significantly shows better improvement in the dynamic balance compared to without elastic band.Keywords: Flexible flatfeet, strengthening exercises, elastic band, dynamic balance, star excursion balance test DOI: 10.15850/ijihs.v3n1.404 Faculty of Medicine Universitas Padjadjaran 2015-04-06 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.fk.unpad.ac.id/index.php/ijihs/article/view/404 International Journal of Integrated Health Sciences; Vol 3, No 1 (2015); 26-32 International Journal of Integrated Health Sciences; Vol 3, No 1 (2015); 26-32 2338-4506 2302-1381 10.15850/ijihs.v3n1 eng https://journal.fk.unpad.ac.id/index.php/ijihs/article/view/404/368 Copyright (c) 2017 International Journal of Integrated Health Sciences http://creativecommons.org/licenses/by-nc/4.0

oai:ojs.journal.fk.unpad.ac.id:article/2829 2023-11-02T04:47:31Z ijihs:ART

Haemopoietic Actions of Justicia secunda Leaf Extracts in Mice Irinmwinuwa, Omo Ifediba, Emeka Oyindamola, Joseph Afonne, Onyenmechi Johnson Anaemia; haemoglobin; haemopoietic effect; Justicia secunda; phenylhydrazine Objective: To evaluate the haemopoietic effects of Justicia secunda leaf ethanol, n-hexane, ethyl acetate, and n-butanol extracts in mice and compare these effects with the effects of standard antianaemic agents.Methods: Sixteen groups of mice, six in each group, were used for the study. Anemia was induced in Groups 1 to 12 using 20 mg/kg i.p. phenylhydrazine (PHZ) daily for 2 days, followed by either ethanol, n-hexane, ethyl acetate or n-butanol extracts for 6 days. Groups 13 and 14 were induced for anemia and then received 200 mg/kg ferrous sulphate and vitamin B12 for 6 days. Group 15 (positive control) received 20 mg/kg PHZ i.p. only, while group 16 (negative control) was untreated. Blood was collected from the retro-orbital plexuses of the mice into EDTA-containing bottles on the 7th day and analyzed for hemoglobin (Hb) level, packed cell volume, mean cell hemoglobin concentration, and mean cell volume. Red blood cell, white blood cell, and platelet counts were also measured.Results: The ethanol leaf extract of J. secunda significantly increased the hematological parameters of mice compared to the positive and negative controls (p < 0.05). However, the n-hexane, ethyl acetate, and n- butanol extracts showed greater hemopoietic effects (p < 0.001) than the ethanol extract and standard antianemic drugs. The extract of J. secunda leaf tended to stimulate erythropoiesis comparable to the standard antianemic drugs, especially the n-hexane.Conclusion: Justicia secunda leaf extracts exert hemopoietic actions in mice, while the n-hexane extract shows greater haemopoietic activities than ferrous sulphate and vitamin B12. Faculty of Medicine Universitas Padjadjaran 2022-09-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.fk.unpad.ac.id/index.php/ijihs/article/view/2829 10.15850/ijihs.v10n2.2829 International Journal of Integrated Health Sciences; Vol 10, No 2 (2022); 65–74 International Journal of Integrated Health Sciences; Vol 10, No 2 (2022); 65–74 2338-4506 2302-1381 eng https://journal.fk.unpad.ac.id/index.php/ijihs/article/view/2829/1744 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/2829/3424 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/2829/3425 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/2829/3574 Copyright (c) 2022 International Journal of Integrated Health Sciences http://creativecommons.org/licenses/by-nc/4.0

oai:ojs.journal.fk.unpad.ac.id:article/3699 2024-07-10T02:22:15Z ijihs:ART

Serum Magnesium Levels in Patients Admitted with Septic Shock and Its Correlation with Outcome Premita, Mayengbam Ajaykumar, Rajkumar Kireeti, P. Singh, Seram Arrhythmias; Hypomagnesemia; Mortality; Septic Shock; Objective: To evaluate the initial serum magnesium levels of critically ill septic shock patients upon admission to the intensive care unit (ICU) and correlate these levels with the patients' requirements and outcomes, including ventilator support, length of stay in the ICU, occurrence of cardiac arrhythmias, and mortality rates.Methods: This was an observational study involving 60 patients who were admitted to the medical Intensive Care Unit (ICU) for septic shock. Serum magnesium levels were measured upon admission to the ICU. A comparison was made between patients with normal and abnormal magnesium levels at the time of admission to evaluate the need for vasopressor support, the average duration of assisted ventilation and dialysis, the incidence of arrhythmia, the average length of ICU stay, and mortality rates.Results: Out of the 60 cases studied, there were 42 males (70.00%) and 18 females (30.00%), resulting in a M:F ratio of 1:0.42. The mean age of both male and female patients was found to be comparable. The need for assisted ventilation and renal replacement therapy was found to be comparable in patients with normal and abnormal serum magnesium levels. The number of days for which assisted ventilation was required, the incidence of arrhythmia, the mean duration of ICU and hospital stay, and mortality were significantly higher in patients with abnormal magnesium levels at the time of ICU admission (P<0.05).Conclusion: Abnormal serum magnesium levels are associated with increased morbidity and mortality in critically ill septic shock patients admitted to the ICU. Faculty of Medicine Universitas Padjadjaran 2024-03-31 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.fk.unpad.ac.id/index.php/ijihs/article/view/3699 10.15850/ijihs.v12.n1.3699 International Journal of Integrated Health Sciences; Vol 12, No 1 (2024); 10-16 International Journal of Integrated Health Sciences; Vol 12, No 1 (2024); 10-16 2338-4506 2302-1381 10.15850/ijihs.v12.n1 eng https://journal.fk.unpad.ac.id/index.php/ijihs/article/view/3699/1933 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/3699/4736 Copyright (c) 2024 International Journal of Integrated Health Sciences http://creativecommons.org/licenses/by-nc/4.0

oai:ojs.journal.fk.unpad.ac.id:article/3881 2025-08-01T02:32:06Z ijihs:CR

General Anesthesia Management of Super Refractory Status Epilepticus in Anti-N-Methyl-D-Aspartate-Receptor (NMDAR) Meningitis Amalia, Putri Shabrina Setiawan, Irvan Melati, Annemarie Chrysantia anesthesia; anti N-Methyl-D-Aspartate-Receptor; convulsion; super refractory status epilepticus Background: Super Refractory Status Epilepticus poses significant management challenges, requiring intensive therapeutic approaches including general anesthesia.Objective: To discuss the management of Super Refractory Status Epilepticus (SRSE) with general anesthesia to control seizures.Case Illustration: A 17-year-old female with tonic-clonic seizures, headache, unclear speech, and a change in behavior, who also appeared to be restless, was presented. She was admitted to the intensive care unit and administered anticonvulsant medication. A brain MRI with contrast showed the impression of meningitis, and cerebrospinal fluid examination showed a positive anti-NMDAR result. First-line therapy involved high-dose steroids and intravenous immunoglobulin for 5 days, followed by second-line therapy with rituximab. Patient received general anesthesia using sevoflurane volatile, dexmedetomidine, continuous rocuronium, propofol, ketamine, and fentanyl due to persistent seizures despite receiving anticonvulsant therapy. Monitoring was conducted for vital signs, seizure activity, and depth of anesthesia using the bispectral index (BIS). Tonic-clonic seizures in patients were successfully managed with general anesthesia. However, facial dyskinesia was still present despite the administration of general anesthesia. Facial dyskinesia worsened upon discontinuation of continuous rocuronium.Conclusion: General anesthesia could be used in the management of SRSE with the aim of controlling seizures and preventing complications arising from continuous seizures. Faculty of Medicine Universitas Padjadjaran 2025-04-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.fk.unpad.ac.id/index.php/ijihs/article/view/3881 10.15850/ijihs.v13n1.3881 International Journal of Integrated Health Sciences; Vol 13, No 1 (2025); 62-68 International Journal of Integrated Health Sciences; Vol 13, No 1 (2025); 62-68 2338-4506 2302-1381 10.15850/ijihs.v13.n1 eng https://journal.fk.unpad.ac.id/index.php/ijihs/article/view/3881/2082 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/3881/4828 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/3881/4829 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/3881/4831 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/3881/4832 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/3881/4833 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/3881/5257 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/3881/5435 Copyright (c) 2025 International Journal of Integrated Health Sciences http://creativecommons.org/licenses/by-nc/4.0

oai:ojs.journal.fk.unpad.ac.id:article/106 2024-03-27T08:38:05Z ijihs:ART

Preliminary Study: Glycemic Index of Brown and White Rice Variant IR64 in Healthy Adult Men Idril, Nur Irika Diana, Aly Wargahadibrata, Abdullah Firmansyah Objective: To measure the glycemic index of brown and white rice in healthy adult men. Methods: The study was conducted in April 2010 at Universitas Padjadjaran, Jatinangor. Subjects of 21 healthy male students were randomly divided into 3 groups, which were given white bread (WB), white rice (WR) and brown rice (BR). Results: The results show that the highest and lowest average values of the blood glucose response was in the WR group at 30 minutes (126.9 mg/dL) and at 120 minutes (87.4 mg/dL), respectively. The glycemic index of brown rice (97.28) was lower compared to the white rice (99.26). Conclusions: Both WR and BR are classified as high glycemic index food. The higher glycemic index of brown rice, compared to the index found in other literatures, may be caused by differences in variant and/or production process. This study suggested the importance of evaluation of local products before promoting it to the community.     Keywords: Blood glucose level, brown rice, glycemic index DOI: 10.15850/ijihs.v1n1.106 Faculty of Medicine Universitas Padjadjaran 2013-09-18 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.fk.unpad.ac.id/index.php/ijihs/article/view/106 International Journal of Integrated Health Sciences; Vol 1, No 1 (2013); 37-41 International Journal of Integrated Health Sciences; Vol 1, No 1 (2013); 37-41 2338-4506 2302-1381 eng https://journal.fk.unpad.ac.id/index.php/ijihs/article/view/106/94

oai:ojs.journal.fk.unpad.ac.id:article/2198 2023-11-02T04:48:58Z ijihs:CR

Differential Diagnosis of Fever of Unknown Origin in Drug Reaction with Eosinophilia and Systemic Symptom (DRESS) Muhammad, Kevin Fachri Ferdian, Ferdy Rahmadi, Andri Reza Case report; DRESS; drug reaction; fever of unknown origin; treatment Objective: To describe an unusual case of drug reaction with eosinophilia and systemic symptoms presenting as fever of unknown origin (FUO) and the diagnostic hurdles that come with the presence of differential diagnosis of FUO, which is tuberculous lymphadenitis.Methods: A 34-year-old female with a chief complaint of fever that has lasted for 3 weeks accompanied with jaundice and skin rashes for 2 weeks was admitted with an indication of FUO. She had a history of carbamazepine consumption for trigerminal neuralgia 2 months prior. Cervical lymphadenopathy was palpable bilaterally and hepatomegaly, elevated liver enzyme, as well as hyperbilirubinemia were observed. After excluding differentials for many causes of prolonged fever, patient was treated for Drug Reaction with Eosinophilia and Systemic Symptom (DRESS) and was given intravenous steroid injections. Fine needle aspiration biopsy was performed for her cervical lymphadenopathy.Results: Biopsy presented a mix of sialadenitis and tuberculous lymphadenopathy. Clinical improvement was observed on the second day after steroid administration. Patient was discharged on the seventh day after steroid administration.  Conclusion: FUO is one of the possible manifestations of DRESS; however, thorough investigation still needed to be done considering the possibility of more than one entity of disease that can cause FUO in patients, such as tuberculous lymphadenopathy seen in this case. Faculty of Medicine Universitas Padjadjaran 2022-03-31 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.fk.unpad.ac.id/index.php/ijihs/article/view/2198 10.15850/ijihs.v10n1.2198 International Journal of Integrated Health Sciences; Vol 10, No 1 (2022); 39-45 International Journal of Integrated Health Sciences; Vol 10, No 1 (2022); 39-45 2338-4506 2302-1381 eng https://journal.fk.unpad.ac.id/index.php/ijihs/article/view/2198/1652 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/2198/2134 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/2198/2871 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/2198/2872 Copyright (c) 2022 International Journal of Integrated Health Sciences http://creativecommons.org/licenses/by-nc/4.0

oai:ojs.journal.fk.unpad.ac.id:article/3215 2025-05-20T08:19:17Z ijihs:ART

Correlation between Acute Phase Symptoms with Neurological Long Covid Symptoms on COVID-19 Survivors Ganiem, Ahmad Rizal Siuliyanty, Siuliyanty Ong, Anam Gamayani, Uni Amalia, Lisda Wibisono, Yusuf Chronic fatigue syndrome; cognitive impairment; Long COVID; poor sleep quality Objective: To investigate prolonged neurological impacts of COVID-19 and establish a connection between initial COVID-19 symptom severity and chronic fatigue syndrome (CFS) development, poor sleep quality (PSQ), and cognitive impairment (CI) in individuals recovered from COVID-19.Methods:  This cross-sectional study recruited COVID-19 survivors at Dr. Hasan Sadikin General Hospital Bandung, Indonesia, between June and December 2021. All participants gave informed consent and underwent interviews on demography, clinical features, long-COVID questionnaire, and neurological examination. Participants underwent cognitive examination (MOCA-INA), Chalder Fatigue Scale and Pittsburgh Sleep Quality Index (PSQI) to assess CI, CFS, and PSQ variables. Chi-Square analysis was performed to determine the probability of neurological long COVID-19 syndrome manifestations using SPSS 24.0.Results: Of the 127 participants recruited, 67.7% were women, median (IQR) age of 33 (21-65) years, and time from hospitalization to examination of nine months (1-13). The most common neurological Long COVID symptoms were PSQ (59.8. %), CFS (51.2%), and CI (33.9%). Participants with more than five acute phase COVID-19 symptoms had a higher probability of CFS and CI (OR 2.38 (1, 16-4.9, CI 95%); OR 2.20 (1.01-4.79, CI 95%)) than those with less than five symptoms. The study did not find a significant correlation between sleep quality and number of acute-phase COVID-19 symptoms (OR 1.56 (0.76-3.20, CI 95%)).Conclusion: Almost two-thirds of the COVID-19 survivors experienced PSQ, more than half had CFS, and almost one-third had CI. The study revealed an increasing likelihood of CFS and CI in COVID-19 survivors as the number of acute COVID-19 symptoms increases. Faculty of Medicine Universitas Padjadjaran 2023-09-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.fk.unpad.ac.id/index.php/ijihs/article/view/3215 10.15850/ijihs.v11n2.3215 International Journal of Integrated Health Sciences; Vol 11, No 2 (2023); 112-119 International Journal of Integrated Health Sciences; Vol 11, No 2 (2023); 112-119 2338-4506 2302-1381 10.15850/ijihs.v11n2 eng https://journal.fk.unpad.ac.id/index.php/ijihs/article/view/3215/1857 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/3215/3905 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/3215/3915 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/3215/3965 Copyright (c) 2023 International Journal of Integrated Health Sciences http://creativecommons.org/licenses/by-nc/4.0

oai:ojs.journal.fk.unpad.ac.id:article/1962 2024-03-27T04:02:38Z ijihs:CR

Review on Acute Cardio-Cerebral Infarction: a Case Report Cotelli, Maria Sofia Manelli, Filippo infarction; magnetic resonance; relapse; spinal cord Objective: To present a case of relapsed spinal cord infarction (SCI) as an acute spinal emergency in an in-patient elderly male patient. Methods: This report presents a case of an in-patient 84 years-old man who was admitted due to acute paraparesis with urge incontinence and sudden worsening after initial improvement. To assess his condition, spine magnetic resonance was performedResults: The spine magnetic resonance confirmed relapse of spinal cord infarction, which also involved the medullar conus.Conclusion: This case report presents a very rare event that is poorly described in literature. A strict follow up of risk factors and regular neurological evaluations during ihospitalization are recommended, especially in older patients. Faculty of Medicine Universitas Padjadjaran 2021-10-19 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.fk.unpad.ac.id/index.php/ijihs/article/view/1962 10.15850/ijihs.v9n2.1962 International Journal of Integrated Health Sciences; Vol 9, No 2 (2021); 73-78 International Journal of Integrated Health Sciences; Vol 9, No 2 (2021); 73-78 2338-4506 2302-1381 10.15850/ijihs.v9n2 eng https://journal.fk.unpad.ac.id/index.php/ijihs/article/view/1962/1642 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/1962/1712 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/1962/1713 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/1962/1731 Copyright (c) 2021 International Journal of Integrated Health Sciences http://creativecommons.org/licenses/by-nc/4.0

oai:ojs.journal.fk.unpad.ac.id:article/3284 2024-01-05T03:40:38Z ijihs:ART

Association between Maternal Hemoglobin Level and Incomplete Abortion in A West Java Tertiary Hospital, Indonesia Anabela, Lisa Milena Handono, Budi Prihatni, Delita Aziz, Muhammad Alamsyah Ritonga, Mulyanusa Amrullah Anemia; Hemoglobin; Incomplete Abortion; Interpregnancy Intervals; Parity. Objective: To evaluate the association between maternal hemoglobin concentrations and incomplete abortion.Methods: An analytic, cross-sectional study with consecutive sampling method was conducted using medical records of 45 pregnant women aged 18 – 35 years old visiting the Obstetrics and Gynecology Department of Dr. Hasan Sadikin General Hospital, Bandung, Indonesia from January 1, 2017 to December 31, 2019. Participants were grouped into incomplete abortion and non-abortion groups.Results: Maternal characteristics in the incomplete abortion group showed that the majority of pregnant women in this group were 25.58 years of age, non-anemic (n=37, 82.22%), had no previous spontaneous abortion (n=40, 88.89%), and were nulliparous (n=25, 55.55%) with a mean interpregnancy interval of 4.03 years. The characteristics in both incomplete abortion group and non-abortion group were homogenous in the level of anemia (p-value=0.380), previous spontaneous abortion (p-value=1.00), and interpregnancy intervals (p-value=0.667). The mean hemoglobin concentration for the incomplete abortion group was 11.81 gr/dL (95% CI, 11.30 to 12.26). Heterogenous data was found in age (p-value=<0.001) and parity (p-value=0.002). Parity was a strong confounder, causing the hemoglobin concentration insignificantly associated to incomplete abortion (p-value=0.884).Conclusion: No statistically significant association is found between hemoglobin concentration and incomplete abortion. Most women with incomplete abortion are around 25 years old, nulliparous, non-anemic with a mean hemoglobin concentration of 11.81 gr/dL with no history of previous abortion, and a rather secure interpregnancy intervals. Faculty of Medicine Universitas Padjadjaran 2023-03-31 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.fk.unpad.ac.id/index.php/ijihs/article/view/3284 10.15850/ijihs.v11n1.3284 International Journal of Integrated Health Sciences; Vol 11, No 1 (2023); 50-56 International Journal of Integrated Health Sciences; Vol 11, No 1 (2023); 50-56 2338-4506 2302-1381 10.15850/ijihs.v11n1 eng https://journal.fk.unpad.ac.id/index.php/ijihs/article/view/3284/1802 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/3284/4005 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/3284/4006 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/3284/4007 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/3284/4008 Copyright (c) 2023 International Journal of Integrated Health Sciences http://creativecommons.org/licenses/by-nc/4.0

oai:ojs.journal.fk.unpad.ac.id:article/4017 2025-08-01T02:32:06Z ijihs:ART

HER2 Reactivity Pattern and Association with Various Tumor Factors in Breast Cancer Patients George, Greeshma Ann Antony, Philips Breast Cancer; HER2; Invasive carcinoma; Triple negative Background: Breast cancer prognosis and therapeutic strategies are strongly influenced by biomarker profiles, particularly HER2 reactivity, which impacts treatment selection and disease progression.Objective: To study the HER2 reactivity pattern and identify the association of HER2 pattern with various tumor factors in patients with breast cancer.Methods: This prospective study comprised of 150 surgically operated female cases of breast cancer admitted to the Department of Pathology for ER, PR, and HER2 testing between December 2015 and October 2017.Results: Of 150 cases, the mean age was 52 years (IQR, 41-63 years). This study showed that majority of tumors were IDC-NOS, grade 2, tumor size T2, and had negative lymph node status. HER2 negative cases were in the majority, as well as the ER/PR+ cases. Triple-negative cases were slightly higher (49 cases). When HER2 was correlated with tumor characteristics, younger patients with HER2-positive were in the majority, with the higher the tumor size is, the greater the chance for HER2 negativity. The majority of IDC cases and all ILC cases showed HER2 negativity. Both medullary cases showed HER2 positive, and one case of mucinous showed HER2 negativity with ER/PR positivity. Irrespective of ER/PR status, the majority of tumors had HER2 negativity.Conclusion: HER2/neu positively correlates with increasing age, menstrual status, tumor size, and tumor grade. No association is found between histological type, lymph node status, and ER/PR. This study also reveals that patient with higher levels of HER2/NEU-overexpression had statistically significant lower levels of ER/PR-positive tumors. In addition, when Her2 neu is positive in tumors, along with ER and PR, it is mostly high-grade. Faculty of Medicine Universitas Padjadjaran 2025-04-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.fk.unpad.ac.id/index.php/ijihs/article/view/4017 10.15850/ijihs.v13n1.4017 International Journal of Integrated Health Sciences; Vol 13, No 1 (2025); 1-7 International Journal of Integrated Health Sciences; Vol 13, No 1 (2025); 1-7 2338-4506 2302-1381 10.15850/ijihs.v13.n1 eng https://journal.fk.unpad.ac.id/index.php/ijihs/article/view/4017/2073 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/4017/5064 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/4017/5065 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/4017/5066 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/4017/5092 Copyright (c) 2025 International Journal of Integrated Health Sciences http://creativecommons.org/licenses/by-nc/4.0

oai:ojs.journal.fk.unpad.ac.id:article/1201 2024-06-11T03:26:57Z ijihs:ART

Gender, Age, Marital Status, and Education as Predictors to Quality of Life in Elderly: WHOQOL-BREF Indonesian Version Gondodiputro, Sharon Hidayati, Aghnia Rizki Rahmiati, Lina Education level, elderly, gender, marital status, quality of life Objective: To analyze the quality of life in elderly with regards to gender, age, marital status, and education.Methods: An analytical study involving 88 (eighty eight) elderly who lived in 6 villages in the suburb area of Jatinangor sub-district, West Java, Indonesiawas performed in June 2017. The inclusion criteria were men and women, ≥60 years old, able to communicate in Indonesian, and a mini mental state examination (MMSE) score of ≥23. The variables in the study were gender, age, marital status, and education. Quality of life (QoL) was measured using translated WHOQOL-BREF. Collected data in the study were analyzed statistically using Chi square, Mann-Whitney, Friedman, Post hoc using Wilcoxon, and Kruskal-Wallis tests.Results: The study discovered that all of the respondents had low QoL score (≤60). The lowest score was the result of physical  domain. There was no significant QoL difference between men and women (p>0.05) but a significant QoL difference regarding to age, marital status and education level was found in the study (p˂0.05).Conclusions: Elderly in suburb area has low QoL and there is a difference in Qol based on age, marital status, and educational level.Keywords: Education level, elderly, gender, marital status, quality of life DOI: 10.15850/ijihs.v6n1.1201 Faculty of Medicine Universitas Padjadjaran 2018-03-29 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.fk.unpad.ac.id/index.php/ijihs/article/view/1201 International Journal of Integrated Health Sciences; Vol 6, No 1 (2018); 36-41 International Journal of Integrated Health Sciences; Vol 6, No 1 (2018); 36-41 2338-4506 2302-1381 eng https://journal.fk.unpad.ac.id/index.php/ijihs/article/view/1201/1153 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/1201/601 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/1201/602 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/1201/603 Copyright (c) 2018 International Journal of Integrated Health Sciences http://creativecommons.org/licenses/by-nc/4.0

oai:ojs.journal.fk.unpad.ac.id:article/2868 2023-11-02T04:47:31Z ijihs:CR

High-risk Neuroblastoma in Young Adult and Long Term Survival with Multimodal Therapy: A Case Report Oehadian, Amaylia Afiati, Afiati Sung, Martina Budiman, Kevin Yonatan Fransisca, Fransisca High-risk Neuroblastoma; Long Term Survival; Young Adult. Objective: To present a case of high-risk, stage four neuroblastoma in a 20-year-old woman who survived more than 21 months with the multimodal therapy.Methods: A case of high-risk, stage four neuroblastoma in a 20-year-old woman who survived more than 21 months with multimodal therapy is reported. The patient initially received neoadjuvant chemotherapy according to the Turkish Pediatric Oncology Group of Neuroblastoma, along with multiple doses of radiotherapy. After two cycles of induction chemotherapy, she successfully underwent tumor debulking surgery.Results: With the multimodal therapy, patient remains in complete remission state and stable disease of the remaining lesions is observed in this patient.Conclusions: Neuroblastoma is a rare disease in adults and associated with a high number of mortality. Early and accurate diagnosis and multimodality of treatments are important to achieve disease control. Long term follow up is necessary for such patients. Faculty of Medicine Universitas Padjadjaran 2022-09-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.fk.unpad.ac.id/index.php/ijihs/article/view/2868 10.15850/ijihs.v10n2.2868 International Journal of Integrated Health Sciences; Vol 10, No 2 (2022); 102-106 International Journal of Integrated Health Sciences; Vol 10, No 2 (2022); 102-106 2338-4506 2302-1381 eng https://journal.fk.unpad.ac.id/index.php/ijihs/article/view/2868/1750 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/2868/3473 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/2868/3474 Copyright (c) 2022 International Journal of Integrated Health Sciences http://creativecommons.org/licenses/by-nc/4.0

oai:ojs.journal.fk.unpad.ac.id:article/3963 2024-11-25T05:49:22Z ijihs:ART

Factors affecting Umbilical Cord Vitamin D Concentration and Its Association with Maternal Vitamin D Level Aggarwal, Aditya Modi, Amit Kumar Singh, K. Rimi Jha, Avinash Kumar Fetal development; neonate; pregnancy; vitamin D Objective: To analyze factors affecting maternal and umbilical cord levels of vitamin D and to understand the correlation between maternal and umbilical cord vitamin D levels.Methods: This was a cross-sectional study conducted at the department of pediatrics of Dr. D. Y. Patil Medical College and Research Centre, Pune, India. Maternal and umbilical cord vitamin D levels were examined in 300 pairs of mother and child over a period of two years. Informed consent was obtained from all participants. The vitamin D level was measured using chemiluminescent immunoassay and classified as either deficient, insufficient or adequate depending on specific cut-offs. Correlations between maternal and neonatal vitamin D levels and demographic factors like religion, socioeconomic status, and sun exposure were also exlored. Statistical tests were performed using the SPSS 21.0 software, with p<0.05 deemed P-valueas significant.Results: There was significantly high prevalence of vitamin D deficiency in neonates, (78.67%). Key factors influencing maternal vitamin D levels were religion (p=0.027), maternal education (p=0.003), gravida status (p=0.035), and sunlight exposure, with sunlight exposure showing a very strong correlation to the deficiency (p<0.001). Moreover, maternal serum calcium levels significantly affected vitamin D status (p<0.001). A significant association was observed between maternal and cord blood vitamin D levels, with the maternal vitamin D level strongly predicted vitamin D status in neonates (p<0.001).Conclusion: The umbilical cord vitamin D level strongly correlates with the maternal vitamin D level, which is  significantly affected by maternal education, residence, pregnancy status, gestational age, and sun exposure. Faculty of Medicine Universitas Padjadjaran 2024-09-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.fk.unpad.ac.id/index.php/ijihs/article/view/3963 10.15850/ijihs.v12.n2.3963 International Journal of Integrated Health Sciences; Vol 12, No 2 (2024); 78-86 International Journal of Integrated Health Sciences; Vol 12, No 2 (2024); 78-86 2338-4506 2302-1381 10.15850/ijihs.v12.n2 eng https://journal.fk.unpad.ac.id/index.php/ijihs/article/view/3963/1996 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/3963/5176 Copyright (c) 2024 International Journal of Integrated Health Sciences http://creativecommons.org/licenses/by-nc/4.0

oai:ojs.journal.fk.unpad.ac.id:article/4119 2025-12-04T07:27:55Z ijihs:ART

In-Hospital Outcomes Comparison Between Off-Pump and On-Pump CABG: Indonesian Tertiary Center Experience Dewi, Triwedya Indra Jungjunan, Ridho Raharjo, Pradana Pratomo Rezkita, Aliya Rahmadewi Hidayat, Syarief Martha, Januar Wibawa Nusjirwan, Rama Akbar, Mohammad Rizki Coronary artery bypass surgery; coronary artery disease; off-pump; on-pump; revascularization Background: Coronary artery disease (CAD) often requires revascularization. Coronary artery bypass grafting (CABG) is a cornerstone intervention that improves patients’ survival. Both on-pump and off-pump CABG have their own advantages and limitations, with reported outcomes vary across studies.Objective: to investigate the differences in the outcomes of patients undergoing off-pump and on-pump CABG.Methods: A retrospective cohort study was performed on 186 patients aged ≥18 years undergoing on-pump or off-pump CABG between June 2020 and December 2023. Outcomes included were all-cause mortality, postoperative acute renal failure, length of postoperative stay, and complete revascularization rate. Comparative analysis was conducted using Chi-Square test and independent T-test. Multivariate analysis, including logistic regression tests, was carried out to identify independent predictors associated with each outcome.Results: The on-pump group presented more diabetes (42.9% vs. 28.4%; P=0.040) and lower left ventricular ejection fraction (LVEF) values (43 [IQR 16–79] vs. 53 [23–75]; P=0.001). Patients in this group also had higher rates of postoperative renal failure (61.5% vs. 24.2%; P<0.001), longer stays (64.8% vs. 41.1%; P=0.001), and better complete revascularization (98.9% vs. 92.6%; P=0.035), but no significant difference in mortality (16.5% vs. 13.7%; P =0.594). Multivariate analysis identified diabetes, LVEF ≤40%, and postoperative renal failure as predictors of mortality.Conclusions: On-pump CABG is associated with higher rates of complete revascularization. However, the adoption of this technique is linked to a higher risk of postoperative acute kidney failure and prolonged hospital stays. No difference in mortality is observed between those with off-pump and on-pump. Faculty of Medicine Universitas Padjadjaran 2025-10-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.fk.unpad.ac.id/index.php/ijihs/article/view/4119 10.15850/ijihs.v13n2.4119 International Journal of Integrated Health Sciences; Vol 13, No 2 (2025); 96-104 International Journal of Integrated Health Sciences; Vol 13, No 2 (2025); 96-104 2338-4506 2302-1381 10.15850/ijihs.v13n2 eng https://journal.fk.unpad.ac.id/index.php/ijihs/article/view/4119/2153 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/4119/5222 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/4119/5268 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/4119/5269 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/4119/5303 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/4119/5823 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/4119/5824 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/4119/5868 Copyright (c) 2025 International Journal of Integrated Health Sciences http://creativecommons.org/licenses/by-nc/4.0

oai:ojs.journal.fk.unpad.ac.id:article/400 2023-11-02T04:53:25Z ijihs:ART

Discharge against Medical Advice in Pediatric Intensive Care Unit and Subsequent Events Somasetia, Dadang Hudaya Isman, Susanto Wonoputri, Nathania Discharge against medical advice (DAMA), pediatric, pediatrics intensive care unit (PICU) Objective: The occurence of discharge against medical advice (DAMA) has impacted globally. Decisions of DAMA in pediatric patients are not made by the patients, but pose life-threatening consequences, especially for children treated in Pediatrics Intensive Care Unit (PICU). The present study aimed to identify the occurence of DAMA and subsequent events to the DAMA patients after treated in PICU of Dr. Hasan Sadikin General Hospital Bandung, Indonesia.Methods: A retrospective study from medical records of DAMA patients from PICU of Dr. Hasan Sadikin General Hospital, Bandung, Indonesia, between April 2011 and April 2012. Results: A total of 195 children aged 1–5 years were admitted. Of this number, 12 (6.2%) were DAMA. Financial problems were the most common reason for DAMA, followed by parents’ perception about their child’s terminal condition. The majority of parents were laborer. Last parents’ education level was mostly elementary school. Most patients who DAMA from PICU died in less than 24 hours.Conclusions: A considerable number of DAMA was found in our PICU. High mortality occured after patients asked for DAMA from PICU.Keywords: Discharge against medical advice (DAMA), pediatric, pediatrics intensive care unit (PICU) DOI: 10.15850/ijihs.v3n1.400 Faculty of Medicine Universitas Padjadjaran 2015-04-06 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.fk.unpad.ac.id/index.php/ijihs/article/view/400 International Journal of Integrated Health Sciences; Vol 3, No 1 (2015); 7-10 International Journal of Integrated Health Sciences; Vol 3, No 1 (2015); 7-10 2338-4506 2302-1381 10.15850/ijihs.v3n1 eng https://journal.fk.unpad.ac.id/index.php/ijihs/article/view/400/364 Copyright (c) 2015 International Journal of Integrated Health Sciences http://creativecommons.org/licenses/by-nc/4.0

oai:ojs.journal.fk.unpad.ac.id:article/2652 2023-11-02T05:01:13Z ijihs:ART

Correlation between serum KL-6 level and severity of SARD-related ILD Pranggono, Emmy Syukrie, Alvy Moenadri, Valentine Natasya Dewi, Sumartini ILD; KL-6; SARD Objective: To understand the correlation between serum KL-6 level and severity of SARD-related ILD in Indonesia.Method: This was a cross-sectional study to evaluate the correlation between serum KL-6 level and Interstitial Lung Disease (ILD) severity based on Chest High-Resolution Computed Tomography (Chest HCRT) among patients with Systemic Autoimmune Rheumatic Disorders (SARD) who visited the Rheumatology Clinic of Dr. Hasan Sadikin General Hospital during the period of January 2019 to February 2020. Secondary data were retrieved from a study on the Effects of Ciplukan Herbs on Organ Fibrosis. KL-6 serum concentration was measured from stored biological material and the correlation between the serum KL-6 level and ILD severity was analyzed by Rank Spearman's test.Results: Thirty-four patients participated in this study with a median age of 37 years-old. Most of the participants were female (94.1%), Sundanese (64.7%), and had systemic sclerosis as an underlying disease (48.5). The median serum KL-6 level was 57.1 U/ml (21.6-444.1). Most participants belonged to severe ILD group (58.8%) with a mean serum KL-6 level of 65.1±48.9 U/ml. The highest mean serum KL-6 level (111.6±121.8) was observed in the moderate ILD group comprising of 32.4% of the participants. The remaining 11.8% participants belonged to mild ILD group with a mean serum KL-6 level of 61.1±24.9 U/ml. Serum KL-6 level was demonstrated to have a weak correlation with ILD severity (r=-0.229, p=0.193).Conclusion. There is an insignificant weak correlation between serum KL-6 level and ILD severity based on chest HRCT in SARD patients. Faculty of Medicine Universitas Padjadjaran 2022-03-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.fk.unpad.ac.id/index.php/ijihs/article/view/2652 10.15850/ijihs.v10n1.2652 International Journal of Integrated Health Sciences; Vol 10, No 1 (2022); 20–25 International Journal of Integrated Health Sciences; Vol 10, No 1 (2022); 20–25 2338-4506 2302-1381 eng https://journal.fk.unpad.ac.id/index.php/ijihs/article/view/2652/1649 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/2652/3142 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/2652/3143 Copyright (c) 2022 International Journal of Integrated Health Sciences http://creativecommons.org/licenses/by-nc/4.0

oai:ojs.journal.fk.unpad.ac.id:article/3544 2024-06-11T07:30:01Z ijihs:ART

Risk Factors for Treatment Drop Out Among Pulmonary Tuberculosis Patients at the UPT Public Health Center in Medan Sunggal Zuhair, Raisa Daffa Ismah, Zata Drug side effect, pulmonary TB, TB treatment drop out AbstractObjective: To determine the factors contributing to treatment dropout in tuberculosis (TB) patients.Methods: This study utilized a case-control design with a sample size of 81 participants. Univariate, bivariate, and multivariate analyses were conducted, and an accidental sampling technique was employed. The study was conducted at the Public Health Center/Puskesmas Medan Sunggal, in the Medan Sunggal District, City of Medan, and North Sumatra Province. The research took place from February to April 2023.Results: The research analysis revealed a significant relationship between knowledge and family support (p<0.05). However, there was no significant relationship found between drug side effects and treatment dropout (p>0.05). This lack of significance may be attributed to the consistent occurrence of side effects throughout the different stages of treatment.Conclusion: In conclusion, this research demonstrates a significant correlation between patients’ knowledge, family support, and treatment dropout (p<0.05). Conversely, no significant correlation was found between drug side effects and treatment dropout (p>0.05).Keywords: Drug side effect, pulmonary TB, TB treatment drop out Faculty of Medicine Universitas Padjadjaran 2024-03-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.fk.unpad.ac.id/index.php/ijihs/article/view/3544 10.15850/ijihs.v12.n1.3544 International Journal of Integrated Health Sciences; Vol 12, No 1 (2024); 36-42 International Journal of Integrated Health Sciences; Vol 12, No 1 (2024); 36-42 2338-4506 2302-1381 10.15850/ijihs.v12.n1 eng https://journal.fk.unpad.ac.id/index.php/ijihs/article/view/3544/1938 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/3544/4350 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/3544/4381 Copyright (c) 2024 International Journal of Integrated Health Sciences http://creativecommons.org/licenses/by-nc/4.0

oai:ojs.journal.fk.unpad.ac.id:article/4327 2025-08-01T02:32:08Z ijihs:ART

Assessment of Disease Progression in Idiopathic and Collagen Vascular ILDs Using Spirometry, DLCO, and 6 Minute-Walk-Test Rawul, Sindhoora Kumar, R. Vijai Rawul, Apoorva Chelluri, Srinivasa I. Singaraju, Saikrishna Connective Tissue Disease-Associated Interstitial Lung Disease; Idiopathic Pulmonary Fibrosis; Pulmonary Function Test; Six-Minute Walk Test Background: Monitoring progression in interstitial lung diseases is essential for timely intervention, with spirometry, DLCO, and 6MWT serving as key functional tests.Objectives: To evaluate disease progression in idiopathic and collagen vascular interstitial lung diseases (ILD) using pulmonary function parameters, including spirometry, DCLO (Diffusing Capacity of the Lungs for Carbon Monoxide), and the six-minute walk test.Methods: This prospective observational study was performed from January  2023 to December 2024 at Shadan Institute of Medical Sciences , Hyderabad, India. In this study, the pulmonary function in 51 ILD patients were assessed using spirometry, DLCO, and the six-minute walk test. Patients underwent detailed clinical evaluation, routine investigations, chest X-ray, ABG analysis, and HRCT to confirm ILD. Those suspected of CTD-ILD had RF and ANA testing, with a complete ANA profile if positive. Subjects were categorized into IPF and CTD-ILD groups. Pulmonary parameters were compared, and standard treatments were administered. Six deaths occurred during follow up period.  For statistical purposes p value less than 0.05 was taken as statistically significant.Results: Fifty-one patients with diffuse parenchymal lung disease were included, with idiopathic pulmonary fibrosis (IPF) (46.4%) and connective tissue disease-associated ILD (CTD-ILD) (44.6%) as the main types. The CTD-ILD patients were younger (mean age 48.64 vs. 61.80 years, p=0.0006) and predominantly female. IPF patients had lower six-minute walk distance (239.73 vs. 312.60 meters, p=0.0066) and SpO2. Strong correlations were observed between lung function parameters in both groups. However, 6MWT showed no correlation in CTD-ILD.Conclusion: In ILD patients, FVC and DLCO were found to be reliable for disease monitoring, while simpler tests like 6MWT and FVC proved to be useful in resource-limited settings. Further research is needed to confirm their role in tracking IPF progression and treatment response. Faculty of Medicine Universitas Padjadjaran 2025-04-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.fk.unpad.ac.id/index.php/ijihs/article/view/4327 10.15850/ijihs.v13n1.4327 International Journal of Integrated Health Sciences; Vol 13, No 1 (2025); 37-43 International Journal of Integrated Health Sciences; Vol 13, No 1 (2025); 37-43 2338-4506 2302-1381 10.15850/ijihs.v13.n1 eng https://journal.fk.unpad.ac.id/index.php/ijihs/article/view/4327/2078 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/4327/5558 Copyright (c) 2025 International Journal of Integrated Health Sciences http://creativecommons.org/licenses/by-nc/4.0

oai:ojs.journal.fk.unpad.ac.id:article/102 2024-03-27T08:38:05Z ijihs:ART

Strategy for the Use of Erythropoetin Alpha to Maintain Hemoglobin Level in Breast Cancer Patient Treated with Anthracycline-base of Adjuvant Chemotherapy Achmad, Dimyati Hariady, Yusuf Hariady Isakh, Benny Abdurrahman, Maman Faried, Ahmad Objective: To evaluate the value of erythropoietin alpha (epoetin) administration, as an alternative treatment of anemia in the operable breast cancer patients.Methods: This is a multicenter phase III randomized clinical trial to evaluate the value of epoetin administration among anemic breast cancer patients who are undergoing anthracyclin-based adjuvant chemotherapy. Sixty four patients were incuded in this trial with initial hemoglobin (Hb) level of 10–12 g/dL. The patients were randomly distributed into two groups: one group received aministration of 40,000 IU epoetin/week for six times a week after operation and the other did not.  In the third week after the operation, both groups were started on a 6 cycles of adjuvant chemotherapy with three weeks intervals. Hb levels were evaluated during every chemotherapy cycle. Results: The Hb levels in the epoetin group were always above 10 g/dL up until the end of the sixth chemotherapy cycle or until the twenty first week post operation without blood transfusion. Conclusions: The administration of epoetin 3 weeks prior and 3 weeks after the first cycles of chemotherapy, maintains a sufficient/normal Hb level in breast cancer patients receiving anthracycline-based chemotherapy.Keywords: Anthracyclin-based chemotherapy, breast cancer, erythropoietin alpha DOI: 10.15850/ijihs.v1n1.102 Faculty of Medicine Universitas Padjadjaran 2013-09-17 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.fk.unpad.ac.id/index.php/ijihs/article/view/102 International Journal of Integrated Health Sciences; Vol 1, No 1 (2013); 8-12 International Journal of Integrated Health Sciences; Vol 1, No 1 (2013); 8-12 2338-4506 2302-1381 eng https://journal.fk.unpad.ac.id/index.php/ijihs/article/view/102/88 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/102/4

oai:ojs.journal.fk.unpad.ac.id:article/2249 2023-11-02T04:49:52Z ijihs:CR

Culprit-Only Versus Complete Revascularization in STEMI Multi-Vessel Disease: A Case Report Putri, Mega Amanda Yahya, Achmad Fauzi Dewi, Triwedya Indra complete revascularization; multivessel disease; percutaneous coronary intervention; STEMI Objective: To revisit data and highlight management of STEMI multi-vessel disease and explore culprit-only versus multi-vessel PCI and optimal timing to achieve complete revascularization.Methods: A 67 years old male with chest pain at rest 2 hours before admission with a history of smoking one pack of cigarette every day, was presented to the hospital. Physical examination was within normal limit with normal hemodynamically; however, elevated cardiac troponin was identified. Electrocardiogram showed STEMI anteroseptal wall with ischemic inferior wall, leading toSTEMI anteroseptal wall, Killip I diagnosis. Primary PCI was performed and multi-vessel disease was found. A complete revascularization single-staged procedure was performed due to his persistent chest pain. PCI of these coronary stenoses is beneficial to reduce risk of cardiac death and recurrent infarction. However, some issues related to PCI of non-culprit coronary arteries lesion and optimal timing to do complete revascularization is still a dilemma. Results: Related to data from some trials, e.g PRAMI, CvLPRIT, DANAM-3-PRIMULTI, COMPARE-ACUTE, COMPLETE, and some meta-analyses, showed benefit and safety of routine PCI of non-culprit lesions as a preventive strategy to reduce morbidity and mortality. Data showed reduce future morbidity and mortality in this setting. Meanwhile, the optimal timing of complete revascularization is still a matter of debate, although some data showed benefit of index procedural PCI.Conclusion: PCI of non-culprit lesions of myocardial infarction is consistently beneficial over culprit-only revascularization in patients with STEMI multi-vessel disease, despite the debate on the optimum timing for complete revascularization in this setting. Faculty of Medicine Universitas Padjadjaran 2021-10-19 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.fk.unpad.ac.id/index.php/ijihs/article/view/2249 10.15850/ijihs.v9n2.2249 International Journal of Integrated Health Sciences; Vol 9, No 2 (2021); 89-94 International Journal of Integrated Health Sciences; Vol 9, No 2 (2021); 89-94 2338-4506 2302-1381 10.15850/ijihs.v9n2 eng https://journal.fk.unpad.ac.id/index.php/ijihs/article/view/2249/1645 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/2249/2213 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/2249/2657 Copyright (c) 2021 International Journal of Integrated Health Sciences http://creativecommons.org/licenses/by-nc/4.0

oai:ojs.journal.fk.unpad.ac.id:article/3471 2025-05-20T08:19:17Z ijihs:ART

Outcome of Posterior Cruciate Ligament Avulsion Fractures from Tibial Attachment Treated by Open Reduction and Internal Fixation Khambalkar, Shouryashil V. Patil, Tanish C. Patil, Jaydeep K. Ghorpade, Kapil R. Naik, Nagesh Fracture; Internal Fixation; Open Reduction; Outcome; Posterior Cruciate Ligament Objectives: To analyze the clinical and functional outcomes of posterior cruciate ligament avulsion fractures treated by open reduction and internal fixation from tibial attachment.Methods: This observational study was conducted at the orthopedics department of a tertiary care medical college. Forty adult patients with PCL avulsion fractures were included in this study based on predefined inclusion and exclusion criteria. All patients were treated by open reduction and internal fixation. Patients were followed up for one year. The Lysholm scale and knee society score were used to assess functional outcomes. A p-value less than 0.05 was considered to be statistically significant.Results: Overall, 34 (75 %) males and 6 (15%) females participated in this study with an M: F ratio of 1:0.17. The mean age of affected patients was 37.3 +/- 7.34 years. Out of 40 patients, 29 (72.50%) patients sustained fractures secondary to road traffic accidents, while 7 (17.50%) had sports-related injuries. There was a highly significant improvement in the Lysholm and Knee Society scores from the time of presentation to the final follow-up (P<0.0001). Only 1 (2.5%) patient developed residual joint instability as evidenced by the drawer test result.Conclusion: Patients with posterior cruciate ligament avulsion fracture treated by Open reduction and internal fixation were found to have excellent results in terms of functional outcomes. Faculty of Medicine Universitas Padjadjaran 2023-09-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.fk.unpad.ac.id/index.php/ijihs/article/view/3471 10.15850/ijihs.v11n2.3471 International Journal of Integrated Health Sciences; Vol 11, No 2 (2023); 85-91 International Journal of Integrated Health Sciences; Vol 11, No 2 (2023); 85-91 2338-4506 2302-1381 10.15850/ijihs.v11n2 eng https://journal.fk.unpad.ac.id/index.php/ijihs/article/view/3471/1853 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/3471/4391 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/3471/4392 Copyright (c) 2023 International Journal of Integrated Health Sciences http://creativecommons.org/licenses/by-nc/4.0

oai:ojs.journal.fk.unpad.ac.id:article/2232 2022-04-11T03:03:33Z ijihs:ART

Effects of Low-level Laser Therapy on Fibroblast Density in Achilles Tendon Rupture Healing Andhika, Cakra Primadhi, Raden Andri Rasyid, Hermawan Nagar Achilles; Fibroblast; Laser; Rupture Objective: To investigate the effect of low-level laser therapy (LLLT) on fibroblast proliferation as a part of the tendon healing cascade. Methods: This was an unpaired comparative experimental animal laboratory study with one control groups and two experimental groups, each consisted of 10 Sprague Dawley rats. The experimental groups 1 and 2 were given infrared irradiation for 15 minutes and 30 minutes per day, respectively, after having their achilles tendon partially cut. Histological assessment was carried out to assess the fibroblast density in healing site after three weeks on intervention. Results: The median values of fibroblast density in group 1, group 2, and control group were 1, 2, and 1, respectively, with a p-value of  0.014. No significant difference (p = 0.123) was identified on Mann-Whitney test between the fibroblast density of group 1 and group 2. The same was also true forgroup 1 and control group (p = 0.315). A significant difference was found between group 2 and control group (p = 0.005). Conclusions: A regime of LLLT irradiation of 30 min/day for two weeks (1080 J cm-2) improves the fibroblast proliferation amidst tendon healing in a partially injured achilles tendon in a rat model, which is not seen in the regime with a 15 min/day duration. This emphasizes the significance of irradiation time to improve tendon healing, despite the deficient understanding of the mechanism. Faculty of Medicine Universitas Padjadjaran 2021-03-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.fk.unpad.ac.id/index.php/ijihs/article/view/2232 10.15850/ijihs.v9n1.2232 International Journal of Integrated Health Sciences; Vol 9, No 1 (2021); 13-18 International Journal of Integrated Health Sciences; Vol 9, No 1 (2021); 13-18 2338-4506 2302-1381 10.15850/ijihs.v9n1 eng https://journal.fk.unpad.ac.id/index.php/ijihs/article/view/2232/1602 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/2232/2175 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/2232/2177 Copyright (c) 2021 International Journal of Integrated Health Sciences http://creativecommons.org/licenses/by-nc/4.0

oai:ojs.journal.fk.unpad.ac.id:article/3073 2024-01-05T03:40:36Z ijihs:ART

Clinical Profile of Mucormycosis during the Second Wave of COVID-19 in a Tertiary Care Center in India Kunhiparambath, Sunil Kumar Oommen, Beena Keeriyatt Govindan, Sajeeth Kumar Nair, Karichery Shilpa Madayambath, Sagesh Amphotericin B; Covid-19; Invasive Fungal Sinusitis; Mucormycosis. Objective: To study the clinical profile and treatment outcome of mucormycosis associated with the second wave of COVID-19 pandemic.Methods: An observational study was conducted in a tertiary care center over a period of 12 months, including a 6-month post treatment follow up. Study included all COVID positive patients with a clinical and radiological evidence of rhino-orbito-cerebral mucormycosis during the second wave of COVID-19. All patients underwent further diagnostic workup and confirmed cases underwent surgical debridement and Amphotericin B was started.Results: A total of 59 patients presented with mucormycosis with the mean age being 52.7 years and unilateral facial and orbital edema as the most common symptoms (28.8%). All were diabetic with HbA1c >7 in 54.2%. The mean duration of presentation was 20.7±7.9 days from the onset of COVID-19 infection. Unilateral involvement of the paranasal sinuses was the most common finding in MRI. Early administration of Amphotericin B with prompt surgical debridement was performed in all cases. Orbital exenteration was conducted in nine patients for better fungal load clearance. Patients showed a good response to surgical debridement and prompt medical treatment, with a mortality rate of 27%.Conclusion: COVID-19 associated mucormycosis is difficult to treat and often presents in late stage. Uncontrolled diabetes, immunocompromised state, and steroid-induced immunosuppression were important risk factors. A close surveillance for early identification and initiation of treatment is mandatory. Repeated surgical debridement to clear the dead tissue is effective to control fungal load.  Faculty of Medicine Universitas Padjadjaran None 2023-03-31 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.fk.unpad.ac.id/index.php/ijihs/article/view/3073 10.15850/ijihs.v11n1.3073 International Journal of Integrated Health Sciences; Vol 11, No 1 (2023); 20-26 International Journal of Integrated Health Sciences; Vol 11, No 1 (2023); 20-26 2338-4506 2302-1381 10.15850/ijihs.v11n1 eng https://journal.fk.unpad.ac.id/index.php/ijihs/article/view/3073/1797 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/3073/3719 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/3073/3720 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/3073/3721 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/3073/3767 Copyright (c) 2023 International Journal of Integrated Health Sciences http://creativecommons.org/licenses/by-nc/4.0

oai:ojs.journal.fk.unpad.ac.id:article/3564 2024-11-25T05:49:20Z ijihs:ART

Nutrition Education Effect in Increasing Knowledge and Ability to Interpret Nutrition Facts in Adolescents Meylinda, Jovita Octa Arinda, Ditia Fitri Yuliana, Indah Sari, Desri Maulina Interpretation ability, knowledge, nutrition education, nutrition facts Objective: To evaluate the effectiveness of nutrition education on the understanding and proficiency in interpreting nutrition labels among adolescents aged 16-18 years..Methods: This quantitative study adopted quasi-experimental and control group designs with a pre-test and post-test approach. The sample size included 60 participants, divided into 2 equal groups, receiving education through lecture method and leaflets, respectively. The intertervention was conducted one day in group 1 and group 2, respectively. Sample selection was conducted using a simple random sampling method. Data were collected through a knowledge questionnaire and details on reading ability were obtained using an interpreting ability checklist through pre-tests and post-tests conducted at the same day. The retrieved data were analyzed using the Wilcoxon Signed Rank Test and the Mann-Whitney U Test (α=0.05).Results: Nutrition education is shown to enhance the understanding (p-value=0,026) and proficiency of students in interpreting nutrition facts (p-value=0,064).Conclusion: Nutrition education had a positive impact on the understanding and skill of adolescents in reading nutrition facts. Thus, developing educational materials that can be readily applied in daily life will help consumers in making more nutritionally informed choices when selecting packaged foods. Faculty of Medicine Universitas Padjadjaran 2024-09-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.fk.unpad.ac.id/index.php/ijihs/article/view/3564 10.15850/ijihs.v12.n2.3564 International Journal of Integrated Health Sciences; Vol 12, No 2 (2024); 117-124 International Journal of Integrated Health Sciences; Vol 12, No 2 (2024); 117-124 2338-4506 2302-1381 10.15850/ijihs.v12.n2 eng https://journal.fk.unpad.ac.id/index.php/ijihs/article/view/3564/2001 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/3564/4393 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/3564/4501 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/3564/4502 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/3564/4522 Copyright (c) 2024 International Journal of Integrated Health Sciences http://creativecommons.org/licenses/by-nc/4.0

oai:ojs.journal.fk.unpad.ac.id:article/4265 2025-12-04T07:27:57Z ijihs:ART

Correlation between Health Service Quality, TB Patient Behavior, and Treatment Compliance Syahadat, Dilla Srikandi Buchair, Nur Hikmah Sari, Nur Fadhilah Azzahra, Nur Azizah Attitude; compliance; service; treatment; tuberculosis Background: Tuberculosis (TB) remains a major public health problem in Indonesia, where treatment adherence is essential for preventing drug resistance, treatment failure, and continued transmission. The quality of health services and patient behavior are key determinants influencing adherence, particularly at the primary healthcare level.Objective: To analyze the effect of health services and tuberculosis (TB) patients’ behavior on adherence to TB treatment in Palu City.Methods: A cross-sectional study was conducted among 100 TB patients attending 14 community health centers (Puskesmas) in Palu City, Indonesia, selected through cluster random sampling. Data were collected from August to September 2024 using structured questionnaires. Univariate and bivariate analyses were performed, with statistical testing conducted using the Spearman rank correlation at a 95% confidence level (α = 0.05).Results: Most respondents were from Talise Health Center (12%), aged 21–29 years (24%), self-employed (50%), and had completed high school education (45%). Overall, 84% were treatment-compliant, and 97% demonstrated a positive attitude. All respondents with a less favorable attitude were non-compliant, while 86.6% of those with a good attitude were compliant. Regarding health services, 96% reported good services, and 86.5% of them were compliant, compared to 25% among those with poor services. Significant associations were found between attitude (ρ = 0.000, r = 0.417), health service quality (ρ = 0.000, r = 0.455), and treatment adherence.Conclusion: There is a significant association between the quality of healthcare services,  patient attitudes, and adherence to TB treatment. Strengthening patient-centered services and ongoing counseling at Puskesmas are essential to sustain treatment success and reduce transmission. Faculty of Medicine Universitas Padjadjaran 2025-10-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.fk.unpad.ac.id/index.php/ijihs/article/view/4265 10.15850/ijihs.v13n2.4265 International Journal of Integrated Health Sciences; Vol 13, No 2 (2025); 138-144 International Journal of Integrated Health Sciences; Vol 13, No 2 (2025); 138-144 2338-4506 2302-1381 10.15850/ijihs.v13n2 eng https://journal.fk.unpad.ac.id/index.php/ijihs/article/view/4265/2158 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/4265/5523 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/4265/5524 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/4265/5525 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/4265/5526 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/4265/5528 Copyright (c) 2025 International Journal of Integrated Health Sciences http://creativecommons.org/licenses/by-nc/4.0

oai:ojs.journal.fk.unpad.ac.id:article/407 2023-11-02T04:53:25Z ijihs:CR

Robotic Surgery for Giant Presacral Dumbbell-Shape Schwannoma Yudoyono, Farid Arifin, Muhammad Zafrullah Dahlan, Rully Hanafi Ompusunggu, Sevline Estethia Ah, Shin Dong Seong, Yi Yoon, Ha Heum, Yoon Do Nyun, Kim Keung da Vinci robotic surgical system, presacral, schwannoma Objective: To demonstrate the feasibility of using da Vinci robotic surgical system to perform spinal surgery.Methods: Magnetic resonance imaging (MRI) of a 29-year-old female patient complaining right pelvic pain for 1 month revealed a 17x8x10 cm non-homogeneous dumbbell shape encapsulated mass with cystic change located in the pelvic cavity and caused an anterior displacement of urinary bladder and colon.Results: There was no systemic complication and pain decrease 24 hours after surgery and  during 2 years of follow up. The patient started a diet 6 hours after the surgery and was discharged 72 hours after the surgery. The pathological diagnosis of the tumor was schwannoma. Conclusions: Giant dumbbell shape presacral schwannomas are rare tumours and their surgical treatment is challenging because of the complex anatomy of the presacral. Clinical application of da Vinci robotic surgical system in the spinal surgical field is currently confined to the treatment of some specific diseases or procedures. However, robotic surgery is expected to play a practical future role as it is minimally invasive. The advent of robotic technology will prove to be a boon to the neurosurgeon.Keywords: da Vinci robotic surgical system, presacral, schwannoma DOI: 10.15850/ijihs.v3n1.407 Faculty of Medicine Universitas Padjadjaran 2015-04-06 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.fk.unpad.ac.id/index.php/ijihs/article/view/407 International Journal of Integrated Health Sciences; Vol 3, No 1 (2015); 33-38 International Journal of Integrated Health Sciences; Vol 3, No 1 (2015); 33-38 2338-4506 2302-1381 10.15850/ijihs.v3n1 eng https://journal.fk.unpad.ac.id/index.php/ijihs/article/view/407/371 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/407/203 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/407/204 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/407/205 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/407/206 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/407/207 Copyright (c) 2017 International Journal of Integrated Health Sciences http://creativecommons.org/licenses/by-nc/4.0

oai:ojs.journal.fk.unpad.ac.id:article/2434 2023-11-02T04:47:31Z ijihs:ART

Under-Two Children Hunger Levels in Indonesia Diana, Rita Andam Putri, Yuliana Livi Stunting; under-two children hunger index; wasting. Objective: To analyze the hunger level of toddlers under 2 years old using the Under-two Children Hunger Index (CHI). Methods: This study used secondary data from the Indonesian Basic Health Survey 2018. This study focused on the development of measurement for under-two children hunger index (CHI) using six indicators of the prevalence of chronic energy deficiency in pregnant women; the prevalence of risk height of pregnant women; the prevalence of under-two children who never being breastfeed; the prevalence of malnutrition for under-two children; the prevalence of wasting for under-two children; and the prevalence of stunting for under-two children. These six indicators were weighted differently and were calculated using the Principal Component Analysis (PCA) method.Results: The calculation of CHI using loading factors as weighted indicators has a higher precision with the percentage of 94.12 percent. With a 2018 CHI score of 46.40, Indonesia is at a serious CHI level. From the 34 provinces in Indonesia, 47.06% of provinces are at an extremely alarming level, 8.82% are at an alarming level, 17.65% are at a serious level, 17.65% are at a moderate level, and 8.82% are at a low level. Efforts can be performed by the government to increase the CHI based on the 6 indicators mentioned above.Conclusion: Based on this analysis, 25 provinces need attention in terms of the CHI level with six, three, and sixteen provinces suffered from a serious, alarming, and extremely alarming levels of CHI, respectively. Nevertheless, CHI is dynamic and should be updated annually to assess the province’s achievement in eradicating hunger. This time-series data is very important to evaluate government programs and programs to accelerate the eradication of under-two children's hunger should focus on the six indicators in this study.  Faculty of Medicine Universitas Padjadjaran 2022-09-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.fk.unpad.ac.id/index.php/ijihs/article/view/2434 10.15850/ijihs.v10n2.2434 International Journal of Integrated Health Sciences; Vol 10, No 2 (2022); 75–81 International Journal of Integrated Health Sciences; Vol 10, No 2 (2022); 75–81 2338-4506 2302-1381 eng https://journal.fk.unpad.ac.id/index.php/ijihs/article/view/2434/1745 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/2434/3194 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/2434/3195 Copyright (c) 2022 International Journal of Integrated Health Sciences http://creativecommons.org/licenses/by-nc/4.0

oai:ojs.journal.fk.unpad.ac.id:article/3767 2024-06-11T07:30:03Z ijihs:ART

Detection of Leptospira sp. Bacteria and Factors Related to the Incidence of Leptospirosis in Semarang City Diyana, Sutra Sutiningsih, Dwi Adi, Mateus Sakundarno Hitipeuw, Derico Detection; Leptospirosis; Microscopy; Rats; Risk Factors Objective: The Case Fatality Rate (CFR) of Leptospirosis in Semarang City has shown a tendency to increase from 2019 to 2022. In 2022, there were 30 cases reported, with 8 deaths (CFR 27%). The purpose of this study was to detect Leptospira sp. bacteria in rats and analyze the risk factors for leptospirosis in Semarang City.Methods: This study employed an observational approach with a Case-Control Study design. The research was conducted in Semarang City from November to December 2023. Non-random sampling techniques were used, specifically the total sampling method, resulting in a sample size of 45 case groups and 45 control groups. Bivariate analysis was performed using the Chi-square test, with a significance level set at <0.05.Results: Based on the Chi-Square test results, the following variables were found to be associated with the incidence of leptospirosis in Semarang City: the presence of rats (p<0.0001), the presence of Leptospira sp. bacteria (p<0.0001), house conditions (p=0.260), sewer condition (p<0.0001), presence of pets (p=0.001), condition of landfills (p=0.001), presence of vegetation (p=0.005), temperature (p=0.299), humidity (p=0.495), lighting (p=0.023), history of wounds (p=0.001), and knowledge level (p=0.025).Conclusion: The risk factors for leptospirosis in Semarang City include the presence of rats, the presence of Leptospira sp. bacteria, sewer conditions, the presence of pets, conditions of landfills, the presence of vegetation, lighting, history of injury, and level of knowledge. Faculty of Medicine Universitas Padjadjaran Southeast Asia One Health University (SEAOHUN) 2024-03-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.fk.unpad.ac.id/index.php/ijihs/article/view/3767 10.15850/ijihs.v12.n1.3767 International Journal of Integrated Health Sciences; Vol 12, No 1 (2024); 48-54 International Journal of Integrated Health Sciences; Vol 12, No 1 (2024); 48-54 2338-4506 2302-1381 10.15850/ijihs.v12.n1 eng https://journal.fk.unpad.ac.id/index.php/ijihs/article/view/3767/1940 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/3767/4666 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/3767/4667 Copyright (c) 2024 International Journal of Integrated Health Sciences http://creativecommons.org/licenses/by-nc/4.0

oai:ojs.journal.fk.unpad.ac.id:article/3908 2025-08-01T02:32:06Z ijihs:CR

Eribulin in Heavily Pre-Treated Metastatic Breast Cancer: A Case Series Kartikasari, Andini Oehadian, Amaylia breast cancer; eribulin; heavily pre-treated; metastases, Background: Treatment options are limited for heavily pre-treated metastatic breast cancer patients, with Eribulin showing promise in improving survival outcomes.Objective: To evaluate Eribulin outcomes in patients with MBC. Metastatic or incurable diseases are observed in 4% to 10% of women despite advances in breast cancer treatment. To address this problem, EMBRACE, an important randomized phase III clinical trial was carried out by comparing eribulin to the treatment selected by physicians for individuals with previously treated locally recurrent or metastatic breast cancer (MBC). The results showed a significant and prolonged increase in median overall survival among patients treated with eribulin, compared to those who received the physician's selected treatment.Case Series: This study presents three patients who showed favorable outcomes after treatment with eribulin, despite multiple lines of previous therapy. Patient 1 was diagnosed with triple-negative breast cancer and initially achieved remission before experiencing a recurrence involving a chest lesion and enlarged lymph nodes. After two cycles of eribulin, the patient showed significant improvement. Patient 2 developed brain and liver metastases following the completion of hormonal therapy, prompting the initiation of eribulin as the next line of treatment. Patient 3 had disease progression despite undergoing multiple lines of hormonal and chemotherapy. Eribulin was administered and patient remained stable.Conclusion: Patients with MBC tend to have substantially favorable outcomes with eribulin chemotherapy even after extensive previous treatment. Faculty of Medicine Universitas Padjadjaran 2025-04-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.fk.unpad.ac.id/index.php/ijihs/article/view/3908 10.15850/ijihs.v13n1.3908 International Journal of Integrated Health Sciences; Vol 13, No 1 (2025); 69-76 International Journal of Integrated Health Sciences; Vol 13, No 1 (2025); 69-76 2338-4506 2302-1381 10.15850/ijihs.v13.n1 eng https://journal.fk.unpad.ac.id/index.php/ijihs/article/view/3908/2083 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/3908/4906 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/3908/4907 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/3908/4908 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/3908/5134 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/3908/5385 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/3908/5386 Copyright (c) 2025 International Journal of Integrated Health Sciences http://creativecommons.org/licenses/by-nc/4.0

oai:ojs.journal.fk.unpad.ac.id:article/107 2024-03-27T08:38:05Z ijihs:ART

Chlamydial Infection Prevalence in Human Immunodeficiency Virus Patients Teja, Feilicia Henrica Rowawi, Rasmia Rowawi Soedarwoto, Asmaja Puspitosari, Diah Rasianti, Rini Rahmatdinata, Rahmatdinata Djadjakusumah, Tony Objective: To determine the prevalence of chlamydial infection in male urethra and female cervix of HIV-positive patients based on PCR assay in Teratai Clinic, Dr. Hasan Sadikin General Hospital Bandung. Methods: A cross sectional observational study with consecutive sampling method, which was conducted in Teratai Clinic during the month of July 2012. All participants underwent history taking, physical examination, and PCR assay for C. trachomatis. Swab samples were obtained from male urethra and female endocervix. Results: Eighty one HIV-positive patients, consisted of 48 males and 33 females were included in this study. The PCR examination for C. trachomatis was positive in 14 of 81 subjects (17.3%), with 10 (20.8%) urethral chlamydial infection in 48 males and four (12.1%) cervical chlamydial infection in 33 females. Conclusions: The study concluded that the prevalence of chlamydial infection in male urethra and female cervix of HIV-positive patients were 20.8% and 12.1%, respectively. Identifying chlamydial infection based on PCR testing should be considered for routine screening test in HIV-positive patients.    Keywords: Chlamydia trachomatis, HIV, prevalence, PCR DOI: 10.15850/ijihs.v1n1.107 Faculty of Medicine Universitas Padjadjaran 2013-08-18 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.fk.unpad.ac.id/index.php/ijihs/article/view/107 International Journal of Integrated Health Sciences; Vol 1, No 1 (2013); 42-48 International Journal of Integrated Health Sciences; Vol 1, No 1 (2013); 42-48 2338-4506 2302-1381 eng https://journal.fk.unpad.ac.id/index.php/ijihs/article/view/107/95

oai:ojs.journal.fk.unpad.ac.id:article/2541 2023-11-02T04:48:58Z ijihs:ART

Depression, Anxiety, and Stress due to Changes in Employment Status during COVID-19 Pandemic: A Study in Badung Districts, Bali, Indonesia Yani, Made Violin Weda Pratiwi, Made Sindy Astri Putra, Agus Indra Yudhistira Diva Diniari, Ni Ketut Sri Anxiety; COVID-19; depression; employment status; stress Objective:  To determine the relationship between depression, anxiety, and stress with the employment status of people in Bali during Covid-19 pandemic.Methods: This study was a cross-sectional analytical study conducted in Bali, Indonesia, in 2021. The instrument used was DASS-21 questionnaire, which was distributed to a total sample size of 96 people. The relationship between variables were analyzed with a p-value of <0.05 as the cut-off for a significant relationship.Results: Depression symptoms had a significant relationship with gender (p=0.024) while anxiety symptoms had a significant association with the employment status during the pandemic (p=0.027). Similarly, stress symptoms also had a significant relationship with gender (p=0.007) and employment status during COVID-19 pandemic (p=0.007).Conclusion: There is a relationship between depression, anxiety, and stress due to changes in employment status during the COVID-19 pandemic in Badung Districts, Bali. Faculty of Medicine Universitas Padjadjaran 2022-03-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.fk.unpad.ac.id/index.php/ijihs/article/view/2541 10.15850/ijihs.v10n1.2541 International Journal of Integrated Health Sciences; Vol 10, No 1 (2022); 12-19 International Journal of Integrated Health Sciences; Vol 10, No 1 (2022); 12-19 2338-4506 2302-1381 eng https://journal.fk.unpad.ac.id/index.php/ijihs/article/view/2541/1648 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/2541/2757 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/2541/2758 Copyright (c) 2022 International Journal of Integrated Health Sciences http://creativecommons.org/licenses/by-nc/4.0

oai:ojs.journal.fk.unpad.ac.id:article/3083 2025-05-20T08:19:17Z ijihs:CR

Crowned Dens Syndrome: A Rare Cause of Sudden Onset Neck Pain Butt, Nauman Ismat Rasheed, Muhammad Bilal Ashfaq, Fahmina Anser, Aniqa Calcium pyrophosphate deposition, crowned dens syndrome, neck pain, neck stiffness Objective: To report a case of Crowned Dens Syndrome (CDS), which is a rare disorder caused by crystal deposition by calcium pyrophosphate dihydrate in the peridontoid soft tissues surrounding the C1 and C2 vertebrae that presents in elderly with sudden onset neck pain, neck stiffness, fever, and elevated inflammatory markers, with periodontal calcification in a halo or crown configuration on radiography considered diagnostic.Methods: A 64-year-old diabetic and hypertensive female patient presented with a 6-day history of sudden onset posterior neck pain and stiffness. Movements of the cervical spine were equally limited in all directions, causing marked aggravation of pain. There was no focal neurologic loss. Her inflammatory markers were markedly raised.Results: Based on radiography, she was diagnosed with Crowned Dens syndrome and started on oral prednisolone, paracetamol, and tizanidine along with topical diclofenac. Oral NSAIDs were contraindicated due to her renal insufficiency.Conclusion: Crowned Dens Syndrome (CDS) is a rare cause of neck pain. Clinicians should consider this syndrome in their differential diagnosis. Timely diagnosis and treatment of CDS will lead to avoidance of unnecessary investigations and medications in such patients, along with a reduction in the length of stay. Faculty of Medicine Universitas Padjadjaran None 2023-09-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.fk.unpad.ac.id/index.php/ijihs/article/view/3083 10.15850/ijihs.v11n2.3083 International Journal of Integrated Health Sciences; Vol 11, No 2 (2023); 120-124 International Journal of Integrated Health Sciences; Vol 11, No 2 (2023); 120-124 2338-4506 2302-1381 10.15850/ijihs.v11n2 eng https://journal.fk.unpad.ac.id/index.php/ijihs/article/view/3083/1860 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/3083/3728 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/3083/3729 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/3083/4066 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/3083/4067 Copyright (c) 2023 International Journal of Integrated Health Sciences http://creativecommons.org/licenses/by-nc/4.0

oai:ojs.journal.fk.unpad.ac.id:article/2165 2023-11-02T04:49:52Z ijihs:CR

Infective Endocarditis with Multiple Valvar Vegetation in Uncorrected Tetralogy Fallot: A Case Report of Rare Condition Cool, Charlotte Johanna Fattima, Eliza Techa Febrianora, Mega Saboe, Aninka Infective Endocarditis; Multiple Valvar Vegetation; Tetralogy of Fallot Objective: To describe a case of an adult patient with uncorrected Tetralogy of Fallot (TOF) who suffered from Infective Endocarditis (IE) that involved the tricuspid and aortic valves.Methods: On October 2019, a-twenty-year-old male with uncorrected TOF was admitted to the emergency department of Dr. Hasan Sadikin General Hospital with a chief complaint of fever. The echocardiography showed the presence of vegetation on the tricuspid valve and aortic valve. The patient was given empirical antibiotics therapy for IE treatment. The serial blood cultures did not yield any organism growth and the transthoracic echocardiography evaluation showed healed vegetation after 21 days of antibiotics treatment.Results: A high turbulence in small VSD and valvular stenosis, as found in TOF, can injure the endocardial surface. While bacterial adherence to the injured endocardial surface can cause IE, no specific criteria available for diagnosing IE in congenital heart disease (CHD) patients compared to other population. In CHD patients, it is necessary to consider the diagnosis of IE presenting with signs of infection or fever. Our patient was known to have uncorrected TOF and was admitted to the hospital with a chief complaint of fever. The uncorrected TOF was complicated by an unusual form of aggressive vegetation involving multiple valves.Conclusion: The incidence of IE in uncorrected TOF is around 4%. Patient is  advised to receive a corrective surgery for the cardiac anomaly. Surgical repair of CHD with no residual lesion reduces the risk of IE. Faculty of Medicine Universitas Padjadjaran 2021-10-19 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.fk.unpad.ac.id/index.php/ijihs/article/view/2165 10.15850/ijihs.v9n2.2165 International Journal of Integrated Health Sciences; Vol 9, No 2 (2021); 79-83 International Journal of Integrated Health Sciences; Vol 9, No 2 (2021); 79-83 2338-4506 2302-1381 10.15850/ijihs.v9n2 eng https://journal.fk.unpad.ac.id/index.php/ijihs/article/view/2165/1643 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/2165/2093 Copyright (c) 2021 International Journal of Integrated Health Sciences http://creativecommons.org/licenses/by-nc/4.0

oai:ojs.journal.fk.unpad.ac.id:article/3136 2024-01-05T03:40:37Z ijihs:ART

Effect of Eye Exercises on Computer Vision Syndrome among Medical Students of Universitas Sumatera Utara, Indonesia Zhuang, Angella Sitepu, Bobby Ramses Erguna Computer Vision Syndrome; Eye exercise. Objective: To determine the effect of eye exercises on Computer Vision Syndrome among batch 2019 medical students of the Faculty of Medicine, Universitas Sumatera Utara, and Indonesia.Methods: This study used analytical true experimental with a Pretest-Posttest Control Group Design. Sample consisted of 86 respondents who were divided into two groups: control and experimental (intervention) groups. Each group consisted of 43 respondents who were sampled randomly using the simple random sampling technique.  Data were collected through the Computer Vision Syndrome Questionnaire (CVS-Q) and analyzed using a statistical software application with a p-value of < 0.05 considered significant.Results: A decrease in the score of Computer Vision Syndrome in the experimental (intervention) group after the eye exercise was observed with a p-value of 0.001 (<0.05). Conclusion: Eye exercise has an effect on the Computer Vision Syndrome.  Faculty of Medicine Universitas Padjadjaran Bobby Ramses Erguna Sitepu, Universitas Sumatera Utara, Department of Opthalmology 2023-03-31 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.fk.unpad.ac.id/index.php/ijihs/article/view/3136 10.15850/ijihs.v11n1.3136 International Journal of Integrated Health Sciences; Vol 11, No 1 (2023); 37-41 International Journal of Integrated Health Sciences; Vol 11, No 1 (2023); 37-41 2338-4506 2302-1381 10.15850/ijihs.v11n1 eng https://journal.fk.unpad.ac.id/index.php/ijihs/article/view/3136/1800 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/3136/3789 Copyright (c) 2023 International Journal of Integrated Health Sciences http://creativecommons.org/licenses/by-nc/4.0

oai:ojs.journal.fk.unpad.ac.id:article/4061 2025-08-01T02:32:07Z ijihs:ART

AI-powered Somatic Cancer Cell Analysis for Early Detection of Metastasis: The 62 principal Cancer Types Buthelezi, Sandile Seeletse, Solly Matshonisa Hungwe, Taurai Mbirimi-Hungwe, Vimbai Cancer; early detection; machine learning; metastasis Background: Early detection of metastasis is critical in improving survival outcomes in cancer patients, with artificial intelligence offering advanced tools for predictive analytics.Objective: To emphasize the importance of early metastasis detection in improving cancer patient outcomes, and to highlight that recent advancements in AI-powered somatic cancer cell analysis may enhance early detection and personalize treatment strategies.Methods: This study leveraged a comprehensive survival and artificial intelligence (AI) powered analysis to identify key genomic and clinical factors influencing cancer prognosis, with a focus on early metastatic detection. The AI algorithms explored the possibility of detecting tumors with a high spread risk. The study underscored the critical role of AI-powered analysis in the early detection of metastasis and the personalization of treatment strategies in cancer care.Results: By leveraging advanced AI algorithms, key predictors of cancer prognosis such as fraction genome alteration, primary tumor site, and smoking history, all of which significantly influence metastasis outcomes, were identified. Furthermore, the models demonstrated exceptional predictive accuracy, with XGBoost and Support Vector Machines achieving an accuracy of 0.95.Conclusion: Integrating AI capabilities into clinical workflows holds the promise of significantly enhancing early detection and treatment of metastatic cancer, thereby improving patient outcomes and optimizing therapeutic interventions. Faculty of Medicine Universitas Padjadjaran 2025-04-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.fk.unpad.ac.id/index.php/ijihs/article/view/4061 10.15850/ijihs.v13n1.4061 International Journal of Integrated Health Sciences; Vol 13, No 1 (2025); 8-16 International Journal of Integrated Health Sciences; Vol 13, No 1 (2025); 8-16 2338-4506 2302-1381 10.15850/ijihs.v13.n1 eng https://journal.fk.unpad.ac.id/index.php/ijihs/article/view/4061/2074 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/4061/5155 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/4061/5156 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/4061/5239 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/4061/5256 Copyright (c) 2025 International Journal of Integrated Health Sciences http://creativecommons.org/licenses/by-nc/4.0

oai:ojs.journal.fk.unpad.ac.id:article/1805 2022-04-11T03:03:32Z ijihs:ART

Erythropoiesis Differences in Various Clinical Phases of Dengue Fever using Immature Reticulocyte Fraction Parameter Oehadian, Amaylia Vidyaniati, Putri Candra, Jeffery Malachi Sumardi, Uun Susandi, Evan Alisjahbana, Bachti Dengue; erythropoiesis; immature reticulocyte fraction Objective: To determine the mechanism of erythropoiesis that led to anemia using the Immature Reticulocyte Fraction (IRF) parameter in various clinical phases of dengue fever.Methods: This study was a comparative analytical research using secondary data derived from the Dengue-associated Endothelial Cell Dysfunction and Thrombocyte Activation (DECENT) research. The study was performed at Dr. Hasan Sadikin Hospital Bandung, Indonesia from March 2011 to March 2012. Patients were grouped into fever, critical, recovery, and convalescent phases and a healthy control was established. Data collected were analyzed using the Kolmogorov-Smirnov normality test, followed by Friedman test and Mann-Whitney post hoc test.Results: There were 244 subjects participating in this study. The median IRF for all subjects was 4.8% with an IQR of 2.4-8.1%. The values of Immature Reticulocyte Fraction in fever-phase, critical-phase, recovery-phase, convalescent-phase and healthy-control were 1.8% (IQR of 0.5-2.85%), 3.6% (IQR of 1.8-5.0%), 7.05% (IQR of 4.08-11.85%, 7.3 % (IQR of 3.95-9.3%) and 4.1% (IQR of 2.2-6.6%), respectively. There was a significant difference in IRF between groups (p<0.05).  The immature Reticulocyte Fraction in fever phase was significantly different from the IRF in other phases and healthy controls (p<0.05).Conclusions:There are changes in erythropoiesis activities detected through the IRF in various clinical phases of dengue infection. Erythropoiesis suppression occurs mainly during the fever phase and starts to be restored in the critical phase. In the recovery and convalescent phases, the erythropoiesis activities increase.  This is the first study describing IRF in multiple phases of dengue disease.  Faculty of Medicine Universitas Padjadjaran 2021-03-23 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.fk.unpad.ac.id/index.php/ijihs/article/view/1805 10.15850/ijihs.v9n1.1805 International Journal of Integrated Health Sciences; Vol 9, No 1 (2021); 7-12 International Journal of Integrated Health Sciences; Vol 9, No 1 (2021); 7-12 2338-4506 2302-1381 10.15850/ijihs.v9n1 eng https://journal.fk.unpad.ac.id/index.php/ijihs/article/view/1805/1600 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/1805/1458 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/1805/1459 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/1805/1557 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/1805/1558 Copyright (c) 2021 International Journal of Integrated Health Sciences http://creativecommons.org/licenses/by-nc/4.0

oai:ojs.journal.fk.unpad.ac.id:article/2840 2024-01-05T03:40:35Z ijihs:ART

Fetal Exposure to Risky Drugs: Analysis of Antenatal Clinic Prescriptions in a Nigerian Tertiary Care Hospital Onah, Paul Otor Idoko, Catherine Chioma Abdulateef, Siyaka Drug prescriptions; Fetal Drug Exposure; Fetal Wellbeing; Low Birth Weight; Pregnancy. Objective: To assess fetal outcomes after in-utero exposure to unsafe drugs.Methods: This was a retrospective cohort study using data from medical records of pregnant women who received antenatal care over a two-year period (2019/2020). Inclusion was based on identification of prescription of potentially risky medications during pregnancy. Medication records, as well as delivery data, were extracted for analysis. The Australian drug evaluation committee classification system of risky medications was used for analysis.Results: Results showed that 44 – 65% of medicines prescribed in pregnancy carry significant risks to fetal wellbeing. Fetal outcomes showed high levels of low birth weight, still birth, and early neonatal death. The common medicines prescribed irrationally in pregnancy were, among others, antibiotics, ACEIs, NSAIDs, Biguanides, and opiates, all of which are associated with adverse fetal outcomes.Conclusion: There is a high level of fetal exposure to risky medications and adverse delivery outcomes. There is a need to improve prescription through prescriber training and awareness raising on existing guidelines on good prescribing practice for pregnant women. Faculty of Medicine Universitas Padjadjaran None 2023-03-31 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.fk.unpad.ac.id/index.php/ijihs/article/view/2840 10.15850/ijihs.v11n1.2840 International Journal of Integrated Health Sciences; Vol 11, No 1 (2023); 1-6 International Journal of Integrated Health Sciences; Vol 11, No 1 (2023); 1-6 2338-4506 2302-1381 10.15850/ijihs.v11n1 eng https://journal.fk.unpad.ac.id/index.php/ijihs/article/view/2840/1794 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/2840/3426 Copyright (c) 2023 International Journal of Integrated Health Sciences http://creativecommons.org/licenses/by-nc/4.0

oai:ojs.journal.fk.unpad.ac.id:article/3988 2024-11-25T05:49:22Z ijihs:ART

Feasibility, Safety, and Efficacy of Segmental Spinal Anesthesia with Predominantly Isobaric Levobupivacaine: A Tertiary Care Hospital Study Goyal, Lalit Gupta, Saloni Nagar, Sachin Bhargava, Vinay ASA grade, levobupivacaine, segmental spinal anesthesia, visual analogue scale Objective: To assess feasibility, safety, and efficacy of segmental spinal anesthesia with isobaric levobupivacaine in patients undergoing various abdominal and lower limb surgeries. Methods: This was a prospective cohort study conducted at the Department of Anesthesiology and Critical Care of Kota Heart Institute and group of hospitals in India. The study involved  100 patients undergoing various abdominal and lower limb surgeries under segmental spinal anesthesia (SSA). Isobaric levobupivacaine 0.5% with fentanyl 20-25 μg or dexmedetomidine 5-10 as adjuvant or  hypobaric levobupivacaine 0.167%  was injected in intervertebral space depending on the surgery. Hemodynamic parameters, postoperative pain level, and adverse effects were analyzed with a p-value less than 0.05 was considered statistically significant.Results: An overall male predominance was observed with a 1:0.515 male-to-female ratio. The most affected age group was 41-50 years (37%), with a mean age of 44.51 ± 11.72 years. ASA classification indicated 34% of patients in ASA I, 40% in ASA II, 24% ASA III and 2% in ASA IV . The primary surgery was laparoscopic cholecystectomy (26%) in normal risk group and orthopedic in high-risk group(20%). Postoperative pain assessment showed mean VAS scores ranging from 1.92 to 3.42 at different time intervals. Common adverse effects were hemodynamic instability (13%), shoulder tip pain (33%), PONV (3%), headache (6%), pruritis (2%) and urinary retention (1%). The hemodynamic instability showed less incidence in ASA III/IV category.Conclusion: Segmental spinal anesthesia can be used successfully for abdominal and lower limb orthopedic surgeries in patients of ASA I to ASA IV. Faculty of Medicine Universitas Padjadjaran 2024-09-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.fk.unpad.ac.id/index.php/ijihs/article/view/3988 10.15850/ijihs.v12.n2.3988 International Journal of Integrated Health Sciences; Vol 12, No 2 (2024); 87-94 International Journal of Integrated Health Sciences; Vol 12, No 2 (2024); 87-94 2338-4506 2302-1381 10.15850/ijihs.v12.n2 eng https://journal.fk.unpad.ac.id/index.php/ijihs/article/view/3988/2005 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/3988/5164 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/3988/5165 Copyright (c) 2024 International Journal of Integrated Health Sciences http://creativecommons.org/licenses/by-nc/4.0

oai:ojs.journal.fk.unpad.ac.id:article/4173 2025-12-04T07:27:55Z ijihs:ART

Association Between Cardiovascular Risk Factors and CAD Severity by CAD-RADS Categories and Comprehensive CTA Score Raharjo, Pradana Pratomo Purnomowati, Augustine Kusumawardhani, Nuraini Yasmin Astuti, Astri Achmad, Chaerul Pramudyo, Miftah Karwiky, Giky Akbar, Mohammad Rizki Coronary artery disease reporting and data system; coronary computed tomography angiography; coronary artery disease severity; comprehensive computed tomography angiography score; cardiovascular risk factors Background: Coronary artery disease (CAD) is the leading cause of mortality and morbidity worldwide, including in Indonesia. Risk factors (RFs) play an important role in both pathogenesis and management of cardiovascular (CV) diseases. Coronary computed tomography angiography (CTA) is a reliable non-invasive diagnostic method. Coronary Artery Disease Reporting and Data System (CAD-RADS) categories and comprehensive CTA score describes CAD severity on coronary CTA and provides additional prognostic value.Objective: To explore the link between traditional cardiovascular risk factors and CAD severity based on CAD-RADS and comprehensive CTA scores.Methods: This retrospective, single-center study was conducted at a tertiary hospital using data from the Cardiovascular Imaging Database of the hospital from January 2020 to June 2022. Data meeting the inclusion and exclusion criteria were analyzed using ordinal and binary regressions.Results: A total of 423 patients' data were analyzed. Ordinal regression revealed significant links between age ≥ 65 years, male gender, hypertension, diabetes, and higher CAD severity based on both CAD-RADS and comprehensive CTA scores. Binary regression showed that older age and male gender were independently associated with CAD-RADS ≥ 3 and comprehensive CTA score ≥ 6. Diabetes was linked to CAD-RADS ≥ 3, and hypertension was tied to a comprehensive CTA score ≥ 6. The number of risk factors showed a trend toward CAD severity (p=0.069) and a significant link with comprehensive CTA score (p=0.012).Conclusion: There is a significant association between traditional cardiovascular risk factors and CAD severity as quantified by both CAD-RADS and comprehensive CTA score. Faculty of Medicine Universitas Padjadjaran 2025-10-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.fk.unpad.ac.id/index.php/ijihs/article/view/4173 10.15850/ijihs.v13n2.4173 International Journal of Integrated Health Sciences; Vol 13, No 2 (2025); 105-112 International Journal of Integrated Health Sciences; Vol 13, No 2 (2025); 105-112 2338-4506 2302-1381 10.15850/ijihs.v13n2 eng https://journal.fk.unpad.ac.id/index.php/ijihs/article/view/4173/2154 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/4173/5304 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/4173/5305 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/4173/5306 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/4173/5340 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/4173/5963 Copyright (c) 2025 International Journal of Integrated Health Sciences http://creativecommons.org/licenses/by-nc/4.0

oai:ojs.journal.fk.unpad.ac.id:article/401 2023-11-02T04:53:25Z ijihs:ART

Ultrasound Guided Fine Needle Aspiration Biopsy in Renal Tumors Tjahjodjati, Tjahjodjati Pitoyo, Joko Renal tumor, sensitivity, specificity, ultasound guided FNAB Objective: To assess the sensitivity and specificity of ultrasound guided fine needle aspiration biopsy (FNAB) in renal tumors.Methods: A diagnostic study was performed on 23 patients with renal tumors who visited the Urology Division, Department of Surgery, Dr. Hasan Sadikin General Hospital from January 2011 to August 2012. First time ultrasound guided was performed to the patients before nephrectomy. Renal tissues that were obtained from both procedures were examined histopathologically, and the result from nephrectomy was used as the gold standard. Analysis was conducted by measuring the sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of the ultrasound guided FNAB. Results: The results showed that the sensitivity value of ultrasound guided FNAB was 85.71%, with 50% specificity, 94.74% PPV and 25% NPV. From 23 patients, only 2 patients had hematoma. Conclusions: Ultrasound guided FNAB is sufficiently sensitive with a fair specificity for diagnosing renal tumors and is safe for patients.Keywords: Renal tumor, sensitivity, specificity, ultasound guided FNAB DOI: 10.15850/ijihs.v3n1.401 Faculty of Medicine Universitas Padjadjaran 2015-04-06 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.fk.unpad.ac.id/index.php/ijihs/article/view/401 International Journal of Integrated Health Sciences; Vol 3, No 1 (2015); 11-13 International Journal of Integrated Health Sciences; Vol 3, No 1 (2015); 11-13 2338-4506 2302-1381 10.15850/ijihs.v3n1 eng https://journal.fk.unpad.ac.id/index.php/ijihs/article/view/401/365 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/401/190 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/401/191 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/401/192 Copyright (c) 2015 International Journal of Integrated Health Sciences http://creativecommons.org/licenses/by-nc/4.0

oai:ojs.journal.fk.unpad.ac.id:article/2695 2023-11-02T04:48:58Z ijihs:ART

Indications and Complications of Orthopedic Hardware Removal in an Indonesian Tertiary Hospital: A Descriptive Study Azzahra, Shadrina Affifa Primadhi, Raden Andri Nurhayati, Titing Sajadi, Muhammad Naseh Achadiyani, Achadiyani Complication; hardware; indication; removal Objective: To acquire clinical data regarding indications of implant removal and complications in orthopedic metal implant removal. Methods: This was a cross-sectional observational descriptive study using patient medical records. The inclusion criterion was all patients who underwent orthopedic metal implant removal during 2018-2020 while the exclusion criterion was unintentional implant removal due to subsequent injury or loosening. Data regarding anatomic regions, indications, and complications were collected and presented in tables.Results: In 112 patients participated in this study consisting of 75 (67%) men and 37 (33%) women, the implants were mainly located in thigh, lower leg, and ankle (53% combined). The most common indication for metal implant removal was conversion (31%), followed by infection (25%) and patient's request (20%). The only complication observed in orthopedic metal implant removal in this study was disturbed wound healing in a small percentage of the patients (16%). Most patients (84%) did not experience any complication due to metal implant removal.Conclusions: Indications for metal implant removal may vary, with or without symptoms. Disturbed wound healing is a complication observed in metal implant removal. Despite the advantages of removal, further analysis and guidelines are needed to avoid unnecessary hardware removal considering the risk of complications. Faculty of Medicine Universitas Padjadjaran 2022-03-31 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.fk.unpad.ac.id/index.php/ijihs/article/view/2695 10.15850/ijihs.v10n1.2695 International Journal of Integrated Health Sciences; Vol 10, No 1 (2022); 26–31 International Journal of Integrated Health Sciences; Vol 10, No 1 (2022); 26–31 2338-4506 2302-1381 eng https://journal.fk.unpad.ac.id/index.php/ijihs/article/view/2695/1650 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/2695/3209 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/2695/3210 Copyright (c) 2022 International Journal of Integrated Health Sciences http://creativecommons.org/licenses/by-nc/4.0

oai:ojs.journal.fk.unpad.ac.id:article/3552 2024-06-11T07:30:02Z ijihs:ART

Analysis of the Relationship between Age and Immunization Completeness with Measles Incidence in the City of Medan in 2022 Harahap, Sunnii Irtiyah Ismah, Zata Hotmaida, Doris Age, Immunization, Measles Objective: To analyze the relationship between age and immunization completeness and the occurrence of measles in Medan City in 2022.Methods: This study is quantitative research with a case-control study design. The respondents in this study are the entire population of Medan City. The sample size for this research is 96 respondents, with 48 in the case group and 48 in the control group, all recorded in the measles case report at the Health Department of Medan City in 2022. The study was conducted from January to July 2023.Results: Forty respondents in this study belonged to the toddler group, and most of whom had an incomplete immunization history. Based on chi-square analysis, a significant relationship was found between age and the occurrence of measles (p-value < 0.05), as well as between immunization completeness and the occurrence of measles (p-value < 0.05) with an odds ratio (OR) of 11.0. This means that respondents who are not immunized are 11 times more likely to experience measles compared to those who are immunized. Respondents with incomplete immunization are also 11 times more likely to experience measles compared to those with complete immunization.Conclusion: There is a significant relationship between age and immunization completeness and the occurrence of measles. Respondents with an incomplete immunization history are at 11 times higher risk of experiencing measles compared to those with a complete immunization history. For future research, it is recommended to increase the number of study respondents and further explore and expand on risk factors such as the history of contact with measles cases in the city of Medan. Faculty of Medicine Universitas Padjadjaran 2024-03-29 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.fk.unpad.ac.id/index.php/ijihs/article/view/3552 10.15850/ijihs.v12.n1.3552 International Journal of Integrated Health Sciences; Vol 12, No 1 (2024); 43-47 International Journal of Integrated Health Sciences; Vol 12, No 1 (2024); 43-47 2338-4506 2302-1381 10.15850/ijihs.v12.n1 eng https://journal.fk.unpad.ac.id/index.php/ijihs/article/view/3552/1939 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/3552/4358 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/3552/4380 Copyright (c) 2024 International Journal of Integrated Health Sciences http://creativecommons.org/licenses/by-nc/4.0

oai:ojs.journal.fk.unpad.ac.id:article/4349 2025-08-01T02:32:08Z ijihs:ART

Correlation between TSH, Prolactin, LH, FSH, Estrogen, and Progesterone in Women with Infertility Khambalkar, Shobha D. Jadhav, Krishna Nitin Hormonal imbalance; Infertility; Prolactin; Thyroid-stimulating hormone Background: Hormonal imbalances play a pivotal role in female infertility, affecting various endocrine pathways that warrant comprehensive evaluation.Objective: To analyze correlations between thyroid-stimulating hormone (TSH), prolactin, luteinizing hormone (LH), follicle-stimulating hormone (FSH), estrogen, and progesterone in women with infertility.Methods: This retrospective observational study was conducted at the Department of Obstetrics and Gynecology of Prakash institute of Medical Sciences, India, between January 2024 and December 2024. Medical records of 140 women (90 with primary infertility and 50 with secondary infertility) aged 19–45 years were analyzed over a one-year period. Hormonal profiles including TSH, prolactin, LH, FSH, estrogen, and progesterone were analyzed. Statistical analyses were performed using the SPSS 23.0 software and  a p-value of less than 0.05 was considered statistically significant.Results: Women with primary infertility were younger and had a shorter duration since marriage compared to those with secondary infertility (p<0.001). Irregular menstrual cycles were significantly more common in primary infertility cases (p=0.002). Thyroid dysfunction was seen in 25% of cases, with hypothyroidism as the most common thyroid function abnormality (14.9%). A strong positive correlation was found between TSH and prolactin levels (r=0.821, p<0.05), whereas a significant negative correlation was present between TSH and LH (r=-0.73, p<0.05) and FSH (r=-0.41, p<0.05). Correlations between TSH and estrogen or progesterone was not found to be statistically significant (P>0.05).Conclusion: TSH levels significantly correlate with prolactin, LH, and FSH levels in women with infertility. These findings underscore the importance of comprehensive endocrine evaluation of women with infertility to optimize diagnosis and management strategies. Faculty of Medicine Universitas Padjadjaran 2025-04-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.fk.unpad.ac.id/index.php/ijihs/article/view/4349 10.15850/ijihs.v13n1.4349 International Journal of Integrated Health Sciences; Vol 13, No 1 (2025); 44-50 International Journal of Integrated Health Sciences; Vol 13, No 1 (2025); 44-50 2338-4506 2302-1381 10.15850/ijihs.v13.n1 eng https://journal.fk.unpad.ac.id/index.php/ijihs/article/view/4349/2079 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/4349/5583 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/4349/5584 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/4349/5585 Copyright (c) 2025 International Journal of Integrated Health Sciences http://creativecommons.org/licenses/by-nc/4.0

oai:ojs.journal.fk.unpad.ac.id:article/103 2024-03-27T08:38:05Z ijihs:ART

Akt–the Mammalian Target of Rapamycin (mTOR) Pathway Inhibition Increases Cervical Cancer Cell Chemosensitivity to Active Form of Irinotecan (SN-38) Septiani, Leri Hidayat, Yudi Mulyana Effendi, Yusuf Sulaeman Djuwantono, Tono Luftimas, Dimas Erlangga Faried, Ahmad Objective: To investigate the molecular pathway of the cytotoxic effect of SN-38 in human cervical cancer cell lines.Methods: Two human cervical cancer cell lines were treated with various concentrations of irinotecan for 24–72 hours and the sensitivity was analysed using the MTT assay. Apoptosis was further observed through microscopic examinations. The protein expression was determined using Western blot analysis.  Results: CaSki cells demonstrated the highest sensitivity to SN-38, whereas HeLa cells showed the lowest. In cervical cancer cells, SN-38 induced apoptosis through an intrinsic- and extrinsic-pathways. In addition, we showed that SN-38 downregulated the phosphorylation of Akt-mTOR pathways in CaSki cells, but not in HeLa cells. Interestingly, in HeLa cells, which were more suggestive of a resistant phenotype, pre-treatment with LY294002 and rapamycin inhibited activation of Akt-mTOR signaling and significantly enhanced the sensitivity of HeLa cells to SN-38. Conclusions: Irinotecan exerts its anti-neoplastic effects on cervical cancer cells by inducing apoptosis through caspase-cascade. Inhibition of Akt-mTOR, LY294002 and rapamycin, which is targeted to Akt-mTOR pathways, may sensitize irinotecan-resistant cervical cancer cells.Keywords: Akt-mTOR pathways anti-neoplastic drugs, cervix cancer cells, LY294002, rapamycin DOI: 10.15850/ijihs.v1n1.103 Faculty of Medicine Universitas Padjadjaran 2013-09-17 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.fk.unpad.ac.id/index.php/ijihs/article/view/103 International Journal of Integrated Health Sciences; Vol 1, No 1 (2013); 13-21 International Journal of Integrated Health Sciences; Vol 1, No 1 (2013); 13-21 2338-4506 2302-1381 eng https://journal.fk.unpad.ac.id/index.php/ijihs/article/view/103/91

oai:ojs.journal.fk.unpad.ac.id:article/2478 2023-11-02T04:49:52Z ijihs:ART

Correlation between Serum Interleukin-6 Level and Modified Rodnan Skin Score in Systemic Sclerosis Patients Riswandi, Dania Artriana Dewi, Sumartini Rahmadi, Andri Reza Disease activity; interleukin-6; modified rodnan skin score; systemic sclerosis Objective: To determine the correlation between serum levels of IL-6 and MRSS in systemic sclerosis patients.Methods: This was a crossectional observational study on patients with SSc visiting the Rheumatology Clinic of Dr. Hasan Sadikin General Hospital Bandung, Indonesia from January 2019 to December 2020. Registered SSc patients, with validated MMRS by a rheumatologist, and available biological materials for IL-6 measurement were included. Patients with other autoimmune diseases, acute infection, diabetes mellitus, and obesity were excluded from this studyResults: Of the 51 SSc patients, 42 patients met the inclusion criteria. Women comprised the majority of these patients (95.2%), while patients’ mean age was 43±12 years. The mean duration of disease was 20 months, with diffuse SSc (78.6%) as the most frequent type. Bivariate analysis showed that IL-6 was positively correlated with MRSS (100-scale) with r=0.397 and p=0.005.Conclusion: There is a medium positive correlation between MRSS and interleukin-6 serum among systemic sclerosis patients visiting Dr. Hasan Sadikin General Hospital Bandung, Indonesia.  Faculty of Medicine Universitas Padjadjaran 2021-10-19 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.fk.unpad.ac.id/index.php/ijihs/article/view/2478 10.15850/ijihs.v9n2.2478 International Journal of Integrated Health Sciences; Vol 9, No 2 (2021); 60-65 International Journal of Integrated Health Sciences; Vol 9, No 2 (2021); 60-65 2338-4506 2302-1381 10.15850/ijihs.v9n2 eng https://journal.fk.unpad.ac.id/index.php/ijihs/article/view/2478/1640 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/2478/2674 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/2478/2675 Copyright (c) 2021 International Journal of Integrated Health Sciences http://creativecommons.org/licenses/by-nc/4.0

oai:ojs.journal.fk.unpad.ac.id:article/3512 2025-05-20T08:19:17Z ijihs:ART

Conservative Management of Pott's Spine and Its Outcome: An Institute-Based Observational Study Jiwani, Rahil Ghosh, Sourabh Giri, Shubham Functional Outcome; McCormick Scale; Pott’s Disease; Tuberculous Spondylitis. Objective: To analyze the functional outcome of cases with Pott’s disease treated solely by antitubercular drugs.Methods: This observational study was conducted at the Department of Orthopedics of a tertiary care medical college. Sixty patients with Pott’s disease were included in this study based on predefined inclusion and exclusion criteria. All patients received antitubercular drugs for nine months. The Modified McCormick Scale (MSS) was used to assess the outcome of patients.Results: Out of 60 patients, 37 (61.67%) were females, and 23 (38.33%) were males, with an M: F ratio of 1:0.62. Most patients had some or the other risk factors and belonged to low socioeconomic status. The most common presenting complaint was low back pain, and the thoracolumbar spine was most commonly involved. There was a significant improvement in the patient’s functional status as assessed by the MSS score.Conclusion: If diagnosed early, patients with Pott’s disease can be treated solely by antitubercular treatment with excellent outcomes. Faculty of Medicine Universitas Padjadjaran 2023-09-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.fk.unpad.ac.id/index.php/ijihs/article/view/3512 10.15850/ijihs.v11n2.3512 International Journal of Integrated Health Sciences; Vol 11, No 2 (2023); 92-98 International Journal of Integrated Health Sciences; Vol 11, No 2 (2023); 92-98 2338-4506 2302-1381 10.15850/ijihs.v11n2 eng https://journal.fk.unpad.ac.id/index.php/ijihs/article/view/3512/1854 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/3512/4386 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/3512/4387 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/3512/4388 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/3512/4390 Copyright (c) 2023 International Journal of Integrated Health Sciences http://creativecommons.org/licenses/by-nc/4.0

oai:ojs.journal.fk.unpad.ac.id:article/2370 2022-04-11T03:03:34Z ijihs:ART

Association between Malnutrition Inflammation Score and Latent Tuberculosis among Chronic Hemodialysis Patients Bandiara, Ria Sukesi, Lilik Indrasari, Astried Rakhimullah, Alif Bagus Afiatin, Afiatin Santoso, Prayudi chronic kidney disease; hemodialysis; latent tuberculosis; malnutrition Objective: To investigate the association of malnutrition with latent tuberculosis (TB) among chronic kidney disease (CKD) patients on hemodialysis (HD).Methods: This was a cross-sectional study conducted at the Hemodiaylisis Unit of Dr. Hasan Sadikin General Hospital, Bandung, Indonesia. Subjects were patients aged >18 years who had undergone HD twice a week for at least three months. Patients suspected of active tuberculosis (TB), malignancy, or immunocompromised were excluded. Latent TB was diagnosed using the interferon-gamma release assays (IGRA). Malnutrition was defined by a malnutrition inflammation score (MIS) of less than 5. All data including age, sex, CKD etiologies, and laboratory findings were obtained and recorded in a case report form.Results: A total of 120 subjects were involved in this study. Subjects with positive, negative, and indeterminate IGRA results were 39.2%, 56.7%, and 4.2%, respectively. There was no significant differences in subjects characteristics between positive and negative IGRA subjects.  The MIS>5 was shown to have no statistically significant association with positive IGRA subjects (OR=3.47, 95%CI 0.93–12.93).Conclusion: Malnutrition based on an MIS score of less than 5 is not statically associated, but clinically associated, with latent TB. Further causal inference study to investigate these associations is needed. Faculty of Medicine Universitas Padjadjaran 2021-03-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.fk.unpad.ac.id/index.php/ijihs/article/view/2370 10.15850/ijihs.v9n1.2370 International Journal of Integrated Health Sciences; Vol 9, No 1 (2021); 19–24 International Journal of Integrated Health Sciences; Vol 9, No 1 (2021); 19–24 2338-4506 2302-1381 10.15850/ijihs.v9n1 eng https://journal.fk.unpad.ac.id/index.php/ijihs/article/view/2370/1604 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/2370/2446 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/2370/2447 Copyright (c) 2021 International Journal of Integrated Health Sciences http://creativecommons.org/licenses/by-nc/4.0

oai:ojs.journal.fk.unpad.ac.id:article/3079 2024-01-05T03:40:36Z ijihs:ART

Oxidative Stress in Seminal Plasma Negatively Influences Sperm Quality in Infertile Males Mahat, Roshan Kumar Bhale, Dhananjay Vasantrao Rathore, Vedika Male infertility; Malondialdehyde; Sperm quality. Objective: To investigate the association between malondialdehyde concentration in the seminal plasma of infertile men and sperm quality.Methods: This case-control study included 60 male participants ranging from 25-40 years old with half of them were fertile and the other half were infertile. Semen analysis was performed as per the WHO standards, and spectrophotometric measurement of seminal plasma malondialdehyde level was done.Results: Results showed that infertile men had significantly a higher mean level of malondialdehyde in their seminal plasma than fertile men (p<0.001), which was inversely associated with sperm count and motility. Also, malondialdehyde was positively associated with abnormal sperm morphology.Conclusions: Elevated malondialdehyde levels in seminal plasma are associated with poor sperm quality. Malondialdehyde testing can, therefore, be used to diagnose and predict the outcome of male infertility. Antioxidants should also be administered to men with infertility to help counteract the effects of oxidative stress. Faculty of Medicine Universitas Padjadjaran 2023-03-31 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.fk.unpad.ac.id/index.php/ijihs/article/view/3079 10.15850/ijihs.v11n1.3079 International Journal of Integrated Health Sciences; Vol 11, No 1 (2023); 27–31 International Journal of Integrated Health Sciences; Vol 11, No 1 (2023); 27–31 2338-4506 2302-1381 10.15850/ijihs.v11n1 eng https://journal.fk.unpad.ac.id/index.php/ijihs/article/view/3079/1798 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/3079/3717 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/3079/3718 Copyright (c) 2023 International Journal of Integrated Health Sciences http://creativecommons.org/licenses/by-nc/4.0

oai:ojs.journal.fk.unpad.ac.id:article/3663 2024-11-25T05:49:21Z ijihs:ART

Tacrolimus Therapy Among Steroid-Resistant Nephrotic Syndrome Children: A Preliminary Study in West Java, Indonesia Widiasta, Ahmedz Wahyudi, Kurnia Rachmadi, Dedi Developing-country, soluble urokinase plasminogen activator receptor, steroid-resistant nephrotic syndrome, tacrolimus Objective: To explore the outcomes of Tac therapy for Steroid-Resistant Nephrotic Syndrome (SRNS) and its implication in reducing the number of CKD events.Methods: An open, prospective, cohort study was conducted at a tertiary hospital in Bandung, West Java, Indonesia. Children (age 1–18 years old) with steroid and cyclophosphamide resistant nephrotic syndrome were enrolled in this study. Blood pressure, urinary protein, serum ureum, and creatinine levels were measured every month, Tac and soluble urokinase plasminogen activator receptor (supaR) levels were assessed at the 0, third, and sixth months.Results: Ten of fifteen subjects enrolled in this study got better within 3–6 months with a trend of decreasing suPAR level and proteinuria, as well as stable blood pressure and serum creatinine and ureum level. During treatment, no side effects of the subjects were found with the Tac level maintain safely.Conclusion: Tac is an effective and safe agent in treating SRNS, especially for those do not respond well to an alkylating agent. Faculty of Medicine Universitas Padjadjaran 2024-09-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.fk.unpad.ac.id/index.php/ijihs/article/view/3663 10.15850/ijihs.v12.n2.3663 International Journal of Integrated Health Sciences; Vol 12, No 2 (2024); 133-141 International Journal of Integrated Health Sciences; Vol 12, No 2 (2024); 133-141 2338-4506 2302-1381 10.15850/ijihs.v12.n2 eng https://journal.fk.unpad.ac.id/index.php/ijihs/article/view/3663/2003 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/3663/4536 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/3663/4537 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/3663/4551 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/3663/4565 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/3663/4566 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/3663/4569 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/3663/4570 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/3663/4571 Copyright (c) 2024 International Journal of Integrated Health Sciences http://creativecommons.org/licenses/by-nc/4.0

oai:ojs.journal.fk.unpad.ac.id:article/4291 2025-12-04T07:27:57Z ijihs:ART

Relationship between Neutrophil-Lymphocyte Ratio and Type of Febrile Seizures Event Putra, Agus Indra Yudhistira Diva Mustika, Putu Pradnyanita Suryawan, Wayan Bikin Febrile seizures; leukocyte; neutrophil; neutrophil-lymphocyte ratio Background: Febrile seizure is a common neurological condition affecting children. Complete blood count (CBC)  is often used as the initial test to help determine the etiology of fever based on hematology parameters in the emergency ward.Objective: To analyze the relationship between neutrophil-lymphocyte ratio (NLR) and the type of febrile seizure  among pediatric patients admitted to Wangaya General Hospital Denpasar, Indonesia.Methods: A cross-sectional design was implemented on a study using medical records of 44 children aged 6 month-5 years old admitted to the Wangaya Hospital between January 1, 2023, and September 8, 2024. Participants were grouped into simple and complex febrile seizures.Results: Among patients who experienced the first febrile seizure, the complex type accounted for most hospitalizations (n=33, 75.0%). The majority of cases occurred in children aged ≤24 months (n=32, 72.7%) with a temperature of >38°C (n=27, 61.4%). Seizure duration was ≤15 minutes in most cases (n=41, 93.9%), with upper Respiratory Infection being the most common etiology (n=20, 45.5%). NLR did not differ significantly between the simple and complex febrile seizures (P value =0.894), with a prevalence ratio (PR) of 1.1. Additionally, leukopenia, lymphocytopenia, and neutrophilia were observed in 28 (63.6%), 23 (52.3%), and 24 (54.5%) patients, respectively.Conclusion: There is no significant relationship between NLR and the type of first febrile seizures. Seizures are more frequently observed in males, particularly those aged 6-24 months with body temperature exceeding 38°C. The mean NLR of 2.78 ± 2.38 and upper respiratory infection are the most frequently associated conditions. Faculty of Medicine Universitas Padjadjaran 2025-10-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.fk.unpad.ac.id/index.php/ijihs/article/view/4291 10.15850/ijihs.v13n2.4291 International Journal of Integrated Health Sciences; Vol 13, No 2 (2025); 145-149 International Journal of Integrated Health Sciences; Vol 13, No 2 (2025); 145-149 2338-4506 2302-1381 10.15850/ijihs.v13n2 eng https://journal.fk.unpad.ac.id/index.php/ijihs/article/view/4291/2159 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/4291/5469 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/4291/5470 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/4291/5494 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/4291/5495 Copyright (c) 2025 International Journal of Integrated Health Sciences http://creativecommons.org/licenses/by-nc/4.0

oai:ojs.journal.fk.unpad.ac.id:article/406 2023-11-02T04:53:25Z ijihs:CR

Normal Pressure Hydrocephalus Following Myodil Myelography Akar, Ezgi Akmil, Mehmet Ufuk Normal pressure hydrocephalus, myelography, myodil   Objective: Fat-saturated contrast agent-enhanced myelography was used for the purpose of diagnosing most spinal lesions from the beginning of the 19th century until the end of the 20th century. Myodil was among the agents used for many years for this purpose.Methods: A rare long-term complication of myodil myelography is presented with a cerebrospinal fluid (CSF) absorption disorder occurring years after myelography that caused a secondary normal pressure hydrocephalus.Results: A case of normal pressure hydrocephalus with a slowly developing clinical picture that emerged years after a ventriculoperitoneal shunt for a myodil myelography 25 years ago due to suspicion of lumbar spinal stenosis was treated. Conclusions: Many acute and chronic complications of fat-saturated contrast agents were reported. Because of these complications and with the technological developments in due course, these agents are replaced by computerized tomography (CT), magnetic resonance imaging (MRI), or hydrophilic contrast agents.Keywords: Normal pressure hydrocephalus, myelography, myodil DOI: 10.15850/ijihs.v3n1.406 Faculty of Medicine Universitas Padjadjaran 2015-04-06 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.fk.unpad.ac.id/index.php/ijihs/article/view/406 International Journal of Integrated Health Sciences; Vol 3, No 1 (2015); 39-43 International Journal of Integrated Health Sciences; Vol 3, No 1 (2015); 39-43 2338-4506 2302-1381 10.15850/ijihs.v3n1 eng https://journal.fk.unpad.ac.id/index.php/ijihs/article/view/406/370 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/406/200 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/406/201 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/406/202 Copyright (c) 2017 International Journal of Integrated Health Sciences http://creativecommons.org/licenses/by-nc/4.0

oai:ojs.journal.fk.unpad.ac.id:article/2613 2023-11-02T04:47:31Z ijihs:ART

Mental Health Overview in Bullying Victim Students: A Descriptive Analysis Lubis, Yusuf Hanafi Septiani Nainggolan, Ivena Hotmarina Harahap, Linda Mutiara Risna, Risna Pangestuty, Sashi Battlefields, bullying, college, mental health, student Objective: To identify the impact of bullying behavior on the mental health of students who are victims of bullying.Methods: This was a cross-sectional descriptive quantitative study on 105 students in Medan Perjuangan district from November - December 2021.  Sampling was performed using accidental sampling techniques on students living in the study area. A questionnaire was used to collect data and analysis was performed using univariate analysis with an estimated value of 95% confidence of 5%. Results: More than 70% of respondents received some forms of bullying such as body shaming, intelligence discrimination, and parental work shaming, discrimination based on their religion and beliefs, and abusive words. More than 60% of students were also discriminated, ridicule, and subjected to physical violence. About 50% of respondents were also bullied based on their financial, racial/ethnicity, and skin color traits and received physical abused.Conclusion: There is a link between mental health conditions and bullying behavior in students who are victims of bullying. Faculty of Medicine Universitas Padjadjaran 2022-09-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.fk.unpad.ac.id/index.php/ijihs/article/view/2613 10.15850/ijihs.v10n2.2613 International Journal of Integrated Health Sciences; Vol 10, No 2 (2022); 82–87 International Journal of Integrated Health Sciences; Vol 10, No 2 (2022); 82–87 2338-4506 2302-1381 eng https://journal.fk.unpad.ac.id/index.php/ijihs/article/view/2613/1746 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/2613/3039 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/2613/3067 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/2613/3068 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/2613/3197 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/2613/3341 Copyright (c) 2022 International Journal of Integrated Health Sciences http://creativecommons.org/licenses/by-nc/4.0

oai:ojs.journal.fk.unpad.ac.id:article/3773 2024-07-10T02:39:55Z ijihs:ART

Interpretation of Platelet Histograms and Its Correlation with Peripheral Smear in Data Showing Thrombocytopenia Shinde, Aparna Modi, Alisha Patil, Amruta Peripheral Smear; Platelet Histogram; Pseudothrombocytopenia; Thrombocytopenia Objective: To analyze the significance of platelet histograms and peripheral smears in understanding thrombocytopenia and compare them for the incidence of pseudothrombocytopenia.Methods: This prospective study was conducted in the Department of Pathology at a tertiary care medical institute. The study included 200 cases of thrombocytopenia. Platelet parameters (PCT, PDW, MPV) were obtained using an autoanalyzer, and peripheral smears were examined manually. Thrombocytopenia cases were classified into hyper-destructive, hypo-productive, and abnormal pooling categories based on etiology and platelet histogram patterns. The incidence of pseudothrombocytopenia was also compared. A P value of less than 0.05 was considered statistically significant. Results: The gender distribution showed a male preponderance (56% male, 44% female). The mean age of the patients was 26.8 years. The study found hyper-destructive thrombocytopenia to be the most common type, with viral fever, sepsis, and malaria being the common etiologies for this type of thrombocytopenia. Histogram analysis revealed distinct patterns for different types of thrombocytopenia. The study also noted a higher incidence of pseudothrombocytopenia in automated analysis compared to manual methods, with a statistically significant difference.Conclusion: Platelet histograms combined with peripheral smear analysis provide crucial information about the etiology and nature of thrombocytopenia. This integrated approach enhances diagnostic accuracy and aid in effective patient management. Faculty of Medicine Universitas Padjadjaran 2024-03-31 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.fk.unpad.ac.id/index.php/ijihs/article/view/3773 10.15850/ijihs.v12.n1.3773 International Journal of Integrated Health Sciences; Vol 12, No 1 (2024); 17-23 International Journal of Integrated Health Sciences; Vol 12, No 1 (2024); 17-23 2338-4506 2302-1381 10.15850/ijihs.v12.n1 eng https://journal.fk.unpad.ac.id/index.php/ijihs/article/view/3773/1935 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/3773/4695 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/3773/4696 Copyright (c) 2024 International Journal of Integrated Health Sciences http://creativecommons.org/licenses/by-nc/4.0

oai:ojs.journal.fk.unpad.ac.id:article/4309 2025-12-04T07:27:54Z ijihs:ART

Impact of Nutrition Education on Dietary Habits among Bachelor-in-Medicine, Bachelor-in-Surgery (MBBS) Students: A Study in an Indian Medical College Kumar, Sudeep Sah, Sumesh Prasad Kumar, Dinesh Arora, Manish Sharma, Shiwani Dietary practices; health promotion; intervention studies; medical students; nutrition education Background: Unhealthy eating patterns, often triggered by academic pressures and erratic schedules, can negatively impact students’ health and hinder their ability to effectively guide future patients. Nutrition education offers a valuable opportunity to promote healthier eating habits by providing critical knowledge that supports both students’ personal wellbeing and professional competence.Objective: To evaluate the effect of nutrition education on eating habits of first-year Bachelor-in-Medicine, Bachelor-in-Surgery (MBBS) among medical students.Methods: A pre-post interventional study was carried out on 200 Phase-1 MBBS students of Muzaffarnagar Medical College between January and June 2024. Initial dietary habits were assessed using a validated questionnaire. A structured session of nutrition education was provided. The dietary habits were then re-assessed after four weeks, and changes were analyzed using paired statistical tests.Results: Data collected after the intervention showed notable enhancements in dietary practices. The percentage of students consuming three balanced meals a day increased from 32% to 68% (p < 0.001). The intake of fast food decreased from 65% to 35%, and the consumption of sugar-sweetened beverages fell from 58% to 30%. The average servings of fruits and vegetables consumed daily rose from 2.1 to 4.5 (p < 0.01). Nutrition knowledge scores presented a 30% improvement, indicating greater awareness.Conclusion: Medical students' eating habits are much improved by nutrition education, underscoring its significance in medical education. Future healthcare workers may benefit from lifelong good eating habits if such programs are incorporated into the curriculum, which would improve patient care and their own health. Faculty of Medicine Universitas Padjadjaran 2025-10-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.fk.unpad.ac.id/index.php/ijihs/article/view/4309 10.15850/ijihs.v13n2.4309 International Journal of Integrated Health Sciences; Vol 13, No 2 (2025); 77-81 International Journal of Integrated Health Sciences; Vol 13, No 2 (2025); 77-81 2338-4506 2302-1381 10.15850/ijihs.v13n2 eng https://journal.fk.unpad.ac.id/index.php/ijihs/article/view/4309/2150 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/4309/5490 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/4309/5491 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/4309/5492 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/4309/5493 Copyright (c) 2025 International Journal of Integrated Health Sciences http://creativecommons.org/licenses/by-nc/4.0

oai:ojs.journal.fk.unpad.ac.id:article/108 2024-03-27T08:38:05Z ijihs:CR

Nephropathy and Encephalopathy in an Indonesian Patient with Dengue Viral Infection Rachmadi, Dedi Anggara, Mohamad Yanuar Objective: To describe unusual manifestation of dengue virus infection that has been increasing in number and elucidate the indirect effect of dengue infection on the central nervous system which may explain the occurence of dengue encephalopathy. Methods: A case report of 6-year-old boy who was admitted with a history of fever for three days, accompanied with decreased consciousness, hypertension, and edema is presented. Laboratory examination showed hemoconcentration, thrombocytopenia, with positive anti dengue Immunoglobulin G (IgG) and IgM, microscopic glomerular hematuria, and proteinuria as well as normal creatinine serum level. He was treated with supportive treatment. Results: After six days, the consciousness was improved and blood pressure was normal.  Proteinuia was alleviated by Day 11 and completely negative on Day 19.  Microscopic glomerular hematuria was negative after 6 months.Conclusions: Recognition of unusual dengue manifestations is important in early diagnosis and effective treatment of the disease.Keywords: Dengue virus infection, encephalopathy, nephropathy DOI: 10.15850/ijihs.v1n1.108 Faculty of Medicine Universitas Padjadjaran 2013-09-18 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.fk.unpad.ac.id/index.php/ijihs/article/view/108 International Journal of Integrated Health Sciences; Vol 1, No 1 (2013); 49-52 International Journal of Integrated Health Sciences; Vol 1, No 1 (2013); 49-52 2338-4506 2302-1381 eng https://journal.fk.unpad.ac.id/index.php/ijihs/article/view/108/96

oai:ojs.journal.fk.unpad.ac.id:article/2558 2023-11-02T04:48:58Z ijihs:ART

Renal Parameters in Mild, Moderate, and Chronic Cigarette Smokers Kumar, Dinesh Sharma, Preeti Kumar, Sudeep Sah, Sumesh Prasad Arora, Manisha Iqbal, Shahid Kumar, Pradeep Albuminuria; cigarette smokers; e-GFR; kidney function; uACR Objective: To explore the link between cigarette smoking and kidney function through renal parameter assessment.Methods: The present study was performed at the Department of Biochemistry Santosh Medical College, Ghaziabad, India, from September 2019 to April 2021. In this study, 140 subjects were included, out of which 35 were non-smokers, 35 smoked  <5 cigarette per day, 35 smoked 5-10 cigarette per day, and the remaining 35 smoked more than 10 cigarettes per day.Results: Blood urea, serum creatinine, urinary albumin, and uACR levels were found to increase significantly (p<0.001) in smokers as compared to non-smokers. These increases were higher among chronic cigarette smokers (p<0.001) as opposed to mild and moderate smokers. In contrast, serum uric acid, e-GFR, and urinary creatinine levels decreased significantly (p<0.001) in smokers when compared to non-smokers, with a higher decrease observed in chronic cigarette smokers (p<0.001) as opposed to the mild and moderate cigarette smokers.Conclusion: Alterations in urinary albumin, serum urea, serum creatinine, urinary creatinine, and e-GFR are associated with the risk of renal dysfunction. Faculty of Medicine Universitas Padjadjaran 2022-03-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.fk.unpad.ac.id/index.php/ijihs/article/view/2558 10.15850/ijihs.v10n1.2558 International Journal of Integrated Health Sciences; Vol 10, No 1 (2022); 1–6 International Journal of Integrated Health Sciences; Vol 10, No 1 (2022); 1–6 2338-4506 2302-1381 eng https://journal.fk.unpad.ac.id/index.php/ijihs/article/view/2558/1646 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/2558/2784 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/2558/2785 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/2558/2786 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/2558/2787 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/2558/2788 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/2558/2789 Copyright (c) 2022 International Journal of Integrated Health Sciences http://creativecommons.org/licenses/by-nc/4.0

oai:ojs.journal.fk.unpad.ac.id:article/2947 2025-05-20T08:19:17Z ijihs:CR

Paradoxical Hemiparesis from Cerebellopontine Angle Tumor: A Case Report Gunawan, James Gaharu, Maula Nuruddin Cerebellopontine Angle; Kernohan-Woltman Notch Phenomenon; Paradoxical Hemiparesis; Vestibular Schwannoma Objective: To report a vestibular schwannoma in the cerebellopontine angle presenting with paradoxical hemiparesis with the Kernohan-Woltman Notch Phenomenon (KWNP).Methods: A 31-year-old female presented to the neurology clinic at Bhayangkara Hospital TK. I R. Said Sukanto, Indonesia, on 29 November 2021 with loss of balance, hearing, vision, and weakness in her left arm and leg. On physical examination, the patient had reduced left arm and leg muscle strengths against resistance (MRC grade 4), face deviation to the left, abnormal finger-to-nose test, dysdiadochokinesia, and inability to perform tandem gait. She was admitted for a brain MRI but did not return to the hospital for re-evaluation and surgery. Results: The brain MRI showed a mass on the left side of the cerebellum with a size of 4.44x3.93x4.93 cm, suggesting vestibular schwannoma. The mass also caused the obliteration of the ventricle, causing hydrocephalus.Conclusion:KWNP is an unusual finding resulting in a paradoxical hemiparesis, a false-localizing neurologic sign. Physicians should recognize KWNP in patients with hemiparesis, especially in space-occupying lesions. Imaging studies can help localize the lesion to minimize misdiagnosis and optimize patient treatment.  Faculty of Medicine Universitas Padjadjaran 2023-09-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.fk.unpad.ac.id/index.php/ijihs/article/view/2947 10.15850/ijihs.v11n2.2947 International Journal of Integrated Health Sciences; Vol 11, No 2 (2023); 125-128 International Journal of Integrated Health Sciences; Vol 11, No 2 (2023); 125-128 2338-4506 2302-1381 10.15850/ijihs.v11n2 eng https://journal.fk.unpad.ac.id/index.php/ijihs/article/view/2947/1859 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/2947/3544 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/2947/3596 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/2947/4210 Copyright (c) 2023 International Journal of Integrated Health Sciences http://creativecommons.org/licenses/by-nc/4.0

oai:ojs.journal.fk.unpad.ac.id:article/2178 2023-11-02T04:49:52Z ijihs:CR

Review on Acute Cardio-Cerebral Infarction: a Case Report Sihite, Teddy Arnold Sitepu, Michi Astuti Rehmenda Mario Effendi, Cut Azlina Acute infarct stroke; acute myocardial infarction; Cardio-cerebral infarction Objective: To describe a case of a Cardio-Cerebral Infarction (CCI) male patient presented with a history of chest pain recognized using electrocardiography, brain computed tomography, and Percutaneous Coronary Intervention (PCI).Methods: A 69 years old man came with history of chest pain since 13 hours before to the emergency room. Electrocardiography, brain computed tomography, and PCI were performed, leading to the diagnosis of CCI.Results: The electrocardiography showed ST Elevation in Antero-lateral, atrial fibrillation and left-sided hemipharesis, which occurred on the second day. Brain computed tomography demonstrated acute infarct stroke, while the Percutaneous Coronary Intervention (PCI) showed one vessel disease with severe stenosis in LAD and implanted stent in proximal-mid LAD. Therapy prescribed was providing antiplatelet and anticoagulation.Discussion: Acute Myocardial Infarction (AMI) and Acute Infarct Stroke (AIS) have a narrow therapeutic time-window and a delayed intervention may results in morbidity and death. Antiplatelet and anticoagulant used in PCI for AMI increase the risk for hemorrhagic, and AIS with thrombolytic increase the risk of cardiac wall rupture in AMI. Direct Oral Anticoagulant (DOAC) treatment should reduce ischaemia and lower bleeding. The optimal time point to start anticoagulant treatment might be between 4-14 days after the onset of stroke. Duration of post-PCI triple therapy should be minimized depending on bleeding and risks of ischemia. Faculty of Medicine Universitas Padjadjaran Faculty of Medicine, University of Padjajaran, Bandung, Indonesia 2021-10-19 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.fk.unpad.ac.id/index.php/ijihs/article/view/2178 10.15850/ijihs.v9n2.2178 International Journal of Integrated Health Sciences; Vol 9, No 2 (2021); 84-88 International Journal of Integrated Health Sciences; Vol 9, No 2 (2021); 84-88 2338-4506 2302-1381 10.15850/ijihs.v9n2 eng https://journal.fk.unpad.ac.id/index.php/ijihs/article/view/2178/1644 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/2178/2731 Copyright (c) 2021 International Journal of Integrated Health Sciences http://creativecommons.org/licenses/by-nc/4.0

oai:ojs.journal.fk.unpad.ac.id:article/3353 2025-05-20T08:19:17Z ijihs:ART

Intention to Consume Alcohol among Dayak Adolescents in Sarawak: An Application of Theory of Planned Behavior Gahamat, Mohd Faiz Rahman, Md Mizanur Safii, Razitasham Daud, Muhammad Siddiq Ajeng, Rudy Ngau Adolescents; Alcohol; Dayak; Theory of Planned Behavior Objectives: To explore the application of a model that integrates various factors that influence Dayak adolescents' intentions to consume alcohol in Sarawak, Malaysia.Methods: A cross-sectional quantitative study was conducted from September 2019 to February 2022. Through multistage stratified cluster sampling, 12 districts were selected from 12 divisions. Respondents were selected randomly and were interviewed using a questionnaire.Results: Structural equation modeling was used to test the Theory of Planned Behavior (TPB) and explore the relationship between various variables and respondents' intention to consume alcohol. The findings suggest that attitude (β=.22, p<.001), subjective norm (β = .33, p < .001), and perceived behavior control (β =−.41, p<.001) influenced the intention to consume alcohol. In contrast, alcohol consumption was associated with intention (β=.15, p < .001), attitude (β=.20, p<.001), and perceived behavior control (β=−.32, p<.001).Conclusion: The findings demonstrated that the TPB model can be used to explore various variables that influence the intention to consume alcohol among Dayak adolescents, with attitude, subjective norm, and perceived behavior control as the variable influencing the intention. This highlights the need for paying attention to those variables when developing age-appropriate strategies that address various social levels to curb alcohol consumption. Given the concerning rates of risky drinking and dependency, school-based health initiatives and focused screening for Dayak adolescents are crucial. Faculty of Medicine Universitas Padjadjaran 2023-09-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.fk.unpad.ac.id/index.php/ijihs/article/view/3353 10.15850/ijihs.v11n2.3353 International Journal of Integrated Health Sciences; Vol 11, No 2 (2023); 63-69 International Journal of Integrated Health Sciences; Vol 11, No 2 (2023); 63-69 2338-4506 2302-1381 10.15850/ijihs.v11n2 eng https://journal.fk.unpad.ac.id/index.php/ijihs/article/view/3353/1850 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/3353/4113 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/3353/4114 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/3353/4329 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/3353/4330 Copyright (c) 2023 International Journal of Integrated Health Sciences http://creativecommons.org/licenses/by-nc/4.0

oai:ojs.journal.fk.unpad.ac.id:article/4099 2025-08-01T02:32:07Z ijihs:ART

Role of Osteopontin in Hypothyroid Anemic Woman and Their Association with Oxidative Stress Sah, Sumesh Prasad Sah, Sonu Kumar, Sudeep Arora, Manisha Kumar, Dinesh Kumar, Raj Osteopontin; oxidative stress; antioxidant status; hypothyroidism; anemia Background: Hypothyroidism is frequently associated with anemia and oxidative stress, necessitating exploration of biomarkers like Osteopontin to better understand disease mechanisms.Objective: To explore the association between Osteopontin, oxidative stress, and antioxidant capacity in hypothyroid woman with or without anemia.Methods: The study was conducted at the Santosh Medical College Department of Biochemistry in Ghaziabad, India, from September 2019 to October 2021. This study was cross-sectional and recruited 360 female subjects, divided into three groups: hypothyroidism with anemia, hypothyroidism without anemia, and normal healthy controls. Osteopontin, thyroid profile, malondialdehyde (MDA) and total antioxidant capacity were measured.Results: Osteopontin, T3, T4, and total antioxidant capacity levels were significantly lower (p<0.001), and the TSH and MDA levels significantly increased (p<0.001) in female subjects experiencing hypothyroidism, with or without anemia, as compared to normal healthy female control groups. Osteopontin demonstrated significant negative relationship with TSH and MDA, while showing a significant positive relationship with T3, T4, and total antioxidant status in both studied groups.Conclusion: Osteopontin and oxidative stress/antioxidant status significantly correlate in female subjects experiencing hypothyroidism, with or without anemia. In these patients, Osteopontin might be a useful biomarker for evaluating antioxidant levels and oxidative stress. Faculty of Medicine Universitas Padjadjaran 2025-04-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.fk.unpad.ac.id/index.php/ijihs/article/view/4099 10.15850/ijihs.v13n1.4099 International Journal of Integrated Health Sciences; Vol 13, No 1 (2025); 17-21 International Journal of Integrated Health Sciences; Vol 13, No 1 (2025); 17-21 2338-4506 2302-1381 10.15850/ijihs.v13.n1 eng https://journal.fk.unpad.ac.id/index.php/ijihs/article/view/4099/2075 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/4099/5208 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/4099/5210 Copyright (c) 2025 International Journal of Integrated Health Sciences http://creativecommons.org/licenses/by-nc/4.0

oai:ojs.journal.fk.unpad.ac.id:article/2142 2022-04-11T03:03:32Z ijihs:CR

Pulmonary Embolism in High-Risk Patients: How to Select Standard Imaging and Management Strategy? Laksono, Sidhi Dewi, Firizkita Halomoan, Reynaldo Computed tomography pulmonary angiography; elderly people; high-risk pulmonary embolism; pulmonary embolism; treatment Objective: To describe the use of computed tomography pulmonary angiography (CTPA) for diagnostic purposes and percutaneous catheter-directed thrombolysis (PCDT) as a treatment choice for high-risk pulmonary embolism (PE) patients.Methods: This case report describes a case of an elderly female presented with dyspnea, cough, fever, and chest pain. No significant medical history was identified.Results: CTPA was conducted and showed multiple thrombus with significant stenosis in several branches of pulmonary artery. Initial anticoagulation was administered without delay. Patient then underwent PCDT to remove the thrombus. No post intervention symptom and systemic complications were noted.Conclusions: Computed tomography pulmonary angiography is useful as the standard imaging modality to help evaluating suspected pulmonary embolism. Percutaneous catheter-directed thrombolysis is indicated to treat high-risk patients with high risk of bleeding. Faculty of Medicine Universitas Padjadjaran 2021-03-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.fk.unpad.ac.id/index.php/ijihs/article/view/2142 10.15850/ijihs.v9n1.2142 International Journal of Integrated Health Sciences; Vol 9, No 1 (2021); 30-35 International Journal of Integrated Health Sciences; Vol 9, No 1 (2021); 30-35 2338-4506 2302-1381 10.15850/ijihs.v9n1 eng https://journal.fk.unpad.ac.id/index.php/ijihs/article/view/2142/1605 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/2142/2043 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/2142/2054 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/2142/2055 Copyright (c) 2021 International Journal of Integrated Health Sciences http://creativecommons.org/licenses/by-nc/4.0

oai:ojs.journal.fk.unpad.ac.id:article/2887 2024-01-05T03:40:35Z ijihs:ART

Adenosine Deaminase as Inflammatory Marker in Type II Diabetes Mellitus Yadav, Sushil Bansal, Megha Kumar, Pradeep Sharma, Preeti Adenosine Deaminase; Inflammatory Markers; Type II Diabetes Mellitus. Objective: To evaluate the enzymatic activity of Adenosine Deaminase in type II diabetes mellitus (T2DM).Methods: This study was conducted on 60 clinically diagnosed type II diabetes mellitus patients, with 60 healthy subjects as the control group. Subjects were enrolled in the study only after their written consent was obtained. The inclusion of diabetes mellitus cases (DM) was conducted as per the WHO guidelines. Estimation of enzymatic activity of serum ADA was performed by Kinetic method using a commercial kit.Result: The observed serum ADA activity in DM patients was 48.34 ± 21.05 U/L, which was significantly higher in comparison to healthy controls (25.02 ± 5.78 U/L). The serum activity raised in about 80% of patients and they had higher values above the reference activity of 30 U/L. The increased activity of ADA among the diabetic subjects indicates inflammatory changes in these individuals.Conclusion: It is possible that in the coming years, a new therapeutic strategy based on anti-inflammatory properties with beneficial effects on diabetic complications can be translated into real clinical treatments. Faculty of Medicine Universitas Padjadjaran None 2023-03-31 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.fk.unpad.ac.id/index.php/ijihs/article/view/2887 10.15850/ijihs.v11n1.2887 International Journal of Integrated Health Sciences; Vol 11, No 1 (2023); 7-11 International Journal of Integrated Health Sciences; Vol 11, No 1 (2023); 7-11 2338-4506 2302-1381 10.15850/ijihs.v11n1 eng https://journal.fk.unpad.ac.id/index.php/ijihs/article/view/2887/1795 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/2887/3486 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/2887/3487 Copyright (c) 2023 International Journal of Integrated Health Sciences http://creativecommons.org/licenses/by-nc/4.0

oai:ojs.journal.fk.unpad.ac.id:article/3991 2024-11-25T05:49:23Z ijihs:ART

Outcome of Minimally Invasive Percutaneous Plate Osteosynthesis Using Locking Compression Plate for Distal Tibial Fractures Rampure, Sagar Choraria, Harsh Hanchate, Krishna Mahadik, Sujay K Deshpande, Shrikant Distal tibial fractures, functional outcome, locking compression plate, percutaneous plate osteosynthesis Objectives: To assess the functional and radiological outcomes of the distal tibia fractures managed surgically with a locking compression plate by MIPPO technique.Methods: This prospective observational study included 34 patients with distal tibial fractures treated at Bharati Vidyapeeth (Deemed to be University) Medical College and Hospital, Sangli, India. After ethics committee approval and informed consent, eligible adults with complex or unfavorable simple, closed fractures were enrolled. Exclusions were patients under 18 with pathological fractures or comorbidities affecting functional outcomes. Standard preoperative protocols and imaging were conducted. All patients were surgically managed with a locking compression plate by MIPPO technique. Postoperatively, exercises and staged weight-bearing were implemented. Follow-up assessments at 45, 90, 135, and 180 days evaluated pain, movement, and radiological union using Olerud and Molander score. Statistical analysis utilized paired t-test and Chi-Square test.Results: Out of 34 patients with distal tibial fractures, 24 (70.6%) were males and 10 (29.4%) were females with a mean age of 41.88 years. Most fractures were 42A1 (35.3%) and 43A2 (32.4%). Post-operative superficial wound infection occurred in 3 (8.8%) and deep infection in 2 (5.9%). Mean union time was 16.62 weeks. Functional outcomes were excellent in 3 (8.8%), good in 22 (64.7%), and fair in 9 (26.5%). At six months, complications included ankle stiffness (29.4%), non-union (20.6%), and malunion (8.8%). No cases had plate or screw breakage.Conclusion: MIPPO technique allows for good functional outcomes while reducing complications, especially in fractures with poor soft tissue conditions. Faculty of Medicine Universitas Padjadjaran 2024-09-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.fk.unpad.ac.id/index.php/ijihs/article/view/3991 10.15850/ijihs.v12.n2.3991 International Journal of Integrated Health Sciences; Vol 12, No 2 (2024); 95-101 International Journal of Integrated Health Sciences; Vol 12, No 2 (2024); 95-101 2338-4506 2302-1381 10.15850/ijihs.v12.n2 eng https://journal.fk.unpad.ac.id/index.php/ijihs/article/view/3991/1997 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/3991/5162 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/3991/5163 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/3991/5211 Copyright (c) 2024 International Journal of Integrated Health Sciences http://creativecommons.org/licenses/by-nc/4.0

oai:ojs.journal.fk.unpad.ac.id:article/4178 2025-12-04T07:27:56Z ijihs:ART

Predictive Factors of Neutropenia Following First Cycle of Chemotherapy in Patients with Non-Hodgkin’s Lymphoma in Bali, Indonesia Pratiwi, Made Sindy Astri Agustini, Made Priska Arya Yani, Made Violin Weda Rena, Ni Made Renny Anggreni Chemotherapy-induced neutropenia; non-Hodgkin lymphoma; risk factor Background: Chemotherapy-induced neutropenia (CIN) is a common hematologic toxicity that increases infection risk, hospitalization, and treatment delay. Limited data exist on predictive factors of CIN among non-Hodgkin’s lymphoma (NHL) patients in Indonesia, particularly in Bali.Objective: To identify predictive factors of neutropenia following the first cycle of chemotherapy in patients with NHL at Prof. I.G.N.G Ngoerah General Hospital, Bali, Indonesia.Methods: This retrospective cohort study included all NHL patients treated from 2020–2023. Eligible patients were aged ≥18 years, received CHOP-based regimens with or without rituximab, and did not receive G-CSF prophylaxis. Data were obtained from medical records. Assessed risk factors were age, gender, BMI, comorbidities, histopathology grading, extranodal involvement, ECOG status, Ann Arbor stage, IPI score, chemotherapy regimen, pre-treatment blood count, eGFR, LDH, and albumin. The incidence of neutropenia was evaluated after the first chemotherapy cycle.Results: The mean age of the eligible patients (n=112) was 54.53 ± 14.64 years; 46 of them (41%) developed neutropenia. Significant factors associated with neutropenia were histopathology grading (p = 0.030), Ann Arbor stage (p = 0.048), IPI score (p = 0.037), chemotherapy regimen (p = 0.019), and LDH above normal (p = 0.049). Multivariate analysis identified high IPI scores (p = 0.016; OR 6.375; 95% CI 1.416–28.698) and CHOP regimen (p = 0.016; OR 3.033; 95% CI 1.230–7.476) as independent predictors of CIN.Conclusion: High IPI scores and CHOP regimens are strong predictors of neutropenia after the first chemotherapy cycle in NHL patients. Early identification of high-risk patients is essential for preventive management and improved treatment outcomes. Faculty of Medicine Universitas Padjadjaran 2025-10-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.fk.unpad.ac.id/index.php/ijihs/article/view/4178 10.15850/ijihs.v13n2.4178 International Journal of Integrated Health Sciences; Vol 13, No 2 (2025); 113-124 International Journal of Integrated Health Sciences; Vol 13, No 2 (2025); 113-124 2338-4506 2302-1381 10.15850/ijihs.v13n2 eng https://journal.fk.unpad.ac.id/index.php/ijihs/article/view/4178/2155 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/4178/5311 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/4178/5312 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/4178/5313 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/4178/5314 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/4178/5315 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/4178/5316 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/4178/5350 Copyright (c) 2025 International Journal of Integrated Health Sciences http://creativecommons.org/licenses/by-nc/4.0

oai:ojs.journal.fk.unpad.ac.id:article/402 2023-11-02T04:53:25Z ijihs:ART

Osteoporosis Risk and Body Mass Index Comparison among Urban and Rural Menopausal Women Tarawan, Vita Muniarti Adnantami, Putri Fatima Adnantama, Putra Habibie Adnantama, Putra Haqiqie Objective: To compare osteoporosis risk factors between urban and rural menopausal women. Methods: This study applied the causal-comparative analysis to compare osteoporosis risk factors between urban and rural menopausal women. The subjects included in this study were 40 urban and 40 rural menopausal women who were randomly recruited. The respondents’ bone mass density was measured using densitometry. This study also examined several aspects, including the respondents’ nutritional status (body mass index calculation) and physical fitness (VO2 max). The correlation between osteoporosis risk and either nutritional status or physical fitness among urban and rural menopausal women were tested using Chi square correlation analysis. Results: This study examined several aspects, including age (years) 58.7±6.1 (urban) and 58.3±6.5 (rural), p=0.815, body mass index (kg/m2) 23.7±3.7 (urban) and 22.7±3.6 (rural), p=0.221, VO2 max (average) 27 (67.5%) (urban) and 25 (62.5%) (rural), p=0.624. The respondents diagnosed as suffering from osteoporosis were statistically measured for the: nutritional status (body mass index) (under) urban 0%, rural (p=0.789) 2.5%, body mass index 7.5% urban, rural (p=0.571) 2.5%, physical fitness condition (VO2 max) (average) urban 7.5%, rural (p=0.850) 5%, VO2 max (poor) urban 7.5%, rural (p=0.880) 5%. Body mass index and bone mass density calculation results described that the nutritional status of urban and rural menopausal women: normal 12 (30%) vs (32.5%), osteopenia 8 (20%) vs (15%), osteoporosis 3 (7.5%) vs (2.5), p=0.571. Conclusions: This study shows that there is no significant difference between osteoporosis risk and nutritional status and physical fitness in urban and rural menopausal women.Keywords: Nutritional status, osteoporosis level, physical fitness DOI: 10.15850/ijihs.v3n1.402 Faculty of Medicine Universitas Padjadjaran 2015-04-06 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.fk.unpad.ac.id/index.php/ijihs/article/view/402 International Journal of Integrated Health Sciences; Vol 3, No 1 (2015); 14-20 International Journal of Integrated Health Sciences; Vol 3, No 1 (2015); 14-20 2338-4506 2302-1381 10.15850/ijihs.v3n1 eng https://journal.fk.unpad.ac.id/index.php/ijihs/article/view/402/366 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/402/193 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/402/194 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/402/195 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/402/196 Copyright (c) 2017 International Journal of Integrated Health Sciences http://creativecommons.org/licenses/by-nc/4.0

oai:ojs.journal.fk.unpad.ac.id:article/2697 2024-06-11T03:08:05Z ijihs:ART

Diabetes Retinopathy Prevalence and Risk Factors among Diabetic Patients Seen at Highland Eye Clinic Mutare Zimbabwe: A Retrospective Study Tatenda Lewis, Musokeri Mena, Wani Salissou, Maibouge Tanko Mahamane Diabetes; hypertension; prevalence; retinopathy. Objective: To determine the prevalence of diabetic retinopathy and its association with hypertension, age, gender, and fasting blood glucose level.Methods: This retrospective study assessed the prevalence of diabetic retinopathy with its associated risk factors on 135 diabetic patients, aged 18 years and above, visiting the Highland Eye Clinic Mutare, Zimbabwe. Data were collected on the age, sex, and type of retinopathy. Based on the identified retinopathy, subjects were divided into no retinopathy, non-proliferative diabetic renopathy, and proliferative diabetic retinopathy groups. Analysis were then performed using multivariate and univariate regression analyses to test the association between the presence of retinopathy and several risk factors, and results were presented in percentages, with P< 0.05  considered to show statistical significance.Results: The average age of the subjects this study was 60.8 ± 14 with female subjects constituted more than half of the total number of subjects (58.5%). Forty four percent were overweight (BMI 25-30), 34.8 % were obese, and the overall prevalence of diabetic retinopathy was 31.1% (non-proliferative diabetic renopathy, 20%; proliferative renopathy, 11.1%). The proportion of subjects with retinopathy increased with duration of DM, being 23.3% in those with a DM duration of less than 10 years and 46.6% in those with a DM duration of more than 10 years. Age and hypertension were significantly associated with the presence of diabetic retinopathy (P< 0.05) in univariate analysis, but no association was identified between retinopathy and fasting blood glucose (chi-square test, P =0.0965)Conclusion: The prevalence of diabetic retinopathy (DR) is high (31.1%), Non-proliferative DR is more common than the proliferative (DR). There is a strong association between diabetic retinopathy, hypertension, and age. Faculty of Medicine Universitas Padjadjaran Africa University Zimbabwe, Highland Eye Clinic 2022-09-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.fk.unpad.ac.id/index.php/ijihs/article/view/2697 10.15850/ijihs.v10n2.2697 International Journal of Integrated Health Sciences; Vol 10, No 2 (2022); 51–58 International Journal of Integrated Health Sciences; Vol 10, No 2 (2022); 51–58 2338-4506 2302-1381 eng https://journal.fk.unpad.ac.id/index.php/ijihs/article/view/2697/1742 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/2697/3215 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/2697/3216 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/2697/3218 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/2697/3219 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/2697/3281 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/2697/3282 Copyright (c) 2022 International Journal of Integrated Health Sciences http://creativecommons.org/licenses/by-nc/4.0

oai:ojs.journal.fk.unpad.ac.id:article/3570 2024-06-11T07:30:02Z ijihs:ART

Subclinical Left Ventricular Dysfunction Prevention in Breast Cancer Patients after FAC Chemotherapy: A Carvedilol Trial Astuti, Astri Sumantra, I Gede Aafiyah, Adila Abdurahman, R. Maman Sihite, Teddy Arnold Akbar, Mohammad Rizki Hasan, Melawati Martanto, Erwan Breast Cancer, Carvedilol, Chemotherapy, Fluorouracil–Adriamycin–Cyclophosphamide, Global Longitudinal Strain Objective:  To assess the cardioprotective effects of Carvedilol in preventing subclinical left ventricular dysfunction (SLVD) in breast cancer patients after completing FAC chemotherapy.Methods: This prospective study employed a quasi-experimental clinical trial conducted from September 2018 to May 2019. Breast cancer patients receiving FAC chemotherapy were divided into two groups: intervention (IG) and control (CG). The IG received Carvedilol 6.25 mg b.i.d., which was increased every three weeks until reaching a tolerated dose. The study evaluated changes in left ventricular global longitudinal strain (GLS) and the incidence of SLVD (GLS reduction ≥15% and GLS >-18%) 24 weeks after initiating the FAC regimen.Result: Of the 81 women enrolled in the study, 31 were in the IG. No significant changes in GLS were observed during or after completing FAC chemotherapy in the IG, whereas the CG showed contradictory results. At the end of the follow-up period, the delta GLS reduction was lower in the IG (0.7; 95% CI -0.60, 3.60) compared to the CG (3.00; 95% CI -2.16, 4.19), with a p-value of 0.035. Similarly, the percentage reduction in GLS was 3.6% in the IG and 14.29% in the CG, resulting in a p-value of 0.05. The incidence rate of SLVD (GLS reduction ≥15% and GLS > -18%) was lower in the IG (41.9% and 25.8%) than in the CG (58% and 48%).Conclusion: Carvedilol may have a cardioprotective effect in preventing the incidence of SLVD, as evaluated by GLS reduction and changes, in women with breast cancer after completing a full cycle of the FAC regimen. Faculty of Medicine Universitas Padjadjaran Universitas Padjadjaran 2024-03-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.fk.unpad.ac.id/index.php/ijihs/article/view/3570 10.15850/ijihs.v12.n1.3570 International Journal of Integrated Health Sciences; Vol 12, No 1 (2024); 55-64 International Journal of Integrated Health Sciences; Vol 12, No 1 (2024); 55-64 2338-4506 2302-1381 10.15850/ijihs.v12.n1 eng https://journal.fk.unpad.ac.id/index.php/ijihs/article/view/3570/1941 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/3570/4396 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/3570/4397 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/3570/4426 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/3570/4427 Copyright (c) 2024 International Journal of Integrated Health Sciences http://creativecommons.org/licenses/by-nc/4.0

oai:ojs.journal.fk.unpad.ac.id:article/4029 2025-08-01T02:32:06Z ijihs:ART

Anemia and Aggression Among Patients with Schizophrenia in Amino Gondohutomo Psychiatric Hospital Noerhidajati, Elly Sofa, Yulia Ratna Woroasih, Sri Hardini, Intan Tri Aggression; Anemia; Schizophrenia Background: Anemia has been identified as a potential modifiable factor influencing aggression levels in individuals with schizophrenia.Objective: To investigate the association between anemia and incidence of aggression in patients with schizophrenia in Amino Gondohutomo Psychiatric Hospital, Semarang, Indonesia.Methods: A cross-sectional study was conducted between January 2022 and December 2023 on patients with schizophrenia in Amino Gondohutomo Psychiatric Hospital, Semarang, Indonesia. Subjects were selected using consecutive sampling technique, and individuals with affective mood disorder and lost to follow-up were excluded from the study. Data were obtained through patients’ medical records, PANSS-EC scores, and hemoglobin measuring devices. Chi-square test and logistic regression were applied for statistical analyses.Results: Of 100 participants, patients with schizophrenia presented with aggression were predominantly above 40 years old (26 patients, 81.3%), women (17 patients, 51.1%), and non-anemic (17 patients, 57.1%). Gender and anemia were significantly associated with aggression in patients with schizophrenia (p <0.05). Schizophrenic patients with anemia had a 7.68-fold greater risk (95% CI: 2.70 – 21.8) of aggression. Men with schizophrenia was associated with a 2.37-fold greater risk (95% CI: 1.00 – 5.60) of aggression.Conclusion: Anemia and men seems to be risk factors of aggression in patients with schizophrenia. Further multicenter studies with larger sample size is needed to support this finding. Faculty of Medicine Universitas Padjadjaran 2025-04-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.fk.unpad.ac.id/index.php/ijihs/article/view/4029 10.15850/ijihs.v13n1.4029 International Journal of Integrated Health Sciences; Vol 13, No 1 (2025); 51-55 International Journal of Integrated Health Sciences; Vol 13, No 1 (2025); 51-55 2338-4506 2302-1381 10.15850/ijihs.v13.n1 eng https://journal.fk.unpad.ac.id/index.php/ijihs/article/view/4029/2080 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/4029/5086 Copyright (c) 2025 International Journal of Integrated Health Sciences http://creativecommons.org/licenses/by-nc/4.0

oai:ojs.journal.fk.unpad.ac.id:article/104 2024-03-27T08:38:05Z ijihs:ART

Histological Description of Meningeal and Periosteal Dural Layers at the Porus of Internal Acoustic Canal in the Vestibular Schwannoma Sutiono, Agung Budi Arifin, Muhammad Zafrullah Faried, Ahmad Ohira, Takayuki Objective: To study the transformation point of meningeal and periosteal dural at the porus of internal acoustic canal (IAC) in order to verify the different thickness of meningeal and periosteal dura in vestibular schwannomas (VS). Methods: Three IAC cadaver specimens and ten samples of VS patients from porus were obtained and analyzed. Samples were stained by using Masson trichrome technique after cutting in 6 micron of thickness. The samples were then observed under light microscopes to understand the meninges pattern in the IAC. Results: The meningeal dura is becoming thin at the porus and disappears at the meatal portion to form epineurium. However, the periosteal dura is lining continuously to the fundus. In VS, the meningeal dura becomes thick and forms a pseudo-capsule in the middle of meatus, known as perineurium. The residual nerve filament was compressed by the tumor parenchyma. Between the tumor and nerve interface, three or more perineureal layers are seen. The perineurium in the cisternal portion was consistently loose and forms the tumor and arachnoid nerve interface. Almost all the nerve filaments are displaced to the tumor periphery near the pseudocapsule. In contrast, the periosteal dural of VS is becoming thin and disappear nearby the middle of meatal portion. This changing site establishes “meningo-periosteal ring” of VS because of the encircling nearby the porus. Conclusions: In IAC, the meningeal dural becomes thin. The periosteal dura is lining continuously to the fundus. In VS, the meningeal dura becomes thick, joins perineurium and forms pesudocapsule near the porus, but the periosteal dura disappeared. This changing point is called meningo-periosteal ring.     Keywords: Meningeal,  periosteal, porus, vestibular schwannomasDOI: 10.15850/ijihs.v1n1.104 Faculty of Medicine Universitas Padjadjaran 2013-08-17 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.fk.unpad.ac.id/index.php/ijihs/article/view/104 International Journal of Integrated Health Sciences; Vol 1, No 1 (2013); 22-28 International Journal of Integrated Health Sciences; Vol 1, No 1 (2013); 22-28 2338-4506 2302-1381 eng https://journal.fk.unpad.ac.id/index.php/ijihs/article/view/104/92

oai:ojs.journal.fk.unpad.ac.id:article/2488 2023-11-02T04:49:52Z ijihs:ART

Hook effect and serum KL-6 in Patients with Systemic Sclerosis-Associated Interstitial Lung Disease (SSc-ILD) Pranggono, Emmy Hermiyanti Moenardi, Valentine Natasya Syukrie, Alvy Dewi, Sumartini hook effect; ILD; KL-6; systemic sclerosis Objective To determine whether serum KL-6 can be used as an alternative diagnostic tool for Systemic Sclerosis-associated ILD (SSc-ILD).Method This was a cross-sectional study with compatibility analysis of SSc patients visiting the rheumatology clinic of Dr. Hasan Sadikin General Hospital, Bandung, Indonesia in 2019-2020. Inclusion criteria were aged 18-60 years, diagnosed with SSc, restrictive spirometry results followed by HRCT thorax, having stored biological materials (<2 years) for serum KL-6 examination, and body mass index of <23 kg/m2. Patients with pneumonia, tuberculosis, history of tuberculosis, malignancy, and cardiac decompensation were excluded. Serum KL-6 level of >397.5 unit/mL was declared as ILD. The compatibility analysis was performed using the Cohen’s Kappa test.Results: Thirty-eight subjects, mostly women (94.7%), with mean age of 39 years participated in this study. Most of the subjects suffered from diffuse systemic sclerosis subtypes (57.9%). Subjects had received cyclophosphamide (10.5%), MMF (2.6%), and other medications. Almost all subjects (97.4%) demonstrated ILD features on HRCT thorax. The median serum KL-6 level was 53.22 Units/mL, which was much lower than the findings in other studies, but the hook effect could not be proven. The Kappa coefficient was found to be 0.003 with a p-value of 0.811.Conclusion There is no compatibility between serum KL-6 level and ILD features based on HRCT thorax in SSc-ILD. The presence of hook effect needs more attention. Faculty of Medicine Universitas Padjadjaran 2021-10-19 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.fk.unpad.ac.id/index.php/ijihs/article/view/2488 10.15850/ijihs.v9n2.2488 International Journal of Integrated Health Sciences; Vol 9, No 2 (2021); 66-72 International Journal of Integrated Health Sciences; Vol 9, No 2 (2021); 66-72 2338-4506 2302-1381 10.15850/ijihs.v9n2 eng https://journal.fk.unpad.ac.id/index.php/ijihs/article/view/2488/1641 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/2488/2688 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/2488/2689 Copyright (c) 2021 International Journal of Integrated Health Sciences http://creativecommons.org/licenses/by-nc/4.0

oai:ojs.journal.fk.unpad.ac.id:article/3216 2025-05-20T08:19:17Z ijihs:ART

Association between Comorbidities and COVID-19 Mortality: a Cross-Sectional Study in a Community Health Center in Indonesia Sutaip, Sutaip Sutiningsih, Dwi Adi, Mateus Sakundarno Diyana, Sutra Rahayu, Siti Azizah Azzahra, Nur Andalusia Sarigando Banilai, Puti Giyantolin, Giyantolin Characteristics, Comorbidity, COVID-19; Risk Factors. Objective: To analyze the risk factors for mortality and comorbidity of COVID-19 patients in a public health center work area in Indonesia.Methods: This was a cross-sectional observational analytic quantitative study using secondary data of 820 confirmed COVID-19 cases in Brebes Public Health Center work area during the period of June 2020–December 2021. Univariate and bivariate analyses were used to analyze the obtained data statistically with a p-value of <0.005 considered significant.Results: Of the 820 confirmed COVID-19 patients, 85.1% recovered and 15.0% died. Analysis on the characteristics of these cases showed that 51.2% females and 48.8 %  males were included in this study, with 77.6% of them were <60 years old. No history of comorbidities was identified in 92.1% of the cases. In remaining cases with comorbidities, Diabetes Mellitus was recognized as the most prevalent (n=39, 4.8%).  Results of the Chi-Square test demonstrated that comorbidity status (p-value = 0.001), place of quarantine (p p=0.000 p>0.05), and diabetes (p=0.000, OR=2.87,  95% CI 19 1.24-0280) were significantly associated with mortality.Conclusion: Comorbidity status, diabetes, and the place quarantine are risk factors for mortality among COVID-19 confirmed cases, especially in Brebes Public Health Center work area. Thus, it is important to increase knowledge about COVID-19 prevention and risks to prevent transmission among those with higher risks for mortality. Further studies on factors related to sustainable supports for COVID-19 patients are also necessary. Faculty of Medicine Universitas Padjadjaran This publication was funded by the SEAOHUN Scholarship Program with the generous support of the American people through United States Agency for International Development (USAID) One Health Workforce - Next Generation (OHW-NG) Award 7200AA19CA00018. 2023-09-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.fk.unpad.ac.id/index.php/ijihs/article/view/3216 10.15850/ijihs.v11n2.3216 International Journal of Integrated Health Sciences; Vol 11, No 2 (2023); 99-106 International Journal of Integrated Health Sciences; Vol 11, No 2 (2023); 99-106 2338-4506 2302-1381 10.15850/ijihs.v11n2 eng https://journal.fk.unpad.ac.id/index.php/ijihs/article/view/3216/1855 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/3216/3906 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/3216/4140 Copyright (c) 2023 International Journal of Integrated Health Sciences http://creativecommons.org/licenses/by-nc/4.0

oai:ojs.journal.fk.unpad.ac.id:article/2377 2022-04-11T03:03:34Z ijihs:CR

Glioblastoma following Hemorrhagic Stroke: A Case Report Kevin, Kevin Yamamoto, Zulham Dewanto, Bayu Brain tumor; Glioblastoma; Hemorrhagic stroke Objective: To report a glioblastoma (GBM) case preceded by a hemorrhagic stroke.Methods: This case reported a 53-year-old male presenting at at Murni Teguh Memorial Hospital, Medan, Indonesia, with a chief complaint of an altered mental state. The condition had been worsened for two weeks. On anamnesis, he was identified to have  experienced intracerebral hemorrhage in January 2020. A follow-up head computed tomography scan was conducted in September 2020, showing a normal condition of the brain. Other oncogenic risk factors were not found. Due to convulsion in October 2020, the patient underwent a magnetic resonance imaging examination showing a cystic right temporoparietooccipital lesion and cerebral edema. Craniotomy tumor removal surgery was performed while the tumor was further examined for histopathological findings. The tumor was diagnosed as glioblastoma with microvascular proliferation and palisading necrosis.Results: There was some associations between hemorrhagic stroke and glioblastoma development.Conclusion: GBM preceded by hemorrhagic stroke is a rare case that can be diagnosed thoroughly by complete clinical and adjunct examinations. Faculty of Medicine Universitas Padjadjaran 2021-03-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.fk.unpad.ac.id/index.php/ijihs/article/view/2377 10.15850/ijihs.v9n1.2377 International Journal of Integrated Health Sciences; Vol 9, No 1 (2021); 36-41 International Journal of Integrated Health Sciences; Vol 9, No 1 (2021); 36-41 2338-4506 2302-1381 10.15850/ijihs.v9n1 eng https://journal.fk.unpad.ac.id/index.php/ijihs/article/view/2377/1606 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/2377/2462 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/2377/2463 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/2377/2464 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/2377/2465 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/2377/2466 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/2377/2467 Copyright (c) 2021 International Journal of Integrated Health Sciences http://creativecommons.org/licenses/by-nc/4.0

oai:ojs.journal.fk.unpad.ac.id:article/3105 2024-01-05T03:40:38Z ijihs:CR

Removal Technique of Penetrating Nail in Head: A Case Report Suhendar, Agus Effendy, Effendy Nails, head injury, surgery Objective: To present a unique case involving a 44-year-old man who sustained a penetrating head injury after nailing his head with a hammer. Despite the severity of his injury, the patient underwent successful surgical treatment and experienced a good recovery.Methods: Clinical and imagery review  was performed on a cranial puncture trauma caused by a metal nail, which penetrated the cranium, dura mater, right parietal cerebral parenchyma, and right ventricle. The nail was lodging next to midline without damaging the superior sagittal sinus. The patient underwent craniotomy nail removal and debridement with normal saline and metronidazole antibiotics.Results: Craniotomy, careful nail extraction, wound debridement, and duraplasty remain the treatment standard for penetrating nail injury in the head. Patient in this case study did not exhibit any signs of neurologic deficit or infection.Conclusion: Proper diagnosis and treatment are required in patients with penetrating brain trauma, with head x-rays and CT scans help in evaluating vascular depth and damage. Craniotomy and debridement are the main treatments for this type of trauma. Faculty of Medicine Universitas Padjadjaran 2023-03-31 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.fk.unpad.ac.id/index.php/ijihs/article/view/3105 10.15850/ijihs.v11n1.3150 International Journal of Integrated Health Sciences; Vol 11, No 1 (2023); 57-62 International Journal of Integrated Health Sciences; Vol 11, No 1 (2023); 57-62 2338-4506 2302-1381 10.15850/ijihs.v11n1 eng https://journal.fk.unpad.ac.id/index.php/ijihs/article/view/3105/1793 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/3105/3755 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/3105/3986 Copyright (c) 2023 International Journal of Integrated Health Sciences http://creativecommons.org/licenses/by-nc/4.0

oai:ojs.journal.fk.unpad.ac.id:article/3915 2024-11-25T05:49:22Z ijihs:ART

Differential White Blood Cell Count and COVID-19 Hospital Length of Stay: A Post-hoc Analysis Gustya, Gita Fajri Nugraha, Darrin Ananda Rakasiwi, Muhammad Ilham Dhiya Azzumar, Farchan Burhan, Erlina COVID-19, length of stay, monocyte, neutrophil, risk factor Objective: To explore the association between differential white blood cell count and hospital length of stay (LOS) in COVID-19 patients.Methods: This study is a post-hoc analysis of two prospective cohort studies involving hospitalized COVID-19 patients who received standard therapy, including antiviral and supportive treatments at Persahabatan Hospital, Jakarta, Indonesia, during the Delta and Omicron dominant pandemic periods. Baseline differential white blood cell count before initiation of therapy were documented. LOS was categorized as ≤10 days and >10 days.Result: Data from 463 subjects were included with most subjects were males (62.2%) with a median age of 54 (14–93) years. The average LOS for subjects was 12.7 (12.1–13.4) days. Bivariate tests showed that lymphocytes, neutrophils, monocytes, neutrophil-lymphocyte ratio (NLR), and neutrophil-monocyte ratio (NMR) had significant association (p <0.05) to LOS. Logistic regression showed that higher monocyte counts were associated with shorter LOS (adjusted OR 0.89; 95% CI 0.840 - 0.943; p < 0.001). ROC curve showed that higher monocyte counts (>8.35 × 10^3/µL) at admission may predict shorter hospitalization (<10 days).Conclusion: Monocyte count may serve as a potential marker for length of stay in COVID-19 patients, offering key insights for optimizing patient management and resource allocation. Faculty of Medicine Universitas Padjadjaran None 2024-09-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.fk.unpad.ac.id/index.php/ijihs/article/view/3915 10.15850/ijihs.v12.n2.3915 International Journal of Integrated Health Sciences; Vol 12, No 2 (2024); 125-132 International Journal of Integrated Health Sciences; Vol 12, No 2 (2024); 125-132 2338-4506 2302-1381 10.15850/ijihs.v12.n2 eng https://journal.fk.unpad.ac.id/index.php/ijihs/article/view/3915/2002 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/3915/4881 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/3915/4914 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/3915/4915 Copyright (c) 2024 International Journal of Integrated Health Sciences http://creativecommons.org/licenses/by-nc/4.0

oai:ojs.journal.fk.unpad.ac.id:article/4319 2025-12-04T07:27:58Z ijihs:ART

Relationship Between Blood Pressure and Intraocular Pressure in Patients at the Ophthalmology Clinic of Hospital X Jakarta, Indonesia Purwakusuma, Anindya Emiraryanti Batubara, Lilian Poerwanto, Eko Blood pressure; hypertension; intraocular pressure; ocular hypertension Background: Hypertension, a prevalent and often asymptomatic condition, has been associated with various ocular disorders. Ocular hypertension, in particular, is a notable risk factor for glaucoma. Understanding the relationship between systemic blood pressure and intraocular pressure is important for early detection of ocular hypertension and prevention of vision-threatening complications.Objective: To analyze the relationship between blood pressure and intraocular pressure, as well as the association between hypertension and ocular hypertension. Methods: This observational analytical study used secondary data from the medical records of 74 patients at the ophthalmology clinic of Hospital X Jakarta, collected between January and March 2023. The sample was selected using purposive sampling. Results: Hypertension was observed in 30 individuals (41%), including 19 females (26%) and 11 individuals aged 70–79 years (15%). Ocular hypertension was reported in 17 individuals (23%), with ten (10) females (14%) and nine (9) individuals aged 60–69 years (12%). Chi-Square analysis showed a significant relationship between blood pressure and intraocular pressure, with a p-value of 0.004 (p<α=0.05). In addition, Spearman's test showed correlations between systolic blood pressure and intraocular pressure in both the right eye (r=0.395; p=0.001) and the left eye (r=0.290; p=0.012). Additionally, there were correlations between diastolic blood pressure and intraocular pressure in the right eye (r=0.234; p=0.045) and the left eye (r=0.230; p=0.049).Conclusion: The relationship between blood pressure and intraocular pressure is found to be significant in this study, suggesting that higher blood pressure levels are associated with an increased risk of elevated intraocular pressure. Faculty of Medicine Universitas Padjadjaran 2025-10-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.fk.unpad.ac.id/index.php/ijihs/article/view/4319 10.15850/ijihs.v13n2.4319 International Journal of Integrated Health Sciences; Vol 13, No 2 (2025); 150-158 International Journal of Integrated Health Sciences; Vol 13, No 2 (2025); 150-158 2338-4506 2302-1381 10.15850/ijihs.v13n2 eng https://journal.fk.unpad.ac.id/index.php/ijihs/article/view/4319/2160 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/4319/5513 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/4319/5514 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/4319/5515 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/4319/5516 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/4319/5518 Copyright (c) 2025 International Journal of Integrated Health Sciences http://creativecommons.org/licenses/by-nc/4.0

oai:ojs.journal.fk.unpad.ac.id:article/839 2024-03-13T06:58:50Z ijihs:ART

Response of Long-Term Memory to Molecular Changes of BDNF in Hippocampus in Various Intensities of Physical Activity Lubis, Leonardo Setiawan, Setiawan Intensity, long-term memory, brain-derived neurotrophic factor, hippocampus Objective: To analyze the physiological response of long-term memory (LTM) to the molecular changes of brain-derived neurotrophic factor (BDNF) in the hippocampus by the treatment of various intensities of physical activity. Methods: Subjects were 7–8 week old male Wistar rats weighed between 201–250 grams. This study was an experimental study with pre-(day-1) and post-(day-14) design. Molecular changes reflected by the changes in the expression of mRNA and protein of BDNF in the hippocampus. Treatment of physical activity on the subjects was running on the Animal Treadmill by grouping of the physical activity: light intensity at a speed of 10 m/min, moderate intensity at a speed of 20 m/min and heavy intensity at a speed of 30 m/min. The treatment’s duration was 30 minutes.Then, analysis of data on pre (day-1) and post (day-14) which were: LTM response based on travel time swimming test, the expression of mRNA (Ct) and protein (%) of BDNF in hippocampus based on RT-PCR and immunohistochemistry. Results: The results showed that moderate intensity group caused the better physiological and molecular responses than the other groups, as follows: travel time (0.6260 vs 0.7270 vs 0.9400 vs. 1.4000 seconds (p<0.05)), mRNA BDNF expression (17.2320 vs 18.8800 vs 19.7540 vs 20.7750 Ct (p<0.05)), and hippocampal BDNF protein expression. Conclusions: The study conclude that the moderate intensity is the best physical activity to improve LTM as showed by the BDNF mRNA expression as well as BDNF protein in hippocampus. Keywords: Intensity, long-term memory, brain-derived neurotrophic factor, hippocampus DOI: 10.15850/ijihs.v4n2.839 Faculty of Medicine Universitas Padjadjaran 2016-09-28 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.fk.unpad.ac.id/index.php/ijihs/article/view/839 International Journal of Integrated Health Sciences; Vol 4, No 2 (2016); 67-72 International Journal of Integrated Health Sciences; Vol 4, No 2 (2016); 67-72 2338-4506 2302-1381 eng https://journal.fk.unpad.ac.id/index.php/ijihs/article/view/839/776 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/839/167 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/839/168 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/839/169 Copyright (c) 2016 International Journal of Integrated Health Sciences http://creativecommons.org/licenses/by-nc/4.0

oai:ojs.journal.fk.unpad.ac.id:article/2768 2023-11-02T04:47:31Z ijihs:ART

Correlation of Abdominal CT scan Score and Alpha-fetoprotein Levels in Hepatocellular Carcinoma Martani, Indira Prawita Sitanggang, Firman Margiani, Ni Widiana, I Gde Asih, Made Ayusta, I Made abdominal computed tomography; alpha fetoprotein; diffuse infiltrative; hepatocellular carcinoma. Objective: To assess the correlation between the Alpha-fetoprotein (AFP) level and characteristics of liver lesions listed in the abdominal computed tomography (CT) scan scores in hepatocellular carcinoma.Methods: This was a retrospective analytic observational study with a cross-sectional design conducted at Sanglah Hospital in January 2017–January 2021. Subjects were patients diagnosed with hepatocellular carcinoma based on clinical and laboratory features. Samples were taken by consecutive sampling. The results of the abdominal CT scan were read by two radiologists with a predetermined abdominal CT scan scoring system. The AFP level data were taken at a maximum of 5 days before an abdominal CT scan was performed.Results: A total of 64 subjects were included in this study. The mean serum AFP level was 1,000 IU/mL (range 0.54–61830 IU/mL). The mean abdominal CT scan score by examiner one was 10.093±5.59, while the examiner two provided a score of 10.281±5.45. The difference in mean CT scan scores between the two examiners was very low and insignificant (mean difference score -0.188; 95% CI -1.894–1.519). The rho Spearman value was 0.918 (p<0.001) between serum AFP levels and abdominal CT scan scores. In the partial correlation, the value of r=0.678 (p<0.001) was obtained after controlling for body mass index (BMI), age, and sex variables.Conclusions: There is a strong positive correlation between serum AFP levels and abdominal CT scan scores in hepatocellular carcinoma patients. Further research is needed with a prospective design to reduce research bias. Faculty of Medicine Universitas Padjadjaran 2022-09-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.fk.unpad.ac.id/index.php/ijihs/article/view/2768 10.15850/ijihs.v10n2.2768 International Journal of Integrated Health Sciences; Vol 10, No 2 (2022); 88–93 International Journal of Integrated Health Sciences; Vol 10, No 2 (2022); 88–93 2338-4506 2302-1381 eng https://journal.fk.unpad.ac.id/index.php/ijihs/article/view/2768/1747 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/2768/3319 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/2768/3378 Copyright (c) 2022 International Journal of Integrated Health Sciences http://creativecommons.org/licenses/by-nc/4.0

oai:ojs.journal.fk.unpad.ac.id:article/3788 2024-06-11T07:30:04Z ijihs:ART

Study of Clinical and Demographic Profile of Scrub Typhus Patients Admitted to a Tertiary Care Hospital in Central India Dahiphle, A. V. Achliya, Amit Chhajed, Neel Rode, Vikram Bhise, Kasturi Clinical Profile; Eschar; Multi-organ Dysfunction Syndrome; Scrub Typhus Objectives: To study epidemiological characteristics, clinical features, laboratory findings, and clinical outcomes in cases of scrub typhus. Additionally, the study aims to identify the predictors of disease severity.Methods: This cross-sectional study was conducted in the Department of General Medicine at Dr PDM Medical College in Amaravati, India. The study duration was 6 months, from July 2023 to December 2023. All clinically confirmed patients with scrub typhus were evaluated through history, clinical examination, and appropriate laboratory investigations. The clinical and laboratory profiles, hospital course, and outcomes were analyzed. Organ dysfunction upon admission was assessed using the sequential organ failure assessment (SOFA) score.Results: A total of 200 cases were included in the study. The majority of the cases were in the age range of 31-40 years, and most of them were males. The highest number of scrub typhus cases occurred in September. The most common presenting symptoms were fever (81%), followed by nausea (37.5%), generalized weakness (34%), abdominal pain, eschar (21.5%), breathlessness, and cough (21% each), headache (19%), vomiting (15%), and altered sensorium (4.5%). The majority of patients (72.5%) did not experience any complications, while 55 patients (27.5%) developed multi-organ dysfunction syndrome (MODS) as a complication. The mortality rate was 1%.Conclusion: Scrub typhus is a significant cause of acute febrile illness in the Vidarbha region of Maharashtra. It can present with various clinical manifestations, with or without an eschar. Early diagnosis and appropriate treatment of these cases can lead to minimal complications. Faculty of Medicine Universitas Padjadjaran 2024-03-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.fk.unpad.ac.id/index.php/ijihs/article/view/3788 10.15850/ijihs.v12.n1.3788 International Journal of Integrated Health Sciences; Vol 12, No 1 (2024); 24-30 International Journal of Integrated Health Sciences; Vol 12, No 1 (2024); 24-30 2338-4506 2302-1381 10.15850/ijihs.v12.n1 eng https://journal.fk.unpad.ac.id/index.php/ijihs/article/view/3788/1936 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/3788/4731 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/3788/4732 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/3788/4733 Copyright (c) 2024 International Journal of Integrated Health Sciences http://creativecommons.org/licenses/by-nc/4.0

oai:ojs.journal.fk.unpad.ac.id:article/4561 2025-12-04T07:27:54Z ijihs:ART

Diagnostic Utility of Claudin-4 Immunohistochemistry in Distinguishing Adenocarcinoma Cells from Reactive Mesothelial Cells in Effusion Cytology Ginnavaram, Mihira Pamu, Pramod Kumar Kesarapu, Swetha Ramakrishna, Narayanan Adenocarcinoma; claudin-4; effusion cytology; immunohistochemistry; mesothelial cells Background: Differentiating adenocarcinoma cells from reactive mesothelial cells in cases of effusion remains a diagnostic challenge due to overlapping morphological features. Claudin-4, a tight junction protein expressed in epithelial but absent in mesothelial cells, has emerged as a potential immunohistochemical (IHC) marker for this distinguishing between these cell types.Objective: to evaluate the diagnostic utility of Claudin-4 immunohistochemistry in differentiating adenocarcinoma cells from reactive mesothelial cells in effusion cytology.Methods: This prospective study was conducted at the Department of Pathology, Nizam’s Institute of Medical Sciences, Hyderabad, India, between June 2023 and December 2024. A total of 77 formalin-fixed paraffin-embedded cell block samples from effusion fluids (pleural, ascitic, and peritoneal) were analyzed. Inclusion criteria comprised cases diagnosed as malignant or reactive on cytology. Claudin-4 immunostaining was performed by using  EP417 clone. Sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of Claudine for differentiating malignant versus non-malignant effusion was calculated.Results: Out of the 77 studied cases, 57 were malignant and 20 were non-malignant. Claudin-4 showed positive membranous staining in 50/57 malignant cases (87.72%) and in none of the non-malignant cases (100% specificity). The PPV was 100%, and NPV was 74.10%. Pulmonary adenocarcinoma was the most common malignancy showing Claudin-4 positivity. Claudin demonstrated excellent specificity for diagnosis of malignant effusions. Conclusion: Claudin-4 immunohistochemistry is highly specific as a reliable marker for differentiating malignant cells from reactive mesothelial cells. Its high specificity and positive predictive value make it a valuable diagnostic tool. However, a negative Claudin-4 immunohistochemistry results should be interpreted cautiously, particularly in clinically suspicious cases. Faculty of Medicine Universitas Padjadjaran 2025-10-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.fk.unpad.ac.id/index.php/ijihs/article/view/4561 10.15850/ijihs.v13n2.4561 International Journal of Integrated Health Sciences; Vol 13, No 2 (2025); 82-88 International Journal of Integrated Health Sciences; Vol 13, No 2 (2025); 82-88 2338-4506 2302-1381 10.15850/ijihs.v13n2 eng https://journal.fk.unpad.ac.id/index.php/ijihs/article/view/4561/2151 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/4561/5897 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/4561/5898 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/4561/5899 Copyright (c) 2025 International Journal of Integrated Health Sciences http://creativecommons.org/licenses/by-nc/4.0

oai:ojs.journal.fk.unpad.ac.id:article/271 2022-02-16T07:15:58Z ijihs:ART

TYT Curve : Pilot Study on Alternatives Standards of Reference to Determine Intrauterine Growth in Low Resource Setting In Indonesia Judistiani, Tina Dewi Yuniaty, Tetty Natalia, Yessika Adelwin Objective: To develop a new intrauterine growth curve based on local population for accurate intrauterine growth retardation (IUGR) infant identification. Methods: An observational analytic method was applied to develop Tina-Yessika-Tetty (TYT) curve derived from 13,405 neonatal anthropometric measurements taken from the medical record database of Dr. Hasan Sadikin General Hospital, Bandung, Indonesia. The infants included in this study were born during the period of January 1st, 2005 to December 31st, 2009. The new curve was then compared to the Lubchenco and Alisjahbana curves. Only 6,814 data met the inclusion and exclusion criteria.    Results: The mean birth weight in this study was lower compared to that of the Lubchenco and Alisjahbana studies. Comparison of the three curves showed that there was a significant difference among the three curves (R=0.998, R2=0.996, p<0.001), which indicates a probability for a newborn classification.Conclusions: TYT curve may be used as an alternative to identify IUGR immediately after birth, especially when detection during pregnancy is not available in low resource setting. A prospective study with a larger population is needed; However, this study has provided an evidence to support the need for timely evaluation for such growth chart as they change over time.    Keywords: Alisjahbana curve, intrauterine growth, Lubchenco curve, TYT curveDOI: 10.15850/ijihs.v2n1.271 Faculty of Medicine Universitas Padjadjaran 2014-07-25 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.fk.unpad.ac.id/index.php/ijihs/article/view/271 International Journal of Integrated Health Sciences; Vol 2, No 1 (2014); 9-14 International Journal of Integrated Health Sciences; Vol 2, No 1 (2014); 9-14 2338-4506 2302-1381 eng https://journal.fk.unpad.ac.id/index.php/ijihs/article/view/271/276 Copyright (c) 2016 International Journal of Integrated Health Sciences

oai:ojs.journal.fk.unpad.ac.id:article/2595 2023-11-02T04:48:58Z ijihs:ART

Paraoxonase 1 Activities and Lipid Parameters in Hypertension and Their Association with Chronic Alcoholism Kumar, Sudeep Batra, Jyoti Sah, Sumesh Prasad Kumar, Dinesh Iqbal, Shahid Arora, Manisha Sharma, Shivani Alcoholism; antioxidants vitamins (E and C); hypertension; lipid parameter; MDA Objective: To determine lipid profile, antioxidant vitamin (E and C), and malondialdehyde (MDA) levels, as well as superoxide dismutase (SOD) levels and paraoxonase 1 (PON 1) activities in alcoholic hypertensive patients.Methods: Five hundred subjects were selected for this study consisting of 250 normal healthy individuals and 250 alcoholic hypertensive subjects. Total cholesterol, triglyceride, and HDL levels were measured using the enzymatic method while the LDL and VLDL levels were calculated by Friedwald equation. The MDA level were measured using thiobarbiturate (TBA) and the Vitamin E and C were measured using the enzymatic method. The SOD and PON 1 activities were measured using phenyl acetate as the substrate.Results: Total cholesterol, triglycerides, LDL, VLDL, and MDA levels were found to be significantly high while the HDL and Vitamin E and C levels decreased among the alcoholic hypertensive subjects when compared to the control. Furthermore, significant decreases in SOD and PON 1 activities were also found among the alcoholic hypertensive subjects as compared to control.Conclusion: Alterations in lipid parameters, antioxidant vitamin levels, MDA level, SOD activities, and PON 1 activities are associated with hypertension that may be enhanced by alcohol intake, which may lead to the development cardiovascular disease.  Faculty of Medicine Universitas Padjadjaran 2022-03-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.fk.unpad.ac.id/index.php/ijihs/article/view/2595 10.15850/ijihs.v10n1.2595 International Journal of Integrated Health Sciences; Vol 10, No 1 (2022); 7–11 International Journal of Integrated Health Sciences; Vol 10, No 1 (2022); 7–11 2338-4506 2302-1381 eng https://journal.fk.unpad.ac.id/index.php/ijihs/article/view/2595/1647 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/2595/2855 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/2595/2856 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/2595/2857 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/2595/2858 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/2595/2859 Copyright (c) 2022 International Journal of Integrated Health Sciences http://creativecommons.org/licenses/by-nc/4.0

oai:ojs.journal.fk.unpad.ac.id:article/3698 2024-06-11T07:30:03Z ijihs:ART

Modified Surgical Treatment for Achilles Tendon Rupture Secondary to Insertional Achilles Tendinopathy Using Midline Dorsal Approach Naik, Nagesh Rahate, Vaijanath Ghorpade, Kapil R. Patil, Jaydeep Patil, Shantanu Achilles Tendon Rupture; Functional Outcome; Midline Dorsal Approach; Surgical Management Objective: To assess the pain relief and functional outcomes of patients who undergo surgical management of Achilles tendon rupture secondary to insertional Achilles tendinopathy and associated conditions using a midline dorsal approach.Methods: This prospective observational study included 30 patients diagnosed with Achilles tendon rupture secondary to insertional Achilles tendinopathy. This study recorded risk factors, predisposing factors, and co-morbidities for all cases. Pain relief and functional improvement were assessed by comparing Visual Analogue Scale (VAS) scores and American Orthopedic Foot and Ankle Score (AOFAS) at the time of presentation and at the final follow-up. This study conducted statistical analysis using SPSS 21.0 software, with a significance level of p<0.05.Results: Of the participants, 17 (56.67%) were male and 13 (43.13%) were female, resulting in a male-to-female ratio of 1:0.76. The mean age of male and female patients was comparable (p=0.7515). The majority of patients (60%) were overweight, while 9 (30%) were obese, and 3 (10%) had a normal body mass index. This study observed a significant reduction in pain and functional improvement in the studied cases, as evidenced by a statistically significant reduction in VAS scores and improvements in AOFAS. Eight (26.66%) patients experienced minor complications that could be managed conservatively, but no major complications were observed.Conclusion: Modified surgical treatment of Achilles tendon rupture secondary to insertional Achilles tendinopathy using a midline dorsal approach leads to significant improvements in pain and functional outcomes, with an acceptable complication rate. Faculty of Medicine Universitas Padjadjaran 2024-03-31 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.fk.unpad.ac.id/index.php/ijihs/article/view/3698 10.15850/ijihs.v12.n1.3698 International Journal of Integrated Health Sciences; Vol 12, No 1 (2024); 1-9 International Journal of Integrated Health Sciences; Vol 12, No 1 (2024); 1-9 2338-4506 2302-1381 10.15850/ijihs.v12.n1 eng https://journal.fk.unpad.ac.id/index.php/ijihs/article/view/3698/1934 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/3698/4744 Copyright (c) 2024 International Journal of Integrated Health Sciences http://creativecommons.org/licenses/by-nc/4.0

oai:ojs.journal.fk.unpad.ac.id:article/2217 2023-11-02T04:49:52Z ijihs:ART

Global Longitudinal Strain of Chronic Granulocytic Leukemia Patients treated with Imatinib and Nilotinib Wijaya, Indra Sumarna, Arief Nurazizah, Eliza Susandi, Evan Martanto, Erwan Chronic granulocytic leukemia; global longitudinal strain; imatinib; Left Ventricular Ejection Fraction, nilotinib. Objective: To determine left ventricular function of patients with Chronic Granulocytic Leukemia in Chronic Phase (CGL-CP) who received imatinib and nilotinib by using Global Longitudinal Strain (GLS) examination.Methods: This was a descriptive study involving 46 CGL-CP patients who received imatinib and nilotinib therapy at the Hemato-Oncology Clinic of the Internal Medicine Departement of Dr. Hasan Sadikin General Hospital,, Bandung, Indonesia. Sampling was performed consecutively during the period of October to December 2019. Variables assessed in this study were age, gender, BMI, length of treatment, hemoglobin level, Left Ventricular Ejection Fraction (LVEF) value, and Global Longitudinal Strain (GLS). Primary data were tested for normality  using the Saphiro-Wilk test. Statistical analysis was performed using SPSS software version 25.0.Results: Thirty-nine patients (seventeen males and twenty-two females with a mean age of 42±11) who had been in therapy for about 8 to 179 months at the time of the study were included as subjects. On average, the GLS results for both treatment groups indicated a normal value based on the classification of the American Society of Echocardiography. The imatinib group gained a score of -22.4% (average range = -16.4% to (-28.1%)), while the nilotinib group gained a score of -21.6% (average range = -18.0% to (-25.9%)). Conclusion: This study described the left ventricular function based on results of GLS in CGL-CP patients receiving imatinib and nilotinib. Faculty of Medicine Universitas Padjadjaran 2021-10-19 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.fk.unpad.ac.id/index.php/ijihs/article/view/2217 10.15850/ijihs.v9n2.2217 International Journal of Integrated Health Sciences; Vol 9, No 2 (2021); 49-54 International Journal of Integrated Health Sciences; Vol 9, No 2 (2021); 49-54 2338-4506 2302-1381 10.15850/ijihs.v9n2 eng https://journal.fk.unpad.ac.id/index.php/ijihs/article/view/2217/1638 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/2217/2778 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/2217/2779 Copyright (c) 2021 International Journal of Integrated Health Sciences http://creativecommons.org/licenses/by-nc/4.0

oai:ojs.journal.fk.unpad.ac.id:article/3457 2025-05-20T08:19:17Z ijihs:ART

Comparative Evaluation of Effectiveness of Rocuronium Bromide vs. Succinyl Choline on Quality of Intubating Conditions during General Anesthesia Burkul, Aditi Memon, Nazima Kulkarni, Vaishnavi Intubation; Muscle Relaxants; Rucuronium; Succinylcholine Objectives: To compare the quality of intubating conditions and hemodynamic responses to the administration of Rocuronium Bromide and Succinyl Choline during general anesthesia.Methods: This was a comparative study conducted at the anesthesiology department of a tertiary care medical college. Sixty patients undergoing various surgeries under general anesthesia were included in this study based on predefined inclusion and exclusion criteria. Patients were divided into Group S (receiving succinylcholine) and Group R (receiving rocuronium). In all patients, the quality of intubating conditions was assessed. Excellent or good conditions were considered to be acceptable intubating conditions, whereas fair and poor conditions were considered unacceptable.Results: Mean age, weight, gender distribution, and ASA grades were comparable in both groups. The overall quality of intubation was found to be better in group S than in group R, and the difference was statistically significant (P=0.004). The duration of action was significantly longer in group R than in group S (P<0.001). Hemodynamic stability was comparable in both the groups, except for heart rate at 10 min, which was higher in Group R than in Group S. Incidence of fasciculation was significantly more in Group S as compared to Group R, and the difference was found to be highly significant (P=0.0001).Conclusion: Succinylcholine for rapid sequence intubation is associated with better intubation conditions than rocuronium. Faculty of Medicine Universitas Padjadjaran 2023-09-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.fk.unpad.ac.id/index.php/ijihs/article/view/3457 10.15850/ijihs.v11n2.3457 International Journal of Integrated Health Sciences; Vol 11, No 2 (2023); 70-78 International Journal of Integrated Health Sciences; Vol 11, No 2 (2023); 70-78 2338-4506 2302-1381 10.15850/ijihs.v11n2 eng https://journal.fk.unpad.ac.id/index.php/ijihs/article/view/3457/1851 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/3457/4383 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/3457/4384 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/3457/4385 Copyright (c) 2023 International Journal of Integrated Health Sciences http://creativecommons.org/licenses/by-nc/4.0

oai:ojs.journal.fk.unpad.ac.id:article/4325 2025-08-01T02:32:07Z ijihs:ART

Impact of Chronic Smoking on Choroidal Thickness: A Comparative Analysis Using Optical Coherence Tomography Mazumdar, Ranabir Maulik, Subhamitra Wasim, Nazir Abdul Choroidal thickness; smoking; optical coherence tomography; vascular compromise Background: Chronic smoking has systemic vascular effects, including alterations in ocular blood flow and choroidal thickness, impacting visual health.Objective: To compare choroidal thickness (CT) in chronic smokers and nonsmokers using optical coherence tomography and to evaluate the effect of smoking duration on CT based on pack-year quartiles (PYQ).Methods: This was a case-control study conducted at the Regional Institute of Ophthalmology, Medical College, Kolkata, India between January 2023 and June 2024. Choroidal thickness was assessed in 120 cases (60 smokers and 60 nonsmokers) over a period of 18 months. Choroidal thickness was measured using Enhanced Depth Imaging Spectral-Domain Optical Coherence Tomography (EDI SD-OCT) at the sub foveal region and 1.5 mm away in the superior, inferior, nasal, and temporal directions. CT between smokers and nonsmokers was compared.  Statistical analysis was performed using the SPSS 23.0 software and a p-value of less than 0.05 was taken as statistically significant.Results: The study analyzed age distribution, ocular parameters, and choroidal thickness in 60 smokers and 60 nonsmokers. The mean age in smokers and nonsmokers was found to be 43.1 ± 7.2 and 40.8 ± 11.4 years respectively. Smokers were found to have a significantly lower sub foveal CT compared to nonsmokers (272.42 ± 13.57 µm vs. 284.94 ± 14.15 µm, p<0.05). Increased smoking exposure significantly correlated with progressive choroidal thinning (p<0.05). Other ocular parameters, such as intraocular pressure (p=0.235) and axial length (p=1.0), were found to be comparable in both groups (p>0.05).Conclusion: There significant choroidal thinning in chronic smokers as compared to nonsmokers with a dose-dependent effect linked to higher smoking exposure. These findings suggest a smoking-induced vascular compromise in the choroid. Faculty of Medicine Universitas Padjadjaran 2025-04-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://journal.fk.unpad.ac.id/index.php/ijihs/article/view/4325 10.15850/ijihs.v13n1.4325 International Journal of Integrated Health Sciences; Vol 13, No 1 (2025); 22-28 International Journal of Integrated Health Sciences; Vol 13, No 1 (2025); 22-28 2338-4506 2302-1381 10.15850/ijihs.v13.n1 eng https://journal.fk.unpad.ac.id/index.php/ijihs/article/view/4325/2076 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/4325/5548 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/4325/5549 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/4325/5550 https://journal.fk.unpad.ac.id/index.php/ijihs/article/downloadSuppFile/4325/5551 Copyright (c) 2025 International Journal of Integrated Health Sciences http://creativecommons.org/licenses/by-nc/4.0 c67e1848a01c2cc03d493f7c7e361c0e